CN106580812A - Acne removing protection cream - Google Patents
Acne removing protection cream Download PDFInfo
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- CN106580812A CN106580812A CN201710078465.2A CN201710078465A CN106580812A CN 106580812 A CN106580812 A CN 106580812A CN 201710078465 A CN201710078465 A CN 201710078465A CN 106580812 A CN106580812 A CN 106580812A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention relates to a skin care product, particularly to an external application paste capable of removing human acne. The acne removing protection cream comprises components A, B, C, D, E, F and G, wherein the component A comprises water, methylparaben, allantoin, betaine, one selected from azelaic acid, an azelaic acid derivative and an azelaic acid cyclodextrin inclusion, nicotinamide and lactobionic acid, the component B comprises OLVEM 1000, glyceryl stearate, isomeric hexadecane, azone, one selected from DC-345 and KF-995, and one selected from 2EHP and R7779, the component C comprises propylene glycol and SEPINOV EMT10, the component D comprises matrine, stemonine and acne busters, the component E comprises water and hexamidine diisocyanate, the component F is Sepigel305, and the component G is essence. According to the present invention, the acne removing protection cream is prepared by using the plants as the raw materials through extracting, does not produce the bad side effect, and has characteristics of safety, reliability, easy use, quick effect, and the like.
Description
Technical field
The present invention relates to a kind of skin care item, can especially remove the external application lotion of human body small pox.
Background technology
Acne is a kind of chronic inflammatory skin of pilosebaceous unit, teenager is mainly apt to occur in, to teenager
Psychology and social influence it is very big, but tend to after puberty nature mitigate or fully recover.The generation of acne is mainly and sebum secretion
Excessively, the factor such as pilosebaceous duct blocking, bacterium infection and inflammatory reaction is closely related.Adolesce male in descendant's body
Hormone is particularly the level of testosterone and raises rapidly, promotes sebaceous glands to develop and produce a large amount of sebums.While pilosebaceous duct
Dyskeratosis cause catheter blockage, dyssebacia, it is micro mist thorn to form horn plug.Multiple-microorganism is especially in hair follicle
Propionibacterium acnes amount reproduction, the lipase that propionibacterium acnes is produced decomposes sebum and generates free fatty, while chemotactic is scorching
Disease cell and medium, finally induce and increase inflammatory reaction.Skin damaged is apt to occur in facial and upper chest and back.The non-inflammation skin of acne
Damage shows as opening and closed comedones.Closed comedones（Also known as hoary hair）Typical skin damaged be about 1 mm in size the colour of skin
Papule, without obvious hair follicle opening.Open comedones（Also known as blackhead）Show as hair follicle opening of the dome-shaped papule with significantly expansion.
Acne further develop can develop into various struvite skin damageds, show as inflamed papules, warts, tubercle and tumour.Inflamed papules
Take on a red color, 1～5 millimeter of diameter；Warts is in the same size, has been filled with white fester；Tubercle is touched with diameter greater than 5 millimeters
Have scleroma and pain；The position of tumour is deeper, is filled with the mixture of fester and blood.These skin damageds can also merge to be formed
Big inflammatory patch and sinus etc..Struvite skin damaged usually leaves pigmentation, erythema perstans, pitting or plumpness after disappearing
Property scar.Clinically acne is divided into into 3 degree, 4 grades according to acne lesions property and the order of severity：1 grade（Slightly）：Only acne；2
Level（Moderate）：In addition to acne, also some inflamed papules；3 grades（Moderate）：In addition to acne, also more inflamed papules or purulence
Blister；4 grades（Severe）：In addition to having acne, inflamed papules and warts, nodosity, tumour or scar are gone back.
It is distributed in face and chest and back, is mainly shown as hoary hair, blackhead, inflammatory mound according to juvenile onset, skin damaged
The features such as polymorphy skin damaged such as rash, warts, clinic is easy to diagnosis, checks typically without other are done.Sometimes for brandy nose, face
Face miliaris disseminata lupus, steatadenoma etc. differentiate.
Acne treatment
1. daily nursing
Daily one to warm water twice washes one's face, cleaning skin, avoids with hand extruding or skin damaged of scratching.Avoid with grease type, powder class cosmetics
With the ointment machin creme containing glucocorticoid.
2. the common method of acne treatment
（1）Local topical medicine tretinoin（Tretinoin emulsifiable paste, adapalene gel, Tazarotene gel）, benzoyl peroxide first
Acyl, antibioticses（Clindamycin, erythromycin, chloramphenicol etc.）, azelaic acid, sulphur lotion etc..
