CN103230460B

CN103230460B - Medicine for treating manic-depressive psychosis and preparation method thereof

Info

Publication number: CN103230460B
Application number: CN201310140370.0A
Authority: CN
Inventors: 彭连志
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-04-23
Filing date: 2013-04-23
Publication date: 2015-03-25
Anticipated expiration: 2033-04-23
Also published as: CN103230460A

Abstract

The invention discloses a medicine for treating manic-depressive psychosis and a preparation method thereof. The medicine is mainly prepared by medicines such as cornu bubali, antelope's horn, rheum officinale and golden cypress by a certain weight ratio. The medicine disclosed by the invention has the effects of nourishing yin to lessen fire, calming liver wind and clearing heat and relieving convulsion, and is quick in effect, good in curative effect and high in cure rate for treating manic-depressive psychosis.

Description

A kind of medicine for the treatment of manic depressive illness and preparation method thereof

Technical field

The present invention relates to a kind of medicine being used for the treatment of manic depressive illness and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Manic depressive illness is the surging or low mental disorder disease for feature of a kind of exception with emotion, have manic state and depressive state two kinds of main manifestations concurrently, can, in the outbreak of same patient interval alternate repetition, can a kind of state be also main recurrent exerbation, to have periodically and can palliative.Be called manic when showing elation between this sick period of disease, when showing as hypothymergasia, be called depression.This kind of patient can repeated multiple timesly show effect in life, the intermission called between twice outbreak.Now the mental status of patient recovers normal completely.Its form of repeatedly falling ill can be all manic at every turn, also can be all depressed at every turn, also can have the irregular alternately outbreak of manicdepressive two kinds of forms.At present, western medicine manic depressive illness poor effect, and have more side effect, therefore, there is very large demand to the Chinese medicine of effectively treating manic depressive illness in people.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment manic depressive illness, thus completes the present invention.

Object of the present invention is just to provide a kind of composition of medicine effectively can treating manic depressive illness.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Medicine of the present invention selects Cornu Bubali, Cornu Saigae Tataricae, Oleum menthae, Radix Et Rhizoma Rhei, Cortex Phellodendri medicine combines, and is made by these drug regimens each efficacy of drugs produce synergism, thus can the recurrence of fast treating manic depressive illness.Wherein select Cornu Bubali to be because its nature and flavor hardship is salty, cold, have the function of heat clearing away, removing heat from blood, removing toxic substances, control calentura headache, high fever coma, macule, tells nosebleed, infantile convulsion, sore throat pharyngeal swelling.Select Cornu Saigae Tataricae to be because its nature and flavor are salty, cold, enter liver, heart channel, have suppressing the hyperactive liver to relieve the wind syndrome, heat clearing away is relieving convulsion, the function of removing toxic substances, and control calentura coma convulsion and faint, delirium is gone mad, and dizzy ， Jing Epilepsy of having a headache is twitched, conjunctivitis.Oleum menthae is selected to be that have dispelling wind, the function of heat clearing away, controls affection due to external wind and heat because its nature and flavor are pungent, cool, nontoxic, headache conjunctival congestion, pharyngalgia, toothache, skin pruritus due to wind pathogen.Radix Et Rhizoma Rhei is selected to be that enter stomach, large intestine, liver footpath, have the poison that purges heat, removing mass is stagnant because its nature and flavor are bitter, cold, the function of clots absorbing blood, control excess-heat constipation, delirium is gone mad, food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi ， lumps in the chest and abdomen, time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, spits blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, urinates red, carbuncle and ulcer toxic swelling, furuncle, burn.Cortex Phellodendri is selected to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, have nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.

The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Cornu Bubali 450-550 grams of Cornu Saigae Tataricae 450-550 grams of Oleum menthae 45-55 grams

Radix Et Rhizoma Rhei 90-110 grams of Cortex Phellodendris 90-110 grams

Preferable amount is

Cornu Bubali 500 grams of Cornu Saigae Tataricae 500 grams of Peppermint Oil 50s gram

Radix Et Rhizoma Rhei 100 grams of Cortex Phellodendris 100 grams

The preparation method of medicine of the present invention is as follows

One, the preparation of water preparation

(1) get the raw materials ready

1, Cornu Bubali: rive, with hot-water soak, pulls out, and pound sheet, dries;

2, Cornu Saigae Tataricae: except plug of boning, files broken;

3, Oleum menthae: remove crude drug;

4, Radix Et Rhizoma Rhei: pick clean impurity, size stepping, stews to moisten to inside and outside humidity even, cuts into slices or is cut into small pieces, dries;

5, Cortex Phellodendri: pick decontamination, washes, and pulls out, runs through, and section or shredding, dry.

(2) prepare

By the Cornu Bubali of described weight, Cornu Saigae Tataricae, Radix Et Rhizoma Rhei, Cortex Phellodendri material medicine, add water 5 times amount, soaks after 120 minutes, intense fire decocts boiling 30 minutes, use slow fire boiling again 20 minutes, filter to obtain a decoction liquor, the medicinal residues filtered are added water 2 times amount, intense fire decocts boiling, use slow fire boiling again 20 minutes, filter to obtain secondary decoction liquor, secondary decoction liquor is poured in container, add Oleum menthae to stir, be divided into 3 doses and take.

