CN108523126A - It is a kind of that there is the composition and preparation method thereof for improving blood glucose level - Google Patents
It is a kind of that there is the composition and preparation method thereof for improving blood glucose level Download PDFInfo
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- CN108523126A CN108523126A CN201810373933.3A CN201810373933A CN108523126A CN 108523126 A CN108523126 A CN 108523126A CN 201810373933 A CN201810373933 A CN 201810373933A CN 108523126 A CN108523126 A CN 108523126A
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- blood glucose
- chestnut
- glucose level
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- 239000008280 blood Substances 0.000 title claims abstract description 52
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- 239000008103 glucose Substances 0.000 title claims abstract description 50
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- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims abstract description 7
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- YLZOPXRUQYQQID-UHFFFAOYSA-N 3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]propan-1-one Chemical compound N1N=NC=2CN(CCC=21)CCC(=O)N1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F YLZOPXRUQYQQID-UHFFFAOYSA-N 0.000 description 1
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- 235000019202 steviosides Nutrition 0.000 description 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/49—Fagaceae (Beech family), e.g. oak or chestnut
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Mycology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
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- General Chemical & Material Sciences (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of compositions and preparation method thereof for having and improving blood glucose level comprising the raw material of following components：25 40 parts of chestnut shell extract, 10 20 parts of mulberry-leaf extract, 35 parts of oat beta glucan, 5 10 parts of balsam pear powder, 12 parts of powder containing chromium yeast, 5 10 parts of Bitter Melon P.E, 10 20 parts of barley malt, 5 10 parts of haematococcus pluvialis powder, 35 parts of common oats fibre, 5 10 parts of yam flour, 12 parts of chrysanthemum powder, 35 parts of buckwheat, 47 parts of radix polygonati officinalis powder, 35 parts of kudzu-vine root powder, 0.1 1 parts of vitamin B2 can also further be added, the composition is full of nutrition, it is convenient, blood glucose level is can effectively improve, there is certain health-care effect.
Description
Technical field
The present invention relates to healthy food and its working process technical field, and in particular to it is a kind of have improve blood glucose level
Alimentation composition and preparation method thereof.
Background technology
With the improvement of the quality of life, dietary structure constantly changes, and more and more high sugared, high lipid foods of intake are led
Diabetogenic incidence rapidly rises, and is currently the multiple common disease in third position for being only second to cardiovascular disease and tumour, diabetes
It is a kind of chronic disease, for Chinese Adult diabetes prevalence up to close to 10%, control and prevention diabetes are very arduous.Prevent or
Person improves that blood glucose level is particularly significant for treatment diabetes, and while drug therapy, diet is also particularly significant, diet control
It is improper to make, and can lead to the fluctuation of blood glucose, or even can aggravate the risk of hyperglycemia.
Have the health products of more research concern Chinese medicine or integration of drinking and medicinal herbs class at present to control blood glucose level.Specially such as China
Sharp CN2014102044678 discloses a kind of nutritional meal replacement powder for being suitable for hyperglycemia population and taking, including food fibre powder, fruit
Vegetable powder, mulberry-leaf extract, maltodextrin, stevioside, hydrolyzing lactoalbumin, multi-vitamins, composite mineral matter, to patient of diabetes
Person has effects that certain auxiliary hyperglycemic, good mouthfeel, and can be eaten as meal replacing food.Chinese patent
CN2008100066094 discloses a kind of special diet of the diabetes patients containing small peptide, and the food is with food-borne small peptide
For primary raw material, the medicine-food two-purposes Chinese herbal medicine extraction such as addition Chinese yam, mulberry leaf, pueraria lobata, sealwort, corn stigma, Poria cocos, dark plum, radix polygonati officinalis
Object, then it is aided with oligopeptide, vitamin and mineral, compound prescription is formed, is extracted by food-borne small peptide, medicine-food two-purpose Chinese herbal medicine
The collective effect of a variety of silver such as bioactive ingredients, oligopeptide in object, can assist and control blood sugar in diabetic patients water
Flat, raising immunity of organisms, prevents diabetic complication.