（2）Oral antibiotic first-selection Tetracyclines（Minocycline, Doxycycline etc.）, secondly it is macrolides（It is red mould
Element）, it is to avoid selection is usually used in the antibiotic such as levofloxacin magnitude for the treatment of system infection.Antibiotic regimen is usual 6～12 weeks.
（3）For serious acne, oral isotretinoin is standard treatment to oral isotretinoin, is also to treat acne at present
Most efficient method.The course for the treatment of is to reach minimum intergal dose 60mg/kg as target.
（4）Anti-androgen therapy such as oral contraceptive Compound Cyproterone Acetate Tablets, it is adaptable to Nv Xingzhong, severe acne
Patient, with the too high performance of androgen levels（Such as crinosity, seborrhea）Or Stein-Leventhal syndrome.Delayed acne and the moon
The female patient that acne significantly increases before menstrual period also contemplates for applying oral contraceptive.
（5）Oral glucocorticoid is mainly used in fulminant or acne conglobata, it then follows short-term, low dose and its other party
The principle of method use in conjunction.
（6）Other are not for being resistant to or be reluctant to receive the patient of drug therapy, it is also contemplated that physical treatment, such as light are moved
Power therapy（PDT）, tartaric acid therapy, laser therapy etc..
3. the classification treatment of acne
（1）1 grade typically adopts local treatment, first-selected topical Retinoids class preparation.
（2）2 grades are combined topical Retinoids classes and benzoyl peroxide or antibiotic, if necessary Combined with Oral antibiotic.
（3）3 grades usually need therapeutic alliance, oral antibiotic joint external application benzoyl peroxide and/or tretinoin medicine
Thing is first-selection.The female patient for having indication also contemplates for anti-androgen therapy.
（4）4 grades of oral isotretinoins are maximally effective treatment methods, can be used as first-line treatment.For inflamed papules and purulence
The more person of blister, also can first system application Antibiotic combination external application benzoyl peroxide, use instead again after skin damaged is obviously improved oral
Isotretinoin sequential therapy.
4. the maintaining treatment of acne
No matter which kind for the treatment of method is adopted, after skin damaged substantially disappears treatment, first-selected topical Retinoids class medicine all should be continued to
Thing, maintaining treatment 6～12 months can combine if necessary benzoyl peroxide.
In accordance with the above, small pox treatment time is long, and some meetings produce side effect to human body.How effectively quickly to be controlled
Treat into our urgent problems.
The content of the invention
It is an object of the invention to provide a kind of effectively remove small pox, short treating period, maintenances and easy to use, while to closing
Property small pox also have preferable removal effect clear acne maintenance frost.
In order to achieve the above object, a kind of clear acne maintenance of the invention frost, it is made up of A, B, C, D, E, F, G；
Described A is by water, methyl hydroxybenzoate, allantoin, glycine betaine, azelaic acid or azelaic acid derivant or azelaic acid cyclodextrin bag
One kind, niacinamide and lactobionic acid composition in compound, wherein with maintenance frost gross weight meter, methyl hydroxybenzoate accounts for 0.1%-0.5%, urinates
Bursin accounts for 0.1%-0.5%, and glycine betaine accounts for 0.5%-6%, and azelaic acid or azelaic acid derivant or azelaic acid cyclodextrin inclusion compound are accounted for
0.5%-5%, niacinamide accounts for 0.5%-5%, and lactobionic acid accounts for 0.1%-3%, and the amount of water is that maintenance frost gross weight is removed after other components
Surplus；
Described B is by OLVEM 1000, tristerin, isomery hexadecane hydrocarbon, azone, DC-345 or KF-995
A kind of composition in kind, 2EHP or R7779, wherein accounting for 1%-5%, tristerin with maintenance frost gross weight meter OLVEM 1000
Account for 1%-5%, isomery hexadecane hydrocarbon accounts for 1%-6%, azone accounts for 0.5%-3%, DC-345 or KF-995 and accounts for 1%-5%, 2EHP or R7779 and accounts for
1%-5%；
Described C is made up of propane diols and SEPINOV EMT10, wherein with maintenance frost gross weight meter, propane diols accounts for 3%-8%,
SEPINOV EMT10 account for 0.5%-3%；
Described D is made up of kuh-seng tuber of stemona element and acne jinx, wherein with maintenance frost gross weight meter, kuh-seng tuber of stemona element accounts for 0.5%-
5%, acne jinx accounts for 1%-7%；
Described E narrows fixed two and constitutes by water with oneself, wherein with maintenance frost gross weight meter, water accounts for 2%, and oneself narrows fixed two and accounts for 0.05%-
0.3%；
Described F is match Bick 305, accounts for the 0.1%-3% of maintenance frost gross weight；
Described G is essence, accounts for the 0.01%-0.03% of maintenance frost gross weight.
