JP2013542958A - アンサマイトシン誘導体を含む細胞傷害性剤 - Google Patents

アンサマイトシン誘導体を含む細胞傷害性剤 Download PDF

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JP2013542958A
JP2013542958A JP2013537819A JP2013537819A JP2013542958A JP 2013542958 A JP2013542958 A JP 2013542958A JP 2013537819 A JP2013537819 A JP 2013537819A JP 2013537819 A JP2013537819 A JP 2013537819A JP 2013542958 A JP2013542958 A JP 2013542958A
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JP2013542958A5 (enExample
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チャリ，ラビ・ヴイ・ジェイ
ウィディソン，ウェイン・シー
ウィルヘルム，シャロン・ディー
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イミュノジェン・インコーポレーテッド
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JP2013537819A 2010-11-03 2011-11-03 アンサマイトシン誘導体を含む細胞傷害性剤 Pending JP2013542958A (ja)

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US40983110P 2010-11-03 2010-11-03
US61/409,831 2010-11-03
PCT/US2011/059131 WO2012061590A1 (en) 2010-11-03 2011-11-03 Cytotoxic agents comprising new ansamitocin derivatives

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JP2013542958A5 JP2013542958A5 (enExample) 2014-12-18

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US (2) US9090629B2 (enExample)
EP (1) EP2635301A4 (enExample)
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CN (2) CN103269712B (enExample)
AU (1) AU2011323316B2 (enExample)
BR (1) BR112013010853A2 (enExample)
CA (1) CA2816681A1 (enExample)
EA (1) EA201390642A1 (enExample)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018521123A (ja) * 2015-06-09 2018-08-02 エックスディーシーエクスプローラー （シャンハイ） カンパニー リミテッド 抗体薬物複合体、中間体、その製造方法、薬学的組成物及び応用
JP2019502746A (ja) * 2016-01-25 2019-01-31 レゲネロン ファーマシューティカルス，インコーポレーテッド メイタンシノイド誘導体、そのコンジュゲート、及び使用方法

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
CN103933575B (zh) 2013-01-23 2017-09-29 上海新理念生物医药科技有限公司 一种三齿型连接子及其应用
WO2014134457A2 (en) * 2013-02-28 2014-09-04 Immunogen, Inc. Conjugates comprising cell-binding agents and cytotoxic agents
EP2961435B1 (en) 2013-02-28 2019-05-01 ImmunoGen, Inc. Conjugates comprising cell-binding agents and cytotoxic agents
EP3964237B1 (en) 2013-03-15 2026-02-18 Regeneron Pharmaceuticals, Inc. Biologically active molecules, conjugates thereof, and therapeutic uses
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
KR102252925B1 (ko) 2013-08-26 2021-05-18 리제너론 파마슈티칼스 인코포레이티드 마크롤라이드 디아스테레오머를 포함하는 약제학적 조성물, 이의 합성 방법 및 치료학적 용도
EP2881735A1 (en) 2013-12-05 2015-06-10 Kittiwake Developments Ltd. Method for Determining the Concentration of Iron Ions in Hydrocarbon Compositions
KR20240142591A (ko) 2015-03-27 2024-09-30 리제너론 파아마슈티컬스, 인크. 메이탄시노이드 유도체, 이의 컨주게이트, 및 사용 방법
SG10202110908WA (en) 2015-05-04 2021-11-29 Cytomx Therapeutics Inc Anti-cd166 antibodies, activatable anti-cd166 antibodies, and methods of use thereof
CN106267225B (zh) 2015-05-29 2020-03-06 上海新理念生物医药科技有限公司 三马来酰亚胺型连接子及其应用
CN106279352B (zh) 2015-05-29 2020-05-22 上海新理念生物医药科技有限公司 海兔毒素10的衍生物及其应用
JP6548751B2 (ja) 2015-06-08 2019-07-24 シャンドン ダンホン ファーマスーティカル カンパニー リミテッドＳｈａｎｄｏｎｇ Ｄａｎｈｏｎｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． イミダゾール誘導体及びその中間体の製造及び結晶型
SG11201803915UA (en) 2015-11-10 2018-06-28 Childrens Research Institute Childrens National Medical Center Echinomycin formulation, method of making and method of use thereof
CN106729743B (zh) * 2015-11-23 2021-09-21 四川科伦博泰生物医药股份有限公司 抗ErbB2抗体-药物偶联物及其组合物、制备方法和应用
JP2019510741A (ja) 2016-02-05 2019-04-18 イミュノジェン・インコーポレーテッド 細胞結合剤・細胞毒性剤コンジュゲートを調製するための効率的なプロセス
KR102775461B1 (ko) 2016-04-01 2025-02-28 어비디티 바이오사이언시스 인크. 핵산-폴리펩타이드 조성물 및 이의 용도
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
GB201615725D0 (en) 2016-09-15 2016-11-02 Polytherics Ltd Novel cytotoxic agents and conjugates thereof
JP7350313B2 (ja) 2016-12-16 2023-09-26 ブルーフィン バイオメディシン， インコーポレイテッド 抗ｃｕｂドメイン含有タンパク質１（ｃｄｃｐ１）抗体、抗体薬物コンジュゲート、およびその使用方法
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
EP3658172A4 (en) 2017-07-25 2021-05-05 TrueBinding, Inc. TREATING CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND HIS LIGAND
CN107652219B (zh) 2017-08-14 2021-06-08 上海新理念生物医药科技有限公司 四马来酰亚胺型连接子及其应用
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
WO2020102777A1 (en) 2018-11-16 2020-05-22 Virtuoso Binco, Inc. Cd38 and icam1 antibodies and uses thereof
IL319265A (en) 2018-12-21 2025-04-01 Avidity Biosciences Inc Anti-transferrin receptor antibodies and their uses
CN113711036B (zh) 2019-01-30 2025-03-18 真和制药有限公司 抗gal3抗体及其用途
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
PH12022550037A1 (en) 2019-07-10 2023-04-12 Cybrexa 3 Inc Peptide conjugates of microtubule-targeting agents as therapeutics
KR20220052918A (ko) 2019-07-10 2022-04-28 싸이브렉사 2, 인크. 치료제로서의 사이토톡신의 펩티드 접합체
EP3797796A4 (en) 2019-08-07 2021-10-27 MabPlex International Co., Ltd. ANTIBODY INGREDIENT CONJUGATES AND USES THEREOF
JP7835441B2 (ja) 2019-12-06 2026-03-25 トゥルーバインディング，インコーポレイテッド Ｇａｌ３とインスリン受容体又はインテグリンとの相互作用を妨害する抗体及びそれらの使用方法
WO2021188390A1 (en) 2020-03-19 2021-09-23 Avidity Biosciences, Inc. Compositions and methods of treating facioscapulohumeral muscular dystrophy
WO2021195469A1 (en) 2020-03-27 2021-09-30 Avidity Biosciences, Inc. Compositions and methods of treating muscle dystrophy
CN116157151A (zh) 2020-05-26 2023-05-23 真和制药有限公司 通过阻断半乳凝素-3治疗炎性疾病的方法
US20230256114A1 (en) * 2020-07-07 2023-08-17 Bionecure Therapeutics, Inc. Novel maytansinoids as adc payloads and their use for the treatment of cancer
US12030888B2 (en) 2021-02-24 2024-07-09 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof
JP2024526764A (ja) 2021-07-13 2024-07-19 トゥルーバインディング，インコーポレイテッド タンパク質凝集を防止する方法
CN113461708A (zh) * 2021-07-22 2021-10-01 深圳市泰尔康生物医药科技有限公司 安丝菌素p-3衍生物及其在制备治疗胃癌药物中的应用
MX2024003266A (es) 2021-09-16 2024-04-03 Avidity Biosciences Inc Composiciones y metodos de tratamiento de la distrofia muscular facioescapulohumeral.
AU2022388722A1 (en) 2021-11-09 2024-05-23 Truebinding, Inc. Methods of treating or inhibiting cardiovascular diseases
CN116239607B (zh) * 2023-01-04 2024-04-09 山东大学 一种美登素衍生物及其生物合成方法与应用
CN119424671A (zh) 2023-08-01 2025-02-14 上海新理念生物医药科技有限公司 含糖基吡啶型连接子的抗体药物偶联物