As can be seen that the pathogensis due to diabetes is complicated, research at present to be laid particular emphasis on using complex composition, is passed through
The mutual compatibility of Multicomponent phase, the concertedness for giving full play to formula are current research hotspots.
The extract control blood glucose level of chestnut skin has certain research at present, and Japanese Patent Laid-Open 2006-1872 is just
Disclose the purposes of chestnut shell extract control blood glucose.Chinese patent CN2014102016199 also discloses that a kind of from from Chinese chestnut
Extraction purification inhibits the method for alpha-glucosidase activity ingredient in shell, can be used for treating diabetes and obesity.
Invention content
The purpose of the present invention is to provide a kind of compositions and preparation method thereof for having and improving blood glucose level, and nutrition is rich
Richness, it is convenient, blood glucose level can be adjusted, improve immunity.
Technical solution of the present invention is as follows.
Include purposes of the composition of chestnut shell extract in preparing the food or drug that have and improve blood glucose level.
It is a kind of that there is the composition for improving blood glucose level, including 25-40 parts of chestnut shell extract, mulberry-leaf extract 10-20
Part, 3-5 part of avenabeta glucosan, chestnut shell extract extracts by shell and endothelium and obtains extract jointly, wherein chestnut shell and interior
The proportioning of skin raw material is 8-12:1-3.
The chestnut shell（Chestnut shell）It is the shell for wrapping up Chinese chestnut meat, the shell is carried if daily purchase Chinese chestnut, rather than
Containing jagged outer pod.
Further, the chestnut shell extract is by being selected from the mixing of one or more of ethyl alcohol, butanol, water
Solvent extracts.
It is considered as a kind of control diabetes to alpha-glucosidase and alpha-amylase activity inhibiting effect in enteron aisle
Effective ways, if introduced in foregoing Background, have correlative study explore chestnut shell extract for alpha-glucosidase and
The inhibiting effect of alpha-amylase activity.It finds under study for action, the improvement of single chestnut shell extract is limited, by being selected from it
His extract and chestnut skin compatible use can promote the effect for improving blood glucose level to a certain extent.
Described there is the composition for improving blood glucose level, component number can also be 40 parts of chestnut shell extract, mulberry leaf
15 parts of extract, 5 parts of avenabeta glucosan.
Further, the composition can also further add balsam pear powder, powder containing chromium yeast（That is Cr-enriched yeast）, it is bitter
Melon extract, barley malt, haematococcus pluvialis powder, common oats fibre, yam flour, chrysanthemum powder, buckwheat, radix polygonati officinalis powder, kudzu-vine root powder, dimension
It is one or more in raw element B2；Constituent content is：5-10 parts of balsam pear powder, 1-2 parts of powder containing chromium yeast, Bitter Melon P.E 5-10
Part, 10-20 parts of barley malt, 5-10 parts of haematococcus pluvialis powder, 3-5 parts of common oats fibre, 5-10 parts of yam flour, 1-2 parts of chrysanthemum powder,
3-5 parts of buckwheat, 4-7 parts of radix polygonati officinalis powder, 3-5 parts of kudzu-vine root powder, 0.1-1 parts of vitamin B2.
Further, above-mentioned component proportion is 30 parts of chestnut shell extract, 15 parts of mulberry-leaf extract, barley malt 15
Part, 5 parts of balsam pear powder, 1 part of powder containing chromium yeast, 10 parts of Bitter Melon P.E, 3 parts of avenabeta glucosan, 10 parts of haematococcus pluvialis powder, swallow
3 parts of wheat fiber, 5 parts of yam flour, 1 part of chrysanthemum powder, 4 parts of buckwheat, 5 parts of radix polygonati officinalis powder, 5 parts of kudzu-vine root powder, 0.3 part of vitamin B2.
