CN103251662A - Application of female carrot lyophilized powder in preparing medicine for treating gout and production technology thereof - Google Patents
Application of female carrot lyophilized powder in preparing medicine for treating gout and production technology thereof Download PDFInfo
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Abstract
The invention discloses an application of female carrot lyophilized powder in preparing a medicine for treating gout and a production technology thereof, relating to a natural plant medicine with an obvious effect on gout recovery, and in particular relating to an application of female carrot lyophilized powder in preparing the medicine and a processing method of the female carrot lyophilized powder. The invention provides an application of female carrot lyophilized powder in preparing a medicine for treating gout, namely that a medicine taking the female carrot lyophilized powder as a key active ingredient can be used for treating gout and does not have any toxic or side effect. The female carrot lyophilized powder can be used for preparing a medicine for treating gout and is used as a key active ingredient of the medicine. The production technology of the female carrot lyophilized powder comprises six links including variety selection, plantation management, pretreatment, low-temperature vacuum dehydration, liquid nitrogen freeze grinding and nitrogen-filled packing.
Description
Technical field
the present invention relates to a kind of natural medicinal plants that rehabilitation has remarkable efficacy to gout, more particularly, relate to the application of female Radix Dauci Sativae lyophilized powder in the aforementioned medicine of preparation, and the processing method of this female Radix Dauci Sativae lyophilized powder.
Background technology
raising day by day along with living standard, epidemiology statistics shows that goat is remarkable ascendant trend, become a kind of important diseases that threatens human health, but up to the present, there is no the active drug that can cure gout in world wide, gout treatment still rests on the aspect of antiinflammatory, pain relieving, uric acid resisting, a kind of temporary transient Therapeutic Method at last, and the delay of uncontrollable disease worsens.In addition, there is serious side effect in the Western medicine majority of the clinical use of goat, very big to hepatic and renal function injure.
gout is a kind of dysbolismus disease, and its mechanism is: purine metabolic disturbance or uric acid are discharged and are reduced, and cause Level of Serum Uric Acid to exceed normal level; Under long-term lasting hyperuricemia state, uric acid is saturation in tissue or knuckle synovia, and urate crystal can separate out, deposit, and stimulates joint to produce inflammatory reaction, causes the gout outbreak.The nutrition and metabolism of the cell that has its source in of gout is undesired, and obstacle has appearred in hepatic and renal function, and corresponding treatment must be had in mind from source of disease, and pain relieving and uric acid resisting are obviously the makeshift of curing the symptoms, not the disease.
Summary of the invention
the present invention is directed to the above-mentioned problems in the prior art, aim to provide the application of a kind of female Radix Dauci Sativae lyophilized powder in preparation treatment gout medicine, the medicine that the female Radix Dauci Sativae lyophilized powder of take is crucial effective ingredient can be cured gout, and without any side effects.
for realizing above-mentioned purpose of the present invention, the present invention adopts following technical scheme.Female Radix Dauci Sativae lyophilized powder can be applied to preparation treatment gout medicine, and as the crucial effective ingredient of this medicine.
radix Raphani originates in China, nutritious, and well edible, medical value is arranged, and its seed, bright root, Ye Junke are used as medicine.The Chinese medicine ancient books and records such as Tang Materia Medica, " Bencao Jingshu ", Compendium of Material Medica are all on the books to its property of medicine: nature and flavor, Xin Gan is cool; Gui Jing, enter lung, stomach warp; Function cures mainly: " therapeutic method to keep the adverse QI flowing downwards rapid digestion of food, remove accumulation of phlegm in the hypochondrium and warming middle-JIAO, tonifying for the deficiency, the chest stuffiness relieving diaphragm, and sharp defecation, the food stagnation removing person of reducing phlegm, the use of boiling is also; Only quench one's thirst, face poison processed, the sector-style gas steam that uncharms, control consumptive lung disease and spit blood, lung-heat phlegmatic cough dysentery person, the use of eating raw is also "." very sharp joint ", " sector-style gas, the heat that uncharms, sharp defecation ", " except the five internal organs apoplexy ", " sharp the five internal organs, make light of one's life by commiting suicide, make us fair and clear flesh thin ".
the Radix Raphani category is numerous, comprises northeast Radix Dauci Sativae, Shandong green turnip, and the Guangdong white turnip etc.Phase at the end of the eighties in last century, " male sterility line " triple crossing Radix Raphani has appearred in China, it is female Radix Dauci Sativae kind (wind resistance is red), this kind is to last by Chinese Famous genetic breeding expert Zhang Shufang, Zhang Ruijun father and son two generations the top female radish varieties in the world meticulously selected in 35 years in nearly ten thousand kinds of test cross combinations, have greatest differences with common Radix Raphani nutrition, main manifestations is the characteristics such as premunition is extremely strong, vitality is extremely vigorous, institute's nutrient containing is more abundant.With the contrast of Radix Raphani potassium, calcium, phosphorus and the selenium four indices of other kinds, see the following form.
