JP2010525805A - 内皮細胞特異性を示すプロモーター及びそのプロモーターを使って血管形成を制御する方法 - Google Patents

内皮細胞特異性を示すプロモーター及びそのプロモーターを使って血管形成を制御する方法 Download PDF

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JP2010525805A
JP2010525805A JP2010505002A JP2010505002A JP2010525805A JP 2010525805 A JP2010525805 A JP 2010525805A JP 2010505002 A JP2010505002 A JP 2010505002A JP 2010505002 A JP2010505002 A JP 2010505002A JP 2010525805 A JP2010525805 A JP 2010525805A
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エヤル ブレイトバート，
リヴナット バンジオ，
ドゥロール ハラッツ，
マイケル ペレド，
ショシャナ グリーンベルガー，
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ヴァスキュラー バイオジェニックス リミテッド
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JP2010505002A 2007-04-30 2008-04-27 内皮細胞特異性を示すプロモーター及びそのプロモーターを使って血管形成を制御する方法 Pending JP2010525805A (ja)

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US11/790,992 US20070286845A1 (en) 2000-11-17 2007-04-30 Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
PCT/IL2008/000543 WO2008132729A2 (en) 2007-04-30 2008-04-27 Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis

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JP2010525805A true JP2010525805A (ja) 2010-07-29
JP2010525805A5 JP2010525805A5 (enExample) 2011-05-26

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US (2) US20070286845A1 (enExample)
EP (1) EP2152317A4 (enExample)
JP (1) JP2010525805A (enExample)
KR (1) KR101525548B1 (enExample)
CN (2) CN103276015A (enExample)
AU (1) AU2008243817B2 (enExample)
CA (1) CA2685394A1 (enExample)
MX (1) MX2009011750A (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014504149A (ja) * 2010-10-28 2014-02-20 ヴァージニア コモンウェルス ユニバーシティ 治療と併用する癌画像診断：セラノスティックス

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071740B2 (en) * 2000-11-17 2011-12-06 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
US8039261B2 (en) * 2000-11-17 2011-10-18 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
AU2003222427B8 (en) 2000-11-17 2010-04-29 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same
US20100282634A1 (en) * 2000-11-17 2010-11-11 Dror Harats Promoters Exhibiting Endothelial Cell Specificity and Methods of Using Same for Regulation of Angiogenesis
US6838452B2 (en) 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
EP1436313B1 (en) * 2001-10-19 2010-09-22 Vascular Biogenics Ltd. Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy
EP2310507A4 (en) * 2008-07-08 2013-03-20 David Gladstone Inst METHOD AND COMPOSITIONS FOR ANGIOGENIC MODULATION
MX338931B (es) 2010-01-05 2016-05-06 Vascular Biogenics Ltd Composiciones y metodo para tratar gliobastoma (gbm).
MX342641B (es) * 2010-01-05 2016-10-07 Vascular Biogenics Ltd Metodos para uso de un agente adenoviral anti-angiogenico especifico.
US20130052165A1 (en) * 2010-01-12 2013-02-28 Livnat Bangio Methods of Producing Adenovirus Vectors and Viral Preparations Generated Thereby
WO2012052878A1 (en) 2010-10-19 2012-04-26 Vascular Biogenics Ltd. Isolated polynucleotides and nucleic acid constructs for directing expression of a gene-of-interest in cells
EP2675901B1 (en) 2011-02-14 2018-05-30 Revivicor, Inc. Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof
KR101989171B1 (ko) 2012-10-17 2019-06-14 바스큘라 바이오제닉스 리미티드 아데노바이러스를 사용하는 치료 방법
US9682154B2 (en) 2013-02-04 2017-06-20 Vascular Biogenics Ltd. Methods of inducing responsiveness to anti-angiogenic agent
CN107630004B (zh) 2017-09-01 2021-01-15 康希诺生物股份公司 降低可复制性腺病毒产生的细胞株及构建方法和应用
EP3697451A1 (en) 2017-10-20 2020-08-26 Vascular Biogenics Ltd. Diagnostic methods for anti-angiogenic agent therapy
JP2022524321A (ja) 2019-03-13 2022-05-02 バスキュラー バイオジェニックス リミテッド 抗腫瘍療法の方法
AU2020271998A1 (en) 2019-04-12 2021-09-30 Vascular Biogenics Ltd. Methods of anti-tumor therapy
CN110714028B (zh) * 2019-11-04 2021-08-31 中国人民解放军第四军医大学 可控性上调Ang-(1-7)靶向性防治低氧性肺动脉高压的表达载体
CN114457003A (zh) 2020-11-10 2022-05-10 维思尔治疗有限公司 预调节血管细胞用于转导的方法、转导方法和保存转导的细胞的方法
CN118434281A (zh) * 2021-09-20 2024-08-02 雷维维科公司 用于异种移植的包含十个基因修饰的多转基因猪
FR3158516A1 (fr) * 2024-01-23 2025-07-25 Asfalia Biologics Production de vecteurs toxiques

