CN103230551B - Traditional Chinese medicine external application preparation for treating chronic viral hepatitis - Google Patents
Traditional Chinese medicine external application preparation for treating chronic viral hepatitis Download PDFInfo
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- CN103230551B CN103230551B CN201310160624.5A CN201310160624A CN103230551B CN 103230551 B CN103230551 B CN 103230551B CN 201310160624 A CN201310160624 A CN 201310160624A CN 103230551 B CN103230551 B CN 103230551B
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Abstract
The invention discloses a traditional Chinese medicine external application preparation for treating chronic viral hepatitis. According to the traditional Chinese medicine, the chronic viral hepatitis is caused by stagnation of liver qi and dampness heat of liver and gallbladder, thus the following traditional Chinese medicines with functions of soothing the liver and regulating qi, clearing heat and expelling dampness and invigorating the spleen and tonifying qi are ground into fine powder: akebia trifoliata koidz, abrus cantoniensis hance, fingered citron, swertia yunnanensis, gentiana scabra bge, milkweed, herba desmodii styracifolii, herba lycopi, herba duchesnea indica, radix paeoniae rubra, sagina subulata, coix seed and rhizoma atractylodis macrocephalae; and the fine powder is prepared into a paste external application preparation by use of honey in a drug manufacturing room of the hospital, and the external application preparation is applied to the acupuncture points of liver and gallbladder channels of a patient. According to clinical tests, the total effective rate reaches 95.2% which is obviously higher than that of a control group; and moreover, a little side effect is caused, the treatment method is simple, and the external application preparation deserves clinical popularization and application.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of external application of Chinese medicine agent for the treatment of chronic viral hepatitis.
Background technology
Viral hepatitis is that a group of being caused by multiple hepatitis virus be take liver injury as main infectious disease, there is very strong infectiousness, if remove not in time body inner virus, virus replication can cause abnormal liver function, patient shows clinical symptoms, as inappetence, feel sick, vomiting, uncomfortable liver area, stomachache, diarrhoea etc., in addition, deterioration along with the state of an illness, patients with chronic viral hepatitis also there will be the symptoms such as spider angioma, jaundice, liver palm, and protracted course of disease, certainly will make progress as hepatic fibrosis, liver cirrhosis, very large to health of people harm; Doctor trained in Western medicine does not have desirable method in treatment at present.External application of Chinese medicine agent of the present invention, by external therapy of Chinese herb, can make medicine directly act on hepatic region skin appearance and absorb, and alleviating medicine stimulates gastrointestinal, avoids the first pass effect of liver, by through liver, helps liver detoxification.Suppress virus replication, fall enzyme, the liver protecting function, the reaction that reduces inflammation, promotes the regeneration of liver cell, thereby can prevent that hepatocellular continuation is downright bad.
Summary of the invention
The object of this invention is to provide a kind of external application of Chinese medicine agent for the treatment of chronic viral hepatitis.The traditional Chinese medical science thinks, the cause of disease of chronic viral hepatitis is depression of liver-QI, dampness-heat in the liver and gallbladder.
The object of the invention is to be achieved through the following technical solutions, the external application of Chinese medicine agent of this treatment chronic viral hepatitis is made by the Chinese medicine of following weight portion: Fructus Akebiae 10-35 part, Herba Abri 5-30 part, Fructus Citri Sarcodactylis 7-13 part, Herba Swertiae yunnanensis 10-25 part, Radix Gentianae 10-15 part, Radix Fici Angustipoliae 3-9 part, Herba Desmodii Styracifolii 9-20 part, Herba Lycopi 8-13 part, Herba Duchesneae Indicae 6-16 part, Radix Paeoniae Rubra 10-15 part, Herba Phyllanthi Urinariae 8-19 part, Semen Coicis 6-20 part, Rhizoma Atractylodis Macrocephalae 10-22 part.
Preferably, 23 parts of Fructus Akebiaes, 18 parts of Herba Abris, 10 parts of Fructus Citri Sarcodactylis, 18 parts of Herba Swertiae yunnanensiss, 13 parts of Radix Gentianaes, 6 parts of Radix Fici Angustipoliae, 15 parts of Herba Desmodii Styracifoliis, 10 parts of Herba Lycopi, 11 parts of Herba Duchesneae Indicaes, 12 parts of Radix Paeoniae Rubra, 14 parts of Herba Phyllanthi Urinariaes, 13 parts of Semen Coiciss, 15 parts of the Rhizoma Atractylodis Macrocephalaes.
