CN103271935A - 泊洛沙姆用于预防和/或治疗心力衰竭的用途 - Google Patents

泊洛沙姆用于预防和/或治疗心力衰竭的用途 Download PDF

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Publication number
CN103271935A
CN103271935A CN2013101207279A CN201310120727A CN103271935A CN 103271935 A CN103271935 A CN 103271935A CN 2013101207279 A CN2013101207279 A CN 2013101207279A CN 201310120727 A CN201310120727 A CN 201310120727A CN 103271935 A CN103271935 A CN 103271935A
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CN
China
Prior art keywords
poloxamer
heart failure
heart
treatment
people
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2013101207279A
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English (en)
Chinese (zh)
Inventor
布鲁斯.E.马克哈姆
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Phrixus Pharmaceuticals Inc
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Phrixus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phrixus Pharmaceuticals Inc filed Critical Phrixus Pharmaceuticals Inc
Publication of CN103271935A publication Critical patent/CN103271935A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/765Polymers containing oxygen
    • A61K31/77Polymers containing oxygen of oxiranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/765Polymers containing oxygen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2013101207279A 2006-08-01 2007-08-01 泊洛沙姆用于预防和/或治疗心力衰竭的用途 Pending CN103271935A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83472806P 2006-08-01 2006-08-01
US60/834,728 2006-08-01

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800367818A Division CN101534843A (zh) 2006-08-01 2007-08-01 泊洛沙姆用于预防和/或治疗心力衰竭的用途

Publications (1)

Publication Number Publication Date
CN103271935A true CN103271935A (zh) 2013-09-04

Family

ID=38805633

Family Applications (4)

Application Number Title Priority Date Filing Date
CN2013101207279A Pending CN103271935A (zh) 2006-08-01 2007-08-01 泊洛沙姆用于预防和/或治疗心力衰竭的用途
CN2011100477182A Pending CN102218077A (zh) 2006-08-01 2007-08-01 泊洛沙姆用于预防和/或治疗心力衰竭的用途
CN2013100791323A Pending CN103222984A (zh) 2006-08-01 2007-08-01 泊洛沙姆用于预防和/或治疗心力衰竭的用途
CNA2007800367818A Pending CN101534843A (zh) 2006-08-01 2007-08-01 泊洛沙姆用于预防和/或治疗心力衰竭的用途

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN2011100477182A Pending CN102218077A (zh) 2006-08-01 2007-08-01 泊洛沙姆用于预防和/或治疗心力衰竭的用途
CN2013100791323A Pending CN103222984A (zh) 2006-08-01 2007-08-01 泊洛沙姆用于预防和/或治疗心力衰竭的用途
CNA2007800367818A Pending CN101534843A (zh) 2006-08-01 2007-08-01 泊洛沙姆用于预防和/或治疗心力衰竭的用途

Country Status (7)

Country Link
US (1) US9155758B2 (https=)
EP (1) EP2046348B1 (https=)
JP (2) JP5537152B2 (https=)
CN (4) CN103271935A (https=)
AU (1) AU2007281531B2 (https=)
CA (1) CA2659909A1 (https=)
WO (1) WO2008016640A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103271935A (zh) 2006-08-01 2013-09-04 普里克萨斯医药股份有限公司 泊洛沙姆用于预防和/或治疗心力衰竭的用途
US8372387B2 (en) * 2007-04-05 2013-02-12 Phrixus Pharmaceuticals, Inc. Compositions and methods for the treatment of heart failure
WO2011156389A2 (en) * 2010-06-07 2011-12-15 The Regents Of The University Of California The islet amyloid polypeptide toxic oligomer is a biomarker of heart or kidney failure in type-2 diabetes mellitus
CA2927361A1 (en) * 2013-10-16 2015-04-23 Mast Therapeutics, Inc. Diuretic induced alterations of plasma volume
KR102525493B1 (ko) 2014-07-07 2023-04-25 라이프래프트 바이오사이언시즈 인코포레이티드 장기 순환 물질이 없는 폴록사머 조성물 및 이의 제조 방법 및 용도
WO2016007542A1 (en) * 2014-07-07 2016-01-14 Mast Therapeutics, Inc. Poloxamer therapy for heart failure
US9757411B2 (en) 2014-07-07 2017-09-12 Aires Pharmaceuticals, Inc. Poloxamer therapy for heart failure
EP4178589A4 (en) * 2020-07-09 2024-07-24 Musc Foundation for Research Development Methods of protecting cells from insults
CN111973623B (zh) * 2020-08-06 2022-04-05 温州医科大学 心力衰竭靶向治疗的速释制剂

