CN1033211C - 脉络宁静脉注射液的工艺方法 - Google Patents

脉络宁静脉注射液的工艺方法 Download PDF

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CN1033211C
CN1033211C CN 92107848 CN92107848A CN1033211C CN 1033211 C CN1033211 C CN 1033211C CN 92107848 CN92107848 CN 92107848 CN 92107848 A CN92107848 A CN 92107848A CN 1033211 C CN1033211 C CN 1033211C
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顾亚夫
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Jinting Pharmaceutical Co., Ltd.
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JINLING PHARMACEUTICAL FACTORY NANJING
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Abstract

本发明提供了一种制取脉络宁静脉注射液的工艺方法，其特征在于：将金银花、牛膝、玄参、石斛四味药按重量计为：金银花10-40%，牛膝15-35%，玄参40-15%，石斛35-10%的比例配伍后，加水浸煮，将煎液浓缩成半固体状，以乙醇淀析，醇液回收乙醇后用醋酸乙酯抽提，提取液用蒸馏水转溶，滤取水溶液加适量吐温-80及20%NaOH溶液调节其pH值至8.5～9.0，即得成品。本发明所提供工艺方法，工艺设备及流程简单，经济，所制得的药品对血栓性疾病疗效显著。

Description

本发明涉及一种医药卫生技术领域中制备脉络宁静脉注射液的工艺方法。
脉络宁静脉注射液是治疗血栓性疾病的一种理想药品，而其制备工艺的复杂与困难是人们一直所要解决的问题。
本发明提供了制备脉络宁静脉注射液的工艺方法，其目的是通过如下方案实现的。根据中医清热养阴、活血化瘀的理论，首先，将金银花、牛膝、玄参、石斛按重量比为：金银花10-40％、牛膝15-35％、玄参40-15％、石斛35-10％的比例配伍并充分混合后放置于反应釜内加水浸煮，沸腾后持续一段时间，热滤过取出清液，再加入煎煮一次，将两次煎液合并，并浓缩至半固体状，然后加乙醇淀析，使最终含醇量为70-75％，静置数小时后以倾倒法取出醇液，常压回收乙醇，使醇液浓缩至原体积的三分之一，再将醇浓缩液以水浴或蒸汽夹套蒸法驱尽余醇，接着以醋酸乙酯萃取7-10次，合并萃取液，回收醋酸乙酯，以水浴蒸尽余留的醋酸乙酯，将醋酸乙酯提取物以总生药量的1/10容积，加新鲜蒸馏水，充分搅拌法使溶解于水的物质转溶于水后，在0℃条件下冷藏12小时，减压滤过，取其澄清液，最后在澄清液中加入0.8％～1.0％容积比的吐温-80，并以20％NaOH溶液调节pH值至指示pH＝8.5～9.0，即得到成品。
本发明经过多年临床观察及药理，药效和生化方面实验研究证明有扩张血管、改善微循环、增加血流量及抗凝血、溶血栓等作用。适用于血栓闭塞性脉管、血栓性静脉炎、脑血栓形成及后遗症等血栓性疾病。经临床长期使用，无一例发生毒副作用。
本发明的最佳实施例为：以金银花25％、牛膝25％、玄参25％、石斛25％配制比例配制的脉络宁静脉注射液，用于血栓闭塞性脉管炎157例，治愈率48.40％，显效率45.85％，总有效率97.50％。高位截肢率2.2％，远期效果优良率71.1％；用于脑血栓形成及后遗症52例，基本治愈率20.5％，显效率38.5％，好转率30.8％，总有效率84.74％。

Claims (2)

1.一种由金银花、牛膝、玄参、石斛四味药制备脉络宁静脉注射液的工艺方法，其特征在于：
a、将金银花、牛膝、玄参、石斛四味药按重量比为：
金银花10-40％，牛膝15-35％，玄参40-15％，石斛35-10％的比例配伍并充分混合；
b、加水浸煮，沸腾后取出清液，再次加水浸煮，沸腾后取出清液；
c、将两次煎液合并，并浓缩至半固体状；
d、加乙醇淀析，静止数小时后以倾倒法取出醇液；
e、常压回收乙醇，浓缩至原体积的三分之一，以水浴或蒸汽夹套蒸法，驱尽余醇；
f、以醋酸乙酯萃取7～10次，合并萃取液，回收醋酸乙酯，以水浴蒸尽余留溶剂；
g、醋酸乙酯提取物以总生药量重1/10容积加新鲜蒸馏水，充分搅拌，使溶解于水的物质转溶于水，0℃冷藏12小时，减压滤过，取其澄清液；
h、在水溶液中加入0.8～1.0％体积比的吐温-80，并以20％NaOH溶液调节pH值至pH＝8.5～9.0。
2.根据权利要求1所述的脉络宁静脉注射液的工艺方法，其特征在于步骤中d加乙醇淀析，使最终含醇量为70-75％。
CN 92107848 1992-12-15 1992-12-15 脉络宁静脉注射液的工艺方法 Expired - Lifetime CN1033211C (zh)

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Cited By (2)

* Cited by examiner, † Cited by third party
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CN1325041C (zh) * 2004-02-12 2007-07-11 山西亚宝药业集团股份有限公司 一种治疗血管闭塞性脉管炎的冻干粉针及其制备方法
CN1698717B (zh) * 2005-04-22 2010-04-28 江苏正大天晴药业股份有限公司 一种中药复方脂肪乳注射液及其制备方法

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US7101577B2 (en) * 2003-08-25 2006-09-05 National Yang-Ming University Extract of plant Dendrobii caulis and preparing process thereof
CN1301127C (zh) * 2004-01-07 2007-02-21 天津天士力制药股份有限公司 一种制备脉络宁注射制剂的工艺方法
CN100446799C (zh) * 2004-01-13 2008-12-31 吴良信 治疗心脑血管疾病药物制剂及其制备方法
CN1304839C (zh) * 2004-03-16 2007-03-14 金陵药业股份有限公司 一种用于治疗血栓闭塞性疾病的大输液的质量控制方法
CN1309369C (zh) * 2004-07-01 2007-04-11 石秀坤 注射用脉络宁粉针剂及其制备方法
CN104116928A (zh) * 2013-04-26 2014-10-29 成都力思特制药股份有限公司 一种含聚乙二醇十二羟基硬脂酸酯的脉络宁注射制剂及其制备方法
CN103694089B (zh) * 2013-12-25 2015-08-05 江苏省中国科学院植物研究所 脉络宁酚的制备方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1325041C (zh) * 2004-02-12 2007-07-11 山西亚宝药业集团股份有限公司 一种治疗血管闭塞性脉管炎的冻干粉针及其制备方法
CN1698717B (zh) * 2005-04-22 2010-04-28 江苏正大天晴药业股份有限公司 一种中药复方脂肪乳注射液及其制备方法

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