CN102188508A - Chinese medicine composition for treating knee osteoarthritis and preparation method thereof - Google Patents
Chinese medicine composition for treating knee osteoarthritis and preparation method thereof Download PDFInfo
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- CN102188508A CN102188508A CN2011101018437A CN201110101843A CN102188508A CN 102188508 A CN102188508 A CN 102188508A CN 2011101018437 A CN2011101018437 A CN 2011101018437A CN 201110101843 A CN201110101843 A CN 201110101843A CN 102188508 A CN102188508 A CN 102188508A
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Abstract
A Chinese medicine composition for treating knee osteoarthritis and a preparation method thereof. The Chinese medicine composition comprises: by weight, 40 to 50 parts of Unprocessed Semen Strychni, 40 to 50 parts of Unprocessed Radix Aconiti, 30 to 40 parts of Unprocessed Radix Aconiti Kusnezoffii, 35 to 45 parts of Frankincense, 50 to 60 parts of Myrrh and 25 to 35 parts of Angelica sinensis. The Chinese medicine composition provided by the invention has favorable effects of activating blood circulation and arresting pain perception on knee osteoarthritis, and clinical data shows that a recurrence rate of knee osteoarthritis is very low after treatment utilizing the Chinese medicine composition.
Description
Technical field
The present invention relates to Chinese medicine composition that is used for the treatment of knee osteoarthritis and preparation method thereof.
Background technology
The method of existing treatment knee osteoarthritis has endo-medicine, external used medicine, operation, acupuncture, massage, physiotherapy and rehabilitation etc.Endo-medicine toxic and side effects for patients is bigger, and the common wound of performing the operation is bigger, and then there are the short shortcoming of curative effect lasting time in acupuncture, massage, physical therapy therapy.
Summary of the invention
The purpose of this invention is to provide and a kind ofly can be used for the treatment of Chinese medicine composition of knee osteoarthritis and preparation method thereof effectively.
The Chinese medicine composition that is used for the treatment of knee osteoarthritis according to the present invention is grouped into by the one-tenth of following weight portion substantially:
Semen Strychni 40-50 part; Radix Aconiti 40-50 part; Radix Aconiti Kusnezoffii 30-40 part; Olibanum 35-45 part; Myrrha 50-60 part; And Radix Angelicae Sinensis 25-35 part.
Preferably in above-mentioned Chinese medicine composition, Semen Strychni is 45 parts; Radix Aconiti is 45 parts; Radix Aconiti Kusnezoffii is 35 parts; Olibanum is 40 parts; Myrrha is 55 parts; And when being classified as 30 parts.
This Chinese medicine composition preferably is made into the ointment form.This Chinese medicine composition also can be made into lotion form.
The method that preparation according to the present invention is used for the treatment of the Chinese medicine ointment of knee osteoarthritis comprises step:
Chinese medicine composition is provided, and this Chinese medicine composition is made up of Semen Strychni 40-50 part, Radix Aconiti 40-50 part, Radix Aconiti Kusnezoffii 30-40 part, Olibanum 35-45 part, Myrrha 50-60 part and Radix Angelicae Sinensis 25-35 part;
With the above-mentioned Chinese medicine composition of 75% alcohol reflux;
Obtain equivalent extract after reclaiming ethanol;
Dilute the gained equivalent extract and obtain diluent;
Add ethyl hydroxybenzoate in the gained diluent and make it to dissolve and obtain mixture solution;
Said mixture solution is carried out sucking filtration and obtains filtrate;
Add carbamide and triethanolamine in the gained filtrate and heating for dissolving and obtain aqueous phase substrate;
With stearic acid, white vaseline, Oleum Ricini with glycerol mixes and heating is dissolved and obtain oil phase component; And
Add the gained oil phase component in the gained aqueous phase substrate and be cooled to room temperature and obtain ointment.
Chinese medicine composition of the present invention is very good to the invigorating blood circulation of knee osteoarthritis, analgesic effect, and clinical data shows that its relapse rate is extremely low.
