CN103222938B - Dermatologic preparation composition containing sugar apple seed extract - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The present invention relates to the Dermatologic preparation composition containing sugar apple seed extract, specifically, the extract prepared from the sugar apple seed of germination, or the sugar apple seed extract prepared using sub-sigmaritical extraction method, compared with conventional common sugar apple seed extract, sugar apple seed extract containing more cyclic peptide and various amino acid can be provided, by using these extracts, the Dermatologic preparation composition of more efficient energy is played.
Description
Technical field
The present invention relates to the Dermatologic preparation composition containing sugar apple seed extract, specifically, it is related to from germination
The extract for preparing of sugar apple seed, or the sugar apple seed extract prepared using sub-sigmaritical extraction method is and conventional
Common sugar apple seed extract is compared, it is possible to provide the sugar apple seed containing further amounts of cyclic peptide and various amino acid is extracted
Thing, by using these extracts, plays the Dermatologic preparation composition of more efficient energy.
Background technology
With aging, containing for the collagen of skin component, elastin laminin, hyaluronic acid and glycoprotein is used as
Amount and arrangement are changed or reduced, and produce oxidative stress by free radical and the harmful oxygen of activity.In addition, entering with aging
Row or ultraviolet influence, the most cells for constituting skin will reinforced epoxy synthase -2 (Cox-2, Cyclooxygenase)
Biosynthesis, the enzyme produces the proinflammatory cytokine for being known to cause inflammation.By these inflammatory factors, conduct will be strengthened
The biosynthesis of the matrix metalloproteinase (MMP, Matrix metalloproteinase) of skin histology catabolic enzyme, enhancing is logical
Cross iNOS (inducible nitric oxide synthase, nitric oxide synthase type) NO (nitrogen oxides) life
Into.It is, intrinsic aging with what is carried out naturally, cytoactive will be reduced, and due to the matrix thing of fine inflammation
The synthesis of matter will be reduced, and various hostile environments produce stress increase and sunray caused by reactive oxygen species
The external causes such as increase can cause decomposition and denaturation to accelerate, and dermal matrix will be destroyed and thinning, cause the various symptoms of skin aging.
Therefore, carry out much preventing and improving the research of the active component of aging phenomenon at present.
Prior art literature
Patent document：KR published patent the 2011-0125247th
The content of the invention
It was found by the inventors of the present invention that in natural extract, the extract of sugar apple seed has excellent anti-aging
Effect, the extract of the sugar apple seed particularly germinateed contains the compositions such as more amino acid than common sugar apple seed,
And more and further amounts of active ingredient is can extract during using sub-sigmaritical extraction method, using the teaching of the invention it is possible to provide better is anti-ageing
Change effect, thus complete the present invention.
Contain kind litchi with a variety of skin improvement effects for including antiageing effect it is therefore an object of the present invention to provide
The Dermatologic preparation composition of branch seed extract.
To reach above-mentioned purpose, the present invention provides the skin for containing the sugar apple seed extract of germination as active ingredient
Skin preparation composition for external use.
Contained in addition, the present invention is provided by the use of sugar apple seed extract prepared by sub-sigmaritical extraction method as active ingredient
Dermatologic preparation composition.
Moreover, the present invention provides kind litchi prepared by the sugar apple seed extract of germination or using sub-sigmaritical extraction method
Branch seed extract anti-aging uses Dermatologic preparation composition as what active ingredient contained.
The composition of the present invention is prepared by using the sugar apple seed extract of germination or using sub-sigmaritical extraction method
Sugar apple seed extract, compared with the sugar apple seed extract that conventional traditional extraction method is extracted, containing further amounts of
Aminoacid ingredient, it is possible to provide more outstanding collagen synthesis effect and Geng Gao antiageing effect.
Embodiment
The Dermatologic preparation composition of the present invention contains sugar apple seed extract as active ingredient.
The sugar apple seed used in the present invention is the seed of custardapple tree, and the scientific name of manaca is Anona
Cherimolia, Anona Squamosa, Anona Reticulata, Anona Muricata etc..
The fruit of manaca is the small block-shaped of the 2-4 inch sizes with soft cream-colored pulp, as custard
Sweet tea, it is refrigerant as peppermint, there is the black seed of 1 centimetre of size in fruit.
The seed of manaca contains 8 kinds of cyclic peptide, with raising skin elasticity and lifting (lifting) effect, and effectively
Suppress inflammation and induce cell factor, so having been used as treating the material of a variety of folkd therapies of skin disease or hickie etc..