Two, the preparation of granule

1, the Cornu Bubali of described weight, Cornu Saigae Tataricae, Radix Et Rhizoma Rhei, Cortex Phellodendri powder are broken into fine powder, then add the Oleum menthae of described weight, be pressed into granule.

2, each serving 10 grams, every day 3 times.

Medicine of the present invention has nourishing YIN to lower pathogenic fire, moisturizes laxation, suppressing the hyperactive liver to relieve the wind syndrome, and the function that heat clearing away is relieving convulsion, is used for the treatment of manic depressive illness, short treating period, instant effect, has no side effect.

Detailed description of the invention

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples include animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 25ml/kg, and normal amount is 15ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The observations of [test example 2] Drug therapy manic depressive illness of the present invention

1, physical data

Accept manic depressive patients totally 150 examples for medical treatment, wherein male 90 example, women 60 example.

2, diagnostic criteria

Manic depressive illness clinical manifestation

The clinical manifestation of color of light in manic patients mental symptom has 3 features, and namely mental state is surging.Analogy is happy soon; Flight of thought one associative process accelerates; Psychomotor excitement.

(1) mental state is surging: this disease is started, and patient can first have the phenomenon such as headache, insomnia, then occurs elation, heart is full of happiness and joy, and patient seems and enlivens multi-lingual, initiatively associates with others, think that anything is concerning being all gratifying, happy him, so ceaselessly pursue fangle.But sometimes again there is irritability.

(2) flight of idea: patient's associative process accelerates, and thought content is abundant and changeable, often changes with the change of extraneous things, the normal phenomenon occurring " with border transfer ".Because the acceleration of ideological trend changes, thus have corresponding behavior miscellaneous, sometimes do this, sometimes do that, but all can not carry it through to the end to every thing feelings, result gets nowhere.

(3) activity increases: due to patient's elation, hyperenergia is vigorous, all interested in what, and what activity is all wanted to participate in, and therefore activity is added.Because patient's passive attention is easy to arouse, therefore aprowl easily divert the aim, not complete forwarding to again in another activity of activity is gone, and result is bustling about, but what is all " imperfectly ", and work efficiency is not high, gives the sense of " pressing affairs ".

3, Therapeutic Method

Select above-mentioned water preparation or granule, take to patient, patient per takes 1 dose, and every day is early, middle and late respectively takes 1 time, within 7 days, is a course for the treatment of, takes 6 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: manic depressive illness disappears, observe half a year without bounce-back person;

Take a turn for the better: manicdepressive symptom is obviously improved, and body constitution progressively strengthens;

Invalid: manic depressive illness, without change, does not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy manic depressive patients 150 example of the present invention, effective 145 examples of result, obvious effective rate is 96.67%, and take a turn for the better 3 examples, and improvement rate is 2%, and invalid 2 examples, total effective rate is 98.67%.

Claims

1. treat a medicine for manic depressive illness, it is characterized in that: it is made up of the crude drug in following weight range:

Radix Et Rhizoma Rhei 90-110 grams of Cortex Phellodendris 90-110 grams;

Preparation process is as follows:

(1) preparation of water preparation

(1) get the raw materials ready

1. Cornu Bubali: rive, with hot-water soak, pulls out, and pound sheet, dries;

2. Cornu Saigae Tataricae: except plug of boning, files broken;

3. Oleum menthae: remove crude drug;

4. Radix Et Rhizoma Rhei: pick clean impurity, size stepping, stews to moisten to inside and outside humidity even, cuts into slices or is cut into small pieces, dries;

5. Cortex Phellodendri: pick decontamination, washes, and pulls out, runs through, and section or shredding, dry;

(2) prepare

By the Cornu Bubali of described weight, Cornu Saigae Tataricae, Radix Et Rhizoma Rhei, Cortex Phellodendri material medicine, add water 5 times amount, soaks after 120 minutes, intense fire decocts boiling 30 minutes, use slow fire boiling again 20 minutes, filter to obtain a decoction liquor, the medicinal residues filtered are added water 2 times amount, intense fire decocts boiling, use slow fire boiling again 20 minutes, filter to obtain secondary decoction liquor, secondary decoction liquor is poured in container, add Oleum menthae to stir, be divided into 3 doses and take;

(2) preparation of granule

(1) Cornu Bubali of described weight, Cornu Saigae Tataricae, Radix Et Rhizoma Rhei, Cortex Phellodendri powder are broken into fine powder, then add the Oleum menthae of described weight, be pressed into granule;

(2) each serving 10 grams, every day 3 times.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Radix Et Rhizoma Rhei 100 grams of Cortex Phellodendris 100 grams.

3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:

(1) preparation of water preparation

(1) get the raw materials ready

1. Cornu Bubali: rive, with hot-water soak, pulls out, and pound sheet, dries;

2. Cornu Saigae Tataricae: except plug of boning, files broken;

3. Oleum menthae: remove crude drug;

(2) prepare

(2) preparation of granule

(2) each serving 10 grams, every day 3 times.