CN103202475B - Balsam pear granules with health care effect and preparation method of balsam pear granules - Google Patents
Balsam pear granules with health care effect and preparation method of balsam pear granules Download PDFInfo
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- CN103202475B CN103202475B CN201310153166.2A CN201310153166A CN103202475B CN 103202475 B CN103202475 B CN 103202475B CN 201310153166 A CN201310153166 A CN 201310153166A CN 103202475 B CN103202475 B CN 103202475B
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Abstract
The invention discloses a health care product with an auxiliary hypoglycemic effect. Balsam pear granules obtained by extracting a balsam pear raw material, concentrating, drying and granulating ensure the flavor, taste and effective component content of balsam pear, and are convenient to carry and take through granulation.
Description
Technical field
The invention belongs to traditional Chinese medicine health care product formulation art, particularly a kind of balsam pear particle with health role and preparation method thereof.
Background technology
Balsam pear (Momordica charantia L.) is Curcurbitaceae Momordica plant, and fruit is Vegetables.Its nature and flavor bitter cold, has heat clearly and washs hot improving eyesight, nourish strong, reduces the effect, particularly seed and fruit such as blood sugar and has very strong physiologically active, has the significantly pharmacological action such as hypoglycemic, antitumor.In recent years, the medical value of balsam pear causes the great attention of Chinese scholars day by day.Research shows that the active principle wherein with blood sugar reducing function is mainly Charantin.Tradition balsam pear is all for dish use, is rarely used in medicinal, low to balsam pear raw material availability, and adopt modernization process to extract the active ingredient in balsam pear, concentrated, the balsam pear particle obtained after dry, compares balsam pear, active ingredient Charantin content is high, consumption is few, and effect is good, and raw material availability is also high, both can be used as medicinal, also can use as the health food of auxiliary hyperglycemic.
Chinese medicinal granule meets the prepared slices of Chinese crude drugs of concocted specification for raw material, extract through modern crafts, concentrated, dry, granulate, refining pure tcm product.Chinese medicinal granule not only can save decoction process, can keep again drug effect and the usefulness of the prepared slices of Chinese crude drugs, adopts the advanced technologies such as finger-print in producing process simultaneously, Chinese medicine is really accomplished safe, efficient, convenient, controlled.Chinese medicinal granule meets the prepared slices of Chinese crude drugs and concocts requirement, does not add sugar, anticorrisive agent and other excipient, can keep the genuineness of Chinese medicine material well.Compared with traditional Chinese medicine medicine materical crude slice, there is the advantage that dosage is little, curative effect is high, easy to carry and use.And Chinese herbal medicine decocting is inconvenient, the duration and degree of heating is difficult to hold, and to put together decoction, not only bother, once decocting process does not reach Medicine standard, often affect the treatment by the tens of taste Chinese herbal medicine of traditional way, and go out to carry take extremely inconvenient.
Summary of the invention
The present invention is in order to overcome the deficiency of traditional decocting medicine technique, by extracting balsam pear raw material, concentrated, dry, granulates, not only ensure that the local flavor of balsam pear, mouthfeel, active constituent content, and by granulating, carry taking convenience.
The present invention first provide a kind of can as the balsam pear particle of the health food of auxiliary hyperglycemic.
The present invention also provides the preparation method of above-mentioned balsam pear particle.
The preparation method of balsam pear particle of the present invention comprises the steps:
(1) extract: dried Frutus Momordicae Charantiae raw material is pulverized, extract 2-4 hour with the 50-80% alcohol heating reflux of 5-10 times of weight, obtain ethanol extract; Filter residue adds the water of 5-10 times of weight again, and heating and refluxing extraction 2-4 hour obtains aqueous extract;
(2) filtration: the ethanol extract of step (1) and aqueous extract are filtered respectively, obtains alcohol extract clear liquid and water extraction gets clear liquid;
(3) concentrated: the alcohol extract clear liquid obtain step (2) and water extraction are got clear liquid and merged, after decompression recycling ethanol, concentrate to obtain thick medicinal extract;
(4) dry: the thick medicinal extract of step (3) is obtained extract powder by spraying dry;
(5) granulate: the extract powder of step (4) is granulated by dry granulating machine.
Preferably, the alcohol reflux Extracting temperature of described step (1) is at 45-80 DEG C; Water refluxing extraction temperature is at 50-100 DEG C.
Preferably, be filtered into by extract pump by 30 object sock filtration in described step (2), respectively balsam pear alcohol extract clear liquid and water extraction get clear liquid.
Preferably, the concentrated of described step (3) is reduced pressure concentration under vacuum 0.06-0.09MPa, is concentrated into the thick medicinal extract that proportion is 15-30 Baume degrees.
