CN103222938A - Skin external composition containing sugar apple seed extract - Google Patents
Skin external composition containing sugar apple seed extract Download PDFInfo
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- CN103222938A CN103222938A CN2012101215571A CN201210121557A CN103222938A CN 103222938 A CN103222938 A CN 103222938A CN 2012101215571 A CN2012101215571 A CN 2012101215571A CN 201210121557 A CN201210121557 A CN 201210121557A CN 103222938 A CN103222938 A CN 103222938A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention relates to a skin external composition containing sugar apple seed extract, especially relates to extract prepared by germinated sugar apple seeds, or extract prepared by a subcritical extraction method, compared with the previous common sugar apple seed extract, the invention can provide a sugar apple seed extract containing more cyclopetides and various amino acids. By using these extracts, the skin external composition can perform higher efficiency.
Description
Technical field
The present invention relates to contain the Dermatologic preparation composition of Sirikaya seed extract, specifically, relate to from the extract of the Sirikaya seed preparation of germinateing, perhaps utilize the Sirikaya seed extract of sub critical extraction method preparation, compare with common Sirikaya seed extract in the past, can provide and contain the more cyclic peptide and the various amino acid whose Sirikaya seed extract of volume,, bring into play more dynamical Dermatologic preparation composition by utilizing these extracts.
Background technology
Along with aging, change or reduce as the content of collagen protein, elastin laminin, hyaluronic acid and the glycoprotein of skin component and arrangement, and produced oxidative stress by free radical and active harmful oxygen.In addition, carry out or the ultraviolet influence along with aged, most of cell of forming skin will reinforced epoxy synthase-2 (Cox-2, biosynthesis Cyclooxygenase), the known proinflammatory cytokine that can cause inflammation of this enzyme generation.By these inflammatory factors, will strengthen matrix metalloproteinase (MMP as the skin histology catabolic enzyme, Matrix metalloproteinase) biosynthesis, strengthen generation by the NO (nitrogen oxide) of iNOS (inducible nitric oxide synthase, inducible nitric oxide synthase).Just, along with the endogenous that carries out naturally is aging, cytoactive will reduce, and because the synthetic of the stroma ground substance of fine inflammation will reduce, and various hostile environments produce stress the increase and the exopathogenic factors such as increase of the reactive oxygen species that causes of sunray can cause and decompose and degeneration is quickened, dermal matrix will destroy and attenuation, causes the various symptoms of skin aging.Therefore, carrying out much preventing and improving the research of the active component of catabiosis at present.
The prior art document
Patent documentation: Korea S's publication 2011-0125247 number
Summary of the invention
The present inventor finds, in natural extract, the extract of Sirikaya seed has good antiageing effect, particularly the extract of the Sirikaya seed of Fa Yaing contains compositions such as more aminoacid than common Sirikaya seed, and can extract when utilizing the sub critical extraction method more and the effective ingredient of volume more, better antiageing effect can be provided, finish the present invention thus.
Therefore, the purpose of this invention is to provide and have the Dermatologic preparation composition that contains Sirikaya seed extract that the various skin that comprises antiageing effect is improved effect.
For achieving the above object, the invention provides the Dermatologic preparation composition that the Sirikaya seed extract that will germinate contains as effective ingredient.
In addition, the invention provides the Dermatologic preparation composition that the Sirikaya seed extract that utilizes sub critical extraction method preparation contains as effective ingredient.
And, the invention provides the aging resistance Dermatologic preparation composition that Sirikaya seed extract that will germinate or the Sirikaya seed extract that utilizes the sub critical extraction method to prepare are contained as effective ingredient.
The Sirikaya seed extract of compositions of the present invention by using the Sirikaya seed extract that germinates or utilizing the sub critical extraction method to prepare, compare with the Sirikaya seed extract that conventional extraction method is in the past extracted, contain the more aminoacid ingredient of volume, more outstanding collagen protein synthesis effect and the antiageing effect of Geng Gao can be provided.
The specific embodiment
Dermatologic preparation composition of the present invention contains Sirikaya seed extract as effective ingredient.
The Sirikaya seed that uses among the present invention is the seed of custardapple tree, and the formal name used at school of Sirikaya is Anona Cherimolia, Anona Squamosa, Anona Reticulata, Anona Muricata etc.