The component proportion of the composition can also be 40 parts of chestnut shell extract, 10 parts of mulberry-leaf extract, barley malt 10
Part, 5 parts of balsam pear powder, 1 part of powder containing chromium yeast, 10 parts of Bitter Melon P.E, 3 parts of avenabeta glucosan, 5 parts of haematococcus pluvialis powder, swallow
3 parts of wheat fiber, 5 parts of yam flour, 1 part of chrysanthemum powder, 3 parts of buckwheat, 4 parts of radix polygonati officinalis powder, 5 parts of kudzu-vine root powder, 0.5 part of vitamin B2.
Preferably, the chestnut shell extract preparation method is：
（1）Chestnut shell, chestnut endothelium are cleaned, dry, crush by pretreatment respectively, and crushing mesh number is 50-80 mesh；
（2）Chestnut endothelium and chestnut shell are put into a concentration of 55-60% ethanol solutions, impregnated 3-5 hours, it then will be in chestnut
Skin and chestnut shell are transferred in extractor, and addition solid-liquid ratio is 1:The ethyl alcohol of 18-24, concentration of alcohol 45-55%, refluxing extraction
2-3 times, each 1-3h；
（3）Merge extracting solution, and residue is removed by filter type；0.5-4h is concentrated under reduced pressure at 40-50 DEG C, is concentrated
Medicinal extract；
（4）Concentrated extract is freeze-dried to obtain powdery chestnut shell extract.
For chestnut extract, chestnut shell, chestnut endothelium extract all have the effect of certain improvement blood glucose,
The study found that when the two is extracted jointly, ingredient has the effect of that mutual promotion dissolution, the effect of the extract obtained want excellent
Improve the effect of blood glucose level when single component extracts.
The preparation method of the composition of the improvement blood glucose level includes the following steps：
（1）Each raw material is weighed according to the weight fraction, is mixed into mixed material；
（2）By mixture milled processed, 80-100 mesh sieve is crossed；
（3）Product is subjected to sterilization treatment, is cooled to room temperature, is packaged to be.
Further, by the way of microwave drying treatment, treatment conditions are sterilization treatment：Microwave power 20-50kW, frequency
Rate is 2450MHz.
Further, the composition can be packaged to be product pocket, convenient for edible.
Further, the product that the preparation method is prepared can be food, health food or drug, for doing
Pre- or improvement blood glucose level.
In prior art research, single component or the monomer reducing blood lipid mechanism extracted from integration of drinking and medicinal herbs class Chinese medicine are
It is deep into molecule and gene level.Different components interfere blood glucose level by multiple approach, multiple links, multiple targets, respectively
A component interaction influences each other, and the concertedness of fully invention formula is the emphasis of research.Composition of the present invention is logical
It crosses selected from a variety of trophic factors combinations for having and improving blood glucose level, can effectively improve blood glucose level, it is full of nutrition, it eats
It is convenient.
Although the existing pertinent literature the study found that chestnut shell extract conduct improvement blood glucose level is used, this
In inventive technique, by chestnut shell and endothelium according to 8-12:The ratio compound collecting of 1-3, is more advantageous to the extraction of active ingredient,
In addition the mutual promoting action of mulberry-leaf extract, oat beta glucan and chestnut shell extract is also brought to improving blood glucose level
Carbohydrate inversion is disaccharide by large effect, alpha-amylase, and disaccharide is hydrolyzed to monosaccharide by alpha-glucosidase, in enteron aisle
Interior is considered as a kind of effective ways of control diabetes to alpha-glucosidase and alpha-amylase activity inhibiting effect.The present invention
Composition as a whole, the collaboration of mutual compatibility promotes, and is especially inhibiting alpha-glucosidase and alpha-amylase activity
And produce unexpected technique effect in terms of adjusting blood glucose level.
