CN103251753B - Traditional Chinese medicine composition for treating streptococcicosis of tilapia mossambica - Google Patents
Traditional Chinese medicine composition for treating streptococcicosis of tilapia mossambica Download PDFInfo
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- CN103251753B CN103251753B CN201310225616.4A CN201310225616A CN103251753B CN 103251753 B CN103251753 B CN 103251753B CN 201310225616 A CN201310225616 A CN 201310225616A CN 103251753 B CN103251753 B CN 103251753B
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Abstract
The invention relates to a traditional Chinese medicine composition for treating streptococcicosis of tilapia mossambica. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-15 parts of chinese barberry roots, 8-10 parts of asarum, 3-5 parts of negundo chastetree fruits, 3-4 parts of rhizoma alismatis, 1-2 parts of groundsel, 1-2 parts of salvia miltiorrhiza, 1-2 parts of platycladi seeds, 2-3 parts of bighead atractylodes rhizome and 3-5 parts of astragalus membranaceus. A preparation method comprises the following steps of: weighing the traditional Chinese medicine raw materials in parts by weight; mixing and crushing a mixture to be about 40-60 meshes; and then packaging to obtain the product. The traditional Chinese medicine composition disclosed by the invention can effectively prevent the streptococcicosis from breaking out in a cultivation process of the tilapia mossambica; the curing rate of cultivated fish schools with the disease is up to 50-70%, so that a passive situation that the tilapia mossambica of a whole pond die once the streptococcicosis breaks out is changed and the financial loss caused by the streptococcicosis of the tilapia mossambica is reduced; and therefore, the traditional Chinese medicine composition has the very important meaning to the development of the tilapia mossambica breeding industry.
Description
Technical field
The present invention relates to feed additive used for aquiculture or drug world, relate to and treat the Chinese medicine composition of tilapia feeding process streptococcus intermedius disease and the application in tilapia feed thereof.
Background technology
Tilapia, is commonly called as African crucian, white salmon fish, is the breed variety that FAO (Food and Agriculture Organization of the United Nation) is recommended to the whole world.Tilapia every year in Chinese cultivation amount up to more than 1,200,000 tons, account for 60% of whole world cultivation amount, mainly concentrate on Guangdong, Guangxi and In Fujian Province, the intensive culture of tilapia is one of pillar of Guangdong Province " shrimp of fish " industrial chain, is also one of main aquaculture of the coastal area such as Guangxi, Fujian.Growth Op Tilapia is rapid, aquaculture cost is low, resistance against diseases is strong, the pathogenic bacteria of many harm four large Chinese carps is on all no impacts of tilapia, but, along with the expansion of intensive culture area and increasing of cultivation density, the disease problem of tilapia is day by day serious, particularly streptococcal infection, once the streptococcicosis of tilapia outburst, infectiousness is strong, persistent period is long, mortality rate is high, and the more difficult control of the higher state of an illness of water temperature, annual megathermal period streptococcus great outburst, usually cause the tilapia full pool death of cultivation, tilapia streptococcicosis is called tilapia cancer by raiser, once mean that outburst just yields to no remedy.Research report shows, tilapia streptococcicosis main pathogen comprises Streptococcus iniae, streptococcus agalactiae, secondary Streptococcus lactis (Lister) Lohnis 1909.554., streptococcus dysgalactiae, sea dog streptococcus, Gall's chain coccus, fish Streptococcus lactis (Lister) Lohnis 1909.554. and Sharpe streptococcus, Etiological is due to streptococcal infection brain, DIABLO warp, the organs such as infringement liver, kidney, it is fallen ill mainly owing to causing, especially in the time that feed nutrition is unbalanced, nitrogen discharged too much, cause the high dissolved oxygen of water body ammonia nitrogen low.In order to prevent and treat cause of disease, the abuse of environmental improvement agent, disinfectant, parasite killing anthelmintic, antibiotic etc, misuse, may produce toxic damages to tilapia, long-term Drug abuse also may cause gene mutation and transfer, streptococcus and other pathogen are developed immunity to drugs, produce superbacteria, antibiotic remains is known from experience the harmful effects such as generation disables, teratogenesis, mutagenesis to people simultaneously, affects health and the sustainable development of tilapia aquaculture.