The fruit of Sirikaya is 2-4 inch size little block-shaped with soft cream-colored sarcocarp, and is sweet as custard, refrigerant as Herba Menthae, and the black seed of 1 centimetre of size is arranged in the fruit.
The seed of Sirikaya contains 8 kinds of cyclic peptide, have the skin elasticity of raising and lift (lifting) effect, and effectively inflammation-inhibiting brings out cytokine, so be used as the material of the multiple folkd therapy of treatment dermatosis or white macula etc. always.
The Sirikaya seed extract that uses among the present invention is to extract from the seed of custardapple tree, preferably extracts in the Sirikaya seed of Fa Yaing.The Sirikaya seed of germination state is compared with germination before, contains more effective ingredient essential to biosis, therefore can provide more potent fruit.
The germination condition of Sirikaya seed is not particularly limited, and can use following method to germinate.In the water of 21-27 ℃ temperature conditions, kept 5-8 hour at this state.Seed soaks in the water, under 25-30 ℃ temperature conditions, illumination condition and dark condition is implemented to germinate repeatedly.At this moment, illumination condition was implemented 16-18 hour, and dark condition was implemented 5-7 hour, cultivated to continue 5-7 days.
In addition, compositions of the present invention will utilize the Sirikaya seed extract of sub critical extraction method (Subcritical Water Extraction) preparation to contain as effective ingredient.At this moment, Sirikaya seed can use the Sirikaya seed before germinateing, and also can use the Sirikaya seed that has germinateed.
In the past in the super critical extraction of Shi Yonging, the density of supercritical fluid and liquid type seemingly, viscosity and diffusion coefficient and gas are seemingly.Therefore, when supercritical fluid is used as the extraction solvent, be easy to be penetrated in the fine pores of plant, obtain suitable molecular density, extract behind the molecule of encirclement desired substance, obtain the extract of desired substance in this way.At this moment, can be made into the material that supercriticality uses as extracting solvent and at first will satisfy avirulence, and because supercriticality is a high temp/high pressure, so explosion hazard can not be arranged, and need have good dissolving ability as extracting solvent.As long as satisfy above-mentioned condition, any material can be made supercritical fluid and extract.
On the other hand, the subcritical technology of using among the present invention is that solvent is being no more than under the state of critical point as extracting solvent, so according to selecting which kind of solvent, obtain the effect identical with supercritical extraction.Make water as solvent among the present invention.In addition, supercritical carbon dioxide can not extract polar substances, thus organic solvent need be used together as secondary solvent, but subcritical water has extraordinary extraction performance, and the excursion of operating condition is wide, can implement the extraction of apolar substance and polar substances.And when utilizing subcritical water to extract, reaction also can be hydrolyzed.
The Sirikaya seed extract that utilizes the sub critical extraction method that uses among the present invention is specifically with following method preparation.Utilize the sub critical extraction device at 50-200MPa Sirikaya seed, preferably under the high pressure of 100MPa, decompose Sirikaya seed, effective component extracting.Pressure is during less than 50MPa, abundant effective component extracting, and pressure is during greater than 200MPa, and relatively high pressure, the extracts active ingredients amount is also little, so extract under the pressure of above-mentioned scope.After the extraction, in filter, filter once, have in the filter of 0.45 μ m hole and filter once, in filter, filter once, remove foreign body and microorganism, obtain subcritical Sirikaya seed extract with 0.2 μ m hole with 1.2 μ m holes.
In the compositions of the present invention, the total amount of relative compositions, can contain the extract of Sirikaya seed of germination of 0.01-95.0 weight % or the subcritical Sirikaya seed extract by method for preparing, preferably contain 5.0-95.0 weight %, be more preferably 10.0-90.0 weight %.Extract contain quantity not sufficient 0.01 weight % the time, can not obtain the effect of composition, and when surpassing 95.0 weight %, can not further improve effect skin, reduce its raw material efficient.
Compositions of the present invention strengthens the synthetic of collagen protein, the skin elasticity that is improved thus, improves the good antiageing effect of wrinkle.
