CN103304404A - 一种2,2-二羟甲基丁酸的制备方法 - Google Patents
一种2,2-二羟甲基丁酸的制备方法 Download PDFInfo
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- CN103304404A CN103304404A CN2013102082302A CN201310208230A CN103304404A CN 103304404 A CN103304404 A CN 103304404A CN 2013102082302 A CN2013102082302 A CN 2013102082302A CN 201310208230 A CN201310208230 A CN 201310208230A CN 103304404 A CN103304404 A CN 103304404A
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020107417A1 (en) * | 2001-02-02 | 2002-08-08 | Toshio Watanabe | Production of dimethylolcarboxylic acid |
CN101381299A (zh) * | 2008-10-14 | 2009-03-11 | 山东轻工业学院 | 一种2,2-二羟甲基丁酸的合成方法 |
US20100331397A1 (en) * | 2009-06-24 | 2010-12-30 | Alios Biopharma, Inc. | 2-5a analogs and their methods of use |
CN102060732A (zh) * | 2009-11-16 | 2011-05-18 | 江苏恒瑞医药股份有限公司 | 5-氨基-4-羟基-n-芳基壬二酰胺类衍生物、其制备方法及其在医药上的应用 |
WO2012135759A1 (en) * | 2011-04-01 | 2012-10-04 | Genentech, Inc. | Combinations of akt inhibitor compounds and abiraterone, and methods of use |
CN102911038A (zh) * | 2012-10-30 | 2013-02-06 | 李先明 | 一种2,2-二羟甲基丙酸的制备方法 |
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- 2013-05-30 CN CN201310208230.2A patent/CN103304404B/zh active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020107417A1 (en) * | 2001-02-02 | 2002-08-08 | Toshio Watanabe | Production of dimethylolcarboxylic acid |
CN101381299A (zh) * | 2008-10-14 | 2009-03-11 | 山东轻工业学院 | 一种2,2-二羟甲基丁酸的合成方法 |
US20100331397A1 (en) * | 2009-06-24 | 2010-12-30 | Alios Biopharma, Inc. | 2-5a analogs and their methods of use |
CN102060732A (zh) * | 2009-11-16 | 2011-05-18 | 江苏恒瑞医药股份有限公司 | 5-氨基-4-羟基-n-芳基壬二酰胺类衍生物、其制备方法及其在医药上的应用 |
WO2012135759A1 (en) * | 2011-04-01 | 2012-10-04 | Genentech, Inc. | Combinations of akt inhibitor compounds and abiraterone, and methods of use |
WO2012135781A1 (en) * | 2011-04-01 | 2012-10-04 | Genentech, Inc. | Combinations of akt inhibitor compounds and chemotherapeutic agents, and methods of use |
CN102911038A (zh) * | 2012-10-30 | 2013-02-06 | 李先明 | 一种2,2-二羟甲基丙酸的制备方法 |
Non-Patent Citations (4)
Title |
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ANDREI GUZAEV等: "Bis(hydroxymethylation) of the active methylene group of 1,3-dicarbonyl and related compounds", 《SYNTHESIS》, vol. 11, 30 November 1997 (1997-11-30), pages 1281 - 1284 * |
史红月等: "2 ,2-二羟甲基丁酸的合成,", 《精细化工》, vol. 20, no. 2, 28 February 2003 (2003-02-28), pages 101 - 104 * |
李佩杰等: "2 ,2-二甲基-5-羟甲基-1 ,3-二氧六环的合成", 《华西药学杂志》, vol. 26, no. 4, 30 August 2001 (2001-08-30), pages 276 - 278 * |
盛继文 等: "2, 2- 二甲基- 5, 5- 二乙氧羰基- 1, 3- 二氧六环的合成", 《山东化工》, vol. 36, no. 7, 15 July 2007 (2007-07-15), pages 8 - 9 * |
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Address after: 264002 Yantai economic and Technological Development Zone, Shandong, Tian Shan Road, No. 17 Patentee after: Wanhua Chemical Group Co., Ltd. Patentee after: Wanhua Chemical (Ningbo) Co., Ltd. Address before: 264002 Yantai City, Shandong province Zhifu District No. 7 Patentee before: Wanhua Chemical Group Co., Ltd. Patentee before: Wanhua Chemical (Ningbo) Co., Ltd. |