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004534509A (ja) * 2000-11-17 2004-11-18 ヴァスキュラー バイオジェニックス リミテッド 内皮細胞特異性を示すプロモーター及びその使用法
US20050048466A1 (en) * 2001-07-12 2005-03-03 Qijun Qian Specific proliferation in tumour cell which can express antioncogene with high efficiency and the use of it
JP2005523718A (ja) * 2002-05-01 2005-08-11 ヴァスキュラー バイオジェニックス リミテッド 内皮細胞特異性を示すプロモーター及びその使用法
JP2005532031A (ja) * 2001-10-19 2005-10-27 ヴァスキュラー バイオジェニックス リミテッド 血管形成の標的化されたダウンレギュレーションおよび抗ガン治療のためのポリヌクレオチド構築物および薬学的組成物および方法

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US207985A (en) * 1878-09-10 Improvement in grain-separators
US4866042A (en) * 1987-11-18 1989-09-12 Neuwelt Edward A Method for the delivery of genetic material across the blood brain barrier
US5464764A (en) * 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US6337209B1 (en) * 1992-02-26 2002-01-08 Glaxo Wellcome Inc. Molecular constructs containing a carcinoembryonic antigen regulatory sequence
CA2108144A1 (en) * 1991-03-06 1992-09-07 Jack A. Roth Methods and compositions for the selective inhibition of gene expression
US5635385A (en) * 1993-09-15 1997-06-03 Temple University-Of The Commonwealth System Of Higher Education Multi-unit ribozyme inhibition of oncogene gene expression
US6037329A (en) * 1994-03-15 2000-03-14 Selective Genetics, Inc. Compositions containing nucleic acids and ligands for therapeutic treatment
US6579697B1 (en) * 1995-05-11 2003-06-17 Yeda Research And Development Co. Ltd. Modulator of TNF/NGF superfamily receptors and soluble oligomeric TNF/NGF superfamily receptors
US8715645B2 (en) * 1994-05-27 2014-05-06 The Regents Of The University Of Colorado Viral vectors encoding apoptosis-inducing proteins and methods for making and using the same
US5747340A (en) * 1994-06-03 1998-05-05 Syntex (U.S.A.) Inc. Targeted gene expression using preproendothelin-1 promoters
US5906827A (en) * 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
GB9506466D0 (en) * 1994-08-26 1995-05-17 Prolifix Ltd Cell cycle regulated repressor and dna element
US5734039A (en) * 1994-09-15 1998-03-31 Thomas Jefferson University Antisense oligonucleotides targeting cooperating oncogenes
US5712149A (en) * 1995-02-03 1998-01-27 Cell Genesys, Inc. Chimeric receptor molecules for delivery of co-stimulatory signals
US6100242A (en) * 1995-02-28 2000-08-08 The Regents Of The University Of California Gene therapies for enhancing cardiac function
US5792453A (en) * 1995-02-28 1998-08-11 The Regents Of The University Of California Gene transfer-mediated angiogenesis therapy
US5916763A (en) * 1995-11-09 1999-06-29 The Regents Of The University Of California Promoter for VEGF receptor
JP2001503273A (ja) * 1996-11-08 2001-03-13 オクラホマ メディカル リサーチ ファウンデーション Ｅｐｃｒ制御エレメントにより調節される内皮特異的発現
NZ336381A (en) * 1996-12-30 2000-11-24 Battelle Memorial Institute Formulation and method for treating neoplasms by inhalation
US6206917B1 (en) * 1997-05-02 2001-03-27 St. Jude Medical, Inc. Differential treatment of prosthetic devices
ES2320603T3 (es) * 1997-07-30 2009-05-25 Emory University Sistemas de expresion, vectores, adn, proteinas de mineralizacion osea novedosos.
EP0909532A1 (en) * 1997-10-16 1999-04-21 Development Center For Biotechnology Environmentally compatible porous material comprising beneficial nematodes and its preparation
US6183737B1 (en) * 1997-10-30 2001-02-06 The General Hospital Corporation Bonding of cartilage pieces using isolated chondrocytes and a biological gel
US5882893A (en) * 1997-12-04 1999-03-16 Millennium Pharmaceuticals, Inc. Nucleic acids encoding muscarinic receptors and uses therefor
US6417168B1 (en) * 1998-03-04 2002-07-09 The Trustees Of The University Of Pennsylvania Compositions and methods of treating tumors
US6180355B1 (en) * 1998-05-07 2001-01-30 University Of Maryland, Baltimore Method for diagnosing and treating chronic pelvic pain syndrome
US6239151B1 (en) * 1998-06-26 2001-05-29 Hoffmann-La Roche Inc. Compounds as inhibitor of tumor necrosis factor alpha release
US6545048B1 (en) * 1999-06-29 2003-04-08 California Institute Of Technology Compositions and methods of treating cancer using compositions comprising an inhibitor or endothelin receptor activity
US6576265B1 (en) * 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
US6376244B1 (en) * 1999-12-29 2002-04-23 Children's Medical Center Corporation Methods and compositions for organ decellularization
US6479064B1 (en) * 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
US6265216B1 (en) * 2000-01-20 2001-07-24 Isis Pharmaceuticals, Inc. Antisense modulation of cot oncogene expression
US6866864B2 (en) * 2000-03-20 2005-03-15 Ahmed Mousa Compositions and methods of use in the treatment of angiogenesis and vascular-related disorders
US6652583B2 (en) * 2000-04-07 2003-11-25 Rhode Island Hospital Cardiac valve replacement
US8071740B2 (en) * 2000-11-17 2011-12-06 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
US8039261B2 (en) * 2000-11-17 2011-10-18 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
AU2003222427B8 (en) * 2000-11-17 2010-04-29 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same
US20100282634A1 (en) * 2000-11-17 2010-11-11 Dror Harats Promoters Exhibiting Endothelial Cell Specificity and Methods of Using Same for Regulation of Angiogenesis
EP1207205A1 (en) * 2000-11-20 2002-05-22 Crucell Holland B.V. Adenoviral replicons
US6438802B1 (en) * 2001-06-07 2002-08-27 Randolph Scott Beeman Locking mechanism and method for securely fastening resilient cords and tubing
US9738907B2 (en) * 2002-02-01 2017-08-22 Oxford Biomedica (Uk) Limited Viral vector
AU2003244347A1 (en) * 2002-02-04 2003-09-02 Takeda Chemical Industries, Ltd. Angiogenesis inhibitors
CN1424401A (zh) * 2003-01-06 2003-06-18 李川源 有条件复制型腺病毒及其构建方法和用途

