CN103263642A - Medicine for treating irregular menstrual period and preparation method thereof - Google Patents
Medicine for treating irregular menstrual period and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating the irregular menstrual period and a preparation method thereof. The medicine is prepared from angelica sinensis, cinnamon, rhizoma cyperi, turmeric, red flower, hematoxylon, sunflower, codonopsis pilosula and moutan bark according to a certain weight proportion. The medicine has the effects of nourishing yin, clearing the heat, promoting qi to activate blood, dissipating blood stasis to stop pain, tonifying kidneys, stopping bleeding and adjusting the menstrual period, has a quick response of treating the irregular menstrual period and is short in treatment period.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of irregular menstrual period and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Irregular menstrual period claims delay of menstrual cycle again, and menoxenia is a kind of common gynaecopathia.Show as the unusual of menstrual cycle or amount of bleeding, or stomachache and General Symptoms before the menstruation, during menstrual period.The cause of disease may be organic disease or malfunction.Hematopathy, hypertension, hepatopathy, endocrinopathy, miscarriage, ectopic pregnancy, hydatidiform mole, reproductive tract infection, tumor (as ovarian tumor, hysteromyoma) etc. all can cause menoxenia.Menoxenia shows as the disorder of menstrual cycle or amount of bleeding, and following several situation is arranged: irregular metrorrhagia, menorrhagia or persistent period are long.Dysfunctional uterine hemorrhage, external genitalia does not have the significant organic pathological changes in referring to, and by the caused metrorrhagia of endocrine regulation unbalance of system.Menoxenia has had a strong impact on women's daily life and work, and is endangering the healthy of women.At present, because Western medicine can't effectively be treated menoxenia, and certain side effect is arranged.
Summary of the invention:
Therefore there is great demand in people to the Chinese medicine of special effect.The inventor has found the medicine of effective treatment irregular menstrual period finally, thereby has finished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.
Purpose of the present invention just provides a kind of composition of medicine for the treatment of irregular menstrual period.
Another object of the present invention has just provided the preparation method of this composition of medicine.
Medicine of the present invention selects Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Cortex Cinnamomi, Rhizoma Cyperi, Rhizoma Curcumae Longae, Flos Carthami, Lignum Sappan, Medulla Tetrapanacis, Herba Leonuri, Radix Glycyrrhizae, sunflower, Radix Codonopsis, Colla Corii Asini, Cortex Moutan, Radix Bupleuri to make up, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat menoxenia.Wherein selecting Radix Angelicae Sinensis for use is that temperature is gone into the heart, liver, spleen channel, and benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of moisturizing laxation because of the sweet suffering of its nature and flavor, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty are just, and be heavy after the bloody dysentery, ulcer sores, incised wound, injury from falling down.Selecting Rhizoma Chuanxiong for use is because its nature and flavor suffering, and temperature is gone into liver, gallbladder meridian, and activating QI to alleviate the depression is arranged, dispeiling pathogenic wind and removing dampness, and the function of promoting blood circulation and stopping pain is controlled air-cooled headache and is revolved dizzyly, and the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Select for use Radix Rehmanniae Preparata to be because its nature and flavor are sweet, tepor is gone into liver, kidney channel, and YIN nourishing is arranged, and the function of enriching blood is controlled deficiency of YIN insufficiency of blood, the waist knee flaccidity, and the chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia is quenched one's thirst, frequency of micturition, deafness, blurred vision.Selecting the Radix Paeoniae Alba for use is that liver, spleen channel are gone in cold, and nourishing blood to suppress the hyperactive liver is arranged because of its nature and flavor picric acid, slow middle pain relieving, and yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Selecting Cortex Cinnamomi for use is that heat is gone into kidney, spleen, urinary bladder channel, and the complement sun is arranged, warming the spleen and stomach, removing accumulated cold because of its property acrid-sweet flavor, the function of promoting blood