| Title | Potassium mg/100g | ? | Calcium mg/100g | ? | Phosphorus mg/100g | ? | Selenium mg/100g | ? |
| Female Radix Dauci Sativae | 1860 | Contrast | 454 | Contrast | 347 | Contrast | 2 | Contrast |
| The northeast Radix Dauci Sativae | 202 | 9.21 doubly | 20 | 2.27 doubly | - | - | 0.089 | 2.25 doubly |
| The Shandong green turnip | 72 | 25.8 doubly | 21 | 2.16 doubly | 30 | 1.16 doubly | 0.65 | 3.08 doubly |
| The Guangdong white turnip | - | - | 30 | 1.51 doubly | 18 | 1.93 doubly | 0.41 | 4.88 doubly |
in addition, also contain protein 1.28%, vitamin C 10.2mg/100g, moisture 91.4%, ferrum 3.17 mg/100g, zinc 3.12 mg/100g, ash 0.66%.
above-mentioned data source is from Chinese Academy of Sciences's nutrition examining report, and report number: No. 2008-01-110, glyphomancy is given birth to by middle section.
female Radix Dauci Sativae belongs to basic food, contains abundant potassium, and the content of its potassium is tens times of common Radix Raphani, and potassium has the effect of regulating patient with gout health acid-base balance.Gout is a kind of purine metabolic disturbance disease, in the composition and decomposition process of purine, the participation of plurality of enzymes need to be arranged, and due to disappearance and the inborn error of metabolism of enzyme, and has caused the generation of gout.Contain in female Radix Dauci Sativae and a variety ofly can promote the beneficiating ingredients such as metabolism, digestive sweet enzyme, catalase, amylase, saccharifying enzyme, also contain glucose, oxidase parathyrine, dehydration pentose, the mucoitin that gasifies simultaneously, organize the compositions such as aminoacid, choline, the nutrient substance catabolism that can effectively assist human body will take in human body goes out external.Female Radix Dauci Sativae also has the function of superpower promotion liver, kidney metabolism, and it can coordinate the five internal organs balance fast, under the effect of peptide nucleic acid(PNA) PNA, by deposition for a long time in vivo the gout calculus of each one resolve into the sodium salt of water, carbon dioxide and solubility.Long-term edible female Radix Dauci Sativae can supplement the transferring enzyme in liver, effectively corrects purine metabolic disturbance, regulates uric acid, and the inflammation of gout outbreak place is alleviated and is eliminated to the concentration of balance blood uric acid, prevent from again forming calculus, thereby the purpose of gout treated in arrival.Female Radix Dauci Sativae is rich in vitamin K, and the anti-urate crystal of this vitamin energy, effectively prevent that bone is thick.
in addition, female Radix Dauci Sativae also has good prevention and therapeutic effect to chronic diseases such as cholelithiasis, renal calculus, flatulence, hyperlipidemia, hypertension, diabetes.
yet fresh female Radix Dauci Sativae has general live plant and preserves ubiquitous defect: the one, the condition of storage complexity, be subject to the restriction that grades of temperature and humidity conditions, environmental microorganism condition, gas group, and it is shorter to preserve the life-span, generally about three months.The 2nd, bright Radix Raphani is directly taken very inconvenient, and moisture is large, volume is large, mouthfeel is poor.The 3rd, assimilation effect is undesirable, chews the degree of grinding that can reach limited, and gastrointestinal absorbs insufficient.Shortcoming based on above three aspects has restricted the therapeutic effect of female Radix Dauci Sativae and the scope of application, makes it not play clinically due effect.
therefore, for addressing the above problem, the present invention also provides a kind of production technology of female Radix Dauci Sativae lyophilized powder; The lyophilized powder that utilizes this technique to produce has not only retained nutrition and the functional component of female Radix Dauci Sativae fully, and, by micronizing cell wall breaking, functional component is discharged more fully, has greatly strengthened the therapeutic efficiency of fresh female Radix Dauci Sativae.
the production technology of female Radix Dauci Sativae lyophilized powder comprises kind selection, Cultivate administration, pretreatment, cryogenic vacuum dehydration, liquid nitrogen deep pulverizing and six links of nitrogen gas packing.
(1) kind is selected: select the seed (i.e. the seed of " wind resistance is red " kind) of being presided over the female Radix Dauci Sativae of " male sterility line " triple crossing research, that Shenyang green star Chinese cabbage institute is produced by Zhang Shufang, Zhang Ruijun father and son.
(2) Cultivate administration: by protection ground technology, realize the anniversary plantation, the plantation place is east longitude 123 degree, north latitude 43 degree, 50 meters of height above sea level, be rich in organic loose fertile sandy soil earth, the deep water conservation of soil and drainage are good, maximum water holding capacity 60 ~ 80%, air humidity is 80 ~ 90%, the illumination abundance; Insecticide adopts the BT Emulsion meet organic grow, and fertilizer adopts the chicken manure fully become thoroughly decomposed as fertilizer, at least 5000 kilograms of every mu of fertilisings; Female Radix Dauci Sativae grows to approximately 100 ~ 300 grams of individual weight, is gathered (testing result shows, the nutrition accumulation of the female Radix Dauci Sativae in this growth stage reaches summit).