The sugar apple seed extract used in the present invention is extracted from the seed of custardapple tree, is preferably germinateed
Extracted in sugar apple seed.The sugar apple seed of germination state is compared with before germination, containing more required to biological phenomena
Active ingredient, therefore stronger effect can be provided.
The germination condition of sugar apple seed is not particularly limited, and following methods germination can be used.In 21-27 DEG C of temperature strip
In the water of part, kept for 5-8 hours in this state.In seed soaking water, under 25-30 DEG C of temperature conditionss, by illumination condition and
Dark condition is implemented to be germinateed repeatedly.Now, illumination condition is implemented 16-18 hours, and dark condition is implemented 5-7 hours, culture
Continue 5-7 days.
In addition, the composition of the present invention will utilize sub-sigmaritical extraction method (Subcritical Water Extraction) system
Standby sugar apple seed extract contains as active ingredient.Now, the manaca kind before germination can be used in sugar apple seed
Son, can also use the sugar apple seed germinateed.
In the super critical extraction used in the past, the density of supercritical fluid is similar with liquid, viscosity and diffusion coefficient with
Gas is similar.Therefore, using supercritical fluid as Extraction solvent in use, in the fine pores for being easy to penetrate into plant,
Appropriate molecular density is obtained, is extracted after the molecule of material needed for surrounding, the extract of material needed for obtaining in this way.This
When, it can be made into the material that supercriticality uses as Extraction solvent and first have to meet non-toxic, and because supercritical state
State is high temp/high pressure, so can not have explosion hazard, and is needed as Extraction solvent with good solvability.Only
Above-mentioned condition is met, any material can be made supercritical fluid and be extracted.
On the other hand, the subcritical technology used in the present invention is to be used as solvent in the state of no more than critical point
Extraction solvent, so according to which kind of solvent selected, obtaining and means of supercritical extraction identical effect.Used in the present invention as solvent
Water.In addition, supercritical carbon dioxide can not extract polar substances, so needing as secondary solvent to make organic solvent together
With, but subcritical water has extraordinary extraction performance, and the excursion of operating condition is wide, can implement apolar substance
And the extraction of polar substances.Moreover, when being extracted using subcritical water, reaction can also be hydrolyzed.
The sugar apple seed extract of the utilization sub-sigmaritical extraction method used in the present invention is specifically to prepare in the following manner.
By sugar apple seed using sub-critical extraction device in 50-200MPa, preferably under 100MPa high pressure, manaca kind is decomposed
Son, effective component extracting.When pressure is less than 50MPa, it is impossible to abundant effective component extracting, and pressure is when being more than 200MPa, relatively
High pressure, extracts active ingredients amount is simultaneously little, so being extracted under the pressure of above range.After extraction, with 1.2 μm of holes
Filter once, filtered once in the filter with 0.45 μm of hole, in the filtering with 0.2 μm of hole in the filter of gap
Filtered in device once, remove foreign matter and microorganism, obtain subcritical sugar apple seed extract.
In the composition of the present invention, the total amount of relative combination can the manaca containing 0.01-95.0 weight % germination
The extract of seed or the subcritical sugar apple seed extract prepared by the above method, preferably comprise 5.0-95.0 weights
Measure %, more preferably 10.0-90.0 weight %.When the content of extract is less than 0.01 weight %, it is impossible to obtain composition to skin
Effect, and during more than 95.0 weight %, it is impossible to further improve effect, reduce its raw material efficiency.
The composition of the present invention strengthens the synthesis of collagen, is thus improved skin elasticity, improves the good of wrinkle
Antiageing effect.
In addition, the composition of the present invention is except the antiageing effect of skin, helps to improve the integrality of skin, can carry
For excellent oxidation resistance, it is possible to provide skin whitening effects, skin moisture-keeping ability improvement, antiphlogistic effects, acne and mistake
The improvement of the skin problems such as quick property dermatitis, sebum regulating effects, pore contractive effect, cutin improvement, skin-tightening
Or regulating effect, the complexion improvement improved by blood circulation, skin irritatin alleviation effects, dynamic equilibrium improve effect etc. comprehensively
Skin condition overall improvement.
The composition of the present invention can carry out formulation containing the medium allowed on cosmeceutical or dermatology or basic reagent
Change.Local all formulations can be applied to, are disperseed for example, solution, gel, solid, anhydrous paste, oil phase can be provided as
In the emulsion of aqueous phase, suspension, microemulsion, microcapsules, subparticle ball or ionic (liposome) and non-ionic small
Capsule dispersantForm, Huo Zheshuan, toner, emulsion, powder, ointment, spraying and hide flaw rod state.Separately
Outside, the form of spraying (airosol) composition of foam form or the propellant further containing compression can also be provided.