Preferably, the drying of described step (4) is that thick medicinal extract is carried out spraying dry, and spraying EAT is 170-190 DEG C, and leaving air temp is 70-90 DEG C.
Preferably, the granulation of described step (5) is granulated by dry granulating machine by Bitter Melon P.E powder, dry granulating machine pressure 20-80MPa, crosses the whole grain of 14-40 mesh sieve, obtain balsam pear particle.
The balsam pear particle obtain said method and dried Frutus Momordicae Charantiae raw material compare, and the results are shown in Table 1.
Table 1
The advantage of balsam pear particle of the present invention: 1, present invention process is the common extraction process of alcohol water, all fully can extract the water-soluble and alcohol soluble active principals in balsam pear, plays its comprehensive therapeutic effect; 2, extract thick medicinal extract and adopt moment spraying dry, remain the original local flavor of balsam pear well; 3, adopt dry granulating machine directly to carry out dry granulation to extract powder, reduce conventional wet granulation technique and need add the impact that auxiliary material brings, quality and the content of product are guaranteed; 4, the simple and products taste of the method technique and color and luster good, in product, Charantin content is high, is not less than 2.0%.
Detailed description of the invention
Come by the following examples to set forth preparation method of the present invention further:
Embodiment 1:
Get balsam pear raw material medicine materical crude slice (dried Frutus Momordicae Charantiae) 10 kilograms, 70% alcohol reflux first adding 6 times of weight extracts 3 hours, and Extracting temperature 65 DEG C, obtains ethanol extract; The dregs of a decoction add the water refluxing extraction 3 hours of 6 times of weight again, and Extracting temperature 90 DEG C, obtains aqueous extract; Ethanol extract and aqueous extract are crossed 30 order sock filtration through pump respectively and obtains alcohol extract clear liquid and water extraction gets clear liquid; Merging alcohol extract clear liquid and water extraction get clear liquid, temperature 65 DEG C, under vacuum 0.08MPa after decompression recycling ethanol, are concentrated into the thick medicinal extract that proportion is 20 Baume degrees (50 DEG C of surveys); Thick medicinal extract is carried out spraying dry, and spraying EAT is 180 DEG C, and leaving air temp is 75 DEG C, makes extract powder 2.0 kilograms; Extract powder is carried out dry granulation under the pressure of 30MPa, sieves, whole grain, make 14-40 order particle, wherein Charantin content is 2.05%.
Embodiment 2:
Get balsam pear raw material medicine materical crude slice (dried Frutus Momordicae Charantiae) 10 kilograms, 65% alcohol reflux first adding 5 times of weight extracts 3 hours, and Extracting temperature 65 DEG C, obtains ethanol extract; The dregs of a decoction add the water refluxing extraction 3 hours of 5 times of weight again, and Extracting temperature 90 DEG C, obtains aqueous extract; Ethanol extract and aqueous extract are crossed 30 order sock filtration through pump respectively and obtains alcohol extract clear liquid and water extraction gets clear liquid; Merging alcohol extract clear liquid and water extraction get clear liquid, temperature 65 DEG C, under vacuum 0.08MPa after decompression recycling ethanol, are concentrated into the thick medicinal extract that proportion is 19 Baume degrees (50 DEG C of surveys); Thick medicinal extract is carried out spraying dry, and spraying EAT is 180 DEG C, and leaving air temp is 75 DEG C, makes extract powder 1.8 kilograms; Extract powder is carried out dry granulation under the pressure of 40MPa, sieves, whole grain, make 14-40 order particle, wherein Charantin content is 2.25%.
Embodiment 3:
Get balsam pear raw material medicine materical crude slice (dried Frutus Momordicae Charantiae) 10 kilograms, 65% alcohol reflux first adding 8 times of weight extracts 3 hours, and Extracting temperature 65 DEG C, obtains ethanol extract; The dregs of a decoction add the water refluxing extraction 3 hours of 8 times of weight again, and Extracting temperature 95 DEG C, obtains aqueous extract; Ethanol extract and aqueous extract are crossed 30 order sock filtration through pump respectively and obtains alcohol extract clear liquid and water extraction gets clear liquid; Merging alcohol extract clear liquid and water extraction get clear liquid, temperature 65 DEG C, under vacuum 0.08MPa after decompression recycling ethanol, are concentrated into the thick medicinal extract that proportion is 22 Baume degrees (50 DEG C of surveys); Thick medicinal extract is carried out spraying dry, and spraying EAT is 180 DEG C, and leaving air temp is 75 DEG C, makes extract powder 2.1 kilograms; Extract powder is carried out dry granulation under the pressure of 50MPa, sieves, whole grain, make 14-40 order particle, wherein Charantin content is 2.11%.