(3) pretreatment: comprise cleaning and sterilizing, coarse crushing and three links of quick-freezing; Female Radix Dauci Sativae after gathering screens out and is subject to disease and pest, and the neat root of Radix Raphani ornamental tassels retains 1 centimeter, and all the other excisions, be respectively charged into carton, with refrigerator car, be transported to processing factory's (refrigerated storage temperature: 0 ~ 3 ℃); Rinse the earth sticked on female Radix Dauci Sativae at processing factory's water well, after eliminating pimple, start the cleaning and sterilizing flow process; The order of cleaning and sterilizing flow process is: once washing, once sterilizing immersion bubble, secondary washing, secondary sterilization immersion bubble, finally cleaning line cleaning (4 times), the disinfectant solution that twice sterilization used is chlorine dioxide 300ppm, and the soak time of at every turn sterilizing is 30 minutes.
female Radix Dauci Sativae dicer by after cleaning and sterilizing, be cut into the Radix Raphani fourth below 0.6 ~ 1 cubic centimetre, then spreads into basin.
then, the Radix Raphani fourth cut is carried out to quick freezing in the freeze tunnel that adopts air cooled chiller, the material central temperature was down to below-4 ℃ in 30 minutes (to be with by maximum generation of ice crystal in 30 minutes, form ice crystal less and be dispersed in cell, prevent that ice crystal from destroying cytoactive), when the material central temperature is down to-25 ~-30 ℃, quick-freezing finishes, and whole quick-freezing process approximately needs 2.5 hours.
(4) cryogenic vacuum dehydration: by pretreated Radix Raphani fourth, through vacuum sublimation drying equipment (manufacture of Shenyang City Xin Yang machinery plant) drying and dehydrating, the temperature of design temperature curve controlled material is 40 ~ 60 ℃, and approximately 10 ~ 12 hours drying and dehydrating time, after drying and dehydrating, material moisture should be lower than 5%.
(5) liquid nitrogen deep is pulverized: the Radix Raphani fourth after the cryogenic vacuum dehydration, adopt liquid nitrogen deep pulverizer (Shanghai Pudong Gaoqiao Testing Machinery Co., Ltd.) to carry out pulverization process, it is-30 ~-150 ℃ that Radix Raphani fourth after step (4) dehydration is pulverized best brittle point, the particle size range of powder is 300 ~ 1000 orders (wherein, preferably 600 orders).Owing to being the micronizing of under the temperature conditions of-100 ~-150 ℃, material being carried out, so nutrition and functional component be without heat loss, the complete breaking cellular wall of cell;-30 ℃ of above smashing fineness of temperature are inadequate, although-150 ℃ of very thin liquid nitrogen costs of the following fineness of temperature can increase substantially, through the test optimum temperature, are-135 ℃.
(6) nitrogen gas packing: packaging process should carry out under the environment of nitrogen, and uses aluminum polyester bag packing, and after inflated with nitrogen, bag mouth heat seal sealing, make female Radix Dauci Sativae lyophilized powder, is placed under the environment of 0 ~ 5 ℃ and preserves.
the tablet of female Radix Dauci Sativae lyophilized powder: female Radix Dauci Sativae lyophilized powder 95%, MCC(microcrystalline Cellulose) 5%, after fully mixing, be pressed into tablet with the dry powder sheeting machine, then with the vesicle packer, it packed.
the capsule of female Radix Dauci Sativae lyophilized powder: female Radix Dauci Sativae lyophilized powder 100%, the fully-automatic capsule packer that adopts the configuration vacuum holding to fill in barn carries out capsule-filling.
the electuary of female Radix Dauci Sativae lyophilized powder: female Radix Dauci Sativae lyophilized powder 100%, carry out powder packaging, interior inflated with nitrogen, make the electuary of every bag of net weight 1 ~ 10 gram.
the effervescent tablet of female Radix Dauci Sativae lyophilized powder: female Radix Dauci Sativae lyophilized powder, sodium bicarbonate, citric acid, MCC, flavorant mix, and are pressed into effervescent tablet.While taking, by warm water, brew disintegrate, directly drink.
the method of taking: every day, each once, measured 3 ~ 6 grams at every turn sooner or later, within 30 days, was a course for the treatment of.
the production technology of female Radix Dauci Sativae ornamental tassels lyophilized powder also comprises kind selection, Cultivate administration, pretreatment, cryogenic vacuum dehydration, liquid nitrogen deep pulverizing and six links of nitrogen gas packing.Difference is, the Cultivate administration link of female Radix Dauci Sativae ornamental tassels lyophilized powder is to grow to 30cm when high at leaf, starts to pluck.And the ornamental tassels lyophilized powder is cut to 1 centimeter length by ornamental tassels with vegetable-chopper after sterilizing in the pretreatment link, spreads into basin.