Preparation method is ground above-mentioned Chinese medicine into powder honey and is adjusted standby.
In side: Fructus Akebiae, Herba Abri, Fructus Citri Sarcodactylis, Herba Swertiae yunnanensis, Radix Gentianae depressed liver-energy dispersing and QI regulating, promoting blood circulation and stopping pain, heat-clearing and toxic substances removing, drying dampness to eliminate phlegm, liver heat removing function of gallbladder promoting, eliminating pathogen in the liver gallbladder fire; Herba Phyllanthi Urinariae, Radix Fici Angustipoliae calming liver and clearing heat, promoting diuresis to remove toxic substance, expelling wind and removing dampness; Herba Desmodii Styracifolii, Herba Lycopi, Herba Duchesneae Indicae, Radix Paeoniae Rubra clearing heat and expelling damp, inducing diuresis for treating stranguria syndrome, blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema, heat-clearing and toxic substances removing, eliminating stasis to stop pain; Semen Coicis, Rhizoma Atractylodis Macrocephalae promoting diuresis to eliminate damp pathogen, spleen invigorating QI invigorating.
Clinical data
1, all cases of physical data are selected from March, 2006～2009 chronic hepatitis 260 examples that year October, undergraduate course was accepted for medical treatment, are divided at random two groups, treatment group 130 examples, male 85 examples, female's 45 examples; 19～75 years old age; The course of disease 4～15 years; Chronic hepatitis B 88 examples, chronic the third type 42 examples.Matched group 130 examples, male 83 examples, female's 48 examples; 20～80 years old age, the course of disease 5～18 years; Chronic hepatitis B 81 examples, chronic hepatitis C 49 examples; Learn by statistics processing (t check) P > 0.05, not statistically significant for two groups.
2, all cases of diagnostic criteria all meet nineteen ninety-five whole nation infectious disease and the < < viral hepatitis of parasitic disease academic conference revision and the diagnostic criteria > > of hepatic fibrosis.Before treatment, all there are abnormal liver function and hepatic fibrosis in various degree abnormal.
3, Therapeutic Method treatment group is used external application of Chinese medicine agent of the present invention, take: Fructus Akebiae 23g, Herba Abri 18g, Fructus Citri Sarcodactylis 10g, Herba Swertiae yunnanensis 18g, Radix Gentianae 13g, Radix Fici Angustipoliae 6g, Herba Desmodii Styracifolii 15g, Herba Lycopi 10g, Herba Duchesneae Indicae 11g, Radix Paeoniae Rubra 12g, Herba Phyllanthi Urinariae 14g, Semen Coicis 13g, Rhizoma Atractylodis Macrocephalae 15g, grind into powder altogether, with Mel furnishing paste, be affixed on bilateral Zhangmen, Qimen, the liver Acupoints such as Jingmen, external application position ointment is divided about 5cm place under right nipple, with gauze and plastic sheeting, cover, immobilization with adhesive tape, every day, replacing was applied ointment or plaster once, every is for 30 times 1 course for the treatment of, matched group gives and protecting the liver, the Primary Cares such as support of suiting the medicine to the illness, give 10% glucose 250mL+ glycyrrhizic acid diamidogen 150mg, day 1 time, dead point, two groups are carried out curative effect statistics after all treating three courses for the treatment of.
Four: criterion of therapeutical effect is effective: cardinal symptom disappears, hepatosplenomegaly is recovered normally or is obviously bounced back, and hepatic region is without obvious tenderness or kowtow pain, and it is normal that liver function indices all recovers; Effective: cardinal symptom disappears or substantially disappears, it is constant and without obvious tenderness and kowtow pain that hepatosplenomegaly is stablized, and liver function index has 4 to recover normal or initial value and decline more than 50%; Invalid: above-mentioned various indexs are without improvement.
Five: after three courses for the treatment of of (1) two group of therapeutic outcome treatment, symptom is improved relatively in Table 1.
After a table 1 liang group is treated three courses for the treatment of, symptom is improved relatively
Two groups of curative effects are learned processing by statistics, P < 0.05.
As can be seen from Table 1, treatment group obvious effective rate, total effective rate, be obviously better than matched group, has significant (P < 0.05).