circulation is controlled decline of the fire from the gate of life, the cold extremities faint pulse, and the YANG-depletion collapse, stomachache is had loose bowels, the colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.Select for use Rhizoma Cyperi to be because the hot little hard work of its nature and flavor is flat, go into liver, tri-jiao channel, the resolving depression of regulating the flow of vital energy, the function of pain relieving regulating menstruation, treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses.Select for use Rhizoma Curcumae Longae to be because its nature and flavor are arduous, temperature is gone into spleen, Liver Channel, and removing blood stasis is arranged, and circulation of qi promoting is stimulated the menstrual flow, and the function of pain relieving is controlled trusted subordinate's feeling of fullness distending pain, brachialgia ， mass in the abdomen, and women's blood stasis amenorrhea, puerperal, the stasis of blood was stopped stomachache, injury from falling down, carbuncle.Selecting Flos Carthami for use is that temperature is gone into the heart, Liver Channel, and promoting blood circulation to restore menstrual flow is arranged because of its nature and flavor suffering, and the function of blood stasis removing pain relieving is controlled amenorrhea ， mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Select for use Lignum Sappan to be because its nature and flavor are sweet, salty, flat, promoting the circulation of blood is arranged, removing blood stasis with potent drugs, detumescence, the function of pain relieving is controlled married woman's vim and vigour cardiac and abdominal pain, amenorrhea, postnatal blood stasis, distending pain dyspnea with rapid respiration, dysentery, tetanus.Selecting Medulla Tetrapanacis for use is that cold has eliminating the pathogens from the lung because of its property slightly sweet flavor, diuresis, and the function of following milk is controlled dysuria, gonorrhea, edema, puerpera's galactostasis.Select for use Herba Leonuri to be because its nature and flavor are arduous, pericardium, Liver Channel are gone in cold, invigorate blood circulation, and blood stasis dispelling, regulating menstruation, the function of the water that disappears is controlled menoxenia, controls Lou difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria is rushed down blood, the carbuncle skin infection.Select for use Radix Glycyrrhizae to be because its nature and flavor are sweet flat, go into spleen, stomach, lung meridian, have and middle emergency, lung moistening, detoxifcation, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, the overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle is given birth to controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.Select sunflower for use, the different name Flos Helianthi, it is sweet in flavor and warm in property, and is nontoxic, dispels the wind, and the function that makes eye bright is controlled headache, blurred vision, swelling of the face can expedite the emergence of again.Select for use Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, the meridian of Foot-TAI YIN edema caused by disorder of QI, invigorating the spleen and replenishing QI is arranged, the function of promoting the production of body fluid is controlled weakness of the spleen and stomach, deficiency of both QI and blood, and fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.Select for use Colla Corii Asini to be because its nature and flavor are sweet, flat, go into lung, liver, kidney channel, nourishing YIN and supplementing blood is arranged, antiabortive function is controlled blood deficiency, and cough due to consumptive disease, is had blood in stool menoxenia, metrorrhagia, vaginal bleeding during pregnancy at haematemesis, epistaxis.Select for use Cortex Moutan to be because its nature and flavor are arduous, the heart, liver, kidney channel are gone in cold, and heat clearing away is arranged, removing heat from blood, and blood, and the function of repercussive is controlled the pathogenic heat attacking blood system in febrile diseases, sends out speckle ， Jing Epilepsy, and tell, be defeated in battle, have blood in stool, the hectic fever due to YIN-deficiency consumptive fever, amenorrhea ， mass in the abdomen, carbuncle and ulcer is pounced on damage.Selecting Radix Bupleuri for use is that liver, gallbladder meridian are gone in cold, and reconciling superficies and interior is arranged, and be soothing the liver because of its nature and flavor hardship, and the function of yang invigorating is controlled alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste deafness, headache and dizziness, malaria, diarrhea proctoptosis, menoxenia, uterine prolapse.