the female Radix Dauci Sativae of integration of edible and medicinal herbs is without any side effects because of its natural green, and the treatment thinking is to have in mind from the disease root, from dispelling the five internal organs wind and cold, repair the Liver and kidney metabolic function, adjust the internal organs metabolic balance and start with, simultaneously high because of the content of its potassium, but quick adjustment human acid-base balance, in and blood uric acid, realize that specimen all controls, through the clinical verification definite effect.
compared with prior art, the invention provides that a kind of rehabilitation has the complete technology of preparing of the natural medicinal plants " female Radix Dauci Sativae and ornamental tassels lyophilized powder " of remarkable efficacy to gout.Female Radix Dauci Sativae (nucleus-sporozoite male sterility line Radix Dauci Sativae) is the outstanding hybrid new breed of gene, have than common variety more nutrition and the functional component of horn of plenty, after it is processed by vacuum sublimation dry technology and nitrogen ultra low temperature crushing technology, form the ultra micro dried powder.By technical scheme of the present invention, solved fresh female Radix Dauci Sativae in storage, the even rotten natural defect of nutritive effect composition easy consumption; Processing adopts omnidistance low temperature and oxygen insulating measure, and the nutritive effect composition of fresh female Radix Dauci Sativae is retained fully; Effectively improve fresh female Radix Dauci Sativae and preserved, carry, eaten inconvenient shortcoming; The complete breaking cellular wall of cell after micronizing, make the advantages such as absorption is more abundant, utilization rate significantly improves, effect is more remarkable.
The specific embodiment
the zoopery of the female Radix Dauci Sativae lyophilized powder of the present invention.
laboratory animal: 74 of SD rats, male and female half and half, body weight 180 ± 20g is provided the quality certification number by Zhejiang Province's Experimental Animal Center: SCXK(Zhejiang) 2008-0033; The Laboratory Animal Facility condition quality certification number: SYXK(Zhejiang) 2008-0112, SYXK(Zhejiang) 2006-0088, rat feeding is in regular grade rat feeding room, and common rat pellet is fed, free diet drinking-water.
experimental apparatus and reagent: 723 visible spectrophotometers, Shanghai spectral instrument company product; Adenine, bio tech ltd difficult to understand is won in Shanghai, specification: 150g/ bottle, lot number: 110315; Concentrated yeast extract powder, the Hang Fu of Fuyang City, Zhejiang Province biological factory, specification: 450g/ bottle, lot number: 1102120; Allopurinol (Allopurinol), SIGMA company product, Lot#070M1560V, Pcode:1000896098, be made into 16.7mg/ml with 0.5% sodium carboxymethyl cellulose before use, sodium carboxymethyl cellulose is made into 0.5% solution with distilled water, places two days later and uses; Testing uric acid test kit (enzymic colorimetric), Ningbo Sai Ke Bioisystech Co., Ltd, lot number: 110221; Triglyceride is measured test kit (enzymic colorimetric), Ningbo Sai Ke Bioisystech Co., Ltd, lot number: 100608; T-CHOL is measured test kit (cholesterol oxidase method), Ningbo Sai Ke Bioisystech Co., Ltd, lot number: 110104; And the female Radix Dauci Sativae lyophilized powder of the present invention, be made into 1g/ml and 0.5g/ml is respectively used to high dose group and the administration of low dose group rat with normal saline.
animal grouping and model are induced: 74 of SD rats, male and female half and half, be divided at random 5 groups, be respectively female Radix Dauci Sativae lyophilized powder high dose group (16), female Radix Dauci Sativae low dose group (16), positive drug allopurinol group (16), model group (16) and blank group (10).Except the blank group, other respectively organize gavage yeast extract 8g/kg/ days at noon every day, and adenine 100mg/kg/ days, induce hyperuricemia rat model.
medication: female Radix Dauci Sativae lyophilized powder high dose group gavages and to give with 0.17g/kg every day, and low dose group gavages and to give with 0.08g/kg every day, minute morning 8:30, twice gavage of 4:30 in afternoon, giving volume is 1.5ml/kg, in the time of guidance model, gives; Positive drug allopurinol group gives after the guidance model surrounding, with 50mg/kg/ days gavages, gives, and the method that gives is with female Radix Dauci Sativae lyophilized powder group; Model group, blank group with the equal-volume normal saline with the method gavage.
blood parameters is measured: respectively at administration, after 4,6 weeks, each organizes the blood sampling of rat eye socket, and separation of serum is surveyed serum uric acid (serum uric acid, SUA).
data analysis: the statistics of biochemical indicator result is carried out the one factor analysis of variance method with SPSS 16.0 softwares.
table 1, administration each rat serum uric acid data description after 4 weeks.
