CN103217364A - Diffusion pool for dynamically adjusting the effective volume - Google Patents
Diffusion pool for dynamically adjusting the effective volume Download PDFInfo
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- CN103217364A CN103217364A CN2013100712872A CN201310071287A CN103217364A CN 103217364 A CN103217364 A CN 103217364A CN 2013100712872 A CN2013100712872 A CN 2013100712872A CN 201310071287 A CN201310071287 A CN 201310071287A CN 103217364 A CN103217364 A CN 103217364A
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- dynamic adjustments
- support
- passage
- diffusion cell
- pond
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- 238000009792 diffusion process Methods 0.000 title claims abstract description 42
- 230000001105 regulatory effect Effects 0.000 claims description 21
- 239000007769 metal material Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 abstract description 10
- 238000005070 sampling Methods 0.000 abstract description 10
- 239000013589 supplement Substances 0.000 abstract 1
- 238000002474 experimental method Methods 0.000 description 11
- 239000003814 drug Substances 0.000 description 6
- 239000012490 blank solution Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000012827 research and development Methods 0.000 description 3
- 230000003068 static effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
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Abstract
The invention provides a diffusion pool for dynamically adjusting the effective volume, which comprises a receiving pool, a dynamic adjusting channel, an adjusting piston and a fine adjustment apparatus. The receiving pool and the dynamic adjusting channel are communicated, and the end of the dynamic adjusting channel far from the receiving pool is connected to the fine adjustment apparatus, and the end of the adjusting piston is fixed to the fine adjustment apparatus, and the end of the adjusting piston is placed in the dynamic adjusting channel, and the fine adjustment apparatus can move the dynamic adjusting channel relative to the piston. The invention is based on a Franz diffusion pool receiving pool for increasing a dynamic adjusting apparatus, minimizing the influence of a supplement blank liquid to the receiving pool after sampling, thereby the concentration in the receiving pool is in a linear relation.
Description
Technical field
The present invention relates to a kind of device that the static saturating film diffusion research of medicine is used that is applied to.
Background technology
Chinese patent database (knowing half tone) discloses " a kind of transdermal diffusion test with instrument (application number: 00217044.2) ", " transdermal test in vitro diffusion experiment instrument (application number: 01207286.9) ", " no bubble diffusion cell (application number: 200920101193.4) ", " be used for diffusion sampling static diffusion cell (application number: 200480008609.8) ", " a kind of experimental provision of testing drug transdermal (application number: 200720079932.5) ", " pick-up unit that a kind of drug transdermal discharges (application number: 96228607.9) " six patents, wherein main device is a diffusion cell, it is a kind of device that the static research of medicine is used that is usually used in, its formation is by supply pool, accept the pond, water-bath device and sample tap constitute, and weak point is: accept pool volume at back its of experiment beginning and be in stationary state.In experimentation, repeatedly sampling if desired, sampling need to replenish blank solution, has reduced the concentration of accepting the pond, causes the rate of propagation instability, then causes in the pond bubble or accepts pond liquid and the sample attaching does not closely influence diffusion effect as not replenishing blank solution.And in process of production because of producing the diffusion cell error that precision problem causes.And late time data when handle to need calculating the accumulative total transit dose algorithm loaded down with trivial details, the problem that accuracy descends.
In view of this, for solving the deficiency in the above-mentioned technology, the inventor is based on the research and development of association area, and constantly test and improvement of process, and then generation of the present invention is arranged.
Summary of the invention
But the object of the present invention is to provide a kind of diffusion cell of dynamic adjustments useful volume, accept on the basis, pond, increase the dynamic adjustments device, the error of the reception tank volume that recoverable causes because of production run at the Franz diffusion cell.Reducing the sampling back, to replenish blank solution linear to accepting the influence of pond concentration, make to accept in the pond concentration.
For reaching above-mentioned purpose, but the invention provides a kind of diffusion cell of dynamic adjustments useful volume, it comprises: accept pond, dynamic adjustments passage, regulating piston and micromatic setting, the described pond of accepting is connected with described dynamic adjustments passage, described dynamic adjustments passage is connected with micromatic setting away from an end of accepting the pond, the head end of described regulating piston is fixed on the micromatic setting, the tail end of regulating piston places in the dynamic adjustments passage, and micromatic setting can move piston with respect to the dynamic adjustments passage.
But the diffusion cell of described dynamic adjustments useful volume, wherein, described micromatic setting has first support and second support, and described second support is fixed in the dynamic adjustments passage away from this end of accepting the pond, and the head end of described regulating piston is fixed on first support; The side that first support is relative with second support respectively is provided with a screw rod accordingly, and two screw rods all are threaded with an inner thread sleeve.
But the diffusion cell of described dynamic adjustments useful volume, wherein, the tail end external diameter of described regulating piston equates with the internal diameter of dynamic adjustments passage.
But the diffusion cell of described dynamic adjustments useful volume, wherein, second stent cover also is fixed with a sliding bar to a side of first support, and described sliding bar passes first support and can move with respect to first support.
