CN103284038A - Hyperglycemic composition and preparation method thereof - Google Patents
Hyperglycemic composition and preparation method thereof Download PDFInfo
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- CN103284038A CN103284038A CN2012105833718A CN201210583371A CN103284038A CN 103284038 A CN103284038 A CN 103284038A CN 2012105833718 A CN2012105833718 A CN 2012105833718A CN 201210583371 A CN201210583371 A CN 201210583371A CN 103284038 A CN103284038 A CN 103284038A
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Abstract
The invention provides a hyperglycemic composition and a preparation method thereof. The hyperglycemic composition comprises the following components by mass percent: 10-85% of resistant dextrin, 1-30% of L-arabinose, 5-65% of polydextrose, 0-8% of fruit powder, 0-8% of tea powder, and 0-8% of yeast powder. The hyperglycemic composition has the beneficial effects of good hypoglycemic effect and good flavor, and is suitable for diabetes to regulate the blood sugar level, and also suitable for a person with a high blood sugar level or people with requirements on blood sugar control to eat along with a meal, so as to control blood sugar and prevent the blood sugar from rising.
Description
Technical field
The present invention relates to field of health care products, particularly a kind of hypoglycemic composition and preparation method thereof.
Background technology
Diabetes are the common diseases among the elderly, and this disease often is difficult to discover when morbidity just, seriously harm humans health.Can control generation and the development of this disease effectively by the restriction of diet, the polyorexia of can not satiating, edible high energy food then can not cause harmful effect to patient's physique again but do not eat high energy food, so need a kind of health products that meet treatment diabetes needs.
Hypoglycemic product can be divided into bread and cheese, health food and medicine according to feedstock property, and is according to prior art, limited as the hypoglycemic product effect of bread and cheese and health food.A lot of hypoglycemic beverage raw materials derive from plant extracts, may bring peculiar smell, bitter taste or other smell that allows the people be difficult to accept, thereby influence local flavor and the mouthfeel of entire product; Though the part plant extracts has effect of lowering blood sugar, also has certain toxic and side effect.Under the prior art, a lot of hypoglycemic beverages are primarily aimed at hyperglycemic patients, are not suitable for the higher person of some slight blood sugar, can't be as people's daily maintenence blood sugar rising product.
Summary of the invention
The present invention proposes a kind of hypoglycemic composition and preparation method thereof, has solved hypoglycemic product in the prior art and has lacked safe and effective, mouthfeel and can be applicable to the high person of slight blood sugar well or glycemic control is had the people's group control blood sugar of demand, the demand that prevention blood sugar raises.
Technical scheme of the present invention is achieved in that
A kind of hypoglycemic composition comprises following mass percent component: resistant dextrin 10-85%, L-arabinose 1-30%, polydextrose 5-65%, Fruit powder 0-8%, tea powder 0-8%, dusty yeast 0-8%.
Further, described dusty yeast comprises a kind of in Cr-enriched yeast, ferrum-rich saccharomyces cerevisiae, Se-enriched yeast or the Zinc-rich saccharomyces cerevisiae.
Further, described tea powder comprises a kind of tea powder in green tea, black tea, oolong tea, white tea or the black tea.
Further, the preparation process of hypoglycemic composition granule is as follows:
1) weighing: take by weighing required raw material;
2) sieve: the vortex oscillation sieve of the raw material that takes by weighing being put into 80 order stainless steel mesh;
3) mix: all raw materials after will sieving are poured in the high-speed mixing granulating machine, do earlier and mix 3min～5min, and then 1min～3min is closed in the ethanol wet mixing that adds 70%～90% concentration;
4) granulate: the softwood that makes is made wet granular with 30 order stainless steel mesh on oscillating granulator;
5) oven dry: again wet granular is placed baking oven, it is 75 ℃ that oven temperature is set, oven dry 3h～4h, moisture≤5.0% of control particle;
6) pack: at last with packing machine in accordance with regulations loading amount pack in the aluminium foil bag.
Described hypoglycemic composition includes but not limited to following: tablet, capsule, oral liquid, granule, pill.
The L-arabinose, English name L-Arabinose claims pectinose, arabinose again; The L-arabinose mainly contains two in the function of use of food and pharmaceutical preparations, and the one, can suppress the enzyme of hydrolysis disaccharide, so suppress because taking in the blood sugar rising that sucrose causes; The 2nd, because of the inhibitory action of L-arabinose to the disaccharide hydrolase, make at the sucrose that is not decomposed in the small intestine and in large intestine, produced lot of organic acids by the microorganism decomposition, this organic acid has inhibitory action to the liver synthctic fat, add L-arabinose inhibitory action to absorption sucrose in small intestine, thereby reduce the generation of new fats in the body.The L-arabinose can use with the sucrose compatibility and also can eat separately.The ratio of adding 3.5% can suppress the absorption of human body 60-70% sucrose in sucrose, and long-term use can reduce blood sugar.Separately edible L-arabinose, effect is identical.
