TWM483083U - Dual sphere liposome structure of lactic acid combined with organic plant extracts for treatment and prevention of atopic dermatitis, eczema, heat rash, child diaper rash, acne and other skin inflammation - Google Patents

Description

A lactic acid bacteria combined with organic plant extract can be used for the treatment and prevention of bismuth microlipid structure of dermatitis such as atopic dermatitis, eczema, sweat rash, diaper rash and acne in children.

This creation is about a double-sphere micro-lipid structure, especially for a lactic acid bacteria combined with organic plant extracts that can be used to treat and prevent dermatitis such as atopic dermatitis, eczema, sweat rash, diaper rash and acne in children. Lipid structure.

Dermatological research has found that patients with atopic dermatitis have poor skin water retention functions compared to the average person, and the skin is relatively dry, while dry skin can make the barrier function of the epidermis worse.

At present, for the treatment and prevention of atopic dermatitis, eczema, sweat rash, diaper rash and acne in children, in the external parts of the skin, if the use of skin care products, the most commonly used is a moisturizer; if using drugs, generally the most Commonly used are steroid creams, antihistamine creams and antibiotic ointments. The dermatologist will advise the patient to rub more moisturizer or lubricant. The traditionally best lubricant is Vaseline because it is very oily, not easy to dry and hardly cause allergies. However, the disadvantage is that it is quite airtight. It makes people feel that the skin can't "breath" and sometimes causes obstructive hair follicle inflammation.

Topical application of steroid creams is still one of the most effective methods at present. But undeniable, steroid creams have many side effects. The use of steroid creams is a sophisticated technique that must take into account the strength of various steroid creams, the nature of the base, the age of the patient and the various parts of the body. For the skin thickness, do not apply the medicine yourself to avoid serious side effects. Topical application of anti-histamine ointment can also effectively prevent patients from over-scratching the skin, but most of these ointments are short-lived, and may also cause side effects such as drowsiness, dry mouth, constipation, affecting learning, arrhythmia, and palpitations. Antibiotic ointments can only reduce the number of colonies of pathogenic Staphylococcus on the skin surface.

Most of the prior art is a chemically synthesized pharmaceutical ingredient that can only be used for a short period of time when it is allergic to the skin. It must not be used for a long time, and it can only cure the symptoms. In the long-term use of these chemically synthesized pharmaceutical ingredients, the dosage used will increase, and the number of uses will certainly increase, and the long-term use will definitely cause irreparable serious side effects to the body.

In addition, the prior art has a disadvantage in that the moisturizing cosmetic has only a moisturizing function; and the chemically synthesized medical component has only a symptomatic therapeutic effect, cannot cure dermatitis, and has many side effects.

One of the aims of the present invention is to provide a globular microlipid structure which can be used for the treatment and prevention of dermatitis such as atopic dermatitis, eczema, sweat rash, diaper rash and acne in children, by organic plant extract, which is externally The composition includes: a lipid-effect layer other than natural oil; a functional layer containing natural organic plant extract; an inner lipid-containing layer containing natural organic oil; and an inner efficacy layer containing active sensitizing lactic acid bacteria fermentation extract It can effectively reduce the severity of dermatitis, and can reduce the chance of recurrence of dermatitis, cure the symptoms and cure the disease.

Another object of the present invention is to provide a structure comprising the above-mentioned double-sphere microlipid, in particular, a lactic acid bacteria combined with organic plant extract for treating and preventing atopic dermatitis, eczema, sweat rash, diaper rash and acne in children, etc. Cosmetic material for the globular microsphere structure of dermatitis.

Another object of the present invention is to provide a method for treating and preventing dermatitis such as atopic dermatitis, eczema, sweat rash, diaper rash, and acne, using a double sphere vesicle structure as described above.

(11) ‧‧‧External lipid efficacy layer

(12) ‧ ‧ external efficacy layer

(21) ‧ ‧ inner lipid efficacy layer

(22) ‧ ‧ internal efficacy layer

The first drawing is a plan view of a preferred embodiment of the present invention.

In one embodiment of the present invention, a lactic acid bacteria combined with organic plant extract can be used for treating and preventing a double sphere microlipid structure of dermatitis such as atopic dermatitis, eczema, sweat rash, diaper rash and acne (first Figure) consists of the following components: outer lipid efficacy layer (11); external efficacy layer (12); inner lipid efficacy layer (21); inner efficacy layer (22).

The outer lipid effect layer (11) and the inner lipid effect layer (21) comprise a selected from the group consisting of natural vegetable oils, long chain fatty acids, and combinations thereof. Natural vegetable oils include, but are not limited to, shea butter, jojoba oil, sunflower oil, and combinations thereof. Long chain fatty acids include, but are not limited to, hydrogenated polyisobutylene, sucrose polystearate or other types of long chain fatty acids and combinations thereof.