But the diffusion cell of described dynamic adjustments useful volume wherein, also is provided with a locking device on described first support, and described locking device passes described first support and can be resisted against on the sliding bar, is used to lock sliding bar.
But the diffusion cell of described dynamic adjustments useful volume, wherein, the described dynamic adjustments passage outside is signable scale.
But the diffusion cell of described dynamic adjustments useful volume, wherein, described regulating piston is the frosted outer wall.
But the diffusion cell of described dynamic adjustments useful volume, wherein, described first support and second support select for use metal material to make.
The invention has the beneficial effects as follows: in experimentation, can change the volume of accepting the pond by regulating piston, before experiment, can accurately regulate diffusion cell concentration, make different batches diffusion cell accept pool volume height unanimity, and in experimentation dynamic adjustments, keep the height of liquid level, reduce the sampling back and replenish blank solution accepting the influence of pond concentration, make that to accept in the pond concentration linear, improve the experimental data precision, reduce experiment back data processing error, for the diffusion experiment in the research and development newtype drug process provides strong rigid condition.
Description of drawings
Fig. 1 is a structural representation of the present invention.
Description of reference numerals: 1-accepts the pond; 2-dynamic adjustments passage; The 3-regulating piston; The 4-micromatic setting; 41-first support; 42-second support; The 5-sliding bar; The 61-screw rod; The 62-inner thread sleeve; The 7-locking device; The 8-supply pool; The 9-liquid taking port.
Embodiment
About the present invention is the application target that reaches above-mentioned and effect and the technological means that adopted, now enumerate preferable feasible embodiment, and shown in the conjunction with figs., details are as follows:
As shown in Figure 1, but the diffusion cell of dynamic adjustments useful volume of the present invention mainly comprise: accept pond 1, dynamic adjustments passage 2, regulating piston 3, micromatic setting 4, sliding bar 5, tangent screw 6 and locking device 7.
With existing accept the pond identical be, the described inlet of accepting pond 1 is communicated with supply pool 8, the liquid taking port 9 of accepting pond 1 is communicated with the sampler (not shown), this is a prior art.
With existing accept the pond different be, the pond 1 of accepting of the present invention also is communicated with dynamic adjustments passage 2, described dynamic adjustments passage 2 is connected with micromatic setting 4 away from an end of accepting pond 1.Wherein, dynamic adjustments passage 2 is with to accept pond 1 junction hatch bore diameter bigger, regulates not influence that fluid exchange is as the criterion in the passage.
Particularly, described micromatic setting 4 has first support 41 and second support 42, and described second support 42 is fixed in dynamic adjustments passage 2 away from an end of accepting pond 1.The head end of described regulating piston 3 is fixed on first support 41, and the tail end of regulating piston 3 places in the dynamic adjustments passage 2, and the tail end external diameter of regulating piston 3 equates with the internal diameter of dynamic adjustments passage 2.The signable scale in described dynamic adjustments passage 2 outsides.Described regulating piston 3 can be the frosted outer wall, guarantees sealing (with reference to glass syringe).
First support 41 respectively is provided with 61, two screw rods 61 of a screw rod accordingly with second support, 42 relative sides and all is threaded with an inner thread sleeve 62, by rotation inner thread sleeve 62, can finely tune the distance between first support 41 and second support 42.
In addition, second support 42 also is fixed with a sliding bar 5 in the face of a side of first support 41, and described sliding bar 5 passes first support 41 and can move with respect to first support 41, keeps when regulating and stablizes, and also play the guiding role.
Also be provided with described locking device 7 on described first support 41, described locking device 7 is provided with screw thread, it is threaded with first support 41 and can be resisted against on the sliding bar 5, is used for sliding bar 5 is locked in first support 41, perhaps removes the locking of the sliding bar 5 and first support 41.
Described first support 41 and second support 42 can select for use metal material to make.
The present invention accepts on the basis, pond at the Franz diffusion cell, increases the dynamic adjustments device.Can be before experiment according to the experiment needs to the original volume of accepting pond 1 and the position of determining regulating piston 3 at the number of times and the amount of sampling, adjustable volume is as the criterion greater than sample volume sum repeatedly.In experimentation, after the sampling, by opening locking device 7, and rotation inner thread sleeve 62, to accept pond 1 liquid level build-up to the preceding height of sampling, assurance is accepted pond 1 liquid level and is fully contacted (and existing diffusion cell is by compensating the maintenance that blank liquid carries out liquid level, but it has changed the concentration of accepting in the pond, has caused the change of accepting pond concentration) with sample.Therefore diffusion cell of the present invention can be proofreaied and correct the volume error of accepting pond 1 before experiment, and scalable is accepted the volume in pond 1 in experimentation.
