CN103230551A - Traditional Chinese medicine external application preparation for treating chronic viral hepatitis - Google Patents
Traditional Chinese medicine external application preparation for treating chronic viral hepatitis Download PDFInfo
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- CN103230551A CN103230551A CN2013101606245A CN201310160624A CN103230551A CN 103230551 A CN103230551 A CN 103230551A CN 2013101606245 A CN2013101606245 A CN 2013101606245A CN 201310160624 A CN201310160624 A CN 201310160624A CN 103230551 A CN103230551 A CN 103230551A
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Abstract
The invention discloses a traditional Chinese medicine external application preparation for treating chronic viral hepatitis. According to the traditional Chinese medicine, the chronic viral hepatitis is caused by stagnation of liver qi and dampness heat of liver and gallbladder, thus the following traditional Chinese medicines with functions of soothing the liver and regulating qi, clearing heat and expelling dampness and invigorating the spleen and tonifying qi are ground into fine powder: akebia trifoliata koidz, abrus cantoniensis hance, fingered citron, swertia yunnanensis, gentiana scabra bge, milkweed, herba desmodii styracifolii, herba lycopi, herba duchesnea indica, radix paeoniae rubra, sagina subulata, coix seed and rhizoma atractylodis macrocephalae; and the fine powder is prepared into a paste external application preparation by use of honey in a drug manufacturing room of the hospital, and the external application preparation is applied to the acupuncture points of liver and gallbladder channels of a patient. According to clinical tests, the total effective rate reaches 95.2% which is obviously higher than that of a control group; and moreover, a little side effect is caused, the treatment method is simple, and the external application preparation deserves clinical popularization and application.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of external application of Chinese medicine agent for the treatment of chronic viral hepatitis.
Background technology
Viral hepatitis is the one group of infectious disease based on liver injury that is caused by multiple hepatitis virus, has very strong infectiousness, if untimely removing body inner virus, virus replication can cause abnormal liver function, the patient shows clinical symptoms, as inappetence, feel sick, vomiting, uncomfortable liver area, stomachache, diarrhoea etc., in addition, deterioration along with the state of an illness, patients with chronic viral hepatitis also symptoms such as spider angioma, jaundice, liver palm can occur, and protracted course of disease, certainly will make progress and be hepatic fibrosis, liver cirrhosis, very big to health of people harm; Doctor trained in Western medicine does not have desirable method in treatment at present.External application of Chinese medicine agent of the present invention by external therapy of Chinese herb, can make medicine directly act on the hepatic region skin appearance and absorb, and alleviating medicine stimulates gastrointestinal, avoids the first pass effect of liver, by through liver, helps liver detoxification.Suppress virus replication, fall enzyme, the liver protecting function, the reaction that reduces inflammation promotes the regeneration of liver cell, thereby can prevent that hepatocellular continuation is downright bad.
Summary of the invention
The purpose of this invention is to provide a kind of external application of Chinese medicine agent for the treatment of chronic viral hepatitis.The traditional Chinese medical science thinks that the cause of disease of chronic viral hepatitis is depression of liver-QI, dampness-heat in the liver and gallbladder.
The objective of the invention is to be achieved through the following technical solutions, the external application of Chinese medicine agent of this treatment chronic viral hepatitis is made by following parts by weight of Chinese traditional medicine: Fructus Akebiae 10-35 part, Herba Abri 5-30 part, Fructus Citri Sarcodactylis 7-13 part, Herba Swertiae yunnanensis 10-25 part, Radix Gentianae 10-15 part, Radix Fici Angustipoliae 3-9 part, Herba Desmodii Styracifolii 9-20 part, Herba Lycopi 8-13 part, Herba Duchesneae Indicae 6-16 part, Radix Paeoniae Rubra 10-15 part, Herba Phyllanthi Urinariae 8-19 part, Semen Coicis 6-20 part, Rhizoma Atractylodis Macrocephalae 10-22 part.
Preferably, 23 parts of Fructus Akebiaes, 18 parts of Herba Abris, 10 parts of Fructus Citri Sarcodactylis, 18 parts of Herba Swertiae yunnanensiss, 13 parts of Radix Gentianaes, 6 parts of Radix Fici Angustipoliae, 15 parts of Herba Desmodii Styracifoliis, 10 parts of Herba Lycopi, 11 parts of Herba Duchesneae Indicaes, 12 parts of Radix Paeoniae Rubra, 14 parts of Herba Phyllanthi Urinariaes, 13 parts of Semen Coiciss, 15 parts of the Rhizoma Atractylodis Macrocephalaes.
Preparation method is ground above-mentioned Chinese medicine into powder honey and is transferred standby.