Along with the forbidding gradually of antibiotic, antibacterials, Chinese herbal medicine plays an important role in the treatment of Animal diseases and prevention, in Chinese herbal medicine, there is natural, the advantage such as toxic and side effects is few, aboundresources, contain and the closely-related alkaloid of immunologic function of animal, flavone, tea polyphenols, oligosaccharide, quintessence oil etc., can promote the health of body, reduce antibiotic use.Therefore, for the problems referred to above in tilapia cultivation, need a kind of important composition for the treatment of tilapia streptococcicosis of exploitation badly, to strengthen anti-stress ability and the immunity of tilapia, prevention and treatment tilapia breeding process streptococcus intermedius disease, reduce antibiotic use, promote health and the sustainable development of tilapia aquaculture.Chinese medicine medical science belongs to the traditional medicine of China, strengthens the immune function of aquatic animal by the use of Chinese herbal medicine, and the sickness rate that reduces aquatic animal becomes study hotspot in recent years.Chinese herbal medicine is as the medicine of diseases prevention and treatment, is particularly useful for that current aquatic products industry is intensive, the needs of large-scale production, is convenient to carry out colony's control of disease in high-density breeding.Chinese herbal medicine have residual less, the pathogenic bacterium advantage such as be difficult for developing immunity to drugs, its effect not only has direct inhibition and killing action for pathogenic microorganism itself, the more important thing is the object-immunity system of feeding is adjusted, improve immune function and the anti-stress ability of animal, using medicinal herb components as medicine or feed additive, the disease control criterion that meets the nuisanceless aquatic products industry of development completely, produces green aquatic product for preventing and treating disease that tilapia cultivation easily occurs.In addition, in Chinese herbal medicine, contain multiple nutritional components and bioactive substance, select suitable herbal variety can also play the technique effect of enhancing tilapia anti-stress ability, promotion Growth Op Tilapia and raising flesh quality.
Summary of the invention
For solving the problem existing in tilapia cultivation in prior art, the present invention aims to provide a kind of Chinese medicine composition for the treatment of tilapia streptococcicosis, it selects multiple natural Chinese medicinal herb components compatibility to form, it on the one hand can treat streptococcal infection tilapia and the streptococcicosis that produces effectively, can also effectively suppress the growth and breeding of environment streptococcus intermedius, reduce the risk that streptococcicosis is broken out simultaneously; On the other hand, can strengthen the anti-stress ability of tilapia, improve the immunity of tilapia, promote the growth of tilapia; It also can avoid antibiotic abuse simultaneously, is conducive to the sound development of culture fishery.
For addressing the above problem, the present invention adopts following technological means:
A Chinese medicine composition that is used for the treatment of tilapia streptococcicosis, is characterized in that, is made up of the raw material of following weight portion: Radix Berberidis 10-15 part, Herba Asari 8-10 part, Fructus Viticis Negundo 3-5 part, Rhizoma Alismatis 3-4 part, Herba Senecionis Scandentis 1-2 part, Radix Salviae Miltiorrhizae 1-2 part, Semen Platycladi 1-2 part, Rhizoma Atractylodis Macrocephalae 2-3 part, Radix Astragali 3-5 part.
Preferably, made by the raw material of following weight portion: 12 parts of Radix Berberidis, 9 parts of Herba Asaris, 4 parts of Fructus Viticis Negundo, 3 parts of Rhizoma Alismatis, 1 part of Herba Senecionis Scandentis, 2 parts of Radix Salviae Miltiorrhizaes, 1 part of Semen Platycladi, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 4 parts of the Radixs Astragali.
Preferably, made by the raw material of following weight portion: 15 parts of Radix Berberidis, 8 parts of Herba Asaris, 5 parts of Fructus Viticis Negundo, 3 parts of Rhizoma Alismatis, 1 part of Herba Senecionis Scandentis, 1 part of Radix Salviae Miltiorrhizae, 2 parts of Semen Platycladi, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 3 parts of the Radixs Astragali.
The preparation method of Chinese medicine composition of the present invention is: take by weight herbal raw material, be crushed to 40-60 order left and right after mixing, pack and get final product.
The application process of Chinese medicine composition of the present invention is: be added into the prevention for tilapia streptococcicosis in compound feed of tilapia by 0.2 ~ 1.2% amount, or be added into the treatment for tilapia streptococcicosis in compound feed of tilapia by 2 ~ 3% amount.
