CN103217364B - Diffusion pool for dynamically adjusting the effective volume - Google Patents
Diffusion pool for dynamically adjusting the effective volume Download PDFInfo
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- CN103217364B CN103217364B CN201310071287.2A CN201310071287A CN103217364B CN 103217364 B CN103217364 B CN 103217364B CN 201310071287 A CN201310071287 A CN 201310071287A CN 103217364 B CN103217364 B CN 103217364B
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Abstract
The invention provides a diffusion pool for dynamically adjusting the effective volume, which comprises a receiving pool, a dynamic adjusting channel, an adjusting piston and a fine adjustment apparatus. The receiving pool and the dynamic adjusting channel are communicated, and the end of the dynamic adjusting channel far from the receiving pool is connected to the fine adjustment apparatus, and the end of the adjusting piston is fixed to the fine adjustment apparatus, and the end of the adjusting piston is placed in the dynamic adjusting channel, and the fine adjustment apparatus can move the dynamic adjusting channel relative to the piston. The invention is based on a Franz diffusion pool receiving pool for increasing a dynamic adjusting apparatus, minimizing the influence of a supplement blank liquid to the receiving pool after sampling, thereby the concentration in the receiving pool is in a linear relation.
Description
Technical field
The present invention relates to a kind of device being applied to the static permeable membrane diffusion research of medicine and using.
Background technology
Chinese patent database (knowing half tone) discloses " a kind of instrument for percutaneous dispersion test (application number: 00217044.2) ", " external osmotic deffusion experiment instrument (application number: 01207286.9) ", " bubble-free diffusion cell (application number: 200920101193.4) ", " for diffusion sampling static diffusion cell (application number: 200480008609.8) ", a kind of experimental provision of testing drug transdermal " (application number: 200720079932.5) ", the pick-up unit of the release of a kind of drug transdermal " (application number: 96228607.9) " six patents, wherein main device is diffusion cell, it is a kind of device being usually used in the research of medicine static state and using, its formation is by supply pool, acceptance pool, water bath device and sample tap are formed, weak point is: after experiment starts, its acceptance pool volume is in stationary state.In experimentation, if need repeatedly to sample, sampling needs supplementary blank solution, reduces the concentration of acceptance pool, causes rate of propagation unstable, then to cause in pond bubble or acceptance pool liquid and sample to attach closely not affect diffusion effect if do not supplemented blank solution.And in process of production because producing the diffusion cell error that precision problem causes.And algorithm is loaded down with trivial details during late time data process needs calculating accumulative transit dose, the problem that accuracy declines.
In view of this, for solving the deficiency in above-mentioned technology, the present inventor based on the research and development of association area, and tests and improvement through continuous, and then has generation of the present invention.
Summary of the invention
The object of the present invention is to provide a kind of dynamic to regulate the diffusion cell of useful volume, on Franz diffusion cell acceptance pool basis, increase dynamic adjustments device, the error of the reception tank volume that recoverable causes because of production run.Supplement blank solution after reducing sampling to the impact of acceptance pool concentration, make concentration in acceptance pool linear.
For reaching above-mentioned purpose, the invention provides the diffusion cell that a kind of dynamic regulates useful volume, it comprises: acceptance pool, dynamic adjustments passage, regulating piston and micromatic setting, described acceptance pool is connected with described dynamic adjustments passage, described dynamic adjustments passage is connected with micromatic setting away from one end of acceptance pool, the head end of described regulating piston is fixed on micromatic setting, the tail end of regulating piston is placed in dynamic adjustments passage, and micromatic setting enables piston move relative to dynamic adjustments passage.
Described dynamic regulates the diffusion cell of useful volume, wherein, described micromatic setting has the first support and the second support, and the second described support is fixed on dynamic adjustments passage this end away from acceptance pool, and the head end of described regulating piston is fixed on the first support; The side that first support is relative with the second support is respectively provided with a screw rod accordingly, and two screw rods are all threaded with an inner thread sleeve.
Described dynamic regulates the diffusion cell of useful volume, and wherein, the trailing end outer diameter of described regulating piston is equal with the internal diameter of dynamic adjustments passage.
Described dynamic regulates the diffusion cell of useful volume, and wherein, the second stent cover is also fixed with a sliding bar to the side of the first support, and described sliding bar also can relative to the first support-moving through the first support.
Described dynamic regulates the diffusion cell of useful volume, wherein, the first described support is also provided with a locking device, and described locking device also can be resisted against on sliding bar, for locking sliding bar through described first support.
Described dynamic regulates the diffusion cell of useful volume, and wherein, signable outside described dynamic adjustments passage have scale.