It is a further object of the present invention to provide a kind of preparation method of above-mentioned clear acne maintenance frost, comprises the following steps that：1st, by A
Heat phase to 75-85 DEG C, by B heat phases to 75-85 DEG C；
2nd, heating is slowly added into B phases in A phases after finishing, and homogeneous once, adds the C phases for having dissolved after stirring, after
Continuous homogeneous 10 minutes；
3rd, stirring and emulsifying 10 minutes after the completion of homogeneous, then slow cooling；
4th, D phases are added after cooling to 45 DEG C, when continuing to be cooled to 40 DEG C E phases is added, F phases are added after stirring at low speed 2-5 minute
Homogeneous is carried out, G phases is eventually adding and is stirred discharging.
For the first time allergy test is done using clear acne maintenance frost, exactly survey in arm and smear on a small quantity behind ear, etc.
Look within 20 minutes or so either with or without rubescent phenomenon of itching, the first step face cleaning if no allergic phenomena is about to begin will after face cleaning
Clear acne maintenance frost uniform application is massaged until absorbing around small pox, slightly, there is positive effect a week, and four weeks was one
The individual course for the treatment of, general two to three courses for the treatment of just can cure substantially.
The clear acne maintenance frost of the present invention adopts plant and is formulated for raw material refinement, does not produce adverse side effect, therefore
It has safe and reliable, and easy to use, the features such as instant effect, it fast and safely can effectively dispel face acne acne, repair
Acne print, removes skin silting, and sterilize anti-inflammatory, and the inflammatory small pox of red and swollen, distending pain is acted on elimination, effective described in formula
Plant component there is cleaning, sterilized and astriction, effectively pore refining and acne can be improved, skin is presented clean bright
Light pool.
Specific embodiment
Make further statement to the present invention with reference to embodiment.
Embodiment 1
A kind of clear acne maintenance frost, is prepared via a method which to obtain：
1st, with maintenance frost gross weight meter, by 0.3% methyl hydroxybenzoate, 0.3% allantoin, 3% glycine betaine, 2.5% nonyl two
Acid, the amount of 3% niacinamide, 2% lactobionic acid, water are that maintenance frost gross weight removes the surplus after other components, and A is constituted after mixing
Phase, and by A heat phases to 75-85 DEG C；With maintenance frost gross weight meter, by the glycerol stearate of 2.5% OLVEM 1000,2.5%
B phases are constituted after ester, 3% isomery hexadecane hydrocarbon, 2% azone, 3% DC-345,3% 2EHP mixing, by B heat phases to 75-
85℃；
2nd, with maintenance frost gross weight meter, 2% SEPINOV EMT10 are dissolved in 5% propane diols, constitute C phases；By step 1
B phases after middle heating is finished are slowly added in A phases, and homogeneous once, then the C for having dissolved is added to above-mentioned after stirring
In the mixture of A phases and B phases, continue homogeneous 10 minutes；
3rd, by stirring and emulsifying after the completion of the mixture homogeneous of above-mentioned A, B, C phase 10 minutes, then slow cooling；
4th, with maintenance frost gross weight meter, D phases will be constituted after 2% kuh-seng tuber of stemona element, 4% acne jinx mixing；By 2% water,
Oneself of 0.15% to narrow and constitute E phases after fixed two mixing；1.8% match Bick 305 is constituted into F phases；0.02% essence is constituted into G phases；Will
Mixture in step 3 adds D phases after cooling to 45 DEG C, E phases is added when continuing to be cooled to 40 DEG C, after stirring at low speed 2-5 minute
Adding F phases carries out homogeneous, is eventually adding G phases and stirs discharging.