In addition, compositions of the present invention is except the antiageing effect of skin, help to improve the integrality of skin, good oxidation resistance can be provided, and the integral body of improving comprehensive skin conditions such as effect, sebum regulating effect, pore contractive effect, cutin are improved effect, skin-tightening or regulating effect, complexion improvements, skin irritation alleviation effects, the dynamic equilibrium that improve by blood circulation improve effect that can provide skin-whitening effect, skin moisture-keeping ability to improve skin problems such as effect, antiphlogistic effects, acne and allergic dermatitis is improved effect.
Compositions of the present invention can contain the medium or the basic reagent that allow on cosmetic conduct and learning or the Dermatology carry out dosage formization.Can be to be applicable to partial all dosage forms, for example, can be provided as the folliculus dispersant that solution, gel, solid, anhydrous paste, oil phase are dispersed in emulsion, suspension, microemulsion, microcapsule, subparticle ball or the ion-type (liposome) and the nonionic of water
Form, perhaps frost, astringent, emulsion, powder, ointment, spraying and hide flaw clavate attitude.In addition, also can provide foam form or further contain the form of spraying (airosol) compositions of the propellant of compression.These compositionss can be according to the usual method preparation of this area.
In addition, compositions of the present invention can contain fatty material, organic solvent, lytic agent, concentrating agents, gel, softening agent, antioxidant, suspending agent, stabilizing agent, foaming agent (foaming agent), aromatic, surfactant, water, ion-type or nonionic emulsifier, filler, the metal ion disintegrating agent, chelating agen, preservative agent, vitamin, blocker, wetting agent, essential oil, dyestuff, pigment, hydrophilic or lipophile activating agent, normally used adjuvant in the cosmetic conduct and learning of any other compositions commonly used or the Dermatology field in lipid vesicle and the cosmetics.The content of above-mentioned adjuvant is normally used amount in cosmetic conduct and learning or the Dermatology field.
In addition, compositions of the present invention contains skin absorbs and promotes material in order to increase antiageing effect.
Below by test example and dosage form example, further specify composition of the present invention and effect.These test examples and dosage form example are just in order to help the understanding of the present invention, and category of the present invention and scope are not limited thereto.
The preparation of embodiment 1 common germination Sirikaya seed extract
The Sirikaya seed of germination state is put into 70 weight % Purified Waters and the alcoholic acid solvent of 30 weight %, placed 6 hours down, extract active component at 25 ℃.After the extraction, in filter, filter once, in filter, filter once, eliminate foreign body, utilize sterilizing filter at last, eliminate microorganism, obtain common Sirikaya seed extract with 1 μ m hole with 3 μ m holes.
The preparation of embodiment 2 subcritical Sirikaya seed extracts
The Sirikaya seed of the state that do not germinate is utilized the sub critical extraction device, effective component extracting under the high pressure of 100MPa.After the extraction, in filter, filter once, in filter, filter once, in filter, filter once, eliminate foreign body and microorganism, obtain subcritical Sirikaya seed extract with 0.2 μ m hole with 0.45 μ m hole with 1.2 μ m holes.
The preparation of embodiment 3 subcritical germination Sirikaya seed extracts
The Sirikaya seed of germination state is utilized the sub critical extraction device, effective component extracting under the high pressure of 100MPa.After the extraction, in filter, filter once, in filter, filter once, in filter, filter once, eliminate foreign body and microorganism, obtain subcritical Sirikaya seed extract with 0.2 μ m hole with 0.45 μ m hole with 1.2 μ m holes.
The preparation of Comparative Examples 1 common Sirikaya seed extract
The Sirikaya seed of the state that do not germinate is put into 70% Purified Water and 30% alcoholic acid solvent, placed 6 hours down, extract active component at 25 ℃.After the extraction, in filter, filter once, in filter, filter once, eliminate foreign body, utilize sterilizing filter at last, eliminate microorganism, obtain common Sirikaya seed extract with 1 μ m hole with 3 μ m holes.
Test example 1 is according to the comparison of the active constituent content of the extracting method of Sirikaya seed extract and germination state
Utilize following amino acid analysis method (OPA method),, analyze each amino acid whose content the Sirikaya seed extract of the foregoing description 1-3 and Comparative Examples 1.Its result is as shown in table 1.
