CN103314004B - 5,7-孕甾二烯-3,20-二酮-二乙二缩酮新的制备方法 - Google Patents

5,7-孕甾二烯-3,20-二酮-二乙二缩酮新的制备方法 Download PDF

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Publication number
CN103314004B
CN103314004B CN201180045623.5A CN201180045623A CN103314004B CN 103314004 B CN103314004 B CN 103314004B CN 201180045623 A CN201180045623 A CN 201180045623A CN 103314004 B CN103314004 B CN 103314004B
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reaction
solvent
compd
compound
preparation
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Chinese (zh)
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CN103314004A (zh
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张建设
王琛琳
陈济谷
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Taizhou Hisound Pharmaceutical Co Ltd
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Taizhou Hisound Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
    • C07J15/005—Retrosteroids (9 beta 10 alfa)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Color Printing (AREA)
CN201180045623.5A 2011-12-02 2011-12-02 5,7-孕甾二烯-3,20-二酮-二乙二缩酮新的制备方法 Active CN103314004B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2011/002022 WO2013078575A1 (fr) 2011-12-02 2011-12-02 Nouveau procédé de préparation de 5,7-prégnadiène-3,20-dione-diéthyl-cétal

Publications (2)

Publication Number Publication Date
CN103314004A CN103314004A (zh) 2013-09-18
CN103314004B true CN103314004B (zh) 2015-07-08

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CN201180045623.5A Active CN103314004B (zh) 2011-12-02 2011-12-02 5,7-孕甾二烯-3,20-二酮-二乙二缩酮新的制备方法

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CN (1) CN103314004B (fr)
WO (1) WO2013078575A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110790808A (zh) * 2019-11-19 2020-02-14 湖南新合新生物医药有限公司 一种5,7-孕甾二烯-3,20-二酮-二乙二缩酮的制备方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104237417B (zh) * 2014-09-30 2017-06-23 华润紫竹药业有限公司 一种地屈孕酮中间体的分析方法
WO2016154772A1 (fr) * 2015-04-02 2016-10-06 台州市海盛制药有限公司 Procédé de préparation de 9β,10α-prégnane-4,6-diène-3,20-dione
CN105669813B (zh) * 2015-12-31 2017-11-07 厦门金达威维生素有限公司 一种维生素d3中间体7‑酮胆固醇乙酸酯的合成方法
CN112876530A (zh) * 2019-11-29 2021-06-01 重庆乾泰生物医药有限公司 一种地屈孕酮中间体的晶型及其制备方法
CN113880904B (zh) * 2020-07-01 2024-04-12 苏州朗科生物技术股份有限公司 合成地屈孕酮的新方法及化合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3014030A (en) * 1959-08-19 1961-12-19 Upjohn Co 9alpha-methylpregnenes, pregnadienes and intermediates therefor
US4464298A (en) * 1982-01-14 1984-08-07 Duphar International Research B.V. Method of preparing Δ5,7-steroids
WO2011073419A1 (fr) * 2009-12-18 2011-06-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nouveaux inhibiteurs stéroïdiens de pgp pour emploi dans l'inhibition de la résistance pléiotrope

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3014030A (en) * 1959-08-19 1961-12-19 Upjohn Co 9alpha-methylpregnenes, pregnadienes and intermediates therefor
US4464298A (en) * 1982-01-14 1984-08-07 Duphar International Research B.V. Method of preparing Δ5,7-steroids
WO2011073419A1 (fr) * 2009-12-18 2011-06-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nouveaux inhibiteurs stéroïdiens de pgp pour emploi dans l'inhibition de la résistance pléiotrope

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110790808A (zh) * 2019-11-19 2020-02-14 湖南新合新生物医药有限公司 一种5,7-孕甾二烯-3,20-二酮-二乙二缩酮的制备方法
CN110790808B (zh) * 2019-11-19 2022-10-28 湖南新合新生物医药有限公司 一种5,7-孕甾二烯-3,20-二酮-二乙二缩酮的制备方法

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Publication number Publication date
CN103314004A (zh) 2013-09-18
WO2013078575A8 (fr) 2013-07-18
WO2013078575A9 (fr) 2013-12-05
WO2013078575A1 (fr) 2013-06-06

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Address after: 317016 chemical raw material base of Zhejiang Province, No. 22 Nanyang Road, Waterfront Park

Applicant after: Taizhou Hisound Pharmaceutical Co., Ltd.

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Free format text: CORRECT: APPLICANT; FROM: TAIZHOU HAISHENG CHENMICAL CO., LTD. TO: TAIZHOU HISOUND PHARMACEUTICAL CO., LTD.

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