Specific implementation mode
Embodiment 1
（1）40 parts of chestnut shell extract, 15 parts of mulberry-leaf extract, 5 parts of avenabeta glucosan are weighed, mixed material is mixed into；
（2）By mixture milled processed, 80-100 mesh sieve is crossed, sterilization treatment is by the way of microwave drying treatment, treatment conditions
For：Microwave power 20-50kW, frequency 2450MHz；
（3）Product is subjected to sterilization treatment, is cooled to room temperature, is packaged to be.
The preparation method of chestnut shell extract is：（1）Chestnut shell, chestnut endothelium are cleaned, are dried, powder by pretreatment respectively
Broken, crushing mesh number is 50-80 mesh, and chestnut shell, chestnut endothelium weight proportion are 9:2；
（2）Chestnut endothelium and chestnut shell are put into a concentration of 55-60% ethanol solutions, impregnated 4 hours, then by chestnut endothelium
It is transferred in extractor with chestnut shell, addition solid-liquid ratio is 1:20 ethyl alcohol, concentration of alcohol 45-55%, refluxing extraction 3 times, often
Secondary 1.5h；
（3）Merge extracting solution, and residue is removed by filter type；3h is concentrated under reduced pressure at 40-50 DEG C, obtains concentration leaching
Cream；
（4）Concentrated extract is freeze-dried to obtain powdery chestnut shell extract.
Embodiment 2
（1）40 parts of chestnut shell extract, 40 parts of mulberry-leaf extract, 30 parts of avenabeta glucosan are weighed, mixed material is mixed into；
（2）By mixture milled processed, 80-100 mesh sieve is crossed, sterilization treatment is by the way of microwave drying treatment, treatment conditions
For：Microwave power 20-50kW, frequency 2450MHz；
（3）Product is subjected to sterilization treatment, is cooled to room temperature, is packaged to be.
The preparation method of chestnut shell extract is：（1）Chestnut shell, chestnut endothelium are cleaned, are dried, powder by pretreatment respectively
Broken, crushing mesh number is 50-80 mesh, and chestnut shell, chestnut endothelium weight proportion are 1:1；
（2）Chestnut endothelium and chestnut shell are put into a concentration of 55-60% ethanol solutions, impregnated 4 hours, then by chestnut endothelium
It is transferred in extractor with chestnut shell, addition solid-liquid ratio is 1:20 ethyl alcohol, concentration of alcohol 45-55%, refluxing extraction 3 times, often
Secondary 1.5h；
（3）Merge extracting solution, and residue is removed by filter type；3h is concentrated under reduced pressure at 40-50 DEG C, obtains concentration leaching
Cream；
（4）Concentrated extract is freeze-dried to obtain powdery chestnut shell extract.
Embodiment 3
Improve the composition of blood glucose level, group is divided into：40 parts of chestnut shell extract, 10 parts of mulberry-leaf extract, 10 parts of barley malt,
5 parts of balsam pear powder, 1 part of powder containing chromium yeast, 10 parts of Bitter Melon P.E, 5 parts of avenabeta glucosan, 5 parts of haematococcus pluvialis powder, oat are fine
3 parts of dimension, 5 parts of yam flour, 1 part of chrysanthemum powder, 3 parts of buckwheat, 4 parts of radix polygonati officinalis powder, 5 parts of kudzu-vine root powder, 0.5 part of vitamin B2.
Preparation method is：（1）Each raw material is weighed according to the weight fraction, is mixed into mixed material；（2）By mixture
Milled processed crosses 80-100 mesh sieve；（3）Product is subjected to sterilization treatment, sterilization treatment is by the way of microwave drying treatment, place
Manage bar part is：Microwave power 20-50kW, frequency 2450MHz；It is cooled to room temperature, is packaged to be.