Amino acid analysis method (OPA method)
1) HPLC condition
---post: zorbax post (being exclusively used in amino acid analysis)
---mobile phase:
The sodium acetate trihydrate of A=1.36g+100 μ l triethylamines → 500ml standardize solution → pH 7.2 (regulating) → THF 1.5ml with acetic acid
The sodium acetate trihydrate of B=1.36g/100ml H
2O → pH 7.2+ methanol 200ml+ACN200ml
---flow velocity: 0.5ml/ minute
---inject: for the injecting program of online derivatization (online derivatization*)
---detector: 338nm
---gradient: at sequence of threads *
2) reagent is prepared
---aminoacid titer: each 10mg/100ml H of reagent such as aspartic acid, glutamic acid, proline, glycine, alanine, valine
2O
---OPA reagent: by the reagent of Hewlett-Packard Corporation's preparation supply, 6 months shelf-lifves, peace doleiform attitude
---borate buffer: 100ml Dan Wei Gong Give, institute is essential to the aminoacid color development
Table 1
From above-mentioned table 1 as can be seen, utilize the amino acid whose content of the Sirikaya seed extract (Comparative Examples 1) that common extracting method obtains to be assumed to be 100% when comparing, the Sirikaya seed extract of germination state (embodiment 1) and to utilize the total amino acids content of the Sirikaya seed extract (embodiment 2) of sub critical extraction method of the present invention preparation be 178%, the total amino acids content that particularly uses the seed of germination state to carry out the germination Sirikaya seed extract (embodiment 3) of sub critical extraction is 246%, clearly increases.
Therefore, can confirm the Sirikaya seed extract and the subcritical germination Sirikaya seed extract of the germination state that uses among the present invention, compare common Sirikaya seed extract in the past, contain more effective ingredient.
The preparation of reference example 1 dosage form example 1-3 and contrast dosage form example 1-2
By the composition of following table 2, the astringent of preparation dosage form example 1-3 and contrast dosage form example 1-2.
Table 2
The preparation method of dosage form example and contrast dosage form example
1) with water-phase component uniform mixing at room temperature.
2) with ethanol phase constituent heating (50-55 ℃), the dissolving mix homogeneously.
3) with above-mentioned 1) under agitation add above-mentioned 2 to), uniform dissolution is mixed.
Test example 2 skin elasticitys are improved effect
In order testing the elasticity of human body skin to be improved effect, to utilize above-mentioned dosage form example 1-3 and contrast dosage form example 1-2, carry out following test.100 of the women in 30-40 year are divided into 5 groups, every group 20, respectively in the morning, continue 4 weeks to be coated on the face twice of every day in the evening after, utilize skin elasticity determinator (Cutometer SEM 575, C+K Electronic Co., Germany), measure skin elasticity and improve effect, its result is shown in following table 3.The end value of table 3 is represented the character of the skin viscoelasticity (viscoelasticity) of skin elasticity determinator.
Table 3
| Substances | The skin elasticity effect |
| Dosage form example 1 | 0.48±0.10 |
| Dosage form example 2 | 0.47±0.10 |
| Dosage form example 3 | 0.53±0.10 |
| Contrast dosage form example 1 | 0.29±0.09 |
| Contrast dosage form example 2 | 0.20±0.09 |
Shown in above-mentioned table 3, contain the situation of the contrast dosage form example 1 of common Sirikaya seed extract, compare the contrast dosage form example 2 that does not contain Sirikaya seed extract, demonstrate 150% skin elasticity reinforced effects; And contain germination Sirikaya seed extract dosage form example 1 and contain the situation of the dosage form example 2 of subcritical Sirikaya seed extract, compare than dosage form example 2, show and be approximately 250% skin elasticity reinforced effects, compare than dosage form example 1, show to be approximately 165% skin elasticity reinforced effects; The situation that contains the dosage form example 3 of subcritical germination Sirikaya seed extract compares than dosage form example 2, shows to be approximately 265% skin elasticity reinforced effects, confirms to have best effect.