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US5198211A (en) * 1986-05-15 1993-03-30 Emory University Method of treating myocardial damage
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
ATE187154T1 (de) * 1991-03-19 1999-12-15 Cytrx Corp Polyoxypropylen/polyoxyethylen copolymere mit verbesserter biologischer aktivität
WO1992022202A1 (en) 1991-06-03 1992-12-23 Alpha Therapeutics Corporation Thrombolytic and perfluorochemical treatment for myocardial infraction
US5605687A (en) * 1992-05-15 1997-02-25 Arch Development Corporation Methods and compositions of a polymer (poloxamer) for repair of electrical injury
US5994348A (en) * 1995-06-07 1999-11-30 Sanofi Pharmaceutical compositions containing irbesartan
AU1312800A (en) 1998-10-09 2000-05-01 Cytrx Corporation Method and composition for treating ischemia and sickle cell anemia
US20020013331A1 (en) * 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
US6761824B2 (en) * 2000-08-17 2004-07-13 Reeve Lorraine E Process for the fractionation of polymers
CA2426811A1 (en) 2000-10-24 2002-08-29 Smithkline Beecham Corporation Novel formulations of carvedilol
WO2003078603A2 (en) * 2002-03-15 2003-09-25 Board Of Regents, The University Of Texas System Strong gene sets for glioma classification
US7550155B2 (en) * 2002-07-29 2009-06-23 Transform Pharmaceuticals Inc. Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses
AU2005289520A1 (en) * 2004-09-27 2006-04-06 Vical Incorporated Formulations and methods for treatment of inflammatory diseases
EP1809272A4 (en) * 2004-10-18 2008-01-02 Maroon Biotech Corp METHOD AND COMPOSITIONS FOR TREATING DAMAGES THROUGH FREE RADICALS
AU2006216420B2 (en) * 2005-02-25 2010-07-15 The Regents Of The University Of Michigan Compositions and methods for treating and preventing cardiomyopathy and heart disease
SI1861080T1 (sl) 2005-03-21 2010-08-31 Santhera Pharmaceuticals Ch Idebenon za zdravljenje miĺ iäśnih distrofij, njegovo pripravo in farmacevtska uporaba
EP2786749A1 (en) 2006-02-03 2014-10-08 Nicox S.A. Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
CN103271935A (zh) 2006-08-01 2013-09-04 普里克萨斯医药股份有限公司 泊洛沙姆用于预防和/或治疗心力衰竭的用途
US8372387B2 (en) * 2007-04-05 2013-02-12 Phrixus Pharmaceuticals, Inc. Compositions and methods for the treatment of heart failure
WO2009078978A2 (en) 2007-12-14 2009-06-25 Phrixus Pharmaceuticals, Inc. Compositions containing polyglycidol-based polymers and uses thereof
WO2009079562A2 (en) 2007-12-17 2009-06-25 The Regents Of The University Of Michigan Compositions and methods for treating and preventing skeletal muscle deficiencies
WO2011066201A2 (en) 2009-11-25 2011-06-03 The Regents Of The University Of Michigan Methods and systems for treating and preventing cardiac injury in dystrophic subjects

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YASUDA SOICHIRO ET AL: "Dystrophic heart failure blocked by membrane sealant poloxamer", 《NATURE》 *

Also Published As

Publication number Publication date
EP2046348A2 (en) 2009-04-15
JP5537152B2 (ja) 2014-07-02
CN102218077A (zh) 2011-10-19
US9155758B2 (en) 2015-10-13
JP2013253103A (ja) 2013-12-19
CN103222984A (zh) 2013-07-31
CA2659909A1 (en) 2008-02-07
US20090246162A1 (en) 2009-10-01
AU2007281531A1 (en) 2008-02-07
WO2008016640A3 (en) 2009-02-05
WO2008016640A2 (en) 2008-02-07
CN101534843A (zh) 2009-09-16
AU2007281531B2 (en) 2013-07-04
JP2009545595A (ja) 2009-12-24
EP2046348B1 (en) 2015-07-22

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Application publication date: 20130904