| Group | N | Average | Standard deviation | Standard error | 95% lower limit of confidence interval of average | The upper limit | Minimum | Maximum |
| The blank group | 10 | 3.25222 | .851407 | .283802 | 2.59777 | 3.90667 | 1.970 | 4.880 |
| Model group | 13 | 4.82462 | 1.418477 | .393415 | 3.96744 | 5.68179 | 2.790 | 7.900 |
| The lyophilized powder high dose group | 15 | 3.21333 | 1.082007 | .279373 | 2.61414 | 3.81253 | 1.050 | 4.760 |
| The lyophilized powder low dose group | 14 | 3.97357 | 1.391881 | .371996 | 3.16992 | 4.77722 | 1.970 | 6.500 |
| Allopurinol | 10 | 4.50500 | 1.220166 | .385850 | 3.63215 | 5.37785 | 2.560 | 6.270 |
| Sum | 62 | 3.84468 | 1.331121 | .151695 | 3.54255 | 4.14680 | .810 | 7.900 |
the multiple comparisons of table 2, administration each rat serum uric acid data after 4 weeks.
| (I) group | (J) group | Equal value difference (I-J) | Standard error | Significance | 95% lower limit of confidence interval | The upper limit |
| The blank group | Model | -1.572393 | .529668 | .018 | -2.93585 | -.20894 |
| The lyophilized powder high dose group | Model | -1.611282 | .462858 | .004 | -2.80275 | -.41981 |
| The lyophilized powder low dose group | Model | -.851044 | .470470 | .259 | -2.06211 | .36002 |
| Allopurinol | Model | -.319615 | .513781 | .958 | -1.64217 | 1.00294 |
table 3, administration each rat serum uric acid data description after 6 weeks.
| Group | N | Average | Standard deviation | Standard error | 95% lower limit of confidence interval of average | The upper limit | Minimum | Maximum |
| The blank group | 10 | 2.4630 | 1.37187 | .43382 | 1.4816 | 3.4444 | .35 | 4.76 |
| Model group | 10 | 6.0500 | 2.51108 | .794407 | 4.2537 | 7.8463 | 2.67 | 11.03 |
| The lyophilized powder high dose group | 15 | 4.2513 | 1.40442 | .36262 | 3.4736 | 5.0291 | 1.86 | 6.97 |
| The lyophilized powder low dose group | 14 | 4.3643 | 1.33440 | .35663 | 3.5938 | 5.1347 | 2.44 | 7.20 |
| Allopurinol | 10 | 2.9160 | 1.32007 | .41744 | 1.9717 | 3.8603 | 1.05 | 5.34 |
| Sum | 59 | 4.0536 | 1.94833 | .25365 | 3.5458 | 4.5613 | .35 | 11.03 |
the multiple comparisons of table 4, administration each rat serum uric acid data after 6 weeks.
| (I) group | (J) group | Equal value difference (I-J) | Standard error | Significance | 95% lower limit of confidence interval | The upper limit |
| The blank group | Model | -3.58700 | .72042 | .000 | -5.3905 | -1.7835 |
| The lyophilized powder high dose group | Model | -1.79867 | .65765 | .028 | -3.4450 | -1.523 |
| The lyophilized powder low dose group | Model | -1.68571 | .66698 | .047 | -3.3554 | -.0160 |
| Allopurinol | Model | -3.13400 | .72042 | .000 | -4.9375 | -1.3305 |
table 5, respectively organize the rats death situation.
| Group | Number of animals | The dead animal number | The surviving animals number |
| The blank group | 10 | 0 | 10 |
| Model group | 16 | 6 | 10 |
| Allopurinol | 16 | 6 | 10 |
| The lyophilized powder high dose group | 16 | 1 | 15 |
| The lyophilized powder low dose group | 16 | 2 | 14 |
administration after 4 weeks on the impact of rat serum uric acid in Table 1,2, allopurinol is administration not, only with the model group same treatment; Table 2 result shows, female Radix Dauci Sativae lyophilized powder high dose group and model group comparison, and serum uric acid level significantly reduces.
administration after 6 weeks on the impact of rat serum uric acid in Table 3,4, table 4 result shows female Radix Dauci Sativae lyophilized powder high and low dose group and model group relatively, serum uric acid level all has remarkable reduction.
and in numerous testing programs, falling the blood uric acid result with the rat of the lyophilized powder of the present invention that gives bright female Radix Raphani 1/50 dosage and show, is identical with the female Radix Dauci Sativae result of the test of the aquatic foods in 50 times of lyophilized powders before.Prove that production technology of the present invention can reduce 50 times than the dosage of edible bright female Radix Dauci Sativae, the product advantage such as greatly improved absorption rate, the edible convenience of female Radix Dauci Sativae and be convenient to store, carry.