Embodiment 2
1st, with maintenance frost gross weight meter, by 0.1% methyl hydroxybenzoate, 0.5% allantoin, 0.5% glycine betaine, 5% nonyl two
Acid derivative, 0.5% niacinamide, 3% lactobionic acid, the amount of water are that maintenance frost gross weight removes the surplus after other components, are mixed
A phases are constituted after conjunction, and by A heat phases to 75-85 DEG C；With maintenance frost gross weight meter, by the stearic acid of 1% OLVEM 1000,5%
B phases are constituted after glyceride, 1% isomery hexadecane hydrocarbon, 3% azone, 1% KF-995,5% 2EHP mixing, by B heat phases extremely
75-85℃；
2nd, with maintenance frost gross weight meter, 3% SEPINOV EMT10 are dissolved in 3% propane diols, constitute C phases；By step 1
B phases after middle heating is finished are slowly added in A phases, and homogeneous once, then the C for having dissolved is added to above-mentioned after stirring
In the mixture of A phases and B phases, continue homogeneous 10 minutes；
3rd, by stirring and emulsifying after the completion of the mixture homogeneous of above-mentioned A, B, C phase 10 minutes, then slow cooling；
4th, with maintenance frost gross weight meter, D phases will be constituted after 0.5% kuh-seng tuber of stemona element, 7% acne jinx mixing；By 2% water,
Oneself of 0.05% to narrow and constitute E phases after fixed two mixing；3% match Bick 305 is constituted into F phases；0.01% essence is constituted into G phases；Will step
Mixture in rapid 3 adds D phases after cooling to 45 DEG C, adds E phases when continuing to be cooled to 40 DEG C, after stirring at low speed 2-5 minute again
Add F phases to carry out homogeneous, be eventually adding G phases and stir discharging.
Embodiment 3
1st, with maintenance frost gross weight meter, by 0.5% methyl hydroxybenzoate, 0.1% allantoin, 6% glycine betaine, 0.5% nonyl two
Sour cyclodextrin inclusion compound, 5% niacinamide, 0.1% lactobionic acid, the amount of water remove remaining after other components for maintenance frost gross weight
Amount, constitutes A phases after mixing, and by A heat phases to 75-85 DEG C；With maintenance frost gross weight meter, by 5% OLVEM's 1000,1%
B phases are constituted after tristerin, 6% isomery hexadecane hydrocarbon, 0.5% azone, 5% DC-345,1% R7779 mixing, will
B heat phases are to 75-85 DEG C；
2nd, with maintenance frost gross weight meter, 0.5% SEPINOV EMT10 are dissolved in 8% propane diols, constitute C phases；By step
B phases after heating is finished in 1 are slowly added in A phases, and homogeneous once, then the C for having dissolved is added to after stirring
In stating the mixture of A phases and B phases, continue homogeneous 10 minutes；
3rd, by stirring and emulsifying after the completion of the mixture homogeneous of above-mentioned A, B, C phase 10 minutes, then slow cooling；
4th, with maintenance frost gross weight meter, D phases will be constituted after 5% kuh-seng tuber of stemona element, 1% acne jinx mixing；By 2% water,
Oneself of 0.3% to narrow and constitute E phases after fixed two mixing；0.1% match Bick 305 is constituted into F phases；0.03% essence is constituted into G phases；Will
Mixture in step 3 adds D phases after cooling to 45 DEG C, E phases is added when continuing to be cooled to 40 DEG C, after stirring at low speed 2-5 minute
Adding F phases carries out homogeneous, is eventually adding G phases and stirs discharging.
Test example
Clear acne maintenance frost is respectively to three groups of 15-60 year people according to obtained in above three combination formula, and per group of 100 people, control is outer
With the clear acne maintenance frost, the product of first group of external application embodiment 1, the product of second group of external application embodiment 2, the 3rd group of external application enforcement
The product of example 3, draws to draw a conclusion through statistics：
Clear acne maintenance frost in accordance with the above, the scheme of embodiment 1 is optimal, and preferably, responding time is most fast, and it can be quick for effect
Face acne acne is safely and effectively dispelled, acne print is repaired, skin silting is removed, sterilize anti-inflammatory, the inflammatory acne to red and swollen, distending pain
Acne is also releived effect, and the effective plant component described in formula has cleaning, sterilized and astriction, can effectively shrink
Pore simultaneously improves acne, makes skin that clean bright gloss is presented.