The specific embodiment
Embodiment 1
The first kind of Chinese medicine composition that is used for the treatment of knee osteoarthritis of the present invention will be obtained behind this Six-element Chinese medicine pulverize of 40g Semen Strychni, 40 Radix Aconiti, 30g Radix Aconiti Kusnezoffii, 35g Olibanum, 50g Myrrha and 25g Radix Angelicae Sinensis.
With 500ml 75% ethanol to first kind of Chinese medicine composition reflux, extract, 50min, obtain equivalent extract after reclaiming ethanol, adding the 400ml distilled water then dilutes the gained equivalent extract, and diluent placed fling to residual ethanol in the water-bath, pH value with diluent is adjusted to 8.5 afterwards, add the 10g ethyl hydroxybenzoate subsequently and make it to dissolve, keep said mixture solution be 3 ℃ and place 11h after carry out sucking filtration, at last gained filtrate is replenished distilled water to 500ml.
35g carbamide and 8ml triethanolamine are added in the above-mentioned gained 500ml filtrate, and be heated to boiling point and dissolve, be cooled to 70 ℃ afterwards naturally, obtain aqueous phase substrate and be incubated standby.
115g stearic acid, 95g white vaseline, 70ml Oleum Ricini and 8ml glycerol mixed and be heated to dissolve, be cooled to 68 ℃ afterwards, obtain oil phase component and be incubated standby.
The gained oil phase component slowly is added in the above-mentioned aqueous phase substrate, and the limit edged stirs to same direction fast, makes two to form and divide fully emulsifiedly, treats that temperature reduces to room temperature fashionable dress box and get final product.
Embodiment 2
The second kind of Chinese medicine composition that is used for the treatment of knee osteoarthritis of the present invention will be obtained behind this Six-element Chinese medicine pulverize of 45g Semen Strychni, 45g Radix Aconiti, 35g Radix Aconiti Kusnezoffii, 40g Olibanum, 55g Myrrha and 30g Radix Angelicae Sinensis.
With 500ml75% ethanol to second kind of Chinese medicine composition reflux, extract, 1h, obtain equivalent extract after reclaiming 75% ethanol, adding the 400ml distilled water then dilutes the gained equivalent extract, and diluent placed fling to residual ethanol in the water-bath, pH value with diluent is adjusted to 9.0 afterwards, add the 15g ethyl hydroxybenzoate subsequently and make it to dissolve, keep said mixture solution be 4 ℃ and place 12h after carry out sucking filtration, at last gained filtrate is replenished distilled water to 500ml.
40g carbamide and 10ml triethanolamine are added in the above-mentioned gained 500ml filtrate, and be heated to boiling point and dissolve, be cooled to 70 ℃ afterwards naturally, obtain aqueous phase substrate and be incubated standby.
120g stearic acid, 100g white vaseline, 80ml Oleum Ricini and 10ml glycerol mixed and be heated to dissolve, be cooled to 70 ℃ afterwards, obtain oil phase component and be incubated standby.
The gained oil phase component slowly is added in the above-mentioned aqueous phase substrate, and the limit edged stirs to same direction fast, makes two to form and divide fully emulsifiedly, treats that temperature reduces to room temperature fashionable dress box and get final product.
Embodiment 3
To obtain the third Chinese medicine composition that is used for the treatment of knee osteoarthritis of the present invention behind this Six-element Chinese medicine pulverize of 50g Semen Strychni, 50g Radix Aconiti, 40g Radix Aconiti Kusnezoffii, 45g Olibanum, 60g Myrrha and 35g Radix Angelicae Sinensis.
With 500ml75% ethanol to the third Chinese medicine composition reflux, extract, 70 minutes, obtain equivalent extract after reclaiming ethanol, adding the 400ml distilled water then dilutes the gained equivalent extract, and diluent placed fling to residual ethanol in the water-bath, pH value with diluent is adjusted to 9.0 afterwards, add the 20g ethyl hydroxybenzoate subsequently and make it to dissolve, keep said mixture solution be 5 ℃ and place 13h after carry out sucking filtration, at last gained filtrate is replenished distilled water to 500ml.
