CN113304252A - Fe-SOD low-temperature plasma skin permeation beautifying treatment process - Google Patents

Fe-SOD low-temperature plasma skin permeation beautifying treatment process Download PDF

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CN113304252A
CN113304252A CN202110658143.1A CN202110658143A CN113304252A CN 113304252 A CN113304252 A CN 113304252A CN 202110658143 A CN202110658143 A CN 202110658143A CN 113304252 A CN113304252 A CN 113304252A
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sod
skin
temperature plasma
low
free radicals
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燕恩亮
夏振涛
郭新娜
王耕云
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y115/00—Oxidoreductases acting on superoxide as acceptor (1.15)
    • C12Y115/01—Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
    • C12Y115/01001—Superoxide dismutase (1.15.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

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  • Cosmetics (AREA)

Abstract

The invention relates to a skin-beautifying, body-beautifying, health-preserving and health-care treatment process by Fe-SOD low-temperature plasma skin permeation, which comprises a water treatment device, a non-electrolytic high-concentration hydrogen water generation device, a Fe-SO iron superoxide dismutase semen mixing and blending device, a low-temperature plasma skin surface permeation device, an ultra-dense small molecular water mist atomization device and a closed spraying device. The exogenous SOD of the invention is beneficial to the functions of delaying skin aging, resisting oxidation and removing stains, and the anti-inflammatory aspect is based on that the SOD is a specific disproportionation reaction catalyst acting on superoxide anion free radicals, so the SOD serving as a medical product has obvious curative effects on treating inflammation, autoimmunity, cardiovascular and cerebrovascular diseases and the like caused by the action of the free radicals.