Claims (2)
1. a kind of clear acne maintenance is white, it is characterised in that：It is made up of A, B, C, D, E, F, G；
Described A is by water, methyl hydroxybenzoate, allantoin, glycine betaine, azelaic acid or azelaic acid derivant or azelaic acid cyclodextrin bag
One kind, niacinamide and lactobionic acid composition in compound, wherein with maintenance frost gross weight meter, methyl hydroxybenzoate accounts for 0.1%-0.5%, urinates
Bursin accounts for 0.1%-0.5%, and glycine betaine accounts for 0.5%-6%, and azelaic acid or azelaic acid derivant or azelaic acid cyclodextrin inclusion compound are accounted for
0.5%-5%, niacinamide accounts for 0.5%-5%, and lactobionic acid accounts for 0.1%-3%, and the amount of water is that maintenance frost gross weight is removed after other components
Surplus；
Described B is by OLVEM 1000, tristerin, isomery hexadecane hydrocarbon, azone, DC-345 or KF-995
A kind of composition in kind, 2EHP or R7779, wherein accounting for 1%-5%, tristerin with maintenance frost gross weight meter OLVEM 1000
Account for 1%-5%, isomery hexadecane hydrocarbon accounts for 1%-6%, azone accounts for 0.5%-3%, DC-345 or KF-995 and accounts for 1%-5%, 2EHP or R7779 and accounts for
1%-5%；
Described C is made up of propane diols and SEPINOV EMT10, wherein with maintenance frost gross weight meter, propane diols accounts for 3%-8%,
SEPINOV EMT10 account for 0.5%-3%；
Described D is made up of kuh-seng tuber of stemona element and acne jinx, wherein with maintenance frost gross weight meter, kuh-seng tuber of stemona element accounts for 0.5%-
5%, acne jinx accounts for 1%-7%；
Described E narrows fixed two and constitutes by water with oneself, wherein with maintenance frost gross weight meter, water accounts for 2%, and oneself narrows fixed two and accounts for 0.05%-
0.3%；
Described F is match Bick 305, accounts for the 0.1%-3% of maintenance frost gross weight；
Described G is essence, accounts for the 0.01%-0.03% of maintenance frost gross weight.
2. the preparation method of a kind of clear acne maintenance frost according to claim 1, it is characterised in that：Comprise the following steps that：
（1）, by A heat phases to 75-85 DEG C, by B heat phases to 75-85 DEG C；
（2）, heating finish after B phases are slowly added in A phases, homogeneous once, adds the C phases for having dissolved after stirring,
Continue homogeneous 10 minutes；
（3）, stirring and emulsifying 10 minutes after the completion of homogeneous, then slow cooling；
（4）, cool to 45 DEG C after add D phases, add E phases, stirring at low speed 2-5 to add F after minute when continuing to be cooled to 40 DEG C
Homogeneous is mutually carried out, G phases is eventually adding and is stirred discharging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710078465.2A CN106580812A (en) | 2017-02-14 | 2017-02-14 | Acne removing protection cream |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710078465.2A CN106580812A (en) | 2017-02-14 | 2017-02-14 | Acne removing protection cream |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106580812A true CN106580812A (en) | 2017-04-26 |
Family
ID=58587556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710078465.2A Pending CN106580812A (en) | 2017-02-14 | 2017-02-14 | Acne removing protection cream |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108187070A (en) * | 2018-03-15 | 2018-06-22 | 山东滨州智源生物科技有限公司 | A kind of preparation method of azelaic acid HYDROXYPROPYL BETA-CYCLODEXTRIN inclusion compound |
| CN108186826A (en) * | 2018-02-13 | 2018-06-22 | 云南诺漫斯生物科技有限公司 | A kind of anti-acne ointment of the ingredient containing American cockroach and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1611212A (en) * | 2003-12-05 | 2005-05-04 | 浙江康恩贝集团养颜堂制药有限公司 | Anchoic acid emulsifiable paste and its preparing method |
| CN102988504A (en) * | 2012-11-29 | 2013-03-27 | 王便草 | Acne-clearing and repairing cream |
| CN106110327A (en) * | 2016-08-03 | 2016-11-16 | 浙江添月生物科技有限公司 | Acne eliminating cream |
-
2017
- 2017-02-14 CN CN201710078465.2A patent/CN106580812A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1611212A (en) * | 2003-12-05 | 2005-05-04 | 浙江康恩贝集团养颜堂制药有限公司 | Anchoic acid emulsifiable paste and its preparing method |
| CN102988504A (en) * | 2012-11-29 | 2013-03-27 | 王便草 | Acne-clearing and repairing cream |
| CN106110327A (en) * | 2016-08-03 | 2016-11-16 | 浙江添月生物科技有限公司 | Acne eliminating cream |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186826A (en) * | 2018-02-13 | 2018-06-22 | 云南诺漫斯生物科技有限公司 | A kind of anti-acne ointment of the ingredient containing American cockroach and preparation method thereof |
| CN108187070A (en) * | 2018-03-15 | 2018-06-22 | 山东滨州智源生物科技有限公司 | A kind of preparation method of azelaic acid HYDROXYPROPYL BETA-CYCLODEXTRIN inclusion compound |
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Application publication date: 20170426 |