Test example 3 collagen protein synthesis facilitation effects
The human body fibroblast after cultivating on the 24 hole plating mediums, is replaced with the culture medium that contains the Sirikaya seed extract of common Sirikaya seed extract and germination by the concentration of table 4.When cultivating the 3rd day, add the DMEM culture medium that contains 10% hyclone to each hole, 0.5ml is added in every hole, then adds L[2, and 3,4,5-3H]-proline 10 μ Ci.After 24 hours, scrape the culture medium and the cell harvesting in each hole, join the trichloroacetic acid (TCA of 5 weight %; Trichloroacetic acid) in the solution after the washing, assigns to 2 in vitro, add the type i collagen albumen of 1unit/ μ l in one of them test tube, cultivated 90 minutes at 37 ℃; Another test tube is 4 ℃ of keepings.Then, these two test tubes are all added 50% trichloroacetic acid of 0.05ml, placed 20 minutes at 4 ℃.Then, centrifugalize 10 minutes under 12000rpm respectively, separately upper strata liquid and precipitate are passed through liquid scintillation counter (LSC), obtain count per minute value (CPM:Count per Minute), utilize following mathematical expression 1, obtain the biosynthesis value (RCB) of the relative collagenic protein of matched group and experimental group, it the results are shown in following table 4.
Mathematical expression 1
Table 4
Shown in the result of above-mentioned table 4, contain the situation of common Sirikaya seed extract, compare the matched group that does not contain Sirikaya seed extract, demonstrate and be approximately 118% relative collagen protein biosynthesis value; And contain the Sirikaya seed extract of germination and contain the situation of subcritical Sirikaya seed extract, compare matched group, demonstrate and be approximately 138% relative collagen protein biosynthesis value; Contain the situation of subcritical germination Sirikaya seed extract, compare matched group, demonstrate 153% relative collagen protein biosynthesis value.
Test example 4 lifts the performance evaluation of effect
50 with worry cutis laxa among the women in 25-30 year are divided into 5 groups, every group 10, time around using respectively, use the astringent of above-mentioned dosage form example 1-3 and contrast dosage form example 1-2 with using method with common cosmetic water, according to the suggestion of user, skin is lifted effect judge with following evaluation criterion.It the results are shown in following table 5.
Evaluation criterion
+++: is very good improves effect;
++: significantly improve effect;
+: some improves effect;
±: do not improve effect, but do not worsen;
-: do not improve effect, and worsen.
Table 5
Shown in the result of above-mentioned table 5, compare the contrast dosage form example 2 that does not contain Sirikaya seed extract and contain the contrast dosage form example 1 of common Sirikaya seed extract, contain the dosage form example 1 of Sirikaya seed extract of germination and the dosage form example that contains the dosage form example 2 of subcritical Sirikaya seed extract and contain subcritical germination Sirikaya seed extract and can confirm to have the rapid and good effect that lifts.
Claims (7)
1. Dermatologic preparation composition is characterized in that, said composition contains the Sirikaya seed extract of germination as effective ingredient.
2. Dermatologic preparation composition is characterized in that, said composition contain utilize sub critical extraction method preparation Sirikaya seed extract as effective ingredient.
3. Dermatologic preparation composition according to claim 2, wherein, described Sirikaya seed is the Sirikaya seed that germinates.
4. Dermatologic preparation composition according to claim 1 and 2, wherein, the total amount of relative compositions, the content of described extract is 0.01-95 weight %.
5. Dermatologic preparation composition according to claim 1 and 2, wherein, described compositions is the aging resistance Dermatologic preparation composition.
6. Dermatologic preparation composition according to claim 1 and 2, wherein, described compositions is a skin elasticity enhancing Dermatologic preparation composition.
