CN103251682A - Medical wine for treating various stomachaches - Google Patents
Medical wine for treating various stomachaches Download PDFInfo
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Abstract
The invention provides a medical wine for treating various stomachaches. The medical wine is technically characterized by being prepared by brewing rice wine with desmodium multiflorum, rhizoma corydalis and prepared liquorice root. The materials in the formula of the medical wine are directed at various stomachaches, so that defect of conventional dosage forms in treating stomachaches. After repeated clinical validation, the formula of the medical wine has the capabilities of warming spleen and stomach for dispelling cold, promoting blood circulation to remove meridian obstruction, removing toxicity for detumescence and regulating qi to alleviate pain so that the effect of relieving and treating various stomachaches is achieved.
Description
Technical field
The invention belongs to tcm field, relate to a kind of preparation and using method for the treatment of the medicated wine of various stomachaches.
Background technology
" stomachache " is a kind of very common symptom, so usually can be ignored by people.In fact the disease that causes " stomachache " is a lot, and some still very serious diseases are arranged.Primary disease Chang Yin suffers from cold, is heated, restraining or depressed emotion, direct stimulation, depression of liver-QI etc. do not cause diet.Generally can be divided into: cold of insufficiency type and stomachache, food stagnation stomachache, energy-stagnation stomachache, blood stasis stomachache.Cold of insufficiency type and stomachache is many because of emptiness of spleen and stomach eating cold and uncooked food excessively food, or due to suffering from cold.Mainly show as vague epigastralgia, intermittently do not stop, stomach is afraid of cold, and the pain relieved by pressing happiness is warm, the then pain relief of a small amount of warm diet of taking food, and with the singultus acid regurgitation, or the vomiting clear water, health is tired, and extremity are not warm, loose stool etc.Food stagnation stomachache is many because of not restraining of diet, due to the voracious stodgy food, so that food stops gastral cavilty, stomach-QI being unable to descend normally.Mainly show as the gastral cavilty distending pain, painful abdominal mass suffocation plug, tenderness, acid regurgitation, the old food flavor of having had the hiccups, with nausea and vomiting, anorexia etc.Unsuccessful because of feelings will more than the energy-stagnation stomachache, direct stimulation, depression of liver-QI, perverse and unreasonable manner is violated due to the stomach.Mainly show as gastral cavilty distension pain, connect and both sides of the chest and chest, or the migration of string pain is indefinite, with belch acid regurgitation, diseases such as indigestion and loss of appetite anorexia.Blood stasis stomachache many because of stagnation of liver-QI with the passing of time, mechanism of qi is jammed, blood is capable be obstructed due to.Mainly show as gastralgia such as acupuncture, localized pain, tenderness, food back pain increases the weight of, just or with spit blood, black etc.
According to the pattern of syndrome difference, the Chinese medicine of selecting for use is also different.Believe that having many people all once to go to pharmacy to buy Chinese patent medicine by oneself treats stomachache, can alleviate sometimes, ineffective sometimes.In fact, the traditional Chinese medical science has the branch of cold and heat and asthenia and sthenia to stomachache, mends that namely sympotoms caused by cold factors are not used warm medicine so medicine for treatment also has Wen Qing to disappear, and heat symptom-complex is used the medicine of a cold nature, and excess syndrome must be with the method for attacking, and deficiency syndrome must be used reinforcement.Stomachache treatment should be by the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs thinking medication of the traditional Chinese medical science, otherwise selects mistake also to affect the treatment.
Dosage forms such as common injection, tablet, capsule enter intestinal through emptying after arriving stomach, and by the blood circle treatment stomachache, the mode of similar whole body administration, effect are often unsatisfactory.Though Chinese medicine decoction can arrive stomach, directly act on the stomach damaged part, decoction needs decoction, and the taste bitterness is used inconvenience, and it is also many to decoct use impurity.The present invention according to the characteristics of stomachache, accurately selects Chinese herbal medicine in order to overcome above shortcoming for use, by the medicated wine mode, directly plays the effect of target spot administration, can effectively treat various stomachaches, especially severe blood stasis stomachache in the treatment.