Description

Fe-SOD low-temperature plasma skin permeation beautifying treatment process
Technical Field
The invention belongs to a cosmetic, and particularly relates to a Fe-SOD low-temperature plasma skin permeation cosmetic treatment process.
Background
Superoxide dismutase (SOD) is a very important biological enzyme in the defense of organisms against oxidative damage. SOD has the capability of eliminating oxygen free radicals in vivo, can better resist the toxicity of oxygen free radicals and other oxide free radicals to cell plasma membranes, and plays an important role in protecting organisms. SOD has been used at home and abroad to treat various diseases such as oxygen poisoning, senile cataract, diabetes, cardiovascular diseases, various inflammations and the like; SOD can also be used as radioprotectant for assisting radiotherapy and chemotherapy, and protecting and transplanting kidney, liver, heart, etc., to reduce adverse side effects caused by large dose of radiation. The cosmetic containing SOD has effects of inhibiting strong oxidation of oxygen free radicals on skin surface, and scavenging free radicals, whitening skin, preventing skin aging, removing speckle, removing acne, removing wrinkle, and relieving inflammation. At present, no treatment process specially aiming at cosmetics containing superoxide dismutase and the like exists in the market.
Disclosure of Invention
In order to solve the defects of the existing structure, the invention provides a skin permeation and beauty treatment process of Fe-SOD low-temperature plasma.
In order to achieve the above purpose, the technical scheme of the invention is as follows: a skin permeation and beauty treatment process of Fe-SOD low-temperature plasma is characterized in that: the device comprises a water treatment device, a non-electrolytic high-concentration hydrogen water generation device, a Fe-SO iron superoxide dismutase semen mixing and blending device, a low-temperature plasma skin surface penetration device, an ultra-dense small molecular water mist atomization device and a closed spraying device, wherein the water treatment device, the non-electrolytic high-concentration hydrogen water generation device, the low-temperature plasma skin surface penetration device, the ultra-dense small molecular water mist atomization device and the closed spraying device are sequentially connected, and the Fe-SO iron superoxide dismutase semen mixing and blending device is connected with the low-temperature plasma skin surface penetration device.
The water treatment device is composed of a pp cotton filter, a non-electrolytic high-concentration hydrogen water device, a food-grade volcanic rock filter material and a food-grade hydrogen particle ceramsite filter material, and is used for killing infection sources such as bacteria in water, the treated water is mixed with a non-electrolytic high-concentration hydrogen water device, the device mainly comprises a food-grade volcanic rock filter material and a food-grade hydrogen particle ceramsite filter material, the water is treated into high-concentration hydrogen-rich water, Fe-SO iron superoxide dismutase sperm is mixed and prepared by a three-wave type pipeline mixer and a micro stirring tank, a low-temperature plasma skin surface penetration device is composed of a plasma generator and a plasma radio frequency operating handle, and the main work of the device is radio frequency cosmetic positioning tissue heating to promote subcutaneous collagen contraction and tensioning, at the same time, cooling is applied to the skin surface, the dermis is heated and the epidermis is kept at normal temperature, and two reactions occur: firstly, the dermis layer of the skin becomes thicker, and wrinkles become lighter or disappear; the ultra-dense small molecule water mist atomizing device mainly comprises a pipeline heater, a small booster pump, an atomizing nozzle and a temperature sensor, and has the main functions of adjusting the mixed Fe-SO iron superoxide dismutase semen to a proper temperature and then spraying the Fe-SO iron superoxide dismutase semen onto the surface of the skin, and the closed spraying device mainly comprises a skin mask and the temperature sensor.
The invention mixes the antioxidant metalloenzyme semen which contains Fe-SOD Oxide Dismutase (SOD) and is also an antioxidant metalloenzyme semen existing in organisms with high-concentration hydrogen-rich water with the temperature 5 ℃ higher than the body temperature of skin according to a proportion, and sprays the antioxidant metalloenzyme semen on the clean skin surface by ultra-dense micromolecular water mist and low-temperature plasma; because Fe-SOD superoxide dismutase can catalyze superoxide anion free radical to generate oxygen and hydrogen peroxide by disproportionation, plays a vital role in the balance of oxidation and oxidation resistance of a body and is inseparable with the occurrence and development of a plurality of diseases, Fe-SO iron superoxide dismutase can effectively eliminate superoxide anion free radicals to avoid excessive damage to cells, because skin aging and damage are important characteristics of human body aging, the human body aging is the result of accumulation or elimination of active oxygen free radicals to generate obstacles, the excessive free radicals in the human body can cause cell damage and pigmentation, and the human skin can be aged and damaged due to direct contact with oxygen, SO the exogenous Fe-SO iron superoxide dismutase can supplement the functions of delaying skin aging, resisting oxidation and removing stains, and the Fe-SO iron superoxide dismutase is based on the function of acting on superoxide anion free radicals in the aspect of resisting inflammation SOD as a medicine product has obvious curative effect on inflammation, autoimmunity, cardiovascular and cerebrovascular diseases and the like caused by the action of free radicals due to the specific disproportionation reaction catalyst. And the SOD can inhibit inflammation types such as arthritis, pleurisy, acute tracheitis and the like by utilizing the antioxidation of the SOD, and the Fe-SO iron superoxide dismutase in the human body can effectively remove superoxide anion free radicals in the aspect of resisting tumors, thereby finally achieving the effect of inhibiting cancer cells.