Chinese medicine composition tool of the present invention has the following advantages and beneficial effect:
The present invention is according to the problem existing in the growth characteristic of tilapia and cultivation, easy ill disease, select natural, the medicinal herb components of safety, follow the preparation principle of " monarch ", kind and the optimum amount of Chinese herbal medicine have finally been determined through repetition test and checking, make wherein Synergistic between various Chinese medicine ingredients, mutually promote, reach fabulous enhancing anti-stress performance, growth promotion, improve immunity, the technique effect of prevention and treatment tilapia streptococcicosis disease, wherein selected Radix Berberidis, also become Radix Berberidis anhweiensis, contain multiple alkaloid, there is heat clearing and damp drying, eliminating fire and detoxication is to effect, streptococcal infection is had to good preventive and therapeutic action, Herba Asari has very strong inhibitory action to Hemolytic streptococcus, dysentery bacterium, Bacillus typhi, tubercule bacillus etc., and its volatile oil has refrigeration function, Fructus Viticis Negundo, contains 0.1% quintessence oil, contains a large amount of terpene substances in quintessence oil, and staphylococcus aureus is had to very strong inhibitory action, Rhizoma Alismatis, contains triterpenoid compound Alisol A etc., has effect of heat clearing away, eliminating dampness by diuresis, and staphylococcus aureus, streptococcal infection are had to therapeutical effect, in Herba Senecionis Scandentis, containing a large amount of alkaloids substances, there is good inhibitory action for common intestinal and Bacteria skin infection, Radix Salviae Miltiorrhizae, has effect of calming heart and tranquilizing mind, blood circulation promoting and blood stasis dispelling, and central nervous system is had to obvious sedation, also has certain antibiotic effect, Semen Platycladi is the seed of Cacumen Platycladi, has the effect of tranquilizing by nourishing the heart, the Rhizoma Atractylodis Macrocephalae, has spleen reinforcing stomach reinforcing, strong body constitution and antibacterial effect, the Radix Astragali has benefit defends the effect of consolidating superficial resistance and strong body constitution, the nonspecific immunity that it can also enhancing body.Above-mentioned Chinese medicine composition can be treated streptococcal infection tilapia and the streptococcicosis that produces on the one hand effectively, can also effectively suppress the growth and breeding of environment streptococcus intermedius simultaneously, reduces the risk that streptococcicosis is broken out; On the other hand, can strengthen the anti-stress ability of tilapia, improve the immunity of tilapia, promote the growth of tilapia; It also can avoid antibiotic abuse simultaneously, is conducive to the sound development of culture fishery.
Adopt Chinese medicine composition of the present invention, can effectively prevent breaking out of tilapia breeding process streptococcus intermedius disease, and for thering is higher cure rate with the cultivation shoal of fish of morbidity, cure rate is up to 50% ~ 70%, broke out once change in the past, the passive present situation of full pool death, has reduced the economic loss that tilapia streptococcicosis is brought, and has great importance for the development of tilapia aquaculture.
Detailed description of the invention
embodiment 1: a kind of Chinese medicine composition that is used for the treatment of tilapia streptococcicosis, made by the raw material of following weight portion: 12 parts of Radix Berberidis, 9 parts of Herba Asaris, 4 parts of Fructus Viticis Negundo, 3 parts of Rhizoma Alismatis, 1 part of Herba Senecionis Scandentis, 2 parts of Radix Salviae Miltiorrhizaes, 1 part of Semen Platycladi, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 4 parts of the Radixs Astragali.Preparation method is: take by weight herbal raw material, be crushed to 40-60 order left and right after mixing, pack and get final product.
embodiment 2:be used for the treatment of a Chinese medicine composition for tilapia streptococcicosis, made by the raw material of following weight portion: 15 parts of Radix Berberidis, 8 parts of Herba Asaris, 5 parts of Fructus Viticis Negundo, 3 parts of Rhizoma Alismatis, 1 part of Herba Senecionis Scandentis, 1 part of Radix Salviae Miltiorrhizae, 2 parts of Semen Platycladi, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 3 parts of the Radixs Astragali.Preparation method is: take by weight herbal raw material, be crushed to 40-60 order left and right after mixing, pack and get final product.
embodiment 3: the control of tilapia streptococcicosis and therapeutic test
prophylactic tria:chinese medicine composition at commercially available mixed feed in the long-term embodiment of the present invention 1 of adding 0.8% has no the generation of streptococcicosis in the whole cycle of feeding; And do not add shoal of fish Chinese medicine composition of the present invention, that commercially available mixed feed is fed, in the process of feeding more or less there is breaking out of streptococcicosis, particularly hot weather, the state of an illness is particularly serious.
therapeutic test: break out the tilapia shoal of fish of streptococcicosis for hot weather, the shoal of fish is divided into 4 groups, adopt respectively different therapeutic modalities, group 1 is matched group, adopts common mixed feed to feed; Group 2 is antibiotic test group, adds the antibiotic for streptococcal infection of 1% left and right in common mixed feed; Group 3 is test group, adds the Chinese medicine composition of 2.5% the embodiment of the present invention 1 in common mixed feed; Group 4 is comparative example's group, adds the Chinese medicine composition of 2.5% following composition: " 5 parts of Radix Berberidis, 4 parts of Herba Asaris, 5 parts of Fructus Viticis Negundo, 3 parts of Rhizoma Alismatis, 1 part of Radix Salviae Miltiorrhizae, 2 parts of Semen Platycladi, 2 parts of the Rhizoma Atractylodis Macrocephalaes " in common mixed feed.Result of the test is to organize 1 mortality rate 90%, cure rate 10%; Organizing 2 mortality rates is 65%, cure rate 35%, and growth is obviously slowed down; Organizing 3 mortality rates is 35%, and cure rate is 65%; Group 4 is 60%, and cure rate is 40%.
