CN103269712B - 包含新型安丝菌素衍生物的细胞毒性剂 - Google Patents

包含新型安丝菌素衍生物的细胞毒性剂 Download PDF

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Publication number
CN103269712B
CN103269712B CN201180062234.3A CN201180062234A CN103269712B CN 103269712 B CN103269712 B CN 103269712B CN 201180062234 A CN201180062234 A CN 201180062234A CN 103269712 B CN103269712 B CN 103269712B
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cell
binding agent
antibody
cancer
esters
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CN103269712A (zh
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R·V·J·查理
W·C·威迪森
S·D·威廉
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Immunogen Inc
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Immunogen Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68033—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a maytansine
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems

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  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201180062234.3A 2010-11-03 2011-11-03 包含新型安丝菌素衍生物的细胞毒性剂 Expired - Fee Related CN103269712B (zh)

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CN201610728548.7A CN106349254A (zh) 2010-11-03 2011-11-03 包含新型安丝菌素衍生物的细胞毒性剂

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US40983110P 2010-11-03 2010-11-03
US61/409,831 2010-11-03
PCT/US2011/059131 WO2012061590A1 (en) 2010-11-03 2011-11-03 Cytotoxic agents comprising new ansamitocin derivatives

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AU (1) AU2011323316B2 (enExample)
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EA (1) EA201390642A1 (enExample)
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AU2011323316A9 (en) 2016-02-18
AU2011323316A1 (en) 2013-05-09
CN103269712A (zh) 2013-08-28
US20160058882A1 (en) 2016-03-03
AU2011323316B2 (en) 2016-02-25
BR112013010853A2 (pt) 2016-08-16
EP2635301A4 (en) 2016-06-01
US20130323268A1 (en) 2013-12-05
US9090629B2 (en) 2015-07-28
EA201390642A1 (ru) 2013-12-30
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MX2013005046A (es) 2013-12-12
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