The device is used for physical treatment in the whole process according to the characteristics of human skin, does not damage the surface of the skin, and has no stimulation and radiation in the process.
The external application method of the product of the invention comprises the following steps: spraying once a week for 3 weeks.
The action mechanism of the invention is as follows: the oral liquid is administered with Fe-SOD superoxide dismutase to scavenge free radicals in vivo, delay skin aging, increase skin moisture-keeping ability, and improve skin laxity and wrinkle; preventing the formation of color spots. If the Fe-SOD superoxide dismutase repairing liquid and the maintaining emulsion are externally used, a protective film for removing free radicals is directly formed on the surface of the skin, and broken skin elastic fibers can be repaired, so that the anti-aging effect on the skin is more remarkable.
Improving skin wrinkles. Fe-SOD superoxide dismutase is a water-soluble substance, and is adsorbed on the skin. It can release and provide nutrients needed by skin metabolism, and can effectively and durably eliminate harmful substances produced in the metabolism, especially the damage of free radicals to skin, tissue and cells, and has effective action on skin mucosa, cells and cell membranes, so as to moisten skin and reduce wrinkles.
It can be used for relieving acne. The action mechanism is as follows: the elimination of superoxide anion by Fe-SOD enhances the pathogenic bacteria attacking ability of phagocyte, improves the anti-inflammatory, anti-infection, self-protection and self-repairing ability, and promotes the focus to heal quickly. Meanwhile, other biological enzymes in the Fe-SOD superoxide dismutase repairing liquid/repairing milk have good auxiliary effects on healing of acnes.
Eczema and dermatitis improving effects. Dermatitis or eczema is an inflammatory reaction of the skin caused by various external or internal irritants. The inflammatory reaction of the body is necessarily participated in by phagocytes, and superoxide anions are generated at the same time, so that the skin is strongly stimulated and operated. The skin inflammation process produces a large amount of free radicals, which make the rash, dermatitis and acne difficult to cure.
The Fe-SOD superoxide dismutase repairing liquid/maintaining emulsion adopts multi-enzyme biological cooperation and coordination synergistic effect thereof to powerfully eliminate and quench free radicals, relieve stimulation and inflammatory injury of superoxide anions to skin tissues, relieve pruritus, accelerate recovery of skin injury parts and focuses, and obviously improve subjective symptoms and clinical characteristics of dermatitis and eczema; has good curative effect on eczema and dermatitis (solar dermatitis, contact dermatitis and neurodermatitis). The test result shows that the effective rates of the Fe-SOD superoxide dismutase on eczema, neurodermatitis, solar dermatitis and contact dermatitis respectively reach 59.5%, 56.7%, 80.0% and 84.6%. Clinical tests show that the disease focus is reduced, a new healthy skin island is generated, the fatigue is relieved, and the sleep is increased when the Fe-SOD oxide dismutase is taken within one week; can be continuously taken to keep good state. Blood examination showed a decrease in leukocyte counts, a decrease in free radicals, and fibrin network repair.
The invention has the beneficial effects that: the exogenous SOD of the invention is beneficial to the functions of delaying skin aging, resisting oxidation and removing stains, and the anti-inflammatory aspect is based on that the SOD is a specific disproportionation reaction catalyst acting on superoxide anion free radicals, so the SOD serving as a medical product has obvious curative effects on treating inflammation, autoimmunity, cardiovascular and cerebrovascular diseases and the like caused by the action of the free radicals. SOD can effectively inhibit inflammation types such as arthritis, pleuritis, acute tracheitis and the like from resisting tumors by utilizing the antioxidation of SOD, and can finally achieve the effect of inhibiting cancer cells by eliminating superoxide anion free radicals in human bodies, and high-concentration hydrogen-rich water can provide comprehensive antioxidation care for body skin, balance internal environment, comprehensively start a self-healing mechanism, and has the specific effects of metabolic repair, immunoregulation, inflammation elimination, allergic constitution improvement, cell mutation prevention, tissue repair promotion, anti-aging, beauty treatment, face nourishing and the like.
Drawings
FIG. 1 is a schematic diagram of the process of the present invention.
Detailed Description
