CN103276015A - 表现出内皮细胞特异性的启动子和使用其调节血管生成的方法 - Google Patents
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| CN107630004B (zh) | 2017-09-01 | 2021-01-15 | 康希诺生物股份公司 | 降低可复制性腺病毒产生的细胞株及构建方法和应用 |
| EP3697451A1 (en) | 2017-10-20 | 2020-08-26 | Vascular Biogenics Ltd. | Diagnostic methods for anti-angiogenic agent therapy |
| JP2022524321A (ja) | 2019-03-13 | 2022-05-02 | バスキュラー バイオジェニックス リミテッド | 抗腫瘍療法の方法 |
| AU2020271998A1 (en) | 2019-04-12 | 2021-09-30 | Vascular Biogenics Ltd. | Methods of anti-tumor therapy |
| CN110714028B (zh) * | 2019-11-04 | 2021-08-31 | 中国人民解放军第四军医大学 | 可控性上调Ang-(1-7)靶向性防治低氧性肺动脉高压的表达载体 |
| CN114457003A (zh) | 2020-11-10 | 2022-05-10 | 维思尔治疗有限公司 | 预调节血管细胞用于转导的方法、转导方法和保存转导的细胞的方法 |
| CN118434281A (zh) * | 2021-09-20 | 2024-08-02 | 雷维维科公司 | 用于异种移植的包含十个基因修饰的多转基因猪 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1424401A (zh) * | 2003-01-06 | 2003-06-18 | 李川源 | 有条件复制型腺病毒及其构建方法和用途 |
| CN1541714A (zh) * | 1995-02-28 | 2004-11-03 | ���������Ǵ�ѧ���»� | 基因转移介导的血管形成疗法 |
| US20060204478A1 (en) * | 2000-11-17 | 2006-09-14 | Dror Harats | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
Family Cites Families (44)
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| US6037329A (en) * | 1994-03-15 | 2000-03-14 | Selective Genetics, Inc. | Compositions containing nucleic acids and ligands for therapeutic treatment |
| US6579697B1 (en) * | 1995-05-11 | 2003-06-17 | Yeda Research And Development Co. Ltd. | Modulator of TNF/NGF superfamily receptors and soluble oligomeric TNF/NGF superfamily receptors |
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| US5747340A (en) * | 1994-06-03 | 1998-05-05 | Syntex (U.S.A.) Inc. | Targeted gene expression using preproendothelin-1 promoters |
| US5906827A (en) * | 1994-06-03 | 1999-05-25 | Creative Biomolecules, Inc. | Matrix for the manufacture of autogenous replacement body parts |
| GB9506466D0 (en) * | 1994-08-26 | 1995-05-17 | Prolifix Ltd | Cell cycle regulated repressor and dna element |
| US5734039A (en) * | 1994-09-15 | 1998-03-31 | Thomas Jefferson University | Antisense oligonucleotides targeting cooperating oncogenes |
| US5712149A (en) * | 1995-02-03 | 1998-01-27 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
| US5792453A (en) * | 1995-02-28 | 1998-08-11 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
| US5916763A (en) * | 1995-11-09 | 1999-06-29 | The Regents Of The University Of California | Promoter for VEGF receptor |
| JP2001503273A (ja) * | 1996-11-08 | 2001-03-13 | オクラホマ メディカル リサーチ ファウンデーション | Ｅｐｃｒ制御エレメントにより調節される内皮特異的発現 |
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| US6206917B1 (en) * | 1997-05-02 | 2001-03-27 | St. Jude Medical, Inc. | Differential treatment of prosthetic devices |
| ES2320603T3 (es) * | 1997-07-30 | 2009-05-25 | Emory University | Sistemas de expresion, vectores, adn, proteinas de mineralizacion osea novedosos. |
| EP0909532A1 (en) * | 1997-10-16 | 1999-04-21 | Development Center For Biotechnology | Environmentally compatible porous material comprising beneficial nematodes and its preparation |
| US6183737B1 (en) * | 1997-10-30 | 2001-02-06 | The General Hospital Corporation | Bonding of cartilage pieces using isolated chondrocytes and a biological gel |
| US5882893A (en) * | 1997-12-04 | 1999-03-16 | Millennium Pharmaceuticals, Inc. | Nucleic acids encoding muscarinic receptors and uses therefor |
| US6417168B1 (en) * | 1998-03-04 | 2002-07-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods of treating tumors |
| US6180355B1 (en) * | 1998-05-07 | 2001-01-30 | University Of Maryland, Baltimore | Method for diagnosing and treating chronic pelvic pain syndrome |
| US6239151B1 (en) * | 1998-06-26 | 2001-05-29 | Hoffmann-La Roche Inc. | Compounds as inhibitor of tumor necrosis factor alpha release |
| US6545048B1 (en) * | 1999-06-29 | 2003-04-08 | California Institute Of Technology | Compositions and methods of treating cancer using compositions comprising an inhibitor or endothelin receptor activity |
| US6576265B1 (en) * | 1999-12-22 | 2003-06-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