(2) changes of liver function situation comparison after treatment
in Table 2.
Changes of liver function situation comparison before and after table 2 liang group treatment
Through t check, treatment group and the front relatively #*P < 0.05 for the treatment of, * * P < 0.01: treatment group and matched group be Δ P < 0.05 relatively
As can be seen from Table 2, external application of Chinese medicine agent treatment chronic viral hepatitis, on liver function recovery, is better than matched group.
The specific embodiment
Embodiment mono-: take Fructus Akebiae 23g, Herba Abri 18g, Fructus Citri Sarcodactylis 10g, Herba Swertiae yunnanensis 18g, Radix Gentianae 13g, Radix Fici Angustipoliae 6g, Herba Desmodii Styracifolii 15g, Herba Lycopi 10g, Herba Duchesneae Indicae 11g, Radix Paeoniae Rubra 12g, Herba Phyllanthi Urinariae 14g, Semen Coicis 13g, Rhizoma Atractylodis Macrocephalae 15g, above-mentioned Chinese medicine is ground altogether honey into powder and adjusted standby.
Embodiment bis-: take Fructus Akebiae 35g, Herba Abri 5g, Fructus Citri Sarcodactylis 7g, Herba Swertiae yunnanensis 25g, Radix Gentianae 10g, Radix Fici Angustipoliae 3g, Herba Desmodii Styracifolii 20g, Herba Lycopi 8g, Herba Duchesneae Indicae 16g, Radix Paeoniae Rubra 15g, Herba Phyllanthi Urinariae 19g, Semen Coicis 6g, Rhizoma Atractylodis Macrocephalae 22g, above-mentioned Chinese medicine is ground altogether honey into powder and adjusted standby.
Embodiment tri-: take Fructus Akebiae 10g, Herba Abri 30g, Fructus Citri Sarcodactylis 13g, Herba Swertiae yunnanensis 10g, Radix Gentianae 15g, Radix Fici Angustipoliae 9g, Herba Desmodii Styracifolii 9g, Herba Lycopi 13g, Herba Duchesneae Indicae 6g, Radix Paeoniae Rubra 10g, Herba Phyllanthi Urinariae 8g, Semen Coicis 20g, Rhizoma Atractylodis Macrocephalae 10g, above-mentioned Chinese medicine is ground altogether honey into powder and adjusted standby.
Claims (1)
1. treat an external application of Chinese medicine agent for chronic viral hepatitis, it is characterized in that this external application of Chinese medicine agent made by the Chinese medicine of following weight: Fructus Akebiae 23g, Herba Abri 18g, Fructus Citri Sarcodactylis 10g, Herba Swertiae yunnanensis 18g, Radix Gentianae 13g, Radix Fici Angustipoliae 6g, Herba Desmodii Styracifolii 15g, Herba Lycopi 10g, Herba Duchesneae Indicae 11g, Radix Paeoniae Rubra 12g, Herba Phyllanthi Urinariae 14g, Semen Coicis 13g, Rhizoma Atractylodis Macrocephalae 15g.
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| CN201310160624.5A CN103230551B (en) | 2013-04-15 | 2013-04-15 | Traditional Chinese medicine external application preparation for treating chronic viral hepatitis |
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| CN103230551B true CN103230551B (en) | 2014-11-26 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105596438A (en) * | 2014-11-21 | 2016-05-25 | 天津海奥斯科技有限公司 | Anti-hepatitis plaster |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1105255A (en) * | 1994-08-05 | 1995-07-19 | 李秋礼 | Plaster for hepatitis B patients |
| CN1393256A (en) * | 2001-06-25 | 2003-01-29 | 刘玉璋 | Medicine for treating variant viral hepatitis B |
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2013
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1105255A (en) * | 1994-08-05 | 1995-07-19 | 李秋礼 | Plaster for hepatitis B patients |
| CN1393256A (en) * | 2001-06-25 | 2003-01-29 | 刘玉璋 | Medicine for treating variant viral hepatitis B |
Non-Patent Citations (2)
| Title |
|---|
| 慢性乙型肝炎中医治疗用药规律探讨;陈四清等;《抗感染药学》;20041231;第1卷(第3期);106-107 * |
| 陈四清等.慢性乙型肝炎中医治疗用药规律探讨.《抗感染药学》.2004,第1卷(第3期),106-107. * |
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