The invention is further described by combining the attached drawings, and the Fe-SOD low-temperature plasma skin permeation cosmetic treatment process is characterized in that: the device comprises a water treatment device 1, a non-electrolytic high-concentration hydrogen water generation device 2, a Fe-SO iron superoxide dismutase semen mixing and blending device 3, a low-temperature plasma skin surface penetration device 4, an ultra-dense small molecule water mist atomization device 5 and a closed spraying device 6, wherein the water treatment device 1, the non-electrolytic high-concentration hydrogen water generation device 2, the low-temperature plasma skin surface penetration device 3, the ultra-dense small molecule water mist atomization device 4 and the closed spraying device 6 are sequentially connected, and the Fe-SO iron superoxide dismutase semen mixing and blending device 5 is connected with the low-temperature plasma skin surface penetration device 6.
The invention mixes the antioxidant metalloenzyme semen which contains Fe-SOD Oxide Dismutase (SOD) and is also an antioxidant metalloenzyme semen existing in organisms with high-concentration hydrogen-rich water with the temperature 5 ℃ higher than the body temperature of skin according to a proportion, and sprays the antioxidant metalloenzyme semen on the clean skin surface by ultra-dense micromolecular water mist and low-temperature plasma; because Fe-SOD superoxide dismutase can catalyze superoxide anion free radical to generate oxygen and hydrogen peroxide by disproportionation, plays a vital role in the balance of oxidation and oxidation resistance of a body and is inseparable with the occurrence and development of a plurality of diseases, Fe-SO iron superoxide dismutase can effectively eliminate superoxide anion free radicals to avoid excessive damage to cells, because skin aging and damage are important characteristics of human body aging, the human body aging is the result of accumulation or elimination of active oxygen free radicals to generate obstacles, the excessive free radicals in the human body can cause cell damage and pigmentation, and the human skin can be aged and damaged due to direct contact with oxygen, SO the exogenous Fe-SO iron superoxide dismutase can supplement the functions of delaying skin aging, resisting oxidation and removing stains, and the Fe-SO iron superoxide dismutase is based on the function of acting on superoxide anion free radicals in the aspect of resisting inflammation SOD as a medicine product has obvious curative effect on inflammation, autoimmunity, cardiovascular and cerebrovascular diseases and the like caused by the action of free radicals due to the specific disproportionation reaction catalyst. And the SOD can inhibit inflammation types such as arthritis, pleurisy, acute tracheitis and the like by utilizing the antioxidation of the SOD, and the Fe-SO iron superoxide dismutase in the human body can effectively remove superoxide anion free radicals in the aspect of resisting tumors, thereby finally achieving the effect of inhibiting cancer cells.
The water treatment device is composed of a pp cotton filter, a non-electrolytic high-concentration hydrogen water device, a food-grade volcanic rock filter material and a food-grade hydrogen particle ceramsite filter material, and is used for killing infection sources such as bacteria in water, the treated water is mixed with a non-electrolytic high-concentration hydrogen water device, the device mainly comprises a food-grade volcanic rock filter material and a food-grade hydrogen particle ceramsite filter material, the water is treated into high-concentration hydrogen-rich water, Fe-SO iron superoxide dismutase sperm is mixed and prepared by a three-wave type pipeline mixer and a micro stirring tank, a low-temperature plasma skin surface penetration device is composed of a plasma generator and a plasma radio frequency operating handle, and the main work of the device is radio frequency cosmetic positioning tissue heating to promote subcutaneous collagen contraction and tensioning, at the same time, cooling is applied to the skin surface, the dermis is heated and the epidermis is kept at normal temperature, and two reactions occur: firstly, the dermis layer of the skin becomes thicker, and wrinkles become lighter or disappear; the ultra-dense small molecule water mist atomizing device mainly comprises a pipeline heater, a small booster pump, an atomizing nozzle and a temperature sensor, and has the main functions of adjusting the mixed Fe-SO iron superoxide dismutase semen to a proper temperature and then spraying the Fe-SO iron superoxide dismutase semen onto the surface of the skin, and the closed spraying device mainly comprises a skin mask and the temperature sensor.

Claims (1)

1. A skin permeation and beauty treatment process of Fe-SOD low-temperature plasma is characterized in that: the device comprises a water treatment device, a non-electrolytic high-concentration hydrogen water generation device, a Fe-SO iron superoxide dismutase semen mixing and blending device, a low-temperature plasma skin surface penetration device, an ultra-dense small molecular water mist atomization device and a closed spraying device, wherein the water treatment device, the non-electrolytic high-concentration hydrogen water generation device, the low-temperature plasma skin surface penetration device, the ultra-dense small molecular water mist atomization device and the closed spraying device are sequentially connected, and the Fe-SO iron superoxide dismutase semen mixing and blending device is connected with the low-temperature plasma skin surface penetration device.
CN202110658143.1A 2021-06-15 2021-06-15 Fe-SOD low-temperature plasma skin permeation beautifying treatment process Withdrawn CN113304252A (en)

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Application Number Priority Date Filing Date Title
CN202110658143.1A CN113304252A (en) 2021-06-15 2021-06-15 Fe-SOD low-temperature plasma skin permeation beautifying treatment process

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