These compositions can be prepared according to the usual method of this area.
In addition, the composition of the present invention can contain fatty material, organic solvent, lytic agent, concentrating agents, gel, softening
Agent, antioxidant, suspending agent, stabilizer, foaming agent (foaming agent), aromatic, surfactant, water, ionic or
It is nonionic emulsifier, filler, metal ion disintegrant, chelating agent, preservative agent, vitamin, blocking agent, wetting agent, required
The cosmetic for any other compositions commonly used in oil, dyestuff, pigment, hydrophily or lipophile activating agent, lipid vesicle and cosmetics
Usually used adjuvant in conduct and learning or dermatology.The content of above-mentioned adjuvant is logical in cosmeceutical or dermatology
The amount often used.
In addition, the composition of the present invention contains skin absorption enhancement material to increase antiageing effect.
Below by test example and formulation example, the composition and effect of the present invention is further illustrated.These test examples and formulation
Example is intended merely to help the understanding of the present invention, and scope of the invention and scope are not limited to this.
The preparation of the common germination sugar apple seed extract of embodiment 1
The sugar apple seed of the state of germination is put into the solvent of 70 weight % Purified Waters and 30 weight % ethanol, at 25 DEG C
It is lower to place 6 hours, extract active component.After extraction, filtered in the filter with 3 μm of holes once, with 1 μm of hole
Filter in filter once, eliminate foreign matter, finally using sterilizing filter, eliminate microorganism, obtain common manaca kind
Seed extract.
The preparation of the subcritical sugar apple seed extract of embodiment 2
By the sugar apple seed for state of not germinateing utilize sub-critical extraction device, under 100MPa high pressure extract effectively into
Point.After extraction, filtered in the filter with 1.2 μm of holes once, one is filtered in the filter with 0.45 μm of hole
It is secondary, filtered in the filter with 0.2 μm of hole once, eliminate foreign matter and microorganism, obtain subcritical sugar apple seed and carry
Take thing.
The preparation of the subcritical germination sugar apple seed extract of embodiment 3
By germinate state sugar apple seed utilize sub-critical extraction device, under 100MPa high pressure extract effectively into
Point.After extraction, filtered in the filter with 1.2 μm of holes once, one is filtered in the filter with 0.45 μm of hole
It is secondary, filtered in the filter with 0.2 μm of hole once, eliminate foreign matter and microorganism, obtain subcritical sugar apple seed and carry
Take thing.
The preparation of the common sugar apple seed extract of comparative example 1
In the solvent that the sugar apple seed for state of not germinateing is put into 70% Purified Water and 30% ethanol, placed at 25 DEG C
6 hours, extract active component.After extraction, filtered in the filter with 3 μm of holes once, in the filtering with 1 μm of hole
Filtered in device once, eliminate foreign matter, finally using sterilizing filter, eliminate microorganism, obtained common sugar apple seed and extract
Thing.
Test example 1 is according to the comparison of the extracting method of sugar apple seed extract and the active constituent content for state of germinateing
Using following amino acid analysis method (OPA methods), to above-described embodiment 1-3 and the manaca of comparative example 1
Seed extract, analyzes the content of each amino acid.Its result is as shown in table 1.
Amino acid analysis method (OPA methods)
1) HPLC conditions
--- post：Zorbax posts (are exclusively used in amino acid analysis)
--- mobile phase：
The A=1.36g μ of sodium acetate trihydrate+100 l triethylamines → 500ml constant volumes → pH 7.2 (being adjusted with acetic acid) →
THF 1.5ml
B=1.36g sodium acetate trihydrate/100ml H2O → pH 7.2+ methanol 200ml+ACN200ml
--- flow velocity：0.5ml/ minutes
--- injection：For On-chip derivatization (online derivatization*) injecting program
--- detector：338nm
--- gradient：In sequence of threads *
2) reagent prepares
--- amino standard acid solution：The reagents such as asparatate, glutamic acid, proline, glycine, alanine, valine are each
10mg/100ml H2O
--- OPA reagents：The reagent of supply, 6 months shelf-lifves, ampulla form are prepared by Hewlett-Packard Corporation
--- borate buffer：The mono- Wei Gong Give of 100ml, to amino acid color development, institute is required
Table 1
As can be seen from the above Table 1, the ammonia of the sugar apple seed extract (comparative example 1) obtained using common extracting method
When the content of base acid is assumed to be 100% and contrasted, the sugar apple seed extract (embodiment 1) for state of germinateing and this hair is utilized
The total amino acid content of sugar apple seed extract (embodiment 2) prepared by bright sub-critical extraction method is 178%, particularly
The total amino acid content of the germination sugar apple seed extract (embodiment 3) of sub-critical extraction is carried out using the seed of germination state
For 246%, it is evident that increase.
