CN103338756B - 药物剂型 - Google Patents

药物剂型 Download PDF

Info

Publication number
CN103338756B
CN103338756B CN201180066162.XA CN201180066162A CN103338756B CN 103338756 B CN103338756 B CN 103338756B CN 201180066162 A CN201180066162 A CN 201180066162A CN 103338756 B CN103338756 B CN 103338756B
Authority
CN
China
Prior art keywords
pharmaceutical dosage
dosage form
polymer
layer
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201180066162.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN103338756A (zh
Inventor
R·P·谢赫
V·皮莱
Y·E·库纳拉
L·C·杜图伊托
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of the Witwatersrand, Johannesburg
Original Assignee
University of the Witwatersrand, Johannesburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of the Witwatersrand, Johannesburg filed Critical University of the Witwatersrand, Johannesburg
Publication of CN103338756A publication Critical patent/CN103338756A/zh
Application granted granted Critical
Publication of CN103338756B publication Critical patent/CN103338756B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201180066162.XA 2010-11-26 2011-11-28 药物剂型 Expired - Fee Related CN103338756B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ZA2010/03740 2010-11-26
ZA201003740 2010-11-26
PCT/IB2011/055331 WO2012070028A1 (en) 2010-11-26 2011-11-28 A pharmaceutical dosage form

Publications (2)

Publication Number Publication Date
CN103338756A CN103338756A (zh) 2013-10-02
CN103338756B true CN103338756B (zh) 2016-03-02

Family

ID=46145444

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180066162.XA Expired - Fee Related CN103338756B (zh) 2010-11-26 2011-11-28 药物剂型

Country Status (6)