In the side: Fructus Akebiae, Herba Abri, Fructus Citri Sarcodactylis, Herba Swertiae yunnanensis, Radix Gentianae depressed liver-energy dispersing and QI regulating, promoting blood circulation and stopping pain, heat-clearing and toxic substances removing, drying dampness to eliminate phlegm, liver heat removing function of gallbladder promoting, eliminating pathogen in the liver gallbladder fire; Herba Phyllanthi Urinariae, Radix Fici Angustipoliae calming liver and clearing heat, promoting diuresis to remove toxic substance, expelling wind and removing dampness; Herba Desmodii Styracifolii, Herba Lycopi, Herba Duchesneae Indicae, Radix Paeoniae Rubra clearing heat and expelling damp, inducing diuresis for treating stranguria syndrome, blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema, heat-clearing and toxic substances removing, eliminating stasis to stop pain; Semen Coicis, Rhizoma Atractylodis Macrocephalae promoting diuresis to eliminate damp pathogen, the spleen invigorating QI invigorating.
Clinical data
1, all cases of physical data are selected from March, 2006～2009 chronic hepatitis 260 examples that year October, undergraduate course was accepted for medical treatment, are divided into two groups at random, and 130 examples are organized in treatment, male 85 examples, women 45 examples; 19～75 years old age; The course of disease 4～15 years; Chronic hepatitis B 88 examples, chronic third type, 42 examples.Matched group 130 examples, male 83 examples, women 48 examples; 20～80 years old age, the course of disease 5～18 years; Chronic hepatitis B 81 examples, chronic hepatitis C 49 examples; Learn processing (t check) P＞0.05, not statistically significant by statistics for two groups.
2, all cases of diagnostic criteria all meet " diagnostic criteria of viral hepatitis and hepatic fibrosis " of nineteen ninety-five whole nation infectious disease and parasitic disease academic conference revision.All there are in various degree abnormal liver function and hepatic fibrosis unusual before the treatment.
3, Therapeutic Method treatment group is used external application of Chinese medicine agent of the present invention, namely take by weighing: Fructus Akebiae 23g, Herba Abri 18g, Fructus Citri Sarcodactylis 10g, Herba Swertiae yunnanensis 18g, Radix Gentianae 13g, Radix Fici Angustipoliae 6g, Herba Desmodii Styracifolii 15g, Herba Lycopi 10g, Herba Duchesneae Indicae 11g, Radix Paeoniae Rubra 12g, Herba Phyllanthi Urinariae 14g, Semen Coicis 13g, Rhizoma Atractylodis Macrocephalae 15g, grind into powder altogether, with Mel furnishing paste, be affixed on the bilateral Zhangmen, Qimen, liver and gall such as Jingmen are through the acupuncture point, external application position ointment is divided about 5cm place under right nipple, cover with gauze and plastic sheeting, immobilization with adhesive tape, every day, replacing was applied ointment or plaster once, and per 30 times is 1 course for the treatment of; Primary Cares such as matched group gives and protecting the liver, the support of suiting the medicine to the illness; Give 10% glucose 250mL+ glycyrrhizic acid diamidogen 150mg, day 1 time, dead point; All treat for two groups and carry out the curative effect statistics after three courses for the treatment of.
Four: the criterion of therapeutical effect produce effects: cardinal symptom disappears, and hepatosplenomegaly is recovered normal or obviously bounced back, and the hepatic region does not have obvious tenderness or kowtows pain, and the every index of liver function all recovers normal; Effectively: cardinal symptom disappearance or basic disappearance the, hepatosplenomegaly are stablized constant and are not had obvious tenderness and kowtow pain, and liver function index has 4 recoveries normally or initial value descends more than 50%; Invalid: above-mentioned various indexs do not have improvement.
Five: doing well,improving relatively sees Table 1 after (1) two group of therapeutic outcome treatment three courses for the treatment of.
Doing well,improving relatively after table 1 a liang group was treated three courses for the treatment of
Two groups of curative effects are learned processing by statistics, P＜0.05.
As can be seen from Table 1, treatment group obvious effective rate, total effective rate obviously are better than matched group, have significance meaning (P＜0.05).
(2) treatment back changes of liver function situation relatively
See Table 2.
The changes of liver function situation relatively before and after the table 2 liang group treatment
Through the t check, treatment group and preceding relatively #*P＜0.05 for the treatment of, * * P＜0.01: treatment group and matched group be Δ P＜0.05 relatively
As can be seen from Table 2, external application of Chinese medicine agent treatment chronic viral hepatitis is better than matched group on liver function recovery.
