CN103301148A - Compound selenic acid lipopolysaccharide emulsifiable paste for preventing and treating radioactive injury and preparation method - Google Patents
Compound selenic acid lipopolysaccharide emulsifiable paste for preventing and treating radioactive injury and preparation method Download PDFInfo
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- CN103301148A CN103301148A CN2013101867851A CN201310186785A CN103301148A CN 103301148 A CN103301148 A CN 103301148A CN 2013101867851 A CN2013101867851 A CN 2013101867851A CN 201310186785 A CN201310186785 A CN 201310186785A CN 103301148 A CN103301148 A CN 103301148A
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- emulsifiable paste
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- ester polysaccharide
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- selenic ester
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Abstract
The invention provides a compound selenic acid lipopolysaccharide emulsifiable paste for preventing and treating radioactive injury and a preparation method. The compound selenic acid lipopolysaccharide emulsifiable paste for preventing and treating radioactive injury takes selenic acid lipopolysaccharide as a main formula for improving the immunocompetence of skins and antioxidant ability, and is compounded with an external emulsifiable paste with vitamin E-assisted potentiation. The compound selenic acid lipopolysaccharide emulsifiable paste through verification of clinical results has protective effect on radioactive injury of skins, and vitamin E and selenic acid lipopolysaccharide have the antioxidant effect by adjusting the immune metabolism and enhancing the activity of GSH-PX (Glutathione Peroxidase). The compound selenic acid lipopolysaccharide emulsifiable paste provided by the invention has the advantages of simpleness in manufacturing, low cost, strong applicability, convenience in popularization and the like, and no adverse reactions appear in clinical use.
Description
Technical field
The present invention relates to prevent and treat compound recipe selenic ester polysaccharide emulsifiable paste and the preparation of radiation injury, belong to the Medicines and Health Product product technical field.
Background technology
Vitamin E is a kind of fatsoluble vitamin that 8 kinds of forms are arranged, and is an important antioxidants, has antioxygenic property, and selenic ester polysaccharide can strengthen the immunoreation of human body and oxidation resistance, and these have all had bibliographical information; Thereby selenic ester polysaccharide can be removed the degraded of cells in vivo free radical enhancing oxide and reach protectiving ultraviolet to the carcinogenesis of human body.Radiotherapy is one of main treatment means of malignant tumor.In the radiotherapy process, be subjected to be easy to according to the normal skin at position
Cause radiation injury, ray divides directly effect and indirect action to the damage of normal tissue cell and tumor tissue cell, wherein the free radical effect accounts for 70%, the skin injury of irradiated site is inevitable in tumour radiotherapy, especially it is particularly serious that local high dose electronics line and X line are treated skin burn, and patient skin wet reaction occurs doing and causes that having an intense pain difficult healing etc. causes treatment not carry out smoothly.
Summary of the invention
The objective of the invention is to have the function that improves the autoimmune ability according to selenic ester polysaccharide, proposing a kind of is the external emulsifiable paste preparation method extremely of main material with the selenic ester polysaccharide, and the patient that this emulsifiable paste is fit to be subject to radiation injury improves the immunocompetence of skin self.
The present invention is achieved through the following technical solutions,
A kind of compound recipe selenic ester polysaccharide emulsifiable paste of preventing and treating radiation injury is characterized in that: described compound recipe selenic ester polysaccharide emulsifiable paste comprise selenic ester polysaccharide, vitamin E and other auxiliary material, wherein based on selenic ester polysaccharide.
Organic selenium content is 0.5～10% in the described selenic ester polysaccharide.
Described auxiliary material comprise carbamide, stearic acid, lanoline, liquid paraffin, glycerol, sodium benzoate, triethanolamine, distilled water.
A kind of preparation method of preventing and treating the compound recipe selenic ester polysaccharide emulsifiable paste of radiation injury comprises the steps:
A. be oil phase with stearic acid, lanoline and liquid paraffin 65-75 ℃ of fusion, slowly add vitamin E;
B. carbamide, sodium benzoate and glycerol are ground into thin pasty state in mortar;
C. selenic ester polysaccharide, triethanolamine and distilled water constant temperature is even to 65-75 ℃ of stirring and dissolving;
D. under constantly stirring, slowly B, A are being joined among the C, treating to stir behind the complete mixing and be cooled to room temperature.
The invention has the advantages that:
1. compound recipe selenic ester polysaccharide emulsifiable paste has protective effect to curing dermal radio lesions, and vitamin E and selenic ester polysaccharide play antioxidation by the activity of regulating immune metabolism, enhancing GSH-PX.
2. it is simple that compound recipe selenic ester polysaccharide emulsifiable paste has making, and with low cost, the suitability is strong, is convenient to advantages such as popularization, and untoward reaction is not seen in clinical use.