Described dynamic regulates the diffusion cell of useful volume, and wherein, described regulating piston is frosted outer wall.
Described dynamic regulates the diffusion cell of useful volume, and wherein, the first described support and the second support select metal material to make.
The invention has the beneficial effects as follows: the volume that can be changed acceptance pool by regulating piston in experimentation, on pretreatment can fine adjustment diffusion cell concentration, make the acceptance pool volume height of the diffusion cell of different batches consistent, and in experimentation dynamic adjustments, maintain the height of liquid level, blank solution is supplemented on the impact of acceptance pool concentration after reducing sampling, make concentration in acceptance pool linear, improve test data precision, reduce the rear data processing error of experiment, for the diffusion experiment in research and development newtype drug process provides strong rigid condition.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Description of reference numerals: 1-acceptance pool; 2-dynamic adjustments passage; 3-regulating piston; 4-micromatic setting; 41-second support; 42-first support; 5-sliding bar; 61-screw rod; 62-inner thread sleeve; 7-locking device; 8-supply pool; 9-liquid taking port.
Embodiment
Relevant the present invention is the technological means reaching above-mentioned application target and effect and adopt, and now enumerate better feasible embodiment, and coordinate shown in accompanying drawing, details are as follows:
As shown in Figure 1, dynamic of the present invention regulates the diffusion cell of useful volume mainly to comprise: acceptance pool 1, dynamic adjustments passage 2, regulating piston 3, micromatic setting 4, sliding bar 5, tangent screw 6 and locking device 7.
Identical with existing acceptance pool, the inlet of described acceptance pool 1 is communicated with supply pool 8, and the liquid taking port 9 of acceptance pool 1 is communicated with sampler (not shown), and this is prior art.
With existing acceptance pool unlike, acceptance pool 1 of the present invention is also communicated with dynamic adjustments passage 2, and described dynamic adjustments passage 2 is connected with micromatic setting 4 away from one end of acceptance pool 1.Wherein, dynamic adjustments passage 2 and acceptance pool 1 junction hatch bore diameter are comparatively large, regulate fluid exchange in passage to be as the criterion not affect.
Specifically, described micromatic setting 4 has the first support 42 and the second support 41, and the second described support 41 is fixed on dynamic adjustments passage 2 one end away from acceptance pool 1.The head end of described regulating piston 3 is fixed on the first support 42, and the tail end of regulating piston 3 is placed in dynamic adjustments passage 2, and the trailing end outer diameter of regulating piston 3 is equal with the internal diameter of dynamic adjustments passage 2.Signable scale outside described dynamic adjustments passage 2.Described regulating piston 3 can be frosted outer wall, ensures sealing (with reference to glass syringe).
The side that first support 42 is relative with the second support 41 is respectively provided with a screw rod 61, two screw rods 61 accordingly and is all threaded with an inner thread sleeve 62, by rotating female screw sleeve 62, can finely tune the distance between the first support 42 and the second support 41.
In addition, the second support 41 is also fixed with a sliding bar 5 in the face of the side of the first support 42, and described sliding bar 5 also can move relative to the first support 42 through the first support 42, remains stable when regulating, also play the guiding role.
The first described support 42 is also provided with described locking device 7, described locking device 7 is provided with screw thread, it is threaded with the first support 42 and can be resisted against on sliding bar 5, for sliding bar 5 is locked in the first support 42, or removes the locking of sliding bar 5 and the first support 41.
The first described support 42 and the second support 41 can select metal material to make.
The present invention is on Franz diffusion cell acceptance pool basis, increases dynamic adjustments device.Can experimentally need the volume to original acceptance pool 1 and the number of times for sampling and amount to determine the position of regulating piston 3 on pretreatment, adjustable volume is greater than repeatedly sample volume sum and is as the criterion.In experimentation, after sampling, by opening locking device 7, and rotating female screw sleeve 62, by height before acceptance pool 1 liquid level build-up to sampling, guarantee acceptance pool 1 liquid level fully contacts with sample (and existing diffusion cell carries out the maintenance of liquid level by compensating blank solution, but that it changes the concentration in acceptance pool, cause the change of acceptance pool concentration).Therefore diffusion cell of the present invention can correct the volume error of acceptance pool 1 on pretreatment, the volume of adjustable acceptance pool 1 in experimentation.