It therefore, it can to confirm the sugar apple seed extract of germination state that is used in the present invention and subcritical germination kind
Litchi chinensis Seeds extract, compared to conventional common sugar apple seed extract, contains more active ingredients.
The formulation of reference example 1 example 1-3 and contrast formulation example 1-2 preparation
By the composition of table 2 below, formulation example 1-3 and contrast formulation example 1-2 toner are prepared.
Table 2
The preparation method of formulation example and contrast formulation example
1) water-phase component is uniformly mixed at room temperature.
2) ethanol phase constituent is heated into (50-55 DEG C), dissolving is well mixed.
3) by it is above-mentioned 1) be added under agitation it is above-mentioned 2), uniform dissolution mixing.
The skin elasticity improvement of test example 2
In order to test the elastic improvement to human body skin, using above-mentioned formulation example 1-3 and contrast formulation example 1-2, enter
The following experiment of row.The women 100 of 30-40 Sui is divided into 5 groups, every group 20, respectively in the morning, evening continue 4 twice daily
After week is coated on the face, using skin elasticity analyzer (Cutometer SEM 575, C+K Electronic Co.,
Germany), skin elasticity improvement is determined, its result is as described in Table 3.The end value of table 3 represents that skin elasticity is determined
The property of the skin viscoplasticity (viscoelasticity) of device.
Table 3
| Substances | Skin elasticity effect |
| Formulation example 1 | 0.48±0.10 |
| Formulation example 2 | 0.47±0.10 |
| Formulation example 3 | 0.53±0.10 |
| Contrast formulation example 1 | 0.29±0.09 |
| Contrast formulation example 2 | 0.20±0.09 |
As shown in Table 3 above, the situation of the contrast formulation example 1 containing common sugar apple seed extract, compared to not containing
There is the contrast formulation example 2 of sugar apple seed extract, show 150% skin elasticity enhancing effect；And contain kind of germination
The situation of the formulation example 1 of Litchi chinensis Seeds extract and the formulation example 2 containing subcritical sugar apple seed extract, compared to contrast medium
Type example 2, display is about 250% skin elasticity enhancing effect, compared to contrast formulation example 1, and display is about 165% skin
Elastic enhancing effect；The situation of formulation example 3 containing subcritical germination sugar apple seed extract, compared to contrast formulation example 2, shows
Show about 265% skin elasticity enhancing effect, confirm have best effect.
The collagen synthesis facilitation effect of test example 3
After human body fibroblast is cultivated on 24 hole plate culture mediums, replace with and contain common kind by the concentration of table 4
The culture medium of Litchi chinensis Seeds extract and the sugar apple seed extract of germination.When cultivating the 3rd day, 10% tire ox will be contained
The DMEM culture mediums of serum are added to each hole, and 0.5ml is added per hole, then add L [2,3,4,5-3H]-μ Ci of proline 10.Through
Cross after 24 hours, the culture medium and cell for scraping each hole are collected, and are added to 5 weight % trichloroacetic acid (TCA；
Trichloroacetic acid) wash in solution after, assign in 2 test tubes, 1unit/ μ l I added in one of test tube
Collagen type, is cultivated 90 minutes at 37 DEG C；Another test tube is in 4 DEG C of keepings.Then, 0.05ml is added to the two test tubes
50% trichloroacetic acid, 4 DEG C place 20 minutes.Then, centrifuged 10 minutes under 12000rpm respectively, on respective
Layer liquid and sediment obtain count per minute value (CPM by liquid scintillation counter (LSC)：Count per Minute), profit
With following mathematical expressions 1, the biosynthesis value (RCB) of control group and the relative collagenic protein of experimental group is obtained, the results are shown in
Table 4 below.
Mathematical expression 1
Table 4
As shown in the result of above-mentioned table 4, the situation containing common sugar apple seed extract, compared to not containing manaca
The control group of seed extract, show about 118% relative collagen biosynthesis value；And contain kind litchi of germination
Branch seed extract and the situation containing subcritical sugar apple seed extract, compared to control group, show about 138%
With respect to collagen biosynthesis value；Situation containing subcritical germination sugar apple seed extract, compared to control group, shows
153% relative collagen biosynthesis value.
Test example 4 lifts the performance evaluation of effect
It is divided into 5 groups by 50 that cutis laxa is worried in the women of 25-30 Sui, every group 10, four time-of-weeks is used respectively, with
Common cosmetic aqueous phase is with toner of the application method using above-mentioned formulation example 1-3 and contrast formulation example 1-2, according to the meaning of user
See, skin lifting effect is judged with following evaluation criterion.The results are shown in table 5 below.