Technology contents
The purpose of this invention is to provide a kind of medicated wine prescription for the treatment of various stomachaches, this prescription selection can be at various stomachache disease, and overcome the normal conventional pharmaceutical dosage form in the deficiency for the treatment of aspect having a stomach-ache, this prescription is through repeatedly experimental verification, confirm this prescription effectively warming spleen and stomach for dispelling cold, promoting blood circulation to remove obstruction in the collateral, removing toxic substances and promoting subsidence of swelling, regulating QI to relieve pain, reach the effect of alleviating and treating various stomachache.
Chinese prescription of the present invention is made up of following each Chinese medicine ingredients: stomachache grass, Rhizoma Corydalis, Radix Glycyrrhizae Preparata
The weight ratio of constituents commonly used of Chinese prescription of the present invention is: 2 parts of stomachache grass, 1 part of Rhizoma Corydalis, 1 part of Radix Glycyrrhizae Preparata
The application process of medicament composing prescription of the present invention is:
(1) the stomachache grass is used as medicine with root, and root is cleaned, and smashs to pieces, dries.Rhizoma Corydalis is chosen decontamination, is soaked in water, and cleans, and solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes.
Stomachache grass, Rhizoma Corydalis and the Radix Glycyrrhizae Preparata that (2) will cook is placed in the hermetic container by weight ratio, adds 20 times of amount home-brew rice wine (unavailable other band cooking wine of this medicine), and soak after at least 15 days and use, according to state of an illness weight, each 50-100ml.
Medicament composing prescription of the present invention is aided with the optimization of clinical application for many years simultaneously with reference to multiple medical science pharmacopeia, has overcome the problem of taboo combination, and prescription is also reduced to 3 flavors by 7 original flavors.Specifically select for use the pharmacodynamics basis of medical herbs to be:
The stomachache grass has another name called Radix Sophorae Tonkinensis, and is cold in nature, sweet in the mouth, hardship, nontoxic (" Kaibao Bencao ").Return lung; Stomach; Liver; Gallbladder meridian.Effect is promoting blood circulation and stopping pain, removing toxic substances and promoting subsidence of swelling, and heat-clearing and toxic substances removing helps digestion, pain relieving.Be used for stomachache, infantile malnutrition, parotitis, lymphadenitis, venom, epigastric pain etc.The Chinese herbal medicine for the treatment of stomachache simply for mountain area, southeast of Guizhou Province preciousness." Guizhou medical herbs ": a little less than the tonify deficiency, invigorate blood circulation preventing the attack (or recurrence) of malaria, analgesia.Control stomachache: Radix Sophorae Tonkinensis seed one minute, grind clothes into powder; Or with root five money, fry in shallow oil the water clothes, (" Guizhou medical herbs ".
Modern medicine analysis and research confirm, it is about 0.93% that Radix Sophorae Tonkinensis, root contain total alkaloids, and wherein matrine 0.52%, oxymatrine 0.35%, and anagyrine and the methylcytisine of trace; And contain sophocarpine.Flavone compound has pterocarpin and 1-Russian red clover Koryo Chinese scholartree glycoside, and the latter gets the 1-maackiain through enzyme hydrolysis, is the pterocarpoid chemical compound, and antitumaous effect is arranged.Other contains tens kinds of alkaloids such as Radix Sophorae Tonkinensis element, Radix Sophorae Tonkinensis chalcone derivative, Radix Sophorae Tonkinensis chromene element, Radix Sophorae Tonkinensis chromene chalcone derivative, Radix Sophorae Tonkinensis chromene element and has comparatively excellent pharmacological effect.Such as:
1. resisting pathogenic microbes effect.