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331598A (en) * 1979-09-19 1982-05-25 Takeda Chemical Industries, Ltd. Maytansinoids
JPH03161490A (ja) * 1989-10-25 1991-07-11 Immunogen Inc メイタンシノイドを含む細胞障害剤及び該細胞障害剤を有効成分とする医薬
JP2005517032A (ja) * 2001-12-21 2005-06-09 イミュノジェン・インコーポレーテッド 反応性ポリエチレングリコール部分を持つ細胞毒性薬剤、ポリエチレングリコール連結基を含んでなる細胞毒性コンジュゲート、ならびにその製造方法および使用方法
JP2007527421A (ja) * 2004-02-23 2007-09-27 ジェネンテック・インコーポレーテッド 複素環式自壊的リンカーおよび結合体
WO2009134976A1 (en) * 2008-04-30 2009-11-05 Immunogen, Inc Potent conjugates and hydrophilic linkers

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030109682A1 (en) * 2001-09-07 2003-06-12 Daniel Santi Maytansines and maytansine conjugates
KR101145506B1 (ko) * 2003-05-20 2012-05-15 이뮤노젠 아이엔씨 새로운 메이탠시노이드를 포함하는 개선된 세포독성체
MXPA06014065A (es) * 2004-06-01 2007-01-31 Genentech Inc Conjugados de droga-anticuerpo y metodos.
ES2579805T3 (es) 2004-09-23 2016-08-16 Genentech, Inc. Anticuerpos y conjugados modificados por ingeniería genética con cisteína
WO2006135371A1 (en) * 2005-06-09 2006-12-21 Kosan Biosciences Incorporated Conjugates with reduced adverse systemic effects

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331598A (en) * 1979-09-19 1982-05-25 Takeda Chemical Industries, Ltd. Maytansinoids
JPH03161490A (ja) * 1989-10-25 1991-07-11 Immunogen Inc メイタンシノイドを含む細胞障害剤及び該細胞障害剤を有効成分とする医薬
JP2005517032A (ja) * 2001-12-21 2005-06-09 イミュノジェン・インコーポレーテッド 反応性ポリエチレングリコール部分を持つ細胞毒性薬剤、ポリエチレングリコール連結基を含んでなる細胞毒性コンジュゲート、ならびにその製造方法および使用方法
JP2007527421A (ja) * 2004-02-23 2007-09-27 ジェネンテック・インコーポレーテッド 複素環式自壊的リンカーおよび結合体
WO2009134976A1 (en) * 2008-04-30 2009-11-05 Immunogen, Inc Potent conjugates and hydrophilic linkers

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN J CANCER RES. 1992 JUL;83(7):761-8, JPN6015034866, ISSN: 0003144546 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018521123A (ja) * 2015-06-09 2018-08-02 エックスディーシーエクスプローラー （シャンハイ） カンパニー リミテッド 抗体薬物複合体、中間体、その製造方法、薬学的組成物及び応用
JP2019502746A (ja) * 2016-01-25 2019-01-31 レゲネロン ファーマシューティカルス，インコーポレーテッド メイタンシノイド誘導体、そのコンジュゲート、及び使用方法

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