The preparation method of chestnut shell extract is：（1）Chestnut shell, chestnut endothelium are cleaned, are dried, powder by pretreatment respectively
Broken, crushing mesh number is 50-80 mesh, and chestnut shell, chestnut endothelium weight proportion are 9:2；
（2）Chestnut endothelium and chestnut shell are put into a concentration of 55-60% ethanol solutions, impregnated 4 hours, then by chestnut endothelium
It is transferred in extractor with chestnut shell, addition solid-liquid ratio is 1:20 ethyl alcohol, concentration of alcohol 45-55%, refluxing extraction 3 times, often
Secondary 1.5h；
（3）Merge extracting solution, and residue is removed by filter type；3h is concentrated under reduced pressure at 40-50 DEG C, obtains concentration leaching
Cream；
（4）Concentrated extract is freeze-dried to obtain powdery chestnut shell extract.
Comparative example 1
（1）Weigh 60 parts of chestnut shell extract；
（2）By chestnut shell extract milled processed, 80-100 mesh sieve is crossed, sterilization treatment is by the way of microwave drying treatment, place
Manage bar part is：Microwave power 20-50kW, frequency 2450MHz；
（3）Product is subjected to sterilization treatment, is cooled to room temperature, is packaged to be.
The preparation method is the same as that of Example 1 for chestnut shell extract.
Comparative example 2-1
（1）By 40 parts of milled processeds of chestnut shell extract, 80-100 mesh sieve is crossed, sterilization treatment uses the side of microwave drying treatment
Formula, treatment conditions are：Microwave power 20-50kW, frequency 2450MHz；
（2）Product is subjected to sterilization treatment, is cooled to room temperature, is packaged to be.
The preparation method of chestnut shell extract is：（1）Chestnut shell is cleaned, drying, is crushed by pretreatment, and crushing mesh number is
50-80 mesh；
（2）Chestnut shell after crushing is put into a concentration of 55-60% ethanol solutions, impregnates 4 hours, then shifts chestnut shell
Into extractor, addition solid-liquid ratio is 1:20 ethyl alcohol, concentration of alcohol 45-55%, refluxing extraction 3 times, each 1.5h；
（3）Merge extracting solution, and residue is removed by filter type；3h is concentrated under reduced pressure at 40-50 DEG C, obtains concentration leaching
Cream；
（4）Concentrated extract is freeze-dried to obtain powdery chestnut shell extract.
Comparative example 2-2
（1）By 40 parts of milled processeds of chestnut shell extract, 80-100 mesh sieve is crossed, sterilization treatment uses the side of microwave drying treatment
Formula, treatment conditions are：Microwave power 20-50kW, frequency 2450MHz；
（2）Product is subjected to sterilization treatment, is cooled to room temperature, is packaged to be.
The preparation method of chestnut shell extract is identical as comparative example 2-1, and raw material is different, and raw material adds identical total weight point
Several chestnut endotheliums replaces chestnut shell.
Experiment effect
Inhibiting effect of the composition to alpha-glucosidase.
It detects PNPG and generates yellow green p-nitrophenol with alpha-glucosaccharase enzyme reaction, sample is judged according to the absorbance of solution
The inhibitory activity of product.
Assay method judges with relatively conventional in the prior art absorbance value, specially：Take 100 μ L of PNPG
（100mmol/L）850 uL phosphate buffers are added.Sample solution is added, sample solution mass concentration is 50 μ g/mL.Control
Group is set as reaction system that is not enzyme, being not added with sample solution, is influenced with eliminating PNPG oxidations generation p-nitrophenol itself
Measurement result, blank group are set as enzyme but do not add sample solution, and ground control is set as addition inhibitor, but does not add enzyme
System.37 DEG C of hatching 10min, are added 50 μ L of alpha-glucosidase, then hatch 50min, and 1mL sodium carbonate is added and terminates reaction,
405nm surveys absorbance；Wherein sample solution is set as embodiment 1, embodiment 2, comparative example 1, comparative example 2-1,2-2.
Inhibiting rate（100%）=100*[A-B-(C-D)]/(A-B)；
Wherein, A is reading of the blank group in A520, and B is reading of the control group in A520, and C is reading of the sample solution in A520,
D is reading of the ground control pipe in A520.