| US6376244B1 (en) * | 1999-12-29 | 2002-04-23 | Children's Medical Center Corporation | Methods and compositions for organ decellularization |
| US6479064B1 (en) * | 1999-12-29 | 2002-11-12 | Children's Medical Center Corporation | Culturing different cell populations on a decellularized natural biostructure for organ reconstruction |
| US6265216B1 (en) * | 2000-01-20 | 2001-07-24 | Isis Pharmaceuticals, Inc. | Antisense modulation of cot oncogene expression |
| US6866864B2 (en) * | 2000-03-20 | 2005-03-15 | Ahmed Mousa | Compositions and methods of use in the treatment of angiogenesis and vascular-related disorders |
| US6652583B2 (en) * | 2000-04-07 | 2003-11-25 | Rhode Island Hospital | Cardiac valve replacement |
| US7067649B2 (en) * | 2000-11-17 | 2006-06-27 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
| US8071740B2 (en) * | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
| ES2338529T3 (es) * | 2000-11-17 | 2010-05-10 | Vascular Biogenics Ltd. | Prometores que exiben especificidad por celulas endoteliales y metodos para su utilizacion. |
| AU2003222427B8 (en) * | 2000-11-17 | 2010-04-29 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
| US20100282634A1 (en) * | 2000-11-17 | 2010-11-11 | Dror Harats | Promoters Exhibiting Endothelial Cell Specificity and Methods of Using Same for Regulation of Angiogenesis |
| EP1207205A1 (en) * | 2000-11-20 | 2002-05-22 | Crucell Holland B.V. | Adenoviral replicons |
| US6438802B1 (en) * | 2001-06-07 | 2002-08-27 | Randolph Scott Beeman | Locking mechanism and method for securely fastening resilient cords and tubing |
| CN1195056C (zh) * | 2001-07-12 | 2005-03-30 | 钱其军 | 一种在肿瘤细胞中特异性增殖及高效表达抗癌基因的重组病毒及其构建方法 |
| EP1436313B1 (en) * | 2001-10-19 | 2010-09-22 | Vascular Biogenics Ltd. | Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy |
| US9738907B2 (en) * | 2002-02-01 | 2017-08-22 | Oxford Biomedica (Uk) Limited | Viral vector |
| AU2003244347A1 (en) * | 2002-02-04 | 2003-09-02 | Takeda Chemical Industries, Ltd. | Angiogenesis inhibitors |
-
2007
- 2007-04-30 US US11/790,992 patent/US20070286845A1/en not_active Abandoned
-
2008
- 2008-04-27 JP JP2010505002A patent/JP2010525805A/ja active Pending
- 2008-04-27 MX MX2009011750A patent/MX2009011750A/es active IP Right Grant
- 2008-04-27 CN CN2013100850374A patent/CN103276015A/zh active Pending
- 2008-04-27 CA CA002685394A patent/CA2685394A1/en not_active Abandoned
- 2008-04-27 EP EP08738245A patent/EP2152317A4/en not_active Withdrawn
- 2008-04-27 AU AU2008243817A patent/AU2008243817B2/en not_active Ceased
- 2008-04-27 CN CN200880022935A patent/CN101808669A/zh active Pending
- 2008-04-27 NZ NZ581511A patent/NZ581511A/en not_active IP Right Cessation
- 2008-04-27 KR KR1020097024041A patent/KR101525548B1/ko not_active Expired - Fee Related
- 2008-04-27 WO PCT/IL2008/000543 patent/WO2008132729A2/en not_active Ceased
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2009
- 2009-11-25 ZA ZA2009/08331A patent/ZA200908331B/en unknown
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2013
- 2013-10-21 US US14/059,426 patent/US20140155467A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1541714A (zh) * | 1995-02-28 | 2004-11-03 | ���������Ǵ�ѧ���»� | 基因转移介导的血管形成疗法 |
| US20060204478A1 (en) * | 2000-11-17 | 2006-09-14 | Dror Harats | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
| CN1424401A (zh) * | 2003-01-06 | 2003-06-18 | 李川源 | 有条件复制型腺病毒及其构建方法和用途 |
Non-Patent Citations (1)
| Title |
|---|
| 贾俊等: "含tk和EGFP双顺反子重组腺病毒载体的构建及其在鼠内皮细胞中的表达", 《口腔医学研究》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008132729A2 (en) | 2008-11-06 |
| KR101525548B1 (ko) | 2015-06-15 |
| JP2010525805A (ja) | 2010-07-29 |
| CA2685394A1 (en) | 2008-11-06 |
| US20140155467A1 (en) | 2014-06-05 |
| EP2152317A4 (en) | 2012-11-14 |
| CN101808669A (zh) | 2010-08-18 |
| US20070286845A1 (en) | 2007-12-13 |
| KR20100017114A (ko) | 2010-02-16 |
| AU2008243817A1 (en) | 2008-11-06 |
| NZ581511A (en) | 2012-02-24 |
| ZA200908331B (en) | 2010-12-29 |
| AU2008243817B2 (en) | 2013-09-19 |
| WO2008132729A3 (en) | 2009-10-22 |
| EP2152317A2 (en) | 2010-02-17 |
| MX2009011750A (es) | 2010-04-27 |
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