The specific embodiment
Below in conjunction with specific embodiment the present invention is elaborated.
Embodiment 1
The component of the compound recipe selenic ester polysaccharide emulsifiable paste of control radiation injury is as follows:
Selenic ester polysaccharide (in selenium) 2.28g vitamin E 100g
Carbamide 50g stearic acid 150g
Lanoline 20g liquid paraffin 250g
Glycerol 50g sodium benzoate 1g
Triethanolamine 20g distilled water is supplemented to 1000g
The preparation method of the compound recipe selenic ester polysaccharide emulsifiable paste of control radiation injury is as follows:
A, be oil phase with stearic acid, lanoline and liquid paraffin 70 ℃ of fusions, slowly add vitamin E;
B, carbamide, sodium benzoate and glycerol are ground into thin pasty state in mortar;
C, selenic ester polysaccharide, triethanolamine and distilled water constant temperature to 70 ℃ stirring and dissolving is even;
D, constantly stir down and slowly B, A are joined among the C, treat to stir behind the complete mixing and be cooled to room temperature.
Above-described embodiment is only in order to technical scheme of the present invention to be described but not design of the present invention and protection domain are limited; those of ordinary skill of the present invention is made amendment to technical scheme of the present invention or is equal to replacement; and not breaking away from aim and the scope of technical scheme, it all should be encompassed in the claim scope of the present invention.
Claims (4)
1. compound recipe selenic ester polysaccharide emulsifiable paste of preventing and treating radiation injury is characterized in that: described compound recipe selenic ester polysaccharide emulsifiable paste comprise selenic ester polysaccharide, vitamin E and other auxiliary material, wherein based on selenic ester polysaccharide.
2. compound recipe selenic ester polysaccharide emulsifiable paste of preventing and treating radiation injury, it is characterized in that: in Se content, organic selenium content is 0.5～10% in the described selenic ester polysaccharide.
3. compound recipe selenic ester polysaccharide emulsifiable paste of preventing and treating radiation injury, it is characterized in that: described auxiliary material comprise carbamide, stearic acid, lanoline, liquid paraffin, glycerol, sodium benzoate, triethanolamine, distilled water.
4. a preparation method of preventing and treating the compound recipe selenic ester polysaccharide emulsifiable paste of radiation injury is characterized in that: comprise the steps:
A. be oil phase with stearic acid, lanoline and liquid paraffin 65-75 ℃ of fusion, slowly add vitamin E;
B. carbamide, sodium benzoate and glycerol are ground into thin pasty state in mortar;
C. selenic ester polysaccharide, triethanolamine and distilled water constant temperature is even to 65-75 ℃ of stirring and dissolving;
D. under constantly stirring, slowly B, A are being joined among the C, treating to stir behind the complete mixing and be cooled to room temperature.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013101867851A CN103301148A (en) | 2013-05-20 | 2013-05-20 | Compound selenic acid lipopolysaccharide emulsifiable paste for preventing and treating radioactive injury and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013101867851A CN103301148A (en) | 2013-05-20 | 2013-05-20 | Compound selenic acid lipopolysaccharide emulsifiable paste for preventing and treating radioactive injury and preparation method |
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| Publication Number | Publication Date |
|---|---|
| CN103301148A true CN103301148A (en) | 2013-09-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2013101867851A Pending CN103301148A (en) | 2013-05-20 | 2013-05-20 | Compound selenic acid lipopolysaccharide emulsifiable paste for preventing and treating radioactive injury and preparation method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796831A (en) * | 2016-04-19 | 2016-07-27 | 北京欣普迪生物科技有限公司 | Medical ray protection agent and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1647815A (en) * | 2004-10-18 | 2005-08-03 | 北京力富生物科技有限责任公司 | Product with protective function to radiation hazard |
-
2013
- 2013-05-20 CN CN2013101867851A patent/CN103301148A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1647815A (en) * | 2004-10-18 | 2005-08-03 | 北京力富生物科技有限责任公司 | Product with protective function to radiation hazard |
Non-Patent Citations (2)
| Title |
|---|
| 林藩平: "维生素E和微量元素硒在营养和免疫上的重要作用-二者可用于预防乳牛乳房炎", 《福建畜牧兽医》 * |
| 陈浩然等: "复方硒乳膏对皮肤放射性损伤防治作用", 《黑龙江医药》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796831A (en) * | 2016-04-19 | 2016-07-27 | 北京欣普迪生物科技有限公司 | Medical ray protection agent and preparation method thereof |
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| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Zhao Rougang Inventor after: Zhang Hongmei Inventor before: Qin Xiaolin |
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| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: QIN XIAOLIN TO: ZHAO ROUGANG ZHANG HONGMEI |
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Application publication date: 20130918 |