CN103314104B - 基于慢病毒载体的抗疟疾免疫化合物 - Google Patents
基于慢病毒载体的抗疟疾免疫化合物 Download PDFInfo
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- CN103314104B CN103314104B CN201180027852.4A CN201180027852A CN103314104B CN 103314104 B CN103314104 B CN 103314104B CN 201180027852 A CN201180027852 A CN 201180027852A CN 103314104 B CN103314104 B CN 103314104B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15023—Virus like particles [VLP]
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- C—CHEMISTRY; METALLURGY
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16023—Virus like particles [VLP]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6072—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses
- C12N2810/6081—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses rhabdoviridae, e.g. VSV
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
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- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10290238.4A EP2385107B1 (en) | 2010-05-03 | 2010-05-03 | Lentiviral vector based immunological compounds against malaria |
| EP10290238.4 | 2010-05-03 | ||
| PCT/EP2011/056887 WO2011138251A1 (en) | 2010-05-03 | 2011-04-29 | Lentiviral vector based immunological compounds against malaria |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103314104A CN103314104A (zh) | 2013-09-18 |
| CN103314104B true CN103314104B (zh) | 2016-11-09 |
Family
ID=42731903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180027852.4A Active CN103314104B (zh) | 2010-05-03 | 2011-04-29 | 基于慢病毒载体的抗疟疾免疫化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9109234B2 (https=) |
| EP (2) | EP2385107B1 (https=) |
| JP (2) | JP5937574B2 (https=) |
| KR (1) | KR20130096164A (https=) |
| CN (1) | CN103314104B (https=) |
| DK (1) | DK2385107T3 (https=) |
| WO (1) | WO2011138251A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9169304B2 (en) | 2012-05-01 | 2015-10-27 | Pfenex Inc. | Process for purifying recombinant Plasmodium falciparum circumsporozoite protein |
| CN103965320A (zh) * | 2013-01-29 | 2014-08-06 | 苏州偲聚生物材料有限公司 | 多肽、包含该多肽的检测器件和检测试剂盒 |
| BR112015030211A2 (pt) | 2013-06-03 | 2017-08-22 | Theravectys | Vetores lentivirais contendo uma sequência promotora a montante da mhc de classe i, mhc de classe ii ou microglobulina beta-2 |
| EP2878674A1 (en) * | 2013-11-28 | 2015-06-03 | Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) | Stable episomes based on non-integrative lentiviral vectors |
| EP3087188A1 (en) * | 2013-12-23 | 2016-11-02 | Theravectys | Lyophilized lentiviral vector particles, compositions and methods |
| US10010607B2 (en) | 2014-09-16 | 2018-07-03 | Institut Curie | Method for preparing viral particles with cyclic dinucleotide and use of said particles for inducing immune response |
| CN106290840A (zh) * | 2015-05-13 | 2017-01-04 | 上海凯创生物技术有限公司 | 间日疟原虫乳胶法检测试剂盒 |
| CN105754962A (zh) * | 2016-01-07 | 2016-07-13 | 中南大学 | 一种单循环复制艾滋病毒样颗粒及其制备方法和应用 |
| WO2017157437A1 (en) | 2016-03-16 | 2017-09-21 | Institut Curie | Method for preparing viral particles with cyclic dinucleotide and use of said particles for treating cancer |