The results show that inhibiting rate is respectively：1 inhibiting rate of embodiment is 95.2%, and the inhibiting rate of embodiment 2 is 90.4%, right
The inhibiting rate of ratio 1 is 86.7%, and comparative example 2-1,2-2 inhibiting rate is 75.7%, 79.8%.
Measure blood glucose level
Test method is：Select SPF grades of male mice, freely ingest, drink water, adaptable fed is forbidden for 24 hours after 1 week, mouse with
Machine is divided into 6 groups：3 low dose group of embodiment, 3 middle dose group of embodiment, 3 high dose group of embodiment, positive drug group, model comparison
Group, blank control group.Experimental group（Except blank control group）It is injected intraperitoneally using modeling agent, fasting 4h after 5d surveys blood glucose, blood glucose value
＞ 10mmol/L are diabetic model group.
Modeling agent：Streptozotocin（STZ）, with 0.1mol/L, the sodium citrate buffer solution Fresh of pH=4.2 is at dense
Degree is 13.0mg/ml solution.
Given the test agent：It is prepared by embodiment 3, prepares the suspension of 10mg/ml, 20mg/ml, 40mg/ml respectively with water dissolution
Liquid.
Positive drug：Acarbose tablet is ground into powdery, and the suspension of a concentration of 10mg/ml is configured to water.
Experimental method：Oral administration gavage is administered, and blank control group is the normal mouse that ingests, and is handled without modeling, model group
The physiological saline of gavage same volume.
Experimental period is 30 days, is administered at regular time and quantity daily.Blood glucose value was measured at the 0th, 10,20,30 day.
Blood glucose decline percentage=（Blood glucose value after blood glucose value-experiment before experiment）Blood glucose value * 100% before/experiment.
Data analysis
Otherness is analyzed using SPSS softwares.
Compared with model group, positive drug group have the function of significantly it is hypoglycemic, the composition of the embodiment of the present invention 3
Three dosage groups also have the effect for improving blood glucose, effect to be weaker than positive drug group, it can be seen that composition of the present invention
There is good effect in terms of improving blood glucose.
| Group | Blood glucose value mmol/L（0d） | Blood glucose value mmol/L（10d） | Blood glucose value mmol/L（20d） | Blood glucose value mmol/L（30d） | Blood glucose declines percentage |
| Low dose group | 20.35±1.22 | 18.34±2.22 | 17.65±1.49 | 16.18±1.25 | 20.49% |
| Middle dose group | 20.14±1.32 | 18.01±2.31 | 16.14±1.56 | 14.01±1.68 | 30.43% |
| High dose group | 20.89±1.28 | 17.45±2.17 | 14.38±1.78 | 11.25±1.78 | 46.15% |
| Blank group | 4.58±0.42 | 4.55±0.74 | 4.54±0.23 | 4.53±0.15 | 1.09% |
| Model control group | 21.13±1.41 | 23.25±2.24 | 26.78±2.64 | 29.37±2.15 | -39.35% |
| Positive drug group | 20.94±1.29 | 15.78±2.14 | 12.46±2.31 | 8.79±1.57 | 58.23% |
Obviously, the above embodiment of the present invention be only to clearly illustrate example of the present invention, and not be to this hair
The restriction of bright embodiment.For those of ordinary skill in the art, it can also do on the basis of the above description
Go out other various forms of variations or variation.There is no necessity and possibility to exhaust all the enbodiments.It is all in the present invention
Spirit and principle within made by all any modification, equivalent and improvement etc., should be included in the guarantor of the claims in the present invention
Within the scope of shield.
Claims (10)
1. purposes of the composition comprising chestnut shell extract in preparing the food or drug that have and improve blood glucose level.
2. a kind of having the composition for improving blood glucose level, it is characterised in that extracted including 25-40 parts of chestnut shell extract, mulberry leaf
10-20 parts of object, 3-5 parts of avenabeta glucosan, by shell and endothelium, extraction obtains extract, wherein chestnut to chestnut shell extract jointly
The proportioning of shell and endothelium raw material is 8-12:1-3.