Experiment shows: Radix Sophorae Tonkinensis has inhibitory action to staphylococcus aureus, acrothesium floccosum and Candida albicans, and tubercule bacillus is had the high-efficiency antimicrobial effect.Matrine solution all has stronger inhibitory action to group B streptococcus, dysentery bacterium (F2), mycetozoan, escherichia coli, staphylococcus aureus and bacillus pyocyaneus.Oxymatrine has inhibitory action to dysentery bacterium, escherichia coli, group B streptococcus, staphylococcus aureus.
Stomach is the main deposit place of food, the entrained various antibacterial major parts of outside food are withered away under stomach sour environment and the various antibody effects of health, can cause damage to digestive tract but still have on a small quantity, common is exactly ulcer class gastropathy, and such gastropathy is difficult to cure.Existing treatment approach is to use in the alkalescent medicine and gastric acid, eliminates unnecessary gastric acid as far as possible for the infringement of ulcer surface, and jellies such as alkalescent medicine such as aluminium hydroxide paste the clothes coat of the stomach simultaneously, have stopped the infringement of gastric acid, allows the coat of the stomach of damage slowly repair.This method is not purpose with the bacteriostasis and sterilization, and therefore, therapeutic effect is easy to repeatedly.
2. antitumor action.
Radix Sophorae Tonkinensis has remarkable result to malignant tumor.Side effect is little, safety, and do not make leukopenia, the experimental animal general state is good.Matrine, oxymatrine have the effect of delayed death to the mice of transplanting S180, also can delayed death to the rat of inoculation solid tumor or ascites tumor. and leukemic hemocyte is increased inhibitory action.Gavage root of subprostrate sophora preserved material 60g/kg/d, totally 16～21 days, for the cervical cancer of inoculating (U14) the obvious suppression effect is arranged.Suppression ratio to sarcoma 180 also reaches more than 25%. the matrine of from root of subprostrate sophora, separating, and all effective to the test of mice ehrlich carcinoma test tube or whole animal test, oxymatrine is then invalid; But the two is all effective to mice S180.Pterocarpoid (Pterocarpoid), d-maackianin-(Sophoiaponicin) contained in the Radix Sophorae Tonkinensis also have inhibitory action to S180, and general dextroisomer is active stronger than left-handed person, and the specific activity glycoside unit of glycoside is strong.Radix Sophorae Tonkinensis all has inhibitory action to acute lymphoblastic type leukemia and the leukocytic dehydrogenase of acute granulocyte type leukaemic, and the former breathing is had slight inhibitory action.
Antitumor action can effectively resist the generation of the carcinogenic situation of Gastric Diseases by Spraying, reduces the risk probability that gastric cancer takes place.
3. to central nervous system's effect.
Contained alkaloid has the obvious suppression effect to the central nervous system in the Radix Sophorae Tonkinensis.Matrine, oxymatrine, sophocarpine etc. all have town, analgesia and reduce the effect of body temperature.Studies show that: oxymatrine, sophocarpine can reduce spontaneous activity in mice, the central inhibitory action of collaborative sub-threshold dose pentobarbital sodium, chloral hydrate or chlorpromazine, the caused central excitation of antagonism amfetamine or caffeine, but can not resist pentetrazole convulsions, to fainting from fear due to the strychnine facilitation is arranged then, increase strychnine convulsions death toll.Matrine, oxymatrine, sophocarpine Dichlorodiphenyl Acetate induced mice is turned round the body number of times that obvious inhibitory action is arranged, and can prolong the pain response time of scalding tail method mice.
Central nerve inhibition can make glandular secretion reduce, and gastric secretion reduces, and gastric acid is suppressed, and effectively reduces the injury of coat of the stomach mucosa, prolongs the time of stomach self-regeneration, reaches the purpose for the treatment of stomachache.
4. to the effect of digestive system.
Experiment shows: Radix Sophorae Tonkinensis can suppress gastric secretion, mice stress ulcer and rat pyloric ligation ulcer, acetic acid ulcer etc. is all had inhibitory action, and can promote the reparation of ulcer.Matrine also has similar effect. and sophora subprostrata have strong anti-gastric-ulcer and suppresses the gastric secretion effect, and the sophoranone effect is taken second place.The mouse liver injury that the rabbit that oxymatrine causes carbon tetrachloride and chmice acute hepatic injury, D-Gal cause all has protective effect, can make that SGPT reduces, hepatic necrosis alleviates.Studies show that: the contained multiple alkaloid of Radix Sophorae Tonkinensis has tangible spasmolysis.