| EP3458086A4 (en) * | 2016-05-19 | 2020-07-29 | The Trustees Of The University Of Pennsylvania | SYNTHETIC IMMUNOGENS TO MALARIA, COMBINATIONS OF THEM AND THEIR USE TO PREVENT AND TREAT MALARIA INFECTIONS |
| CA3069780A1 (en) | 2016-08-09 | 2018-02-15 | Aarhus Universitet | Modulation of ifi16 and sting activity |
| EP3357506A1 (en) * | 2017-02-02 | 2018-08-08 | Institut Pasteur | Multiple malaria pre-erythrocytic antigens and their use in the elicitation of a protective immune response in a host |
| EP3357504A1 (en) * | 2017-02-02 | 2018-08-08 | Institut Pasteur | Functional screening of antigenic polypeptides - use for the identification of antigens eliciting a protective immune response and for the selection of antigens with optimal protective activity |
| CN109251929A (zh) * | 2018-04-27 | 2019-01-22 | 杭州贝英福生物科技有限公司 | 一种干扰二化螟几丁质酶基因CsCht10的siRNA |
| EP3796931A1 (en) | 2018-05-23 | 2021-03-31 | Institut Pasteur | Malaria pre-erythrocytic antigens as a fusion polypeptide and their use in the elicitation of a protective immune response in a host |
| EP3820997A4 (en) * | 2018-07-09 | 2022-09-21 | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College | Viral-vectored vaccine for malaria |
| CN109022456B (zh) * | 2018-07-24 | 2021-03-02 | 江南大学 | 一种表达卵形疟原虫ama1蛋白的病毒疫苗的制备方法 |
| GB201906283D0 (en) * | 2019-05-03 | 2019-06-19 | Moredun Res Institute | Vector |
| CN116322793A (zh) * | 2020-09-01 | 2023-06-23 | 宾夕法尼亚大学董事会 | 改进的使用科卡尔包膜的t细胞转导用慢病毒载体的生成 |
| US12304929B2 (en) * | 2021-04-12 | 2025-05-20 | Sk Bioscience Co., Ltd. | Recombinant RSV live vaccine strain and the preparing method thereof |
| EP4326769A1 (en) | 2021-04-20 | 2024-02-28 | Institut Curie | Compositions and methods for use in immunotherapy |
| EP4326321A1 (en) | 2021-04-20 | 2024-02-28 | Institut Curie | Compositions and methods for use in immunotherapy |
| CN116987157B (zh) * | 2023-09-27 | 2023-11-28 | 深圳华大生命科学研究院 | 一种弹状病毒包膜蛋白、含其的靶向慢病毒载体及其应用 |
| CN121005787B (zh) * | 2025-10-22 | 2025-12-26 | 南京鸿明生物科技有限公司 | 一种嵌合型包膜糖蛋白、其制备方法及涉及该包膜糖蛋白的包膜质粒、包装方法和试剂盒 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994028930A1 (en) * | 1993-06-11 | 1994-12-22 | Virogenetics Corporation | Malaria recombinant poxvirus vaccine |
| WO2004043488A1 (en) * | 2002-11-12 | 2004-05-27 | Statens Serum Institut | Malaria vaccine |
| WO2007095201A2 (en) * | 2006-02-15 | 2007-08-23 | The Regents Of The University Of California | Pseudotyped retroviral vectors and methods of use thereof |
| WO2009019612A2 (en) * | 2007-08-03 | 2009-02-12 | Institut Pasteur | Lentiviral gene transfer vectors and their medicinal applications |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2777909B1 (fr) | 1998-04-24 | 2002-08-02 | Pasteur Institut | Utilisation de sequences d'adn de structure triplex pour le tranfert de sequences de nucleotides dans des cellules, vecteurs recombinants contenant ces sequences triplex |
| ATE449858T1 (de) | 1999-10-11 | 2009-12-15 | Pasteur Institut | Lentivirale vektoren für die herstellung von immunotherapeutischen zusammensetzungen |
| ATE351916T1 (de) | 1999-10-12 | 2007-02-15 | Pasteur Institut | Lentivirale triplex-dns, und vektoren und rekombinante zellen, die lentivirale triplex-dns enthalten |
| WO2004055187A1 (en) | 2002-12-17 | 2004-07-01 | Crucell Holland B.V. | Recombinant viral-based malaria vaccines |