Resistant dextrin is a kind of solubility dietary substances, only 15% in small intestine by enzymic digestion, and remainder enters large intestine, 75% of primary quantity is fermented in large intestine at leisure gradually, 10% excretes.Take in resistant dextrin and can cause that therefore hypoglycemia and blood insulin reaction have its mechanism of auxiliary hyperglycemic function is to delay and suppress digesting and assimilating carbohydrate, and improve the tip tissue to the sensitivity of insulin, reduction is to the requirement of insulin. and water miscible resistant dextrin is along with the formation of gel, stoped the diffusion of carbohydrate, postponed the absorption in intestines, thereby suppressed carbohydrate and absorbed the rising of back blood sugar and the reaction that blood insulin raises, then there is not such effect during picked-up monose. resistant dextrin can change the secretion of intestinal hormone in addition, secretion as pancreatic secretion reduces, thereby has suppressed the absorption of carbohydrate.
Polydextrose is the special carbohydrate of a kind of low in calories, sugar-free, low-glycemic, has the characteristics of water-soluble dietary fiber and prebiotics.It is to be formed through the high-temperature fusion polycondensation by naturally occurring glucose, sorbierite, citric acid, is the polysaccharide of the glucose composition of random crosslinking.Polydextrose can hinder food and fully contact with digestive juice, suppresses the glucagon secretion, impels glucose absorption to slow down, thereby reduces level of postprandial blood sugar, gives full play to the effect of insulin, prevents diabetes.
Saccharomycete generally has very high nutritive value, particularly contains more protein, and a lot of B family vitamins, nucleic acid and mineral matter also can produce some health care active materials simultaneously; Can not only directly be developed to nutraceutical, also can further be prepared into the multiple nutrients active material, as the carrier of nutraceutical, will make nutritional health food after nutritious yeast and the functional yeast deep processing.For example: be carrier with the yeast, replenish health food and the food of special nutrients of some micronutrients, as Cr-enriched yeast, ferrum-rich saccharomyces cerevisiae, Se-enriched yeast, Zinc-rich saccharomyces cerevisiae etc.; Namely in the culture medium of producing yeast, increase iron, zinc, selenium concentration, contain these more materials in the yeast thereby make, replenish needed by human body.
Tea powder, tea include multiple flavonoids polyphenoils, and the inflammatory reaction that can resist over oxidation is a kind of desirable natural hypoglycemic drink.Moreover, tea also contains Tea Polyphenols, can strengthen the tough domestic animal of capillary, prevents that capillary rupture is hemorrhage; Tannic acid in the tealeaves can reduce cholesterol, prevention of arterial sclerosis and headstroke.Wherein the mechanism of Tea Polyphenols hypoglycemic is mainly reflected in the activity that improves insulin sensitivity, suppresses relevant enzymes in glucose running carrier activity, the inhibition enteron aisle, the oxidative damage that reduces pancreatic and five aspects of downward modulation control gluconeogenesis expression of gene.
Experiment one
1 animal used as test
Choose healthy male mice, body weight is 26 ± 2g.
2 materials
2.1 reagent
Alloxan (C
4H
2N
2O
4H
2O, molecular weight 160.08), blood sugar detection kit, potassium chloride, anthrone, absolute ethyl alcohol and sodium chloride.
2.2 high heat feed
Lard 10%, sucrose 15%, yolk powder 15%, casein 5%, cholesterol 1.2%, sodium taurocholate 0.2%, calcium bicarbonate 0.6%, stone flour 0.4% and mouse normal diet 52.6%.
2.3 instrument
Blood glucose meter, visible spectrophotometer, table model high speed centrifuge and balance.
3 experimental techniques
3.1 the foundation of alloxan diabetes mouse model and grouping
Choose some of healthy male mices, give common beverages adaptability before the experiment and feed 5d, get 10 mouse at random as normal group, all the other lumbar injection alloxans are set up zoic model with hyperglycemia: alloxan is made into 2% parenteral solution with physiological saline, every the disposable injection 200mg/kg of mouse alloxan solution.Normal group injection equivalent physiological saline.Tail vein blood after 72 hours, measure fasting blood sugar FBG(mmol/L), FBG〉11mmol/L is modeling success mouse, choose the FBG value and be 40 of the modeling of 11-15mmol/L success mouse, be divided into four groups at random, every group 10, be respectively model group, medicine group and experiment low dose group and control experiment high dose group.