The specific embodiment
The drug dose of the present invention's combination also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has better curative effect in following weight range
Radix Angelicae Sinensis 15-25 gram Rhizoma Chuanxiong 10-20 gram Radix Rehmanniae Preparata 15-25 gram
Radix Paeoniae Alba 8-15 gram Cortex Cinnamomi 8-15 gram Rhizoma Cyperi 10-20 gram
Rhizoma Curcumae Longae 10-20 gram Flos Carthami 8-15 gram Lignum Sappan 8-15 gram
Medulla Tetrapanacis 8-15 gram Herba Leonuri 15-25 gram Radix Glycyrrhizae 8-15 gram
Sunflower 10-20 gram Radix Codonopsis 10-15 gram Colla Corii Asini 8-12 gram
Cortex Moutan 8-12 gram Radix Bupleuri 10-15 gram
Wherein, be preferably
Radix Angelicae Sinensis 20 gram Rhizoma Chuanxiongs 15 gram Radix Rehmanniae Preparata 20 grams
The Radix Paeoniae Alba 10 gram Cortex Cinnamomis 10 gram Rhizoma Cyperis 15 grams
Rhizoma Curcumae Longae 15 gram Flos Carthamis 10 gram Lignum Sappans 10 grams
Medulla Tetrapanacis 10 gram Herba Leonuris 20 gram Radix Glycyrrhizaes 10 grams
Sunflower 15 gram Radix Codonopsis 12 gram Colla Corii Asini 10 grams
Cortex Moutan 10 gram Radix Bupleuri 12 grams
The preparation method of medicine of the present invention is as follows
One, gets the raw materials ready
1, Radix Angelicae Sinensis: choose roguing and sanction, clean, moistening dries in the air when suitable to inside and outside humidity slightly, and section is dried;
2, Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices drying behind the moistening;
3, Radix Rehmanniae Preparata: get crude drug, steam to surperficial corvinus, take out, when solarization is done to eighty per cant, section, drying;
4, the Radix Paeoniae Alba: choose roguing and sanction, size separately is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;
5, Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the time spent smashes, or scrapes off rough bark, and with the eliminating cold for resuscitation water infiltration for a moment, section is dried;
6, Rhizoma Cyperi: choose decontamination, grind into particle, winnow with a dustpan fine, soft fur and smalls;
7, Rhizoma Curcumae Longae: choose decontamination, be soaked in water, pick up, run through the back section, dry;
8, Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
9, Lignum Sappan: get crude drug, be sawn into short section, be split into fragment or pound sheet again;
10, Medulla Tetrapanacis: get crude drug, remove impurity, section;
11, Herba Leonuri: choose decontamination, clean, run through, cutting is dried;
12, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water when saturating to eighty per cant, pull out, run through section, airing;
13, sunflower: choose clean impurity, dry;
14, Radix Codonopsis: clean silt, run through reed, section is dried;
15, Colla Corii Asini: smash usefulness to pieces;
16, Cortex Moutan: choose decontamination, remove core, clean, run through, section is dried;
17, Radix Bupleuri: choose decontamination, clean silt, pull out, run through the back section, dry.
Two, preparation
1, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Cortex Cinnamomi, Rhizoma Cyperi, Rhizoma Curcumae Longae, Flos Carthami, Lignum Sappan, Medulla Tetrapanacis, Herba Leonuri, Radix Glycyrrhizae, sunflower, Radix Codonopsis, Colla Corii Asini, Cortex Moutan, the Radix Bupleuri with described weight decocts with water, add for the first time 6 times of amounts of water, intense fire decocts boiling 10 minutes, reuse slow fire boiling 20 minutes, time decoction liquor of namely winning.
2, will filter the back medicinal residues for the first time and add 3 times of amounts of water, and decoct boiling, the reuse slow fire boiling namely got decoction liquor for the second time in 20 minutes.
3, twice decoction liquor mixed, simmered in water again 15 minutes, medicinal liquid is divided into 2 doses.
Medicine of the present invention has nourishing YIN and clearing away heat, promoting flow of QI and blood, the silt pain relieving of loosing, reinforcing the kidney and arresting hemorrhage, the effect of regulating menstrual cycle, treatment irregular menstrual period instant effect, short treating period, cure rate height.
Below further sets forth the beneficial effect of medicine of the present invention by testing example, these are tested and routinely comprise that the animal toxicity test of medicine of the present invention and clinical observation test.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 20 of rabbit, the male and female dual-purpose, body weight 2.0-2.5kg divides two groups, and 10 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 30ml/kg, and normal amount is 10ml/kg, and administering mode is the administration by gavage administration, serve on 7 days every day twice, observes administration reaction every day, and the result shows that two groups of rabbit activities, diet are normal, and medicine does not have bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's 150 examples for medical treatment, 20-30 years old age, 40 examples, 30-40 years old 70 example, 40-50 years old 40 example.
