CN103328497A - 环孢菌素类似物 - Google Patents

环孢菌素类似物 Download PDF

Info

Publication number
CN103328497A
CN103328497A CN2011800596461A CN201180059646A CN103328497A CN 103328497 A CN103328497 A CN 103328497A CN 2011800596461 A CN2011800596461 A CN 2011800596461A CN 201180059646 A CN201180059646 A CN 201180059646A CN 103328497 A CN103328497 A CN 103328497A
Authority
CN
China
Prior art keywords
cyclosporin
sar
methyl
ethyl
chr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800596461A
Other languages
English (en)
Chinese (zh)
Inventor
W·R·卡林
C·S·V·弗里德里希
M·E·贾斯特
M·E·斯特恩
C·S·绍姆博格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of CN103328497A publication Critical patent/CN103328497A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Analytical Chemistry (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN2011800596461A 2010-10-12 2011-10-11 环孢菌素类似物 Pending CN103328497A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39244910P 2010-10-12 2010-10-12
US61/392,449 2010-10-12
PCT/US2011/055791 WO2012051194A1 (en) 2010-10-12 2011-10-11 Cyclosporin analogs

Publications (1)

Publication Number Publication Date
CN103328497A true CN103328497A (zh) 2013-09-25

Family

ID=44883784

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800596461A Pending CN103328497A (zh) 2010-10-12 2011-10-11 环孢菌素类似物

Country Status (13)

Country Link
US (3) US20120088734A1 (https=)
EP (1) EP2627664B1 (https=)
JP (2) JP5805774B2 (https=)
KR (1) KR20140026329A (https=)
CN (1) CN103328497A (https=)
AU (1) AU2011316690C1 (https=)
BR (1) BR112013008864A2 (https=)
CA (1) CA2814192A1 (https=)
IL (1) IL225617A0 (https=)
MX (1) MX2013004061A (https=)
RU (1) RU2013119869A (https=)
SG (1) SG189880A1 (https=)
WO (1) WO2012051194A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022193482A1 (zh) * 2021-03-18 2022-09-22 北京大学深圳研究生院 环孢素衍生物的合成方法
CN118834148A (zh) * 2024-09-20 2024-10-25 天津凯莱英制药有限公司 一种l-青霉胺的制备方法

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9573978B2 (en) 2010-08-12 2017-02-21 S&T Global, Inc. Cyclosporin derivatives for the treatment and prevention of a viral infection
MX2013004062A (es) 2010-10-12 2013-07-22 Allergan Inc Analogos de ciclosporina.
BR112013008864A2 (pt) * 2010-10-12 2016-06-28 Allergan Inc análogos d ciclosporina
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
WO2012079172A1 (en) * 2010-12-15 2012-06-21 Isotechnika Pharma Inc. Cyclosporine analogue molecules modified at amino acid 1 and 3
JP2015519368A (ja) * 2012-06-01 2015-07-09 アラーガン インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンａ類似体
GB201222455D0 (en) * 2012-12-13 2013-01-30 Perioc Ltd Novel pharmaceutical formulations and their use in the treatment of periodontaldisease
WO2014138425A1 (en) 2013-03-08 2014-09-12 Allergan, Inc. Cyclosporine a-steroid conjugates
US9914755B2 (en) 2015-01-08 2018-03-13 Allergan, Inc. Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized
US10077289B2 (en) 2015-03-31 2018-09-18 Allergan, Inc. Cyclosporins modified on the MeBmt sidechain by heterocyclic rings
CN109476705B (zh) * 2016-05-17 2024-02-27 美国科技环球有限公司 新型环孢菌素衍生物及其用途
US10610104B2 (en) 2016-12-07 2020-04-07 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
EP3554346B1 (en) 2016-12-14 2024-01-31 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with an immunosuppressant
WO2019246312A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
WO2021173474A1 (en) * 2020-02-26 2021-09-02 Bacainn Biotherapeutics, Ltd. Cyclosporine compositions and methods of use
EP4724081A2 (en) * 2023-06-08 2026-04-15 Hepion Pharmaceuticals, Inc. Solid state forms of rencofilstat

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101130058A (zh) * 2006-08-23 2008-02-27 华北制药集团新药研究开发有限责任公司 一种环孢菌素a眼用乳剂及其制备方法
CN101511357A (zh) * 2006-05-19 2009-08-19 西尼克斯公司 治疗和预防眼部疾病的方法
CN101687013A (zh) * 2007-05-04 2010-03-31 阿勒根公司 环孢菌素在治疗具有人工晶状体的患者中的用途