3.2 blood sugar intervening measure
Control group and model group mouse are fed at twice with normal diet and feed, and freely drink water.The medicine group is irritated stomach with glibenclamide 0.1g/kg body weight (being diluted to 0.2mL with physiological saline), once a day on the basis that normal diet is fed; Experimental group is on the basis that normal diet is fed, and the experiment high dose group is irritated stomach with granule 2g dissolving of the present invention, and the experiment low dose group is irritated stomach with granule 1g dissolving of the present invention, once a day.Feed 30d continuously.
3.3 method of testing
3.3.1 general index
Observe the health status that sensory manifestation such as mouse cerebration, hair situation, defecation situation, diet situation are come out.
3.3.2 blood glucose value and rate of descent
Adopt blood taking needle to puncture palpebra interna, get blood 50 μ l, with 5 times of physiological saline dilutions, the centrifugal 10min of 4000r/mim, separation of serum is measured mouse fasting blood-glucose (FBG) with Reagent kit of glucose.30d surveys fasting blood sugar (fasting is preceding with experiment), relatively each treated animal blood glucose value and blood sugar decline percentage continuously.
Blood glucose value before the blood sugar rate of descent %=(experiment-experiment back blood glucose value)/the preceding blood glucose value of experiment * 100%
3.3.3 hepatic glycogen is measured
Get eyeball behind the nursing 15d and get blood, put to death, get its liver, clean with the precooling physiological water, with the filter paper suction, take by weighing 0.5 and restrain the freezing preservation of low temperature refrigerator.During mensuration, take out and to be placed to room temperature, add 30% Klorvess Liquid 1.5mL, boil 20min, put coldly, add the 3mL absolute ethyl alcohol, boil, the centrifugal 10min of 4000r/mim, the supernatant that inclines, sediment is settled to 25mL with distilled water, measures with anthrone method.
4 results
4.1 control blood sugar beverage is to the influence of the general health condition of mouse
Mouse spirit is active before the modeling, and diet is normal, and defecation is normal; After the modeling success, the mouse listlessness, situations such as many drinks to be eaten, and body is become thin, defecation frequency increases appear, but after the perfusion, the glibenclamide group takes a turn for the better than the obvious mental status of other group mouse of modeling, diet, defecation are normal, the experiment high dose group gavage control blood sugar beverage after the 3rd day spirit take a turn for the better gradually, it is normal that diet, defecation all obviously are tending towards, the experiment low dose group is in that to gavage control blood sugar beverage the 5th day mental restoration normal, diet, the defecation situation of also getting well.Perfusion later stage medicine group and experimental mice health condition are good, diet, defecation, activity abnormal conditions do not occur.
4.2 control blood sugar beverage is to the influence of mouse fasting blood-glucose and hepatic glycogen
Analyzing above blood sugar test data can reach a conclusion: experiment back model group blood glucose value and hepatic glycogen content all are higher than normal group, and difference very remarkable (P＜0.01), and the modeling success is described.Test high dose group and experiment low dose group and all obviously reductions of model group contrast blood sugar, equal difference is (P＜0.05 or P＜0.01) significantly, and experiment high dose group blood sugar test value reaches 47.1% than initial blood sugar decline after raising 30d, and blood sugar decreasing effect is the most remarkable; Experiment high dose group and experiment low dose group hepatic glycogen content all are higher than model group, difference very remarkable (P＜0.01).
Experimental result shows: the control blood sugar beverage that granule of the present invention provides gavages mouse, can play protection to the glycometabolism of mouse and do usefulness, significantly increases hepatic glycogen and stores, thereby reach the effect that reduces blood sugar.
Experiment two
Choose 35 fasting blood sugars greater than the crowd of 7mmol/L, survey its postprandial plasma glucose level (the normally blood glucose value that recorded in 2 hours after the meal) respectively.Take control blood sugar solid beverage provided by the invention with meal on request then, cross 2h and survey its blood glucose value, uninterruptedly take 15d, experiment is surveyed its fasting blood sugar respectively after finishing again.Record testing result, and the result is carried out analytic statistics, reach a conclusion: test crowd postprandial plasma glucose level decline 2.3 ± 2.2mmol/L(mean+SD), the average range of decrease 24.6%, total effective rate is 88.6%; Fasting blood sugar decline 1.6 ± 1.4mmol/L(mean+SD), the average range of decrease 19.6%, total effective rate is 91.4%.