Diffusion cell of the present invention can change the volume of acceptance pool 1 in experimentation by regulating piston 3, on pretreatment can fine adjustment diffusion cell concentration, makes the acceptance pool volume height of the diffusion cell of different batches consistent.And in experimentation dynamic adjustments, maintain the height of liquid level, blank solution is supplemented on the impact of acceptance pool concentration after reducing sampling, make concentration in acceptance pool 1 linear, improve test data precision, reduce the rear data processing error of experiment, for the diffusion experiment in research and development newtype drug process provides strong rigid condition.
The above description of this invention is illustrative, and nonrestrictive, and those skilled in the art is understood, and can carry out many amendments, change or equivalence, but they all will fall within the scope of protection of the present invention within the spirit and scope of claim restriction to it.
Claims (7)
1. the diffusion cell of a dynamic adjustment useful volume, it is characterized in that, comprise: acceptance pool, dynamic adjustments passage, regulating piston and micromatic setting, described acceptance pool is connected with described dynamic adjustments passage, described dynamic adjustments passage is connected with micromatic setting away from one end of acceptance pool, described micromatic setting has the first support and the second support, the second described support is fixed on dynamic adjustments passage this end away from acceptance pool, and the head end of described regulating piston is fixed on the first support; The side that first support is relative with the second support is respectively provided with a screw rod accordingly, two screw rods are all threaded with an inner thread sleeve, the tail end of described regulating piston is placed in dynamic adjustments passage, and micromatic setting enables piston move relative to dynamic adjustments passage.
2. dynamic according to claim 1 regulates the diffusion cell of useful volume, and it is characterized in that, the trailing end outer diameter of described regulating piston is equal with the internal diameter of dynamic adjustments passage.
3. dynamic according to any one of claim 1 to 2 regulates the diffusion cell of useful volume, it is characterized in that, second stent cover is also fixed with a sliding bar to the side of the first support, and described sliding bar also can relative to the first support-moving through the first support.
4. dynamic according to claim 3 regulates the diffusion cell of useful volume, it is characterized in that, the first described support is also provided with a locking device, and described locking device also can be resisted against on sliding bar, for locking sliding bar through described first support.
5. dynamic according to any one of claim 1 to 2 regulates the diffusion cell of useful volume, it is characterized in that, is labeled with scale outside described dynamic adjustments passage.
6. dynamic according to any one of claim 1 to 2 regulates the diffusion cell of useful volume, and it is characterized in that, described regulating piston is frosted outer wall.
7. dynamic according to any one of claim 1 to 2 regulates the diffusion cell of useful volume, and it is characterized in that, the first described support and the second support select metal material to make.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310071287.2A CN103217364B (en) | 2013-03-06 | 2013-03-06 | Diffusion pool for dynamically adjusting the effective volume |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310071287.2A CN103217364B (en) | 2013-03-06 | 2013-03-06 | Diffusion pool for dynamically adjusting the effective volume |
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| CN103217364A CN103217364A (en) | 2013-07-24 |
| CN103217364B true CN103217364B (en) | 2015-05-13 |
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| CN104422634A (en) * | 2013-08-22 | 2015-03-18 | 中国科学院大连化学物理研究所 | Method for characterization of polyelectrolyte plate hydrogel or hydrogel film density |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5390539A (en) * | 1992-09-25 | 1995-02-21 | Modern Controls, Inc. | Device for measuring the permeability of a membrane to water vapor |
| CN201277221Y (en) * | 2008-10-28 | 2009-07-22 | 襄樊市长源东谷实业有限公司 | Hydraulic clamp spring type manual locking oil cylinder |
| CN201514365U (en) * | 2009-10-29 | 2010-06-23 | 艾丹 | Bubble-free diffusion cell |
| CN102777213A (en) * | 2011-05-11 | 2012-11-14 | 陈刚 | Air inlet and distribution device of engine and engine formed by same |
-
2013
- 2013-03-06 CN CN201310071287.2A patent/CN103217364B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5390539A (en) * | 1992-09-25 | 1995-02-21 | Modern Controls, Inc. | Device for measuring the permeability of a membrane to water vapor |
| CN201277221Y (en) * | 2008-10-28 | 2009-07-22 | 襄樊市长源东谷实业有限公司 | Hydraulic clamp spring type manual locking oil cylinder |
| CN201514365U (en) * | 2009-10-29 | 2010-06-23 | 艾丹 | Bubble-free diffusion cell |
| CN102777213A (en) * | 2011-05-11 | 2012-11-14 | 陈刚 | Air inlet and distribution device of engine and engine formed by same |
Non-Patent Citations (1)
| Title |
|---|
| 透皮给药研究中体外扩散池的改进;李志鸿等;《中国医药工业杂志》;19951231;第26卷(第7期);309,310,329 * |
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