The specific embodiment
Embodiment one: take by weighing Fructus Akebiae 23g, Herba Abri 18g, Fructus Citri Sarcodactylis 10g, Herba Swertiae yunnanensis 18g, Radix Gentianae 13g, Radix Fici Angustipoliae 6g, Herba Desmodii Styracifolii 15g, Herba Lycopi 10g, Herba Duchesneae Indicae 11g, Radix Paeoniae Rubra 12g, Herba Phyllanthi Urinariae 14g, Semen Coicis 13g, Rhizoma Atractylodis Macrocephalae 15g, above-mentioned Chinese medicine is ground honey altogether into powder and is transferred standby.
Embodiment two: take by weighing Fructus Akebiae 35g, Herba Abri 5g, Fructus Citri Sarcodactylis 7g, Herba Swertiae yunnanensis 25g, Radix Gentianae 10g, Radix Fici Angustipoliae 3g, Herba Desmodii Styracifolii 20g, Herba Lycopi 8g, Herba Duchesneae Indicae 16g, Radix Paeoniae Rubra 15g, Herba Phyllanthi Urinariae 19g, Semen Coicis 6g, Rhizoma Atractylodis Macrocephalae 22g, above-mentioned Chinese medicine is ground honey altogether into powder and is transferred standby.
Embodiment three: take by weighing Fructus Akebiae 10g, Herba Abri 30g, Fructus Citri Sarcodactylis 13g, Herba Swertiae yunnanensis 10g, Radix Gentianae 15g, Radix Fici Angustipoliae 9g, Herba Desmodii Styracifolii 9g, Herba Lycopi 13g, Herba Duchesneae Indicae 6g, Radix Paeoniae Rubra 10g, Herba Phyllanthi Urinariae 8g, Semen Coicis 20g, Rhizoma Atractylodis Macrocephalae 10g, above-mentioned Chinese medicine is ground honey altogether into powder and is transferred standby.
Claims (2)
1. external application of Chinese medicine agent for the treatment of chronic viral hepatitis is characterized in that this external application of Chinese medicine agent made by following parts by weight of Chinese traditional medicine: Fructus Akebiae 10-35 part, Herba Abri 5-30 part, Fructus Citri Sarcodactylis 7-13 part, Herba Swertiae yunnanensis 10-25 part, Radix Gentianae 10-15 part, Radix Fici Angustipoliae 3-9 part, Herba Desmodii Styracifolii 9-20 part, Herba Lycopi 8-13 part, Herba Duchesneae Indicae 6-16 part, Radix Paeoniae Rubra 10-15 part, Herba Phyllanthi Urinariae 8-19 part, Semen Coicis 6-20 part, Rhizoma Atractylodis Macrocephalae 10-22 part.
2. a kind of external application of Chinese medicine agent for the treatment of chronic viral hepatitis according to claim 1 is characterized in that this external application of Chinese medicine agent made by following parts by weight of Chinese traditional medicine: 23 parts of Fructus Akebiaes, 18 parts of Herba Abris, 10 parts of Fructus Citri Sarcodactylis, 18 parts of Herba Swertiae yunnanensiss, 13 parts of Radix Gentianaes, 6 parts of Radix Fici Angustipoliae, 15 parts of Herba Desmodii Styracifoliis, 10 parts of Herba Lycopi, 11 parts of Herba Duchesneae Indicaes, 12 parts of Radix Paeoniae Rubra, 14 parts of Herba Phyllanthi Urinariaes, 13 parts of Semen Coiciss, 15 parts of the Rhizoma Atractylodis Macrocephalaes.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596438A (en) * | 2014-11-21 | 2016-05-25 | 天津海奥斯科技有限公司 | Anti-hepatitis plaster |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1105255A (en) * | 1994-08-05 | 1995-07-19 | 李秋礼 | Plaster for hepatitis B patients |
| CN1393256A (en) * | 2001-06-25 | 2003-01-29 | 刘玉璋 | Medicine for treating variant viral hepatitis B |
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- 2013-04-15 CN CN201310160624.5A patent/CN103230551B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1105255A (en) * | 1994-08-05 | 1995-07-19 | 李秋礼 | Plaster for hepatitis B patients |
| CN1393256A (en) * | 2001-06-25 | 2003-01-29 | 刘玉璋 | Medicine for treating variant viral hepatitis B |
Non-Patent Citations (1)
| Title |
|---|
| 陈四清等: "慢性乙型肝炎中医治疗用药规律探讨", 《抗感染药学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596438A (en) * | 2014-11-21 | 2016-05-25 | 天津海奥斯科技有限公司 | Anti-hepatitis plaster |
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