2, diagnostic criteria
Menoxenia shows as the disorder of menstrual cycle or amount of bleeding, and following several situation is arranged:
Irregular metrorrhagia.Comprise: menorrhagia or persistent period are long.Be common in hysteromyoma, endometrial polyp, endometrial hyperplasia, endometriosis etc.; Hypomenorrhea is all few through amount and menstrual period; Polymenorrhea is that menstruation is less than 25 days at interval; It is that menstruation was longer than 35 days at interval that menstrual cycle prolongs; Irregular bleeding can be caused by a variety of causes, hemorrhage irregular.More than several situations can be caused by local cause, endocrine reason or systemic disease.
Dysfunctional uterine hemorrhage.External genitalia does not have the significant organic pathological changes in referring to, and by the caused metrorrhagia of endocrine regulation unbalance of system.Be modal a kind of in the menoxenia, be common in adolescence and climacteric.Be divided into ovulation property and anovulatory two classes, about 85% case belongs to the anovulatory function.
3, Therapeutic Method
Select above-mentioned medicament for use, take to the patient, take 1 dose at every turn, every day early, respectively obey 1 time evening, 20 days is a course for the treatment of, takes two courses for the treatment of continuously.
4, efficacy assessment standard
Produce effects: treatment back clinical symptom disappearance, it is normal that menstrual cycle recovers, and observes and do not have the recidivist half a year;
Take a turn for the better: clinical symptoms is obviously improved, and it is normal that menstrual cycle progressively recovers;
Invalid: clinical partial symptoms disappears or does not have change, does not reach improvement standard person.
5, therapeutic outcome
In above-mentioned treatment, with Drug therapy irregular menstrual period patient 150 examples of the present invention, produce effects 144 examples as a result, obvious effective rate is 96%, 4 examples that take a turn for the better, improvement rate is 2.67%, invalid 2 examples, total effective rate is 98.67%.
Claims (3)
1. medicine for the treatment of irregular menstrual period, it is characterized in that: it is to be made by the crude drug in the following weight range:
Radix Angelicae Sinensis 15-25 gram Rhizoma Chuanxiong 10-20 gram Radix Rehmanniae Preparata 15-25 gram
Radix Paeoniae Alba 8-15 gram Cortex Cinnamomi 8-15 gram Rhizoma Cyperi 10-20 gram
Rhizoma Curcumae Longae 10-20 gram Flos Carthami 8-15 gram Lignum Sappan 8-15 gram
Medulla Tetrapanacis 8-15 gram Herba Leonuri 15-25 gram Radix Glycyrrhizae 8-15 gram
Sunflower 10-20 gram Radix Codonopsis 10-15 gram Colla Corii Asini 8-12 gram
Cortex Moutan 8-12 gram Radix Bupleuri 10-15 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Radix Angelicae Sinensis 20 gram Rhizoma Chuanxiongs 15 gram Radix Rehmanniae Preparata 20 grams
The Radix Paeoniae Alba 10 gram Cortex Cinnamomis 10 gram Rhizoma Cyperis 15 grams
Rhizoma Curcumae Longae 15 gram Flos Carthamis 10 gram Lignum Sappans 10 grams
Medulla Tetrapanacis 10 gram Herba Leonuris 20 gram Radix Glycyrrhizaes 10 grams
Sunflower 15 gram Radix Codonopsis 12 gram Colla Corii Asini 10 grams
Cortex Moutan 10 gram Radix Bupleuri 12 grams.