Shown by above result of the test, the involved in the present invention Chinese medicine composition that is used for the treatment of tilapia streptococcicosis can effectively prevent and treat tilapia breeding process streptococcus intermedius and infect the generation of disease, its dominant mechanism is to suppress the growth of pathogenic bacterium in water, improves the resistance of fry to pathogenic bacterium simultaneously.And feed after tilapia feed additive special of the present invention, the anti-stress ability of tilapia and immunocompetence strengthen, and the tolerance of high temperature anoxia is made moderate progress, and have improved the survival rate of fry.And in the situation that other conditions are identical, the speed of growth tool of the fry that is added with feed additive of the present invention fed has greatly improved, and individuality is obviously greater than contrast and contrast test group, and mouthfeel and quality have also obtained larger improvement.
In Guangdong, Fujian, large-scale cultivation field, Guangxi breeding process, the involved in the present invention Chinese medicine composition that is used for the treatment of tilapia streptococcicosis also embodies obvious superiority simultaneously, and average cure rate is up to 68 ~ 75%.
Raw material of the present invention all can be bought from the market.Disclosed is above only specific embodiments of the invention, but the present invention is not limited thereto, and the changes that any person skilled in the art can think of, within all should dropping on protection scope of the present invention.
Claims (4)
1. a Chinese medicine composition that is used for the treatment of tilapia streptococcicosis, is characterized in that, is made up of the raw material of following weight portion: Radix Berberidis 10-15 part, Herba Asari 8-10 part, Fructus Viticis Negundo 3-5 part, Rhizoma Alismatis 3-4 part, Herba Senecionis Scandentis 1-2 part, Radix Salviae Miltiorrhizae 1-2 part, Semen Platycladi 1-2 part, Rhizoma Atractylodis Macrocephalae 2-3 part, Radix Astragali 3-5 part; Preparation method is: take by weight herbal raw material, be crushed to 40-60 order after mixing, pack and get final product.
2. the Chinese medicine composition that is used for the treatment of tilapia streptococcicosis according to claim 1, preferably, is made up of the raw material of following weight portion: 12 parts of Radix Berberidis, 9 parts of Herba Asaris, 4 parts of Fructus Viticis Negundo, 3 parts of Rhizoma Alismatis, 1 part of Herba Senecionis Scandentis, 2 parts of Radix Salviae Miltiorrhizaes, 1 part of Semen Platycladi, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 4 parts of the Radixs Astragali.
3. according to claim
1the described Chinese medicine composition that is used for the treatment of tilapia streptococcicosis, preferably, is made up of the raw material of following weight portion: 15 parts of Radix Berberidis, 8 parts of Herba Asaris, 5 parts of Fructus Viticis Negundo, 3 parts of Rhizoma Alismatis, 1 part of Herba Senecionis Scandentis, 1 part of Radix Salviae Miltiorrhizae, 2 parts of Semen Platycladi, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 3 parts of the Radixs Astragali.
4. prepare a method for the Chinese medicine composition that is used for the treatment of tilapia streptococcicosis claimed in claim 1, concrete preparation method is: take herbal raw material by described weight portion, be crushed to 40-60 order after mixing, pack and get final product.
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| CN104472873B (en) * | 2014-11-18 | 2017-07-21 | 广东海因特生物技术集团有限公司 | A kind of feed addictive for improving liver of hybrid tilapia function, preventing streptococcosis |
| CN105596419A (en) * | 2016-01-06 | 2016-05-25 | 广东省农业科学院动物卫生研究所 | Compound Chinese herb preparation capable of improving disease resistance of tilapia and application of compound Chinese herb preparation |
| CN106260772A (en) * | 2016-08-19 | 2017-01-04 | 广西正五海洋产业股份有限公司 | A kind of special feed formula improving tilapia body constitution |
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| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
| CN101045078A (en) * | 2006-03-27 | 2007-10-03 | 樊国平 | Oral medicine of combined traditional Chinese and Western medicine for treating bacteric rotten branchia disease of grass carp |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
| CN101045078A (en) * | 2006-03-27 | 2007-10-03 | 樊国平 | Oral medicine of combined traditional Chinese and Western medicine for treating bacteric rotten branchia disease of grass carp |
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