| FR2872170B1 (fr) | 2004-06-25 | 2006-11-10 | Centre Nat Rech Scient Cnrse | Lentivirus non interactif et non replicatif, preparation et utilisations |
| US8158413B2 (en) | 2005-10-17 | 2012-04-17 | Institut Pasteur | Lentiviral vector-based vaccine |
| AU2006284756B2 (en) | 2005-08-31 | 2012-06-07 | Genvec, Inc. | Adenoviral vector-based malaria vaccines |
| TR201802221T4 (tr) * | 2007-08-13 | 2018-03-21 | Glaxosmithkline Biologicals Sa | Aşılar. |
-
2010
- 2010-05-03 EP EP10290238.4A patent/EP2385107B1/en active Active
- 2010-05-03 DK DK10290238.4T patent/DK2385107T3/en active
-
2011
- 2011-04-29 WO PCT/EP2011/056887 patent/WO2011138251A1/en not_active Ceased
- 2011-04-29 KR KR1020127031691A patent/KR20130096164A/ko not_active Withdrawn
- 2011-04-29 EP EP11716434A patent/EP2566956A1/en not_active Withdrawn
- 2011-04-29 US US13/695,683 patent/US9109234B2/en active Active
- 2011-04-29 JP JP2013508445A patent/JP5937574B2/ja active Active
- 2011-04-29 CN CN201180027852.4A patent/CN103314104B/zh active Active
-
2015
- 2015-07-15 US US14/799,633 patent/US9822153B2/en active Active
- 2015-11-30 JP JP2015233691A patent/JP2016041076A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994028930A1 (en) * | 1993-06-11 | 1994-12-22 | Virogenetics Corporation | Malaria recombinant poxvirus vaccine |
| WO2004043488A1 (en) * | 2002-11-12 | 2004-05-27 | Statens Serum Institut | Malaria vaccine |
| WO2007095201A2 (en) * | 2006-02-15 | 2007-08-23 | The Regents Of The University Of California | Pseudotyped retroviral vectors and methods of use thereof |
| WO2009019612A2 (en) * | 2007-08-03 | 2009-02-12 | Institut Pasteur | Lentiviral gene transfer vectors and their medicinal applications |
Non-Patent Citations (4)
| Title |
|---|
| Antigens for pre-erythrocytic malaria vaccines: building on success;C. SPEAKE1 & P. E. DUFFY;《Parasite Immunology》;20090901;第31卷(第9期);全文 * |
| Enhanced protective immunity against malaria by vaccination with a recombinant adenovirus encoding the circumsporozoite protein of Plasmodium lacking the GPI-anchoring motif;Oscar Bruna-Romero et al.;《Vaccine》;20040909;第22卷;摘要 * |
| Plasmodium: Mammalian codon optimization of malaria plasmid DNA vaccines enhances antibody responses but not T cell responses nor protective immunity;Carlota Dobao et al.;《Experimental Parasitology》;20090202;第122卷(第2期);摘要) * |
| Viral vectors in malaria vaccine development;K. J. LIMBACH & T. L. RICHIE;《Parasite Immunology》;20090626;第31卷(第9期);第503页右栏至504页左栏 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011138251A8 (en) | 2013-04-18 |
| DK2385107T3 (en) | 2016-12-12 |
| JP2016041076A (ja) | 2016-03-31 |
| CN103314104A (zh) | 2013-09-18 |
| EP2385107B1 (en) | 2016-08-24 |
| JP2013527760A (ja) | 2013-07-04 |
| US9822153B2 (en) | 2017-11-21 |
| EP2385107A8 (en) | 2014-03-12 |
| US20130171195A1 (en) | 2013-07-04 |
| KR20130096164A (ko) | 2013-08-29 |
| EP2566956A1 (en) | 2013-03-13 |
| US9109234B2 (en) | 2015-08-18 |
| BR112012027999A2 (pt) | 2017-03-21 |
| JP5937574B2 (ja) | 2016-06-22 |
| EP2385107A1 (en) | 2011-11-09 |
| US20150368307A1 (en) | 2015-12-24 |
| WO2011138251A1 (en) | 2011-11-10 |
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