5. to the effect of immunologic function
Experimental results show that: Radix Sophorae Tonkinensis has excitation to reticuloendothelial system, and phagocyte is increased.The rat that oxymatrine causes models of passive skin irritability of rats due to the Radix Trichosanthis and intradermal injection Radix Trichosanthis initiatively skin allergy all has obvious inhibitory action, and its mechanism of action is the rising of tiring that has suppressed serum antibody; Still can suppress rabbit anteserum IgE antibody and generate, point out it that effect of remarkable anti-I type allergy is arranged.
6. effect in increasing leukocyte.
Matrine, oxymatrine have the obvious treatment effect to the rabbit leukopenia that causes through roentgen radiation x.Oxymatrine 200mg/kg can obviously prevent the rabbit leucocytes reduction that the 60Co irradiation causes in pre-irradiation continuous intramuscular injection in 2 days; The murine interleukin decline that irradiation is caused also has obvious therapeutic effect. and oxymatrine also has the rising effect to the normal rabbits peripheral blood leucocyte.
7. antiinflammatory action.
Matrine, oxymatrine, sophocarpine all have significant antiinflammatory action.Mouse peritoneal capillary permeability due to the matrine Dichlorodiphenyl Acetate increases, mice auricle swelling, Ovum Gallus domesticus album or antler glue due to the Oleum Tiglii cause rat paw edema and granuloma induced by implantation of cotton pellets all have obvious inhibitory action. and the oxymatrine intramuscular injection is similar to hydrocortisone, can obviously resist the exudative inflammation that Oleum Tiglii, carrageenin (rat) and acetic acid (mice) bring out.
Blood stasis stomachache many because of stagnation of liver-QI with the passing of time, mechanism of qi is jammed, blood is capable be obstructed due to, normal with serious ulcer inflammation, adopt stomachache grass treatment general plan, can promoting blood circulation and hemostasis, repair the coat of the stomach mucosa because of ulcerative lesions; The sterilization removing toxic substances and promoting subsidence of swelling is alleviated stomachache; Antiinflammatory is antibacterial; The gastric acid inhibitory secretion, strengthening immune system.So this Chinese medicine is rare medicine with synergistic therapeutic action.
Rhizoma Corydalis, acrid in the mouth, hardship, warm in nature.Promoting blood circulation to remove blood stasis is arranged, the function of promoting the circulation of QI pain relieving.The traditional Chinese medical science thinks, Rhizoma Corydalis is hot to loose, hardship is let out, temperature is led to, and has both gone into blood system, goes into edema caused by disorder of QI again, the gas in can promoting the circulation of blood, and the blood in again can circulation of qi promoting, the smooth blood of gas is capable, and general rule is not bitterly.Its analgesic effect is remarkable, and site of action is extensive, and lasting and avirulence is better simply analgesic.Clinical confirmation this product analgesic effect is strong than Olibanum, Myrrha, Oletum Trogopterori, is the pain relieving good medicine in the Chinese medicine, and gastral cavilty is had a pain and victory is particularly imitated in abdominal pain during menstruation, and the compatibility effect is better.Rhizoma Corydalis promoting blood circulation to remove blood stasis, promoting the circulation of QI pain relieving, this medicine compatibility stomachache grass has symptomatic treatment benefit preferably for blood stasis type and Qi-stagnation type stomachache.Property of medicine temperature is cold complementary, the mediation property of medicine, and stomach function regulating is supported spleen, has a lasting medicinal property.