Evaluation criterion
+++：Very good improvement；
++：Obvious improvement；
+：Some improvements；
±：There is no improvement, but do not deteriorate；
-：There is no improvement, and deteriorate.
Table 5
As shown in the result of above-mentioned table 5, compared to the contrast formulation example 2 not containing sugar apple seed extract and containing general
The contrast formulation example 1 of logical sugar apple seed extract, the formulation example 1 of the sugar apple seed extract containing germination and faces containing Asia
The formulation example 2 of boundary's sugar apple seed extract and containing it is subcritical germination sugar apple seed extract formulation example can confirm tool
There is rapid and good lifting effect.
Claims (6)
1. Dermatologic preparation composition, it is characterised in that said composition contains the sugar apple seed extract of germination as effective
Composition,
Wherein, the extract is extracted using the mixed solvent of 70 weight % Purified Waters and 30 weight % ethanol.
2. Dermatologic preparation composition, it is characterised in that said composition contains the manaca kind prepared using sub-sigmaritical extraction method
Seed extract as active ingredient, wherein, sugar apple seed is the sugar apple seed of germination, and is existed by solvent of subcritical water
The extract is extracted under 50-200MPa pressure.
3. Dermatologic preparation composition according to claim 1 or 2, wherein, the total amount of relative combination, the extract
Content be 0.01-95 weight %.
4. Dermatologic preparation composition according to claim 1 or 2, wherein, the composition is anti-aging with outside skin
Use agent composition.
5. Dermatologic preparation composition according to claim 1 or 2, wherein, the composition is skin elasticity enhancing use
Dermatologic preparation composition.
6. Dermatologic preparation composition according to claim 1 or 2, wherein, the composition is collagen biology conjunction
Into enhancing Dermatologic preparation composition.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2012-0009325 | 2012-01-31 | ||
| KR1020120009325A KR101871927B1 (en) | 2012-01-31 | 2012-01-31 | Skin external composition containing sugar apple seed extract |
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| Publication Number | Publication Date |
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| CN103222938A CN103222938A (en) | 2013-07-31 |
| CN103222938B true CN103222938B (en) | 2017-08-11 |
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| CN104815001B (en) * | 2015-04-15 | 2018-12-25 | 烟台新时代健康产业有限公司 | A kind of method for extraction and purification obtaining anti-tumor active ingredient substance from linseed oil |
| CN107951770B (en) * | 2017-12-06 | 2020-11-10 | 绿馨颜（惠州）生物科技有限公司 | Instant wrinkle-removing eye cream and preparation method thereof |
| CN108542841A (en) * | 2018-04-25 | 2018-09-18 | 佛山市芊茹化妆品有限公司 | A kind of shampoo for pets of submissive lightening hair |
| CN114042008A (en) * | 2021-11-26 | 2022-02-15 | 杭州配方师科技有限公司 | Essence containing cyclopeptide fatty acid compound and preparation method thereof |
| CN114515261B (en) * | 2022-01-11 | 2023-05-05 | 仲恺农业工程学院 | Male conditioning essence and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2895906A1 (en) * | 2006-01-06 | 2007-07-13 | Limousine D Applic Biolog Dite | Use of an active ingredient obtained from Annona squamosa for a cosmetic composition e.g. to fight against cutaneous aging, appearance of wrinkles and to improve the biomechanical properties of the skin |
| CN102317307A (en) * | 2009-02-16 | 2012-01-11 | 利普泰股份公司 | Peptides used in the treatment and/or care of the skin, mucous membranes and/or scalp and their use in cosmetic or pharmaceutical compositions |
-
2012
- 2012-01-31 KR KR1020120009325A patent/KR101871927B1/en active IP Right Grant
- 2012-04-23 CN CN201210121557.1A patent/CN103222938B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2895906A1 (en) * | 2006-01-06 | 2007-07-13 | Limousine D Applic Biolog Dite | Use of an active ingredient obtained from Annona squamosa for a cosmetic composition e.g. to fight against cutaneous aging, appearance of wrinkles and to improve the biomechanical properties of the skin |
| CN102317307A (en) * | 2009-02-16 | 2012-01-11 | 利普泰股份公司 | Peptides used in the treatment and/or care of the skin, mucous membranes and/or scalp and their use in cosmetic or pharmaceutical compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| KR101871927B1 (en) | 2018-07-02 |
| CN103222938A (en) | 2013-07-31 |
| KR20130088225A (en) | 2013-08-08 |
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