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004534509A (ja) * 2000-11-17 2004-11-18 ヴァスキュラー バイオジェニックス リミテッド 内皮細胞特異性を示すプロモーター及びその使用法
US20050048466A1 (en) * 2001-07-12 2005-03-03 Qijun Qian Specific proliferation in tumour cell which can express antioncogene with high efficiency and the use of it
JP2005532031A (ja) * 2001-10-19 2005-10-27 ヴァスキュラー バイオジェニックス リミテッド 血管形成の標的化されたダウンレギュレーションおよび抗ガン治療のためのポリヌクレオチド構築物および薬学的組成物および方法
JP2005523718A (ja) * 2002-05-01 2005-08-11 ヴァスキュラー バイオジェニックス リミテッド 内皮細胞特異性を示すプロモーター及びその使用法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6013027035; 咽頭 １７, 2005, ８９-９１ *
JPN6013027036; 日本外科学会雑誌 Ｖｏｌ．１０４　臨時増刊号, 2003, Ｐａｇｅ．１９１-１９２ *
JPN6013027039; Ｂｉｏｔｈｅｒａｐｙ ２０（３）, 2006, ｐｐ．２６１-２６９ *

Cited By (1)

* Cited by examiner, † Cited by third party
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JP2014504149A (ja) * 2010-10-28 2014-02-20 ヴァージニア コモンウェルス ユニバーシティ 治療と併用する癌画像診断：セラノスティックス

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KR101525548B1 (ko) 2015-06-15
CA2685394A1 (en) 2008-11-06
US20140155467A1 (en) 2014-06-05
EP2152317A4 (en) 2012-11-14
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US20070286845A1 (en) 2007-12-13
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KR20100017114A (ko) 2010-02-16
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