case 1: Mrs Liu, people from Dalian, 78 years old.The beginning sixties in last century suffers from nephritis, once because penicillin anaphylaxis rescues 2 days, rear out of danger.Within 2005, because of nephropathy, again be hospitalized for treatment, sb.'s illness took a turn for the worse for hospital diagnosis, to uremia, develops.Within 2008, make a definite diagnosis and suffer from gout, metabolic arthritis value reaches 630, takes Western medicine and controls, and uric acid remains on more than 300 substantially, but the gout attack times is more and more frequent.The kidney inspection shows that the many indexs such as urine protein, erythrocyte are undesired, and pain in the lumbar region is often arranged, and trick is ice-cold, dizzy sensation.The rear uric acid resisting medicine of stopping using, change the edible female Radix Dauci Sativae lyophilized powder of the present invention after half a year, and serum uric acid level, through several times repeatedly, finally is down to the 330umol/L left and right, and continuous 3 detections afterwards all remain in normal range.Various malaise symptoms disappeared fully in the past, and kidney detects indices and all recovers normally, and during taking female Radix Dauci Sativae lyophilized powder, gout did not recur again.
case 2: Mr. Feng, senior engineer, people from Ningbo City, Zhejiang Province, 45 years old now.First 36 years old when morbidity of gout, use afterwards the uric acid resisting medicine that relieves the pain to be treated always, but the disease delay do not control, and in recent years, gouty nephropathy appears.Edible female Radix Dauci Sativae lyophilized powder of the present invention is after 20 days, and urine urgency-frequency appears in health, waist acid is swollen, oral ulcer, tells the reactions such as salt water, eye discharge increase; After one month, long-term higher blood pressure is tending towards normally, and health vigor in the past obviously increases; After 50 days, serious inflammatory reaction appears, arthralgia aggravation, and inflammatory reaction continues after about one week, and the discovery tophus is obviously dwindled, deliquescing; After two months, color ultrasound shows that renal calculus disappears.
case 3: Wu, man, 17 years old, high school senior, Jinan, Shandong Province people.Physical examination result blood uric acid test value 701umol/L, belong to hyperuricemia.Its mother considers the grievous injury of uric acid resisting medicine to kidney, and employing is taken female Radix Dauci Sativae lyophilized powder of the present invention measure and treated.According to the eating method requirement, every day is twice edible female Radix Dauci Sativae lyophilized powder sooner or later, each 5 grams.Edible after two weeks, go to hospital to detect, Level of Serum Uric Acid 404.6 umol/L, recover normal.
case 4: Mr. Wang, man, 42 years old, No. 1 Hospital Affiliated to Chinese Medical Univ associate chief physician.Suffer from gout 3 years, use early stage the medicines such as colchicine, allopurinol, vertical markon's celestial being to be treated, weaken gradually because of curative effect of medication afterwards, and highlight a series of side effects of pharmaceutical drugs, frequency of disease development increases, during outbreak, the pain increased, therefore stop using said medicine, changes and take the female Radix Dauci Sativae lyophilized powder of the present invention.Edible after one week, pain disappears.In conjunction with diet control, gout is effectively alleviated at present, is continuing to make thoroughly to recover in this way.
Claims (7)
1. the application of female Radix Dauci Sativae lyophilized powder in preparation treatment gout medicine is characterized in that: female Radix Dauci Sativae lyophilized powder can be applied to preparation treatment gout medicine, and as the crucial effective ingredient of this medicine.
2. the production technology of a female Radix Dauci Sativae lyophilized powder is characterized in that: the production technology of female Radix Dauci Sativae lyophilized powder comprises that kind selection, Cultivate administration, pretreatment, cryogenic vacuum dehydration, liquid nitrogen deep pulverize and six links of nitrogen gas packing;
(1) kind is selected: the seed of selecting the female Radix Dauci Sativae of " male sterility line " triple crossing of Shenyang green star Chinese cabbage institute product;
(2) Cultivate administration: by protection ground technology, realize the anniversary plantation, the plantation place is east longitude 123 degree, north latitude 43 degree, 50 meters of height above sea level, be rich in organic loose fertile sandy soil earth, the deep water conservation of soil and drainage are good, maximum water holding capacity 60 ~ 80%, air humidity is 80 ~ 90%, the illumination abundance; Insecticide adopts the BT Emulsion meet organic grow, and fertilizer adopts the chicken manure fully become thoroughly decomposed as fertilizer, at least 5000 kilograms of every mu of fertilisings; Female Radix Dauci Sativae grows to approximately 100 ~ 300 grams of individual weight, is gathered (testing result shows, the nutrition accumulation of the female Radix Dauci Sativae in this growth stage reaches summit);
(3) pretreatment: comprise cleaning and sterilizing, coarse crushing and three links of quick-freezing; Female Radix Dauci Sativae after gathering screens out and is subject to disease and pest, and the neat root of Radix Raphani ornamental tassels retains 1 centimeter, and all the other excisions, be respectively charged into carton, with refrigerator car, be transported to processing factory's (refrigerated storage temperature: 0 ~ 3 ℃); Rinse the earth sticked on female Radix Dauci Sativae at processing factory's water well, after eliminating pimple, start the cleaning and sterilizing flow process; The order of cleaning and sterilizing flow process is: once washing, once sterilizing immersion bubble, secondary washing, secondary sterilization immersion bubble, finally cleaning line cleaning (4 times), the disinfectant solution that twice sterilization used is chlorine dioxide 300ppm, and the soak time of at every turn sterilizing is 30 minutes;