Experiment three
Certain male sex, 45 years old, suffer from diabetes, blood glucose value was generally 12-14mmol/L in 2 hours after the meal at ordinary times, and fasting blood sugar is generally 8-11mmol/L.For verifying this invention product effect, this patient does not take depressor, and by every day the breakfast, lunch and dinner immediately after meals take the control blood sugar solid beverage that this invention provides, take back 2h and survey postprandial plasma glucose level, and when eat breakfast every morning, survey its fasting blood sugar, take 10d continuously.Record is also analyzed the blood sugar test result: postprandial plasma glucose level is the average range of decrease 41.7% of 6.5-8.3mmol/L; Fasting blood sugar is the average range of decrease 23.6% of 4.2-6.7mmol/L, and it is quite remarkable that blood sugar reduces effect.This user estimates fine to control blood sugar solid beverage provided by the invention.
Can be reached a conclusion by above experiment: it is effective that control blood sugar solid beverage provided by the invention raises for the control postprandial blood sugar.
Description of drawings
In order to be illustrated more clearly in the embodiment of the invention or technical scheme of the prior art, to do to introduce simply to the accompanying drawing of required use in embodiment or the description of the Prior Art below, apparently, accompanying drawing in describing below only is some embodiments of the present invention, for those of ordinary skills, under the prerequisite of not paying creative work, can also obtain other accompanying drawing according to these accompanying drawings.
Fig. 1 is the preparation flow block diagram of a kind of hypoglycemic composition granule of the present invention.
The specific embodiment
Below in conjunction with the accompanying drawing in the embodiment of the invention, the technical scheme in the embodiment of the invention is clearly and completely described, obviously, described embodiment only is the present invention's part embodiment, rather than whole embodiment.Based on the embodiment among the present invention, those of ordinary skills belong to the scope of protection of the invention not making the every other embodiment that obtains under the creative work prerequisite.
Embodiment 1: resistant dextrin 80%, L-arabinose 5%, polydextrose 10%, olong tea powder 4%, dusty yeast 1%.
With reference to figure 1; the preparation flow of a kind of hypoglycemic granule of the present invention: take by weighing resistant dextrin; the L-arabinose; polydextrose; olong tea powder and dusty yeast; put into the vortex oscillation sieve of 80 order stainless steel mesh; to mix 30min in all mixed powders input three-dimensional mixers after sieving; again mixed powder is poured in the high-speed mixing granulating machine; do earlier and mix 3min～5min; and then add the ethanol wet mixing 1min～5min of 70%～90% concentration; the softwood that makes is made wet granular with 30 order stainless steel mesh on oscillating granulator; again wet granular is placed baking oven; it is 75 ℃ that oven temperature is set; oven dry 3h～4h; moisture≤5.0% of control particle, loading amount is packed in the aluminium foil bag in accordance with regulations at last.
Embodiment 2: resistant dextrin 80%, L-arabinose 5%, polydextrose 10%, green tea powder 4%, dusty yeast 1%.
Its preparation method is with embodiment 1, so do not repeat.
Embodiment 3: resistant dextrin 80%, L-arabinose 5%, polydextrose 10%, black tea powder 4%, dusty yeast 1%.
Its preparation method is with embodiment 1, so do not repeat.
Embodiment 4: resistant dextrin 80%, L-arabinose 5%, polydextrose 10%, black tea powder 4%, dusty yeast 1%.
Its preparation method is with embodiment 1, so do not repeat.
Embodiment 5: resistant dextrin 77%, L-arabinose 5%, polydextrose 15%, lemon powder 2%, dusty yeast 1%.
Its preparation method is with embodiment 1, so do not repeat.
Embodiment 6: resistant dextrin 75%, L-arabinose 5%, polydextrose 15%, luxuriant pomegranate powder 4%, dusty yeast 1%.
Its preparation method is with embodiment 1, so do not repeat.
Embodiment 7: resistant dextrin 68%, L-arabinose 8%, polydextrose 11%, strawberry powder 12%, dusty yeast 1%.
Its preparation method is with embodiment 1, so do not repeat.
Embodiment 8: resistant dextrin 75%, L-arabinose 6%, polydextrose 11%, lemon powder 2%, black tea powder 6%.
Embodiment 9: resistant dextrin 72%, and L-arabinose 8%, polydextrose 17% is smeared tea powder 2%, Cr-enriched yeast 1%.