Diffusion cell of the present invention can change the volume of accepting pond 1 by regulating piston 3 in experimentation, can accurately regulate diffusion cell concentration before experiment, make different batches diffusion cell accept pool volume height unanimity.And in experimentation dynamic adjustments, keep the height of liquid level, reduce the sampling back and replenish blank solution accepting the influence of pond concentration, make that to accept in the pond 1 concentration linear, improve the experimental data precision, reduce experiment back data processing error, for the diffusion experiment in the research and development newtype drug process provides strong rigid condition.
The above description of this invention is illustrative, and nonrestrictive, and those skilled in the art is understood, and can carry out many modifications, variation or equivalence to it within spirit that claim limits and scope, but they will fall within the scope of protection of the present invention all.
Claims (8)
1. but the diffusion cell of a dynamic adjustments useful volume, it is characterized in that, comprise: accept pond, dynamic adjustments passage, regulating piston and micromatic setting, the described pond of accepting is connected with described dynamic adjustments passage, described dynamic adjustments passage is connected with micromatic setting away from an end of accepting the pond, the head end of described regulating piston is fixed on the micromatic setting, and the tail end of regulating piston places in the dynamic adjustments passage, and micromatic setting can move piston with respect to the dynamic adjustments passage.
2. but the diffusion cell of dynamic adjustments useful volume according to claim 1, it is characterized in that, described micromatic setting has first support and second support, described second support is fixed in the dynamic adjustments passage away from this end of accepting the pond, and the head end of described regulating piston is fixed on first support; The side that first support is relative with second support respectively is provided with a screw rod accordingly, and two screw rods all are threaded with an inner thread sleeve.
3. but the diffusion cell of dynamic adjustments useful volume according to claim 1 is characterized in that, the tail end external diameter of described regulating piston equates with the internal diameter of dynamic adjustments passage.
4. but according to the diffusion cell of each described dynamic adjustments useful volume in the claim 1 to 3, it is characterized in that, second stent cover also is fixed with a sliding bar to a side of first support, and described sliding bar passes first support and can move with respect to first support.
5. but the diffusion cell of dynamic adjustments useful volume according to claim 4 is characterized in that, also is provided with a locking device on described first support, and described locking device passes described first support and can be resisted against on the sliding bar, is used to lock sliding bar.
6. but according to the diffusion cell of each described dynamic adjustments useful volume in the claim 1 to 3, it is characterized in that the described dynamic adjustments passage outside indicates scale.
7. but according to the diffusion cell of each described dynamic adjustments useful volume in the claim 1 to 3, it is characterized in that described regulating piston is the frosted outer wall.
8. but according to the diffusion cell of each described dynamic adjustments useful volume in the claim 1 to 3, it is characterized in that described first support and second support select for use metal material to make.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310071287.2A CN103217364B (en) | 2013-03-06 | 2013-03-06 | Diffusion pool for dynamically adjusting the effective volume |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310071287.2A CN103217364B (en) | 2013-03-06 | 2013-03-06 | Diffusion pool for dynamically adjusting the effective volume |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103217364A true CN103217364A (en) | 2013-07-24 |
| CN103217364B CN103217364B (en) | 2015-05-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310071287.2A Active CN103217364B (en) | 2013-03-06 | 2013-03-06 | Diffusion pool for dynamically adjusting the effective volume |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104422634A (en) * | 2013-08-22 | 2015-03-18 | 中国科学院大连化学物理研究所 | Method for characterization of polyelectrolyte plate hydrogel or hydrogel film density |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5390539A (en) * | 1992-09-25 | 1995-02-21 | Modern Controls, Inc. | Device for measuring the permeability of a membrane to water vapor |
| CN201277221Y (en) * | 2008-10-28 | 2009-07-22 | 襄樊市长源东谷实业有限公司 | Hydraulic clamp spring type manual locking oil cylinder |
| CN201514365U (en) * | 2009-10-29 | 2010-06-23 | 艾丹 | Bubble-free diffusion cell |
| CN102777213A (en) * | 2011-05-11 | 2012-11-14 | 陈刚 | Air inlet and distribution device of engine and engine formed by same |
-
2013
- 2013-03-06 CN CN201310071287.2A patent/CN103217364B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5390539A (en) * | 1992-09-25 | 1995-02-21 | Modern Controls, Inc. | Device for measuring the permeability of a membrane to water vapor |
| CN201277221Y (en) * | 2008-10-28 | 2009-07-22 | 襄樊市长源东谷实业有限公司 | Hydraulic clamp spring type manual locking oil cylinder |
| CN201514365U (en) * | 2009-10-29 | 2010-06-23 | 艾丹 | Bubble-free diffusion cell |
| CN102777213A (en) * | 2011-05-11 | 2012-11-14 | 陈刚 | Air inlet and distribution device of engine and engine formed by same |
Non-Patent Citations (1)
| Title |
|---|
| 李志鸿等: "透皮给药研究中体外扩散池的改进", 《中国医药工业杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104422634A (en) * | 2013-08-22 | 2015-03-18 | 中国科学院大连化学物理研究所 | Method for characterization of polyelectrolyte plate hydrogel or hydrogel film density |
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| CN103217364B (en) | 2015-05-13 |
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