In one embodiment of the present invention, the outer lipid-effect layer (11) is a central spherical structure comprising jojoba oil, sunflower oil, shea butter, vitamin B5, hydrogenated polyisobutylene, sucrose polystearic acid. Ester and other ingredients. In one embodiment of the present work, the outer efficacy layer (12) comprises an organic plant extract. Organic plant extracts include, but are not limited to, organic chamomile extracts, organic calendula extracts, and combinations thereof. Preferably, the outer efficacy layer (12) contains urea, an organic chamomile extract, and an organic calendula extract.

In one embodiment of the present invention, the inner lipid layer (21) is a central globular structure comprising jojoba oil, sunflower oil, organic borage oil, vitamin E, hydrogenated polyisobutylene, sucrose polystearate. And other ingredients. In one embodiment of the present invention, the inner efficacy layer (22) comprises active sensitizing lactic acid bacteria fermentation extract, hyaluronic acid and a combination thereof, and the main active ingredients are: whey protein, natural lactic acid, amino acid, fatty acid, Antibacterials, vitamins and natural moisturizing factors. Examples of lactic acid bacteria include, but are not limited to, Lactobacillus rhamnosus GG, Lactobacillus acidophilus, Lactobacillus plantarum , Lactobacillus casei , Lactobacillus paracasei, and combinations thereof. In one example, the active Shumin lactic acid bacteria fermentation extract is obtained by using Lactobacillus rhamnosus GG , Lactobacillus acidophilus , Lactobacillus plantarum , Lactobacillus casei , Lactobacillus paracasei and other five strains of sensitizing lactic acid bacteria, by means of composite symbiotic fermentation technology, with fresh milk at temperature The culture is carried out at 37 ° C to 40 ° C and then obtained through an extraction process. According to an embodiment of the present invention, the active sensitizing lactic acid bacteria fermentation metabolic essence and the organic plant extract formed by the above four efficacy layers can be used for treating and preventing atopic dermatitis, eczema, sweat rash, diaper rash in children and The globular microlipid structure of dermatitis such as acne.

The above four efficacy layers form a complete lactic acid bacteria combined with organic plant extracts for the treatment and prevention of atopic dermatitis, eczema, sweat rash, diaper rash, acne and other dermatitis bismuth microlipid structure of cosmetic raw materials .

Preferably, the particle size of the double sphere vesicle structure is preferably from 50 to 300 nm.

The bilayer membrane structure of the liposome (ie, the outer lipid effect layer (11) and the inner lipid effect layer (21)) is quite close to the cell membrane structure, and has good compatibility with the skin, and can simultaneously transport water solubility and Oil-soluble substance. The micro-lipid has the function of continuous release, and the active ingredient contained in it is first released from the outer layer, and slowly released in the inner layer. The coating of the micro-lipid It not only prevents the oxidized active ingredient from being damaged, but also easily passes through the gap between the epidermal cells of the skin and brings the active ingredients to the inner layer of the skin.

The advantages of the microlipid structure are as follows: the active ingredient substance can be stabilized, the layer release of the active ingredient substance can be controlled, the transdermal delivery efficiency of the active ingredient substance can be obviously improved, and the active ingredient substance can be effectively increased for the local application site, It can effectively reduce the waste of active ingredient substances.

The double-sphere microlipid structure of the present invention, wherein two lipid layers (ie, the outer lipid effect layer (11) and the inner lipid effect layer (21)) are selected from the group consisting of jojoba oil, sunflower oil, hydrogenated polyisobutylene and sucrose. The composition of stearate or the like, the lipid composition is coated outside the inner and outer efficacy layers, and together constitutes the bisphere vesicle structure of the present invention.

The first embodiment of the present invention is a plan view of a preferred embodiment of the present invention. At the beginning, the outer lipid-effect layer (11) is applied to the skin and massaged slowly until the skin is completely absorbed. It will be absorbed by the epidermal cells of the skin and release the active ingredient substance of the outer lipid-effect layer. The active ingredients of the outer lipid-effect layer (11) are: shea butter, vitamin B5 and the like, and the outer lipid-effect layer ( 11) It has anti-inflammatory, protects skin sebum, promotes cell metabolism, softens and dryes skin, changes skin cell energy conversion rate, and promotes its natural repair function.

In the continuation, the external effect layer (12) starts to release the active ingredient substance, and the active ingredients of the external effect layer (12) are: organic chamomile extract, organic marigold extract, urea and the like, and the external effect layer (12) has antibacterial effect. It can reduce inflammation, moisturize, reduce burns, blisters, inflamed wounds and help wound healing.

Continued, the inner lipid effect layer (21), began to release the active ingredient substance, lactone The active ingredient of the quality layer (21) is: organic borage oil, vitamin E and the like, and the inner lipid effect layer (21) has the functions of soothing dry skin and itching, improving skin abnormal symptoms, providing skin essential lipids, and promoting cells. The effect of regeneration.