45g carbamide and 12ml triethanolamine are added in the above-mentioned gained 500ml filtrate, and be heated to boiling point and dissolve, be cooled to 70 ℃ afterwards naturally, obtain aqueous phase substrate and be incubated standby.
125g stearic acid, 105g white vaseline, 90ml Oleum Ricini and 12ml glycerol mixed and be heated to dissolve, be cooled to 72 ℃ afterwards, obtain oil phase component and be incubated standby.
The gained oil phase component slowly is added in the above-mentioned aqueous phase substrate, and the limit edged stirs to same direction fast, makes two to form and divide fully emulsifiedly, treats that temperature reduces to room temperature fashionable dress box and get final product.
The usage of above gained ointment (emulsifiable paste) is: evenly smear one deck (about 0.25cm) with emulsifiable paste at knee joint peripheral, wipe 15min with rubbing method, reuse warm water cleans, and once a day, continuous 7 times is a course of treatment.Clinical data shows that ointment of the present invention is having unique effect aspect the treatment knee osteoarthritis, especially after the manipulation of massage treatment.Chinese medicine composition of the present invention is very good to the invigorating blood circulation of knee osteoarthritis, analgesic effect, and relapse rate is extremely low.
Understand for example that below Chinese medicine composition of the present invention is made into the process and the using method thereof of ointment form.But, it will be appreciated by those skilled in the art that Chinese medicine composition of the present invention is not limited to this easy to use and ointment form of carrying, but can be made into any suitable form that for example directly fried is lotion.Therefore, it will be appreciated by those skilled in the art that above-mentioned embodiment only is used for explaining and explanation the present invention, is not to be used for it is carried out any restriction.
Claims (6)
1. Chinese medicine composition that is used for the treatment of knee osteoarthritis, the one-tenth by following weight portion is grouped into substantially:
Semen Strychni 40-50 part; Radix Aconiti 40-50 part; Radix Aconiti Kusnezoffii 30-40 part; Olibanum 35-45 part; Myrrha 50-60 part; And Radix Angelicae Sinensis 25-35 part.
2. Chinese medicine composition according to claim 1, wherein Semen Strychni is 45 parts; Radix Aconiti is 45 parts; Radix Aconiti Kusnezoffii is 35 parts; Olibanum is 40 parts; Myrrha is 55 parts; And when being classified as 30 parts.
3. Chinese medicine composition according to claim 1 and 2, wherein this Chinese medicine composition is made into the ointment form.
4. Chinese medicine composition according to claim 1 and 2, wherein this Chinese medicine composition is made into lotion form.
5. method for preparing the Chinese medicine ointment that is used for the treatment of knee osteoarthritis comprises step:
Chinese medicine composition is provided, and this Chinese medicine composition is made up of Semen Strychni 40-50 part, Radix Aconiti 40-50 part, Radix Aconiti Kusnezoffii 30-40 part, Olibanum 35-45 part, Myrrha 50-60 part and Radix Angelicae Sinensis 25-35 part;
With the above-mentioned Chinese medicine composition of alcohol reflux;
Obtain equivalent extract after reclaiming ethanol;
Dilute the gained equivalent extract and obtain diluent;
Add ethyl hydroxybenzoate in the gained diluent and make it to dissolve and obtain mixture solution;
Said mixture solution is carried out sucking filtration and obtains filtrate;
Add carbamide and triethanolamine in the gained filtrate and heating for dissolving and obtain aqueous phase substrate;
With stearic acid, white vaseline, Oleum Ricini with glycerol mixes and heating is dissolved and obtain oil phase component; And
Add the gained oil phase component in the gained aqueous phase substrate and be cooled to room temperature and obtain ointment.