Its preparation method is with embodiment 1, so do not repeat.
Embodiment 10: resistant dextrin 72%, and L-arabinose 8%, polydextrose 17% is smeared tea powder 2%, ferrum-rich saccharomyces cerevisiae 1%.
Its preparation method is with embodiment 1, so do not repeat.
Embodiment 11: resistant dextrin 69%, L-arabinose 8%, polydextrose 15%, lemon powder 2%, black tea powder 5%, Se-enriched yeast 1%.
Its preparation method is with embodiment 1, so do not repeat.
The above only is preferred embodiment of the present invention, and is in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (4)
1. hypoglycemic composition and preparation method thereof is characterized in that, comprises following mass percent component: resistant dextrin 10-85%, L-arabinose 1-30%, polydextrose 5-65%, Fruit powder 0-8%, tea powder 0-8%, dusty yeast 0-8%.
2. hypoglycemic composition as claimed in claim 1 is characterized in that, described dusty yeast comprises a kind of dusty yeast in Cr-enriched yeast, ferrum-rich saccharomyces cerevisiae, Se-enriched yeast or the Zinc-rich saccharomyces cerevisiae.
3. hypoglycemic composition as claimed in claim 1 is characterized in that, described tea powder comprises a kind of tea powder in green tea, black tea, oolong tea, white tea or the black tea.
4. the preparation method of hypoglycemic composition as claimed in claim 1 is characterized in that, the preparation process of described hypoglycemic composition granule is as follows:
1) weighing: take by weighing required raw material;
2) sieve: the vortex oscillation sieve of the raw material that takes by weighing being put into 80 order stainless steel mesh;
3) mix: all raw materials after will sieving are poured in the high-speed mixing granulating machine, do earlier and mix 3min～5min, and then 1min～3min is closed in the ethanol wet mixing that adds 70%～90% concentration;
4) granulate: the softwood that makes is made wet granular with 30 order stainless steel mesh on oscillating granulator;
5) oven dry: again wet granular is placed baking oven, it is 75 ℃ that oven temperature is set, oven dry 3h～4h, moisture≤5.0% of control particle;
6) pack: at last with packing machine in accordance with regulations loading amount pack in the aluminium foil bag.
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Cited By (7)
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| CN104187670A (en) * | 2014-09-02 | 2014-12-10 | 高鹏 | Special dietary formula for assisting patients with diabetes in regulating blood sugar |
| CN105998198A (en) * | 2016-07-28 | 2016-10-12 | 岳小鸥 | Health product for improving hyperlipidemia, hyperglycemia and hypertension and preparation method thereof |
| CN106387900A (en) * | 2016-09-09 | 2017-02-15 | 杨森健 | Composition for regulating blood lipid, blood pressure and blood sugar, as well as application thereof |
| CN107372698A (en) * | 2017-07-05 | 2017-11-24 | 徐丽 | A kind of flour dispensing for being used for bakery product and using with function of polysaccharide |
| CN107535789A (en) * | 2016-06-28 | 2018-01-05 | 中宏生物工程有限责任公司 | A kind of solid composite and beverage for adjusting postprandial blood sugar |
| CN108294296A (en) * | 2018-01-17 | 2018-07-20 | 福建清道夫生物工程有限公司 | A kind of functional Monascus composition and preparation method thereof |
| CN110200291A (en) * | 2019-06-21 | 2019-09-06 | 吉林农业大学 | A kind of hypoglycemic dietary fiber particles and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104187670A (en) * | 2014-09-02 | 2014-12-10 | 高鹏 | Special dietary formula for assisting patients with diabetes in regulating blood sugar |
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| CN105998198A (en) * | 2016-07-28 | 2016-10-12 | 岳小鸥 | Health product for improving hyperlipidemia, hyperglycemia and hypertension and preparation method thereof |
| CN106387900A (en) * | 2016-09-09 | 2017-02-15 | 杨森健 | Composition for regulating blood lipid, blood pressure and blood sugar, as well as application thereof |
| CN107372698A (en) * | 2017-07-05 | 2017-11-24 | 徐丽 | A kind of flour dispensing for being used for bakery product and using with function of polysaccharide |
| CN108294296A (en) * | 2018-01-17 | 2018-07-20 | 福建清道夫生物工程有限公司 | A kind of functional Monascus composition and preparation method thereof |
| CN110200291A (en) * | 2019-06-21 | 2019-09-06 | 吉林农业大学 | A kind of hypoglycemic dietary fiber particles and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN103284038B (en) | 2014-12-03 |
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