3. the composition according to claim 2 for improving blood glucose level, it is characterised in that the chestnut shell extract is
It is extracted by being selected from one or more of ethyl alcohol, butanol, water mixed solvent.
4. the composition according to claim 2 for improving blood glucose level, it is characterised in that can also further add balsam pear
Powder, powder containing chromium yeast, Bitter Melon P.E, barley malt, haematococcus pluvialis powder, common oats fibre, yam flour, chrysanthemum powder, buckwheat,
It is one or more in radix polygonati officinalis powder, kudzu-vine root powder, vitamin B2.
5. the composition according to claim 4 for improving blood glucose level, it is characterised in that component proportion is balsam pear powder 5-10
Part, 1-2 parts of powder containing chromium yeast, 5-10 parts of Bitter Melon P.E, 10-20 parts of barley malt, 5-10 parts of haematococcus pluvialis powder, oat are fine
3-5 parts of dimension, 5-10 parts of yam flour, 1-2 parts of chrysanthemum powder, 3-5 parts of buckwheat, 4-7 parts of radix polygonati officinalis powder, 3-5 parts of kudzu-vine root powder, vitamin B2
0.1-1 parts.
6. the composition according to claim 2 for improving blood glucose level, it is characterised in that chestnut shell extract preparation method
For：
（1）Chestnut shell, chestnut endothelium are cleaned, dry, crush by pretreatment respectively, and crushing mesh number is 50-80 mesh；
（2）Chestnut endothelium and chestnut shell are put into a concentration of 55-60% ethanol solutions, impregnated 3-5 hours, it then will be in chestnut
Skin and chestnut shell are transferred in extractor, and addition solid-liquid ratio is 1:The ethyl alcohol of 18-24, concentration of alcohol 45-55%, refluxing extraction
2-3 times, each 1-3h；
（3）Merge extracting solution, and residue is removed by filter type；0.5-4h is concentrated under reduced pressure at 40-50 DEG C, is concentrated
Medicinal extract；
（4）Concentrated extract is freeze-dried to obtain powdery chestnut shell extract.
7. a kind of preparation method of the composition of the improvement blood glucose level described in claim 5, it is characterised in that including following step
Suddenly：
（1）Each raw material is weighed according to the parts by weight, is mixed into mixed material；
（2）By mixture milled processed, 80-100 mesh sieve is crossed；
（3）Product is subjected to sterilization treatment, is cooled to room temperature, is packaged to be.
8. preparation method according to claim 7, it is characterised in that the sterilization treatment is using microwave drying treatment
Mode, treatment conditions are：Microwave power 20-50kW, frequency 2450MHz.
9. preparation method according to claim 7, it is characterised in that the product that the preparation method is prepared can be with
It is processed as health food or drug.
10. the particular use of the composition described in claim 2-6, for intervening or improving blood glucose level.
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| CN112262989A (en) * | 2020-11-04 | 2021-01-26 | 光瀚健康咨询管理(上海)有限公司 | Protein sugar-control meal replacement powder and preparation method thereof |
| CN112471257A (en) * | 2020-11-23 | 2021-03-12 | 江西阳光乳业股份有限公司 | Yoghourt with functions of reducing blood sugar and blood fat |
| CN112471257B (en) * | 2020-11-23 | 2023-10-20 | 江西阳光乳业股份有限公司 | Yoghurt with blood glucose and blood lipid reducing functions |
| CN112401239A (en) * | 2020-12-07 | 2021-02-26 | 广州正广生物科技有限公司 | Composition for reducing blood sugar and preparation method and application thereof |
| CN112544766A (en) * | 2020-12-09 | 2021-03-26 | 杭州衡美食品科技有限公司 | Nut stick suitable for hyperglycemia population and preparation method thereof |
| CN112544766B (en) * | 2020-12-09 | 2024-03-15 | 杭州衡美食品科技有限公司 | Nut bar suitable for hyperglycemia population to eat and preparation method thereof |
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