Female Radix Dauci Sativae dicer by after cleaning and sterilizing, be cut into the Radix Raphani fourth below 0.6 ~ 1 cubic centimetre, then spreads into basin;
Then, the Radix Raphani fourth cut is carried out to quick freezing in the freeze tunnel that adopts air cooled chiller, the material central temperature was down to below-4 ℃ in 30 minutes, when the material central temperature is down to-25 ~-30 ℃, quick-freezing finishes, and whole quick-freezing process approximately needs 2.5 hours;
(4) cryogenic vacuum dehydration: by pretreated Radix Raphani fourth, through vacuum sublimation drying equipment drying and dehydrating, the temperature of design temperature curve controlled material is 40 ~ 60 ℃, and approximately 10 ~ 12 hours drying and dehydrating time, after drying and dehydrating, material moisture should be lower than 5%;
(5) liquid nitrogen deep is pulverized: the Radix Raphani fourth after the cryogenic vacuum dehydration, adopt the liquid nitrogen deep pulverizer to carry out pulverization process, it is-30 ~-150 ℃ that Radix Raphani fourth after step (4) dehydration is pulverized best brittle point, and the particle size range of powder is 300 ~ 1000 orders (wherein, preferably 600 orders); Owing to being the micronizing of under the temperature conditions of-100 ~-150 ℃, material being carried out, so nutrition and functional component be without heat loss, the complete breaking cellular wall of cell;-30 ℃ of above smashing fineness of temperature are inadequate, although-150 ℃ of very thin liquid nitrogen costs of the following fineness of temperature can increase substantially, through the test optimum temperature, are-135 ℃;
(6) nitrogen gas packing: packaging process should carry out under the environment of nitrogen, and uses aluminum polyester bag packing, and after inflated with nitrogen, bag mouth heat seal sealing, make female Radix Dauci Sativae lyophilized powder, is placed under the environment of 0 ~ 5 ℃ and preserves.
3. the production technology of a female Radix Dauci Sativae ornamental tassels lyophilized powder is characterized in that: the production technology of female Radix Dauci Sativae ornamental tassels lyophilized powder comprises that kind selection, Cultivate administration, pretreatment, cryogenic vacuum dehydration, liquid nitrogen deep pulverize and six links of nitrogen gas packing;
(1) kind is selected: the seed of selecting the female Radix Dauci Sativae of " male sterility line " triple crossing of Shenyang green star Chinese cabbage institute product;
(2) Cultivate administration: by protection ground technology, realize the anniversary plantation, the plantation place is east longitude 123 degree, north latitude 43 degree, 50 meters of height above sea level, be rich in organic loose fertile sandy soil earth, the deep water conservation of soil and drainage are good, maximum water holding capacity 60 ~ 80%, air humidity is 80 ~ 90%, the illumination abundance; Insecticide adopts the BT Emulsion meet organic grow, and fertilizer adopts the chicken manure fully become thoroughly decomposed as fertilizer, at least 5000 kilograms of every mu of fertilisings; Grow to 30cm when high at the Radix Dauci Sativae ornamental tassels, start to pluck;
(3) pretreatment: comprise cleaning and sterilizing, coarse crushing and three links of quick-freezing; Female Radix Dauci Sativae ornamental tassels after gathering screens out and is subject to disease and pest, and the neat root of Radix Raphani ornamental tassels retains 1 centimeter, and all the other excisions, be respectively charged into carton, with refrigerator car, is transported to processing factory, refrigerated storage temperature: 0 ~ 3 ℃; The order of cleaning and sterilizing flow process is: once washing, once sterilizing immersion bubble, secondary washing, secondary sterilization immersion bubble, finally at the cleaning line, clean 4 times, and the disinfectant solution that twice sterilization used is chlorine dioxide 300ppm, the soak time of at every turn sterilizing is 30 minutes;
Female Radix Dauci Sativae ornamental tassels by after cleaning and sterilizing, be cut to 1 centimeter length with vegetable-chopper, spreads into basin;
Then, the female Radix Dauci Sativae ornamental tassels cut is broken, carry out quick freezing in the freeze tunnel that adopts air cooled chiller, the material central temperature was down to below-4 ℃ in 30 minutes, when the material central temperature is down to-25 ~-30 ℃, quick-freezing finishes, and whole quick-freezing process approximately needs 2.5 hours;
(4) cryogenic vacuum dehydration: pretreated female Radix Dauci Sativae ornamental tassels is broken, through vacuum sublimation drying equipment drying and dehydrating, the temperature of design temperature curve controlled material is 40 ~ 60 ℃, and approximately 10 ~ 12 hours drying and dehydrating time, after drying and dehydrating, material moisture should be lower than 5%;
(5) liquid nitrogen deep is pulverized: the female Radix Dauci Sativae ornamental tassels after the cryogenic vacuum dehydration is broken, adopt the liquid nitrogen deep pulverizer to carry out pulverization process, it is-30 ~-150 ℃ that Radix Raphani fourth after step (4) dehydration is pulverized best brittle point, and the particle size range of powder is 300 ~ 1000 orders;
(6) nitrogen gas packing: packaging process should carry out under the environment of nitrogen, and uses aluminum polyester bag packing, and after inflated with nitrogen, bag mouth heat seal sealing, make female Radix Dauci Sativae ornamental tassels lyophilized powder, is placed under the environment of 0 ~ 5 ℃ and preserves.