7. Dermatologic preparation composition according to claim 1 and 2, wherein, described compositions is a collagen protein biosynthesis enhancing Dermatologic preparation composition.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2012-0009325 | 2012-01-31 | ||
| KR1020120009325A KR101871927B1 (en) | 2012-01-31 | 2012-01-31 | Skin external composition containing sugar apple seed extract |
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| CN103222938A true CN103222938A (en) | 2013-07-31 |
| CN103222938B CN103222938B (en) | 2017-08-11 |
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| CN201210121557.1A Active CN103222938B (en) | 2012-01-31 | 2012-04-23 | Dermatologic preparation composition containing sugar apple seed extract |
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| CN (1) | CN103222938B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815001A (en) * | 2015-04-15 | 2015-08-05 | 烟台新时代健康产业有限公司 | Extraction and purification method for acquiring anti-tumor active ingredient substances from linseed oil |
| CN107951770A (en) * | 2017-12-06 | 2018-04-24 | 绿馨颜（惠州）生物科技有限公司 | It is a kind of to remove wrinkle eye cream and preparation method thereof immediately |
| CN108542841A (en) * | 2018-04-25 | 2018-09-18 | 佛山市芊茹化妆品有限公司 | A kind of shampoo for pets of submissive lightening hair |
| CN114042008A (en) * | 2021-11-26 | 2022-02-15 | 杭州配方师科技有限公司 | Essence containing cyclopeptide fatty acid compound and preparation method thereof |
| CN114515261A (en) * | 2022-01-11 | 2022-05-20 | 仲恺农业工程学院 | Conditioning essence for men and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2895906A1 (en) * | 2006-01-06 | 2007-07-13 | Limousine D Applic Biolog Dite | Use of an active ingredient obtained from Annona squamosa for a cosmetic composition e.g. to fight against cutaneous aging, appearance of wrinkles and to improve the biomechanical properties of the skin |
| CN102317307A (en) * | 2009-02-16 | 2012-01-11 | 利普泰股份公司 | Peptides used in the treatment and/or care of the skin, mucous membranes and/or scalp and their use in cosmetic or pharmaceutical compositions |
-
2012
- 2012-01-31 KR KR1020120009325A patent/KR101871927B1/en active IP Right Grant
- 2012-04-23 CN CN201210121557.1A patent/CN103222938B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2895906A1 (en) * | 2006-01-06 | 2007-07-13 | Limousine D Applic Biolog Dite | Use of an active ingredient obtained from Annona squamosa for a cosmetic composition e.g. to fight against cutaneous aging, appearance of wrinkles and to improve the biomechanical properties of the skin |
| CN102317307A (en) * | 2009-02-16 | 2012-01-11 | 利普泰股份公司 | Peptides used in the treatment and/or care of the skin, mucous membranes and/or scalp and their use in cosmetic or pharmaceutical compositions |
Non-Patent Citations (2)
| Title |
|---|
| （加）石（SHI, J.）主编、魏新林等译: "《功能性食品活性成分与加工技术》", 31 August 2010, 中国轻工业出版社 * |
| 辽宁省朝阳地区农业学校: "《植物生活（初级本）》", 31 July 1984, 农业出版社 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815001A (en) * | 2015-04-15 | 2015-08-05 | 烟台新时代健康产业有限公司 | Extraction and purification method for acquiring anti-tumor active ingredient substances from linseed oil |
| CN104815001B (en) * | 2015-04-15 | 2018-12-25 | 烟台新时代健康产业有限公司 | A kind of method for extraction and purification obtaining anti-tumor active ingredient substance from linseed oil |
| CN107951770A (en) * | 2017-12-06 | 2018-04-24 | 绿馨颜（惠州）生物科技有限公司 | It is a kind of to remove wrinkle eye cream and preparation method thereof immediately |
| CN107951770B (en) * | 2017-12-06 | 2020-11-10 | 绿馨颜（惠州）生物科技有限公司 | Instant wrinkle-removing eye cream and preparation method thereof |
| CN108542841A (en) * | 2018-04-25 | 2018-09-18 | 佛山市芊茹化妆品有限公司 | A kind of shampoo for pets of submissive lightening hair |
| CN114042008A (en) * | 2021-11-26 | 2022-02-15 | 杭州配方师科技有限公司 | Essence containing cyclopeptide fatty acid compound and preparation method thereof |
| CN114515261A (en) * | 2022-01-11 | 2022-05-20 | 仲恺农业工程学院 | Conditioning essence for men and preparation method thereof |
| CN114515261B (en) * | 2022-01-11 | 2023-05-05 | 仲恺农业工程学院 | Male conditioning essence and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| KR101871927B1 (en) | 2018-07-02 |
| CN103222938B (en) | 2017-08-11 |
| KR20130088225A (en) | 2013-08-08 |
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