Finally: the inner efficacy layer (22) begins to release the active ingredient substance. The active ingredient of the inner efficacy layer (22) is: five strains of sensitizing lactic acid bacteria (IMMUPRO 5L), Lactobacillus rhamnous GG, Lactobacillus acidopphilus, Lactobacillus plantarum, Lactobacillus casei And Lactobacillus paracasei and hyaluronic acid and other compositions have the functions of regulating body immune function, providing nutrients necessary for skin lipids and skin growth, repairing weak acid sebum membrane, maintaining the ecological balance of normal skin flora, and reducing dermatitis. The severity and probability of repeated occurrences.

According to the implementation method of the present invention, the active ingredient substances in the four efficacy layers (ie, the outer lipid effect layer (11), the outer efficacy layer (12), the inner lipid effect layer (21) and the inner efficacy layer (22) may also be used. In response to the special properties of the multi-lipid multilayer structure, the active ingredient substance of each effect layer will be applied to the skin and massaged slowly until the skin is completely absorbed. Slow release, during the release process, the additive effect of each active ingredient can be achieved, and the effect is better than the previous technology.

(11) ‧‧‧External lipid efficacy layer

(12) ‧ ‧ external efficacy layer

(21) ‧ ‧ inner lipid efficacy layer

(22) ‧ ‧ internal efficacy layer

Claims (10)

A lactic acid bacteria combined with organic plant extract can be used for the treatment and prevention of atopic dermatitis, eczema, sweat rash, diaper rash of pediatric diarrhea and acne and other globular microlipid structure, and its external and internal components include: a lipid-efficiency layer other than natural oil; a layer containing a natural organic plant extract; an inner lipid-containing layer containing a natural organic fat; and an inner layer containing an active-sensitive lactic acid bacteria fermentation extract. The lactic acid bacteria combined with organic plant extract as described in claim 1 can be used for the treatment and prevention of bismuth microlipid structure of dermatitis such as atopic dermatitis, eczema, sweat rash, diaper rash and acne in children. The active ingredient substance is safely stored for a long time, and the external component is prevented from damaging the active ingredient substance. The lactic acid bacteria combined with organic plant extract as described in claim 1 can be used for the treatment and prevention of bismuth microlipid structure of dermatitis such as atopic dermatitis, eczema, sweat rash, diaper rash and acne in children, each of which The efficacy layer is composed of active substances already existing in nature. It is not chemically synthesized. After use, it can not only improve various inflammatory symptoms of the skin, but also reduce the incidence of dermatitis, and it also produces no side effects at all. The lactic acid bacteria combined with organic plant extract as described in claim 1 can be used for the treatment and prevention of bismuth microlipid structure of dermatitis such as atopic dermatitis, eczema, sweat rash, diaper rash and acne in children, and the like. The lipid effect layer and the inner lipid effect layer contain jojoba oil, sunflower oil, hydrogenated polyisobutylene and sucrose polystearate, and the like. The lactic acid bacteria combined with organic plant extract as described in claim 1 can be used for the treatment and prevention of bismuth microlipid structure of dermatitis such as atopic dermatitis, eczema, sweat rash, diaper rash and acne in children, and the like. The lipid-effect layer contains the active ingredient substances shea butter, vitamin B5 and the like. The lactic acid bacteria combined with organic plant extract as described in claim 1 can be used for the treatment and prevention of bismuth microlipid structure of dermatitis such as atopic dermatitis, eczema, sweat rash, diaper rash and acne in children, and the like. The efficacy layer contains an active ingredient substance organic chamomile extract, organic calendula extract, urea and the like. The lactic acid bacteria combined with organic plant extract as described in claim 1 can be used for the treatment and prevention of a double sphere microlipid structure of dermatitis such as atopic dermatitis, eczema, sweat rash, diaper rash and acne in children, The lipid-effect layer is composed of an active ingredient substance organic borage oil, vitamin E and the like. The lactic acid bacteria combined with organic plant extract as described in claim 1 can be used for the treatment and prevention of a double sphere microlipid structure of dermatitis such as atopic dermatitis, eczema, sweat rash, diaper rash and acne in children, The efficacy layer consists of five strains of sensitizing lactic acid bacteria (IMMUPRO 5L), Lactobacillus rhamnous GG, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei and Lactobacillus paracasei with hyaluronic acid and the like. The lactic acid bacteria combined with organic plant extract as described in claim 1 can be used for the treatment and prevention of bismuth microlipid structure of dermatitis such as atopic dermatitis, eczema, sweat rash, diaper rash and acne in children. For external skin care products, it provides skin with weak acid protective film, adjusts allergies, repairs damaged skin, supplies skin nutrition, does not irritate skin, resists inflammation, antibacterial, itching and other effects, and can reduce dermatitis. The probability of seriousness and recurrence. A lactic acid bacteria combined with organic plant extract as described in claim 1 can be used for the treatment and prevention of bismuth microlipid structure of dermatitis such as atopic dermatitis, eczema, sweat rash, diaper rash and acne in children, wherein The double sphere micro-lipid structure can be applied to dosage forms such as creams and lotions.