Radix Glycyrrhizae Preparata, sweet in the mouth, property is flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.The person that is usually used in the gastric ulcer, duodenal ulcer person, neurastheniac, bronchial asthma person, thrombophlebitis patient." property of medicine opinion ": cold type of pain in the main abdomen, control infantile convulsion, except distention and fullness in the abdomen; The tonification the five internal organs; Make all poison of drug." pearl sac ": enrich blood nourishing the stomach.On stomachache treatment type, Radix Glycyrrhizae Preparata invigorating the spleen and replenishing QI, except distention and fullness in the abdomen has effect for asthenic cold type and the stomachache of stagnation of QI due to dyspepsia type.
Stomachache has comparatively fierce effect for blood stasis to consider the stomachache grass, and the stomachache grass is cool in nature, is unfavorable for private treatment stomachache.So cooperate Rhizoma Corydalis, Radix Glycyrrhizae Preparata to use.Rhizoma Corydalis is warm in nature, promoting blood circulation to remove blood stasis, and the promoting the circulation of QI pain relieving is convenient to cooperate the performance of careless effect of having a stomachache, the use for the treatment of Radix Glycyrrhizae Preparata then has been in harmonious proportion the property of medicine, makes the bitterness of Rhizoma Corydalis and stomachache grass obtain relaxing, simultaneously, the Radix Glycyrrhizae Preparata invigorating the spleen and replenishing QI, relieving spasm to stop pain can effectively promote the performance of whole drug effect.
The present invention has created this pharmaceutical composition, is used for the treatment of various types of stomachaches, especially for serious blood stasis type stomachache, except selecting suitable medical material compatibility for use, outside the specific aim treatment stomachache, greatest feature is exactly the characteristics according to stomachache, selects for use the mode of medicated wine to treat stomachache.Traditional stomachache treatment administering mode is still oral solid formulation and decoction, powder etc.Reach the purpose that treatment is had a stomachache by the whole body administration, targeting is strong and general toxicity is bigger.On the contrary, targeted therapy has become more and more valued therapeutic modality.
The consideration of medicated wine of the present invention is that each Effective Components of Chinese Herb has certain dissolubility in ethanol-water system, can effectively be extracted, and the invalid impurity effect of avoiding whole medication to introduce is healthy.Such as, contained corydaline, Tetrahydropalmatine have analgesic activity in the Rhizoma Corydalis, and especially Tetrahydropalmatine analgesia index is higher.And this compounds has dissolubility preferably in ethanol, is beneficial to stripping and extracts.Main component glycyrrhizic acid in the Radix Glycyrrhizae claims glycyrrhizin again, a kind of tetraterpene derivatives.For the glucosulfone aldehyde glycosides (seeing glycosides) of enoxolone, be the sweet taste composition of Radix Glycyrrhizae, be present in the glycyrrhiza genus water-soluble and ethanol.The effective ingredient of stomachache grass is various alkaloidss, and certain dissolubility is also arranged in oil-water mixed system.Itself has sterilizing function ethanol, and the absorption function of stomach mainly is ethanol etc., but not main nutrient substance.See desirable selection so adopt ethanol as carrier right and wrong regular guest.
Clinical efficacy
Clinical data: 44 examples all are the out-patient, male's 27 examples, women's 17 examples; 26 years old to 68 years old age, 47 years old mean age.All cases all have stomachache in various degree, during outbreak with flatulence, gastric acid, indigestion and loss of appetite, road gas, feel sick, vomiting, noisy, or hunger, loose stool, have blood in stool, spiritlessness and weakness, deficiency of QI with disinclination to talk, irritations such as back pain.
1 Therapeutic Method
Stomachache grass, Rhizoma Corydalis and the Radix Glycyrrhizae Preparata that cooks is placed in the hermetic container by weight ratio, adds 20 times of amount home-brew rice wine (unavailable other band cooking wine of this medicine), soak after at least 15 days and use, according to state of an illness weight, every day 1-2 time, each 50-100ml.Generally need 2-4 the course for the treatment of 15 days course for the treatment of, and course of disease length is sent out the author repeatedly and need be added 2 courses for the treatment of in addition.