3. according to the preparation method of claim 1 or 2 described medicines, it comprises the following steps:
(1) gets the raw materials ready
(1) Radix Angelicae Sinensis: choose roguing and sanction, clean, moistening dries in the air when suitable to inside and outside humidity slightly, and section is dried;
(2) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices drying behind the moistening;
(3) Radix Rehmanniae Preparata: get crude drug, steam to surperficial corvinus, take out, when solarization is done to eighty per cant, section, drying;
(4) Radix Paeoniae Alba: choose roguing and sanction, size separately is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;
(5) Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the time spent smashes, or scrapes off rough bark, and with the eliminating cold for resuscitation water infiltration for a moment, section is dried;
(6) Rhizoma Cyperi: choose decontamination, grind into particle, winnow with a dustpan fine, soft fur and smalls;
(7) Rhizoma Curcumae Longae: choose decontamination, be soaked in water, pick up, run through the back section, dry;
(8) Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
(9) Lignum Sappan: get crude drug, be sawn into short section, be split into fragment or pound sheet again;
(10) Medulla Tetrapanacis: get crude drug, remove impurity, section;
(11) Herba Leonuri: choose decontamination, clean, run through, cutting is dried;
(12) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water when saturating to eighty per cant, pull out, run through section, airing;
(13) sunflower: choose clean impurity, dry;
(14) Radix Codonopsis: clean silt, run through reed, section is dried;
(15) Colla Corii Asini: smash usefulness to pieces;
(16) Cortex Moutan: choose decontamination, remove core, clean, run through, section is dried;
(17) Radix Bupleuri: choose decontamination, clean silt, pull out, run through the back section, dry;
(2) preparation
(1) Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Cortex Cinnamomi, Rhizoma Cyperi, Rhizoma Curcumae Longae, Flos Carthami, Lignum Sappan, Medulla Tetrapanacis, Herba Leonuri, Radix Glycyrrhizae, sunflower, Radix Codonopsis, Colla Corii Asini, Cortex Moutan, the Radix Bupleuri with described weight decocts with water, add for the first time 6 times of amounts of water, intense fire decocts boiling 10 minutes, reuse slow fire boiling 20 minutes, time decoction liquor of namely winning;
(2) will filter the back medicinal residues for the first time and add 3 times of amounts of water, and decoct boiling, the reuse slow fire boiling namely got decoction liquor for the second time in 20 minutes;
(3) twice decoction liquor mixed, simmered in water again 15 minutes, medicinal liquid is divided into 2 doses.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520673A (en) * | 2013-10-12 | 2014-01-22 | 谭钦文 | Traditional Chinese medicine for treating deficiency of Qi and blood syndrome type of menopathy |
| CN103520672A (en) * | 2013-10-12 | 2014-01-22 | 谭钦文 | Traditional Chinese medicine for treating menopathy belonging to the type of syndrome of dampness-heat of liver channel |
| CN103536887A (en) * | 2013-10-30 | 2014-01-29 | 谭钦文 | Traditional Chinese medicament for treating hypomenorrhea with symptoms of blood stasis and channel blockage |
| CN105288011A (en) * | 2015-10-29 | 2016-02-03 | 丁芬 | Traditional Chinese medicine composition for treating irregular menstruation and pelvic inflammation |
| CN106377669A (en) * | 2016-12-08 | 2017-02-08 | 张云侠 | Medicament for treating female amenorrhea and preparation method of medicament |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1440776A (en) * | 2003-04-09 | 2003-09-10 | 江西汇仁药业有限公司 | Chinese medicine for regulating menstruation and nourishing blood |
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2013
- 2013-06-01 CN CN201310212690.2A patent/CN103263642B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1440776A (en) * | 2003-04-09 | 2003-09-10 | 江西汇仁药业有限公司 | Chinese medicine for regulating menstruation and nourishing blood |
Non-Patent Citations (1)
| Title |
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| 于丽军: "姚五达治疗月经病的特点", 《北京中医杂志》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520673A (en) * | 2013-10-12 | 2014-01-22 | 谭钦文 | Traditional Chinese medicine for treating deficiency of Qi and blood syndrome type of menopathy |
| CN103520672A (en) * | 2013-10-12 | 2014-01-22 | 谭钦文 | Traditional Chinese medicine for treating menopathy belonging to the type of syndrome of dampness-heat of liver channel |
| CN103520673B (en) * | 2013-10-12 | 2015-05-27 | 神艳 | Traditional Chinese medicine for treating deficiency of Qi and blood syndrome type of menopathy |
| CN103536887A (en) * | 2013-10-30 | 2014-01-29 | 谭钦文 | Traditional Chinese medicament for treating hypomenorrhea with symptoms of blood stasis and channel blockage |
| CN105288011A (en) * | 2015-10-29 | 2016-02-03 | 丁芬 | Traditional Chinese medicine composition for treating irregular menstruation and pelvic inflammation |
| CN106377669A (en) * | 2016-12-08 | 2017-02-08 | 张云侠 | Medicament for treating female amenorrhea and preparation method of medicament |
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| CN103263642B (en) | 2015-03-25 |
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