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (en) 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
US4839342A (en) 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
US5474979A (en) 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
FR2757522B1 (fr) 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757521B1 (fr) 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2762843B1 (fr) * 1997-04-30 1999-12-10 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
PT1086124E (pt) * 1998-06-12 2004-04-30 Chem Ag C Ciclosporinas novas
US6254860B1 (en) * 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
US20050059583A1 (en) * 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US7676680B2 (en) 2005-07-08 2010-03-09 Morgan Stanley Systems and methods for distributing private placement documents
US7288520B2 (en) 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
KR20110031973A (ko) * 2008-07-10 2011-03-29 알러간, 인코포레이티드 눈 및 피부의 질환 및 상태를 치료하기 위한 사이클로스포린 유도체
TWI564475B (zh) * 2010-07-02 2017-01-01 艾克頌美孚上游研究公司 低排放之三循環動力產生系統和方法
US8902844B2 (en) 2010-07-06 2014-12-02 Lg Electronics Inc. Method and device for allocating wireless resources for a machine type communication device in a wireless communication system
BR112013008864A2 (pt) * 2010-10-12 2016-06-28 Allergan Inc análogos d ciclosporina
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
PT2646043T (pt) * 2010-12-03 2017-05-09 S&T Global Inc Novos derivados ciclosporina para o tratamento e prevenção de uma infeção viral
CN103987399A (zh) * 2011-08-19 2014-08-13 美国科技环球有限公司 用于治疗和预防病毒感染的新型环孢菌素衍生物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101511357A (zh) * 2006-05-19 2009-08-19 西尼克斯公司 治疗和预防眼部疾病的方法
CN101130058A (zh) * 2006-08-23 2008-02-27 华北制药集团新药研究开发有限责任公司 一种环孢菌素a眼用乳剂及其制备方法
CN101687013A (zh) * 2007-05-04 2010-03-31 阿勒根公司 环孢菌素在治疗具有人工晶状体的患者中的用途

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022193482A1 (zh) * 2021-03-18 2022-09-22 北京大学深圳研究生院 环孢素衍生物的合成方法
US11840582B2 (en) 2021-03-18 2023-12-12 Peking University Shenzhen Graduate School Synthesis method of cyclosporine derivatives
CN118834148A (zh) * 2024-09-20 2024-10-25 天津凯莱英制药有限公司 一种l-青霉胺的制备方法
CN118834148B (zh) * 2024-09-20 2025-01-21 天津凯莱英制药有限公司 一种l-青霉胺的制备方法

Also Published As

Publication number Publication date
JP2013540776A (ja) 2013-11-07
JP2016029050A (ja) 2016-03-03
AU2011316690C1 (en) 2017-01-19
JP5805774B2 (ja) 2015-11-10
US20150065433A1 (en) 2015-03-05
IL225617A0 (en) 2013-06-27
KR20140026329A (ko) 2014-03-05
BR112013008864A2 (pt) 2016-06-28
SG189880A1 (en) 2013-06-28
RU2013119869A (ru) 2014-11-20
MX2013004061A (es) 2013-07-22
US20170029469A1 (en) 2017-02-02
WO2012051194A1 (en) 2012-04-19
US9493511B2 (en) 2016-11-15
US20120088734A1 (en) 2012-04-12
CA2814192A1 (en) 2012-04-19
EP2627664B1 (en) 2018-04-04
EP2627664A1 (en) 2013-08-21
AU2011316690B2 (en) 2016-07-07
JP6250608B2 (ja) 2017-12-20
AU2011316690A1 (en) 2013-05-02
US10065992B2 (en) 2018-09-04

Similar Documents

Publication Publication Date Title
CN103328497A (zh) 环孢菌素类似物
US10077289B2 (en) Cyclosporins modified on the MeBmt sidechain by heterocyclic rings
CN103261212A (zh) 环孢菌素类似物
US9266927B2 (en) Cyclosporin A analogs
JP2023098936A (ja) 新規ペプチド及びその新規ペプチドを活性成分として含む眼疾患の治療のための医薬組成物
HK1189898A (en) Cyclosporin analogs
CA3119921C (en) Peptides and pharmaceutical compositions for treating eye diseases
HK1188459A (en) Cyclosporin analogs
HK40061089B (zh) 用於治疗眼病的肽和药物组合物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1189898

Country of ref document: HK

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20130925

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1189898

Country of ref document: HK