2 observation index and method
Symptom score:
1. not having gastric abscess and symptom counted 0 fen;
2. accidental have slight gastric abscess, and persistent period 8-10min was in interior 1 minute;
3. gastric abscess often, persistent period 20-30min was with interior note 2 minutes;
4. frequent gastric abscess is remembered 3 fens more than the super 1h of persistent period.
3 criterions of therapeutical effect
1. cure: no gastric abscess, flatulence, gastric acid, indigestion and loss of appetite, nauseating, vomiting, noisy, symptom such as spit blood, have blood in stool, there is not the recidivist after the drug withdrawal.
2. effective: gastric abscess, flatulence, gastric acid, indigestion and loss of appetite, nauseating, vomiting, noisy, symptom such as spit blood or have blood in stool is clearly better before the treatment.
3. invalid: above-mentioned symptom and sign do not have obvious improver after treating 1 course for the treatment of.
4 therapeutic outcomes
Cure 44 examples, effective 39 examples, invalid 5 examples, total effective rate 88.6%.
5. model case
1, Nan Meng village Zhou Wenji, the man treated chronic gastropathy for many years in 2005, and 3 jin of medicated wine recoveries from illness were not turned over disease in 35 years so far, and are healthy.
2, Nan Meng village poplar three younger sisters, the woman, 56 years old, two examination in hospital were late gastric cancer to treatment in 2005 through Guizhou Province, all day pain unbearably, take medicine through we treatment and to have a rest one month in a week, go county hospital inspection recovery from illness.
3, the Liu Ji village is around the Ms, and 40 years old, treatment in 2009, medicated wine is 3 jin under the acute gastropathy, and recovery from illness is recurrence so far.
4, silk screen Mei Meng village Medulla Junci craftsman, the man, the winter in 2008 was controlled acute gastropathy, 4 jin in following medicated wine, recovery from illness is not recurrence so far.
Specific embodiment
(1) the stomachache grass is used as medicine with root, and root is cleaned, and smashs to pieces, dries.Rhizoma Corydalis is chosen decontamination, is soaked in water, and cleans, and solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes.
Stomachache grass 200g, Rhizoma Corydalis 100g and the Radix Glycyrrhizae Preparata 100g that (2) will cook place in the hermetic container, add 8kg home-brew rice wine (unavailable other band cooking wine of this medicine), and soak after 15 days and use, according to state of an illness weight, every day 1-2 time, each 50-100ml.Generally need 2-4 the course for the treatment of 15 days course for the treatment of, and course of disease length is sent out the author repeatedly and need be added 2 courses for the treatment of in addition.
Claims (1)
- One kind the treatment various stomachaches medicated wine, this medicated wine preparation process is as follows:Grass, Rhizoma Corydalis and 2: 1: 1 by weight the proportioning of Radix Glycyrrhizae Preparata of will having a stomachache places in the hermetic container, adds home-brew rice wine, soaks to obtain medicated wine.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903346A (en) * | 2006-08-01 | 2007-01-31 | 于世琴 | Traditional Chinese medicine for treating gastric carcinoma |
| CN101612374A (en) * | 2008-06-25 | 2009-12-30 | 王翠荣 | A kind of healthy medicated wine for the treatment of stomachache |
| CN101766774A (en) * | 2010-04-07 | 2010-07-07 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicine composite for treating duodenal ulcer and preparation method thereof |
-
2013
- 2013-05-31 CN CN2013102105094A patent/CN103251682A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903346A (en) * | 2006-08-01 | 2007-01-31 | 于世琴 | Traditional Chinese medicine for treating gastric carcinoma |
| CN101612374A (en) * | 2008-06-25 | 2009-12-30 | 王翠荣 | A kind of healthy medicated wine for the treatment of stomachache |
| CN101766774A (en) * | 2010-04-07 | 2010-07-07 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicine composite for treating duodenal ulcer and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 成新谦等主编: "《新编药物学》", 30 December 1985 * |
| 王四旺等主编: "《分子中药研究与方法学》", 30 September 2012 * |
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Application publication date: 20130821 |