4. the female Radix Dauci Sativae lyophilized powder made according to claim 2 or 3, the tablet manufacturing technique of female Radix Dauci Sativae ornamental tassels lyophilized powder, it is characterized in that: female Radix Dauci Sativae lyophilized powder 95%, MCC 5%, after fully mixing, be pressed into tablet with the dry powder sheeting machine, then with the vesicle packer, it packed.
5. the female Radix Dauci Sativae lyophilized powder made according to claim 2 or 3, the effervescent tablet production technology of female Radix Dauci Sativae ornamental tassels lyophilized powder is characterized in that: female Radix Dauci Sativae lyophilized powder, sodium bicarbonate, citric acid, MCC, flavorant mix, and are pressed into effervescent tablet.
6. the female Radix Dauci Sativae lyophilized powder made according to claim 2 or 3, the capsule manufacture technique of female Radix Dauci Sativae ornamental tassels lyophilized powder, it is characterized in that: female Radix Dauci Sativae lyophilized powder 100%, the fully-automatic capsule packer that adopts the configuration vacuum holding to fill in barn carries out capsule-filling.
7. the female Radix Dauci Sativae lyophilized powder made according to claim 2 or 3, the electuary production technology of female Radix Dauci Sativae ornamental tassels lyophilized powder is characterized in that: female Radix Dauci Sativae lyophilized powder 100%, carry out powder packaging, and interior inflated with nitrogen, make the electuary of every bag of net weight 1 ~ 10 gram.
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| CN106722976A (en) * | 2017-04-01 | 2017-05-31 | 陈培森 | There are the health products of alleviation and therapeutic action to gout |
| CN106942578A (en) * | 2017-03-08 | 2017-07-14 | 杨涵 | A kind of natural meals for controlling purine intake and promoting uric acid excretion |
| CN107495051A (en) * | 2017-07-31 | 2017-12-22 | 武汉禾幸环保技术有限公司 | A kind of processing method of active instant drink |
| CN107821721A (en) * | 2017-12-08 | 2018-03-23 | 沈阳萝膳堂医疗产业管理有限公司 | A kind of food therapeutic composition with treatment gout and preparation method thereof |
| CN109998057A (en) * | 2019-04-23 | 2019-07-12 | 辽宁抗风竤生物医药科技有限责任公司 | Dietary product and preparation method thereof with the effect that enhances human immunity |
| CN110169571A (en) * | 2019-05-28 | 2019-08-27 | 沈阳抗风竤生物技术有限公司 | For improving the food therapeutic composition of fecundity |
| CN110170031A (en) * | 2019-05-28 | 2019-08-27 | 沈阳抗风竤生物技术有限公司 | For dissolving the food therapeutic composition of tophus |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106174498A (en) * | 2016-07-15 | 2016-12-07 | 明光市昊昊蜂业有限公司 | A kind of processing method of drone pupa freeze-dried powder |
| CN106942578A (en) * | 2017-03-08 | 2017-07-14 | 杨涵 | A kind of natural meals for controlling purine intake and promoting uric acid excretion |
| CN106722976A (en) * | 2017-04-01 | 2017-05-31 | 陈培森 | There are the health products of alleviation and therapeutic action to gout |
| CN107495051A (en) * | 2017-07-31 | 2017-12-22 | 武汉禾幸环保技术有限公司 | A kind of processing method of active instant drink |
| CN107821721A (en) * | 2017-12-08 | 2018-03-23 | 沈阳萝膳堂医疗产业管理有限公司 | A kind of food therapeutic composition with treatment gout and preparation method thereof |
| CN107821721B (en) * | 2017-12-08 | 2020-11-17 | 沈阳萝膳堂医疗产业管理有限公司 | Dietotherapy composition for treating gout and preparation method thereof |
| CN109998057A (en) * | 2019-04-23 | 2019-07-12 | 辽宁抗风竤生物医药科技有限责任公司 | Dietary product and preparation method thereof with the effect that enhances human immunity |
| CN110169571A (en) * | 2019-05-28 | 2019-08-27 | 沈阳抗风竤生物技术有限公司 | For improving the food therapeutic composition of fecundity |
| CN110170031A (en) * | 2019-05-28 | 2019-08-27 | 沈阳抗风竤生物技术有限公司 | For dissolving the food therapeutic composition of tophus |
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| CN103251662B (en) | 2016-05-18 |
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