Country Link
US (1) US9808418B2 (https=)
EP (1) EP2646006B1 (https=)
JP (1) JP5912126B2 (https=)
CN (1) CN103338756B (https=)
WO (1) WO2012070028A1 (https=)
ZA (1) ZA201304709B (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103611187A (zh) * 2013-11-15 2014-03-05 无锡中科光远生物材料有限公司 一种时序性释放药物的组织工程支架的制备方法
WO2015186108A1 (en) * 2014-06-05 2015-12-10 University Of The Witwatersrand, Johannesburg 2 layers tablet oral dosage form for various drug release
CZ308594B6 (cs) * 2014-09-29 2020-12-23 VÝZKUMNÝ ÚSTAV VETERINÁRNÍHO LÉKAŘSTVÍ, v.v.i. Mukoadhezivní nosiče částic, způsob přípravy a použití
AU2016258179B2 (en) 2015-05-06 2021-07-01 Synagile Corporation Pharmaceutical suspensions containing drug particles, devices for their administration, and methods of their use
WO2017024237A1 (en) * 2015-08-06 2017-02-09 The Johns Hopkins University Composition and method for treatment of metabolic disorders
CN106822007B (zh) 2015-09-11 2021-12-31 西姆莱斯股份公司 口服制剂
US11129798B2 (en) * 2016-08-19 2021-09-28 Aron H. Blaesi Fibrous dosage form
US12194158B2 (en) 2016-01-27 2025-01-14 Instar Technologies A.S. Oromucosal nanofiber carriers for therapeutic treatment
US12427121B2 (en) 2016-05-05 2025-09-30 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
KR20230137362A (ko) 2016-05-05 2023-10-04 어퀘스티브 테라퓨틱스, 아이엔씨. 강화된 전달 에프네프린 조성물
US12433850B2 (en) 2016-05-05 2025-10-07 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine and prodrug compositions
GB201614100D0 (en) * 2016-08-17 2016-09-28 Globalacorn Ltd Carriers
KR102592782B1 (ko) 2017-01-23 2023-10-20 에이에프와이엑스 테라퓨틱스 에스에이 전기방사 섬유에 기반한 2층 제품의 제조 방법
IL268185B2 (en) * 2017-01-23 2024-01-01 Afyx Therapeutics As Method for preparing electrospun fibers with a high content of a bioadhesive substance
CN107184560B (zh) * 2017-06-03 2021-02-02 寿光富康制药有限公司 二甲双胍胃滞留片及制备方法
EP3634507B1 (en) * 2017-06-07 2025-01-15 EGY-Nano Pharma, LP Oral prolonged drug delivery platforms
EP3687508A1 (en) * 2017-09-26 2020-08-05 Aquestive Therapeutics, Inc. Delivery pharmaceutical compositions including permeation enhancers
GB2572566B (en) * 2018-04-03 2022-01-12 Zewail City Of Science And Tech Wound healing system comprising layers of nanofiber matrices separately carrying a mucoadhesive, a drug and a moisture indicator, and use thereof
CN108589045B (zh) * 2018-04-10 2021-06-08 华南理工大学 一种负载益生元和/或益生菌的纳米纤维膜及制备与应用
JP7040418B2 (ja) * 2018-11-21 2022-03-23 株式会社村田製作所 錠剤
US12194294B2 (en) * 2019-01-29 2025-01-14 The Regents Of The University Of California Oral drug delivery devices and methods using iontophoresis
CN109908108B (zh) * 2019-03-15 2022-05-03 深圳市光远生物材料有限责任公司 一种载药纳米复合纤维膜系统及其制备方法和应用
EP3968980A1 (en) 2019-05-14 2022-03-23 Clexio Biosciences Ltd. Treatment of nocturnal symptoms and morning akinesia in subjects with parkinson's disease
KR20220016149A (ko) * 2019-05-29 2022-02-08 미쯔비시 케미컬 주식회사 나노 메쉬 적층체, 도전 회로의 제조 방법, 및 나노 메쉬 첩부 키트
CN112107559B (zh) * 2019-06-20 2023-09-08 普济生物科技（台州）有限公司 口腔透粘膜药物剂型
CN110934894B (zh) * 2019-12-09 2021-11-30 西南交通大学 一种载两歧双歧杆菌的抗肿瘤纤维局部埋植剂及其制备方法和应用
AU2021214417B2 (en) * 2020-01-31 2023-11-02 Havas, Thomas Ernest ASSOC PROF Drug delivery device
CN115843240B (zh) 2020-05-11 2026-04-17 西姆莱斯股份公司 固体粘膜粘附组合物
ES2876401B2 (es) * 2020-05-11 2024-04-05 Bioinicia S L Parches auto-adhesivos de fibras para la liberación controlada de bioactivos
KR20220010658A (ko) * 2020-07-17 2022-01-26 엠엑스바이오 주식회사 의료용 나노 섬유 필름
WO2022195476A1 (en) 2021-03-15 2022-09-22 Clexio Biosciences Ltd. Gastroretentive devices for assessment of intragastric conditions
JP7611783B2 (ja) * 2021-04-21 2025-01-10 順也 藤森 フィトケミカル組成物の製造方法
EP4422607A4 (en) 2021-10-25 2025-09-03 Aquestive Therapeutics Inc ORAL AND NASAL COMPOSITIONS AND METHODS OF TREATMENT
CN114287634B (zh) 2022-01-07 2022-08-19 东北农业大学 包埋益生菌的阿拉伯胶复合纤维/胶囊及其制备方法和应用
CN121668141A (zh) * 2023-07-12 2026-03-17 哈尔滨商业大学 一种胃滞留形状记忆复合膜

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032172A1 (en) * 1998-11-27 2000-06-08 Kanji Takada An oral formulation for gastrointestinal drug delivery
WO2004041118A2 (en) * 2002-10-31 2004-05-21 Umd, Inc. Therapeutic compositions for drug delivery to and through covering epithelia
WO2009153633A1 (en) * 2008-06-19 2009-12-23 University Of Witwatersrand, Johannesburg Pharmaceutical dosage form for the site-specific delivery of more than one active pharmaceutical ingredient

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001054667A1 (en) 2000-01-28 2001-08-02 Smithkline Beecham Corporation Electrospun pharmaceutical compositions
EP1542662A1 (en) * 2002-09-28 2005-06-22 McNEIL-PPC, INC. Immediate release dosage form comprising shell having openings therein
JP5600005B2 (ja) 2007-09-05 2014-10-01 太陽化学株式会社 水溶性電界紡糸シート
US20110305768A1 (en) 2008-07-01 2011-12-15 The Johns Hopkins University Quick-dissolving oral thin film for targeted delivery of therapeutic agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032172A1 (en) * 1998-11-27 2000-06-08 Kanji Takada An oral formulation for gastrointestinal drug delivery
WO2004041118A2 (en) * 2002-10-31 2004-05-21 Umd, Inc. Therapeutic compositions for drug delivery to and through covering epithelia
WO2009153633A1 (en) * 2008-06-19 2009-12-23 University Of Witwatersrand, Johannesburg Pharmaceutical dosage form for the site-specific delivery of more than one active pharmaceutical ingredient