6. method according to claim 5, wherein Semen Strychni is 45 parts; Radix Aconiti is 45 parts; Radix Aconiti Kusnezoffii is 35 parts; Olibanum is 40 parts; Myrrha is 55 parts; And when being classified as 30 parts.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201110101843 CN102188508B (en) | 2011-04-22 | 2011-04-22 | Chinese medicine composition for treating knee osteoarthritis and preparation method thereof |
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| CN 201110101843 CN102188508B (en) | 2011-04-22 | 2011-04-22 | Chinese medicine composition for treating knee osteoarthritis and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614265A (en) * | 2012-04-26 | 2012-08-01 | 河南中医学院 | Swelling-diminishing and pain-relieving self-emulsifying ointment |
| CN104161821A (en) * | 2014-08-19 | 2014-11-26 | 杨少辉 | Traditional Chinese medicine liniment for promoting blood circulation to remove meridian obstruction |
| CN108210682A (en) * | 2018-02-27 | 2018-06-29 | 黄建民 | A kind of promoting blood circulation medicine puree and preparation method for treating Osteoarthritis |
| CN108210583A (en) * | 2018-03-14 | 2018-06-29 | 泸州市谢国清中草药配方研究有限公司 | A kind of Chinese medicine composition for treating rheumatism and rheumatoid, preparation and preparation method thereof |
| CN108379410A (en) * | 2018-05-16 | 2018-08-10 | 方建中 | Treat the Chinese medicine for the treatment of bone diseases |
| CN108524741A (en) * | 2018-07-13 | 2018-09-14 | 王少林 | A kind of external use plaster for treating osteoarthrosis |
| CN108888661A (en) * | 2018-08-02 | 2018-11-27 | 张洁 | Chinese medicine hot castrate package, Preparation method and use |
| CN109908212A (en) * | 2019-01-21 | 2019-06-21 | 刘景照 | A kind of arthritis cream |
| CN112546132A (en) * | 2021-01-21 | 2021-03-26 | 中国人民解放军总医院第一医学中心 | Preparation method of bone-strengthening powder |
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| CN1389255A (en) * | 2002-07-25 | 2003-01-08 | 佑金马 | Composite Chinese medicine for treating rheumarthritis and rheumatoid arthritis |
| CN1462628A (en) * | 2003-06-19 | 2003-12-24 | 贾松 | Pasting medicated plaster for treating bone disease |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614265A (en) * | 2012-04-26 | 2012-08-01 | 河南中医学院 | Swelling-diminishing and pain-relieving self-emulsifying ointment |
| CN104161821A (en) * | 2014-08-19 | 2014-11-26 | 杨少辉 | Traditional Chinese medicine liniment for promoting blood circulation to remove meridian obstruction |
| CN108210682A (en) * | 2018-02-27 | 2018-06-29 | 黄建民 | A kind of promoting blood circulation medicine puree and preparation method for treating Osteoarthritis |
| CN108210583A (en) * | 2018-03-14 | 2018-06-29 | 泸州市谢国清中草药配方研究有限公司 | A kind of Chinese medicine composition for treating rheumatism and rheumatoid, preparation and preparation method thereof |
| CN108379410A (en) * | 2018-05-16 | 2018-08-10 | 方建中 | Treat the Chinese medicine for the treatment of bone diseases |
| CN108524741A (en) * | 2018-07-13 | 2018-09-14 | 王少林 | A kind of external use plaster for treating osteoarthrosis |
| CN108888661A (en) * | 2018-08-02 | 2018-11-27 | 张洁 | Chinese medicine hot castrate package, Preparation method and use |
| CN109908212A (en) * | 2019-01-21 | 2019-06-21 | 刘景照 | A kind of arthritis cream |
| CN112546132A (en) * | 2021-01-21 | 2021-03-26 | 中国人民解放军总医院第一医学中心 | Preparation method of bone-strengthening powder |
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| CN102188508B (en) | 2013-01-30 |
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