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Electrospinning Nanofibers of Polyaniline and Polyaniline / (Polystyrene and Polyethylene Oxide) Blends;Manuel J. Díaz-de León et al.;《Proceeding of The National Conference On Undergraduate Research (NCUR)》;20010317;全文 *
Electrospun Nanofibers Bundles;Daoheng Sun et al.;《Proceedings of the 1st IEEE International Conference on Nano/Micro Engineered and Molecular Systems》;20060121;第1322－1326页 *
Gastrointestinal mucoadhesive patch system (GI-MAPS) for oral administration of G-CSF, a model protein;S. Eiamtrakarn et al.;《Biomaterials》;20021231;第23卷;145–152 *

Also Published As

Publication number Publication date
JP2013544259A (ja) 2013-12-12
US20130337022A1 (en) 2013-12-19
EP2646006A1 (en) 2013-10-09
WO2012070028A1 (en) 2012-05-31
EP2646006B1 (en) 2015-02-25
US9808418B2 (en) 2017-11-07
ZA201304709B (en) 2015-03-25
EP2646006A4 (en) 2014-06-25
JP5912126B2 (ja) 2016-04-27
CN103338756A (zh) 2013-10-02

Similar Documents

Publication Publication Date Title
CN103338756B (zh) 药物剂型
Gaydhane et al. Electrospun nanofibres in drug delivery: advances in controlled release strategies
KR101386096B1 (ko) 음이온성 단백질 약물 전달을 위한 키토산 나노섬유, 그 제조방법 및 그 키토산 나노섬유를 포함하는 경점막 투여제
Torres-Martínez et al. Drugs loaded into electrospun polymeric nanofibers for delivery
Sinha et al. Bioabsorbable polymers for implantable therapeutic systems
CN113825495A (zh) 用于智能释放的不可注射水凝胶调配物
CN101415442B (zh) 控释凝胶
CN112107559B (zh) 口腔透粘膜药物剂型
TWI619517B (zh) 凝膠組成物及凝膠組成物的製造方法
EP3295932A2 (en) Stable odf composition containing hardly soluble therapeutic agent
Cheaburu-Yilmaz et al. Polysaccharide containing gels for pharmaceutical applications
WO2007102447A1 (ja) 付着型マイクロカプセル
Esuendale et al. Cellulosic on transdermal drug delivery system: a review
KR20210121576A (ko) 고분자 마이크로 입자, 고분자 마이크로 입자의 제조방법, 이를 포함하는 의료용 조성물, 미용 조성물, 의료 용품 및 미용 용품
EP3494970A2 (en) Hardly soluble therapeutic agents belonging to bcs class ii or iv suspended in the liquid formulation and/or in the final nanofibrous structure
CN105828812A (zh) 胃内滞留口服药物组合物
Sabareesh et al. Nanoparticles Loaded Mucoadhesive Buccal Patches-Review
Vijayakumar et al. Drug carriers, polymers as: Synthesis, characterization, and in vitro evaluation
MANFREDI et al. The use of electrospinning in the development of systems for buccal drug delivery: a review
More et al. THIS ARTICLE PRESENTS ON: OVERVIEW OF VARIOUS POLYMERS UTILIZED IN PHARMACEUTICAL DRUG DELIVERY SYSTEMS
Sharma et al. ELECTROSPUN POLYMERIC NANOFIBER FOR SUBLINGUAL DRUG DELIVERY-A REVIEW
Khatri et al. Pharmaceutical Considerations of Nasal In-Situ Gel As A Drug Delivery System
Chandrasekar et al. AN EXTENSIVE REVIEW ON MUCOADHESIVE MICROSPHERES AS CARRIERS IN DRUG DELIVERY
Wang Research progress of buccal mucosal bioadhesive materials
CN108704142B (zh) 一种生物降解高分子药物缓释材料及其制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20160302

Termination date: 20191128

CF01 Termination of patent right due to non-payment of annual fee