Embodiment 4:
Get balsam pear raw material medicine materical crude slice (dried Frutus Momordicae Charantiae) 10 kilograms, 65% alcohol reflux first adding 10 times of weight extracts 2 hours, and Extracting temperature 65 DEG C, obtains ethanol extract; The dregs of a decoction add the water refluxing extraction 2 hours of 10 times of weight again, and Extracting temperature 95 DEG C, obtains aqueous extract; Ethanol extract and aqueous extract are crossed 30 order sock filtration through pump respectively and obtains alcohol extract clear liquid and water extraction gets clear liquid; Merging alcohol extract clear liquid and water extraction get clear liquid, temperature 65 DEG C, under vacuum 0.08MPa after decompression recycling ethanol, are concentrated into the thick medicinal extract that proportion is 21 Baume degrees (50 DEG C of surveys); Thick medicinal extract is carried out spraying dry, and spraying EAT is 185 DEG C, and leaving air temp is 85 DEG C, makes extract powder 2.3 kilograms; Extract powder is carried out dry granulation under the pressure of 60MPa, sieves, whole grain, make 14-40 order particle, wherein Charantin content is 2.02%.
Embodiment 5:
Get balsam pear raw material medicine materical crude slice (dried Frutus Momordicae Charantiae) 10 kilograms, 65% alcohol reflux first adding 7 times of weight extracts 2 hours, and Extracting temperature 65 DEG C, obtains ethanol extract; The dregs of a decoction add the water refluxing extraction 2 hours of 7 times of weight again, and Extracting temperature 95 DEG C, obtains aqueous extract; Ethanol extract and aqueous extract are crossed 30 order sock filtration through pump respectively and obtains alcohol extract clear liquid and water extraction gets clear liquid; Merging alcohol extract clear liquid and water extraction get clear liquid, temperature 65 DEG C, under vacuum 0.08MPa after decompression recycling ethanol, are concentrated into the thick medicinal extract that proportion is 20 Baume degrees (50 DEG C of surveys); Thick medicinal extract is carried out spraying dry, and spraying EAT is 185 DEG C, and leaving air temp is 85 DEG C, makes extract powder 2.1 kilograms; Extract powder is carried out dry granulation under the pressure of 20MPa, sieves, whole grain, make 14-40 order particle, wherein Charantin content is 2.13%.
Above technical scheme and embodiment are only and describe the present invention and not being construed as limiting the invention, and it will be appreciated by those skilled in the art that and can carry out multiple change and equivalencing and not deviate from connotation of the present invention and scope.
Claims (1)
1. there is a balsam pear particle for auxiliary hyperglycemic effect, it is characterized in that preparation method comprises step as follows:
Get balsam pear raw material medicine materical crude slice dried Frutus Momordicae Charantiae 10 kilograms, 65% alcohol reflux first adding 5 times of weight extracts 3 hours, and Extracting temperature 65 DEG C, obtains ethanol extract; The dregs of a decoction add the water refluxing extraction 3 hours of 5 times of weight again, and Extracting temperature 90 DEG C, obtains aqueous extract; Ethanol extract and aqueous extract are crossed 30 order sock filtration through pump respectively and obtains alcohol extract clear liquid and water extraction gets clear liquid; Merging alcohol extract clear liquid and water extraction get clear liquid, temperature 65 DEG C, under vacuum 0.08MPa after decompression recycling ethanol, are concentrated into the thick medicinal extract that proportion is 19 Baume degrees; Thick medicinal extract is carried out spraying dry, and spraying EAT is 180 DEG C, and leaving air temp is 75 DEG C, makes extract powder 1.8 kilograms; Extract powder is carried out dry granulation under the pressure of 40MPa, sieves, whole grain, make 14-40 order particle.
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| CN103623059B (en) * | 2013-12-04 | 2016-01-06 | 湖南希尔天然药业有限公司 | A kind of pharmaceutical composition and application thereof, containing its medicament |
| CN108013469A (en) * | 2017-11-27 | 2018-05-11 | 福建省农业科学院农业生物资源研究所 | A kind of preparation method of auxiliary hyperglycemic balsam pear tablet |
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| CN1431005A (en) * | 2003-01-23 | 2003-07-23 | 上海诺金科生物科技有限公司 | Product containing extractive of balsam pear and pumpkin possessing functions of reducing blood sugar and fat |
| CN1631193A (en) * | 2004-12-28 | 2005-06-29 | 广东省农业科学院农业生物技术研究所 | Instant balsam pear cold tea and its making method |
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| CN101167970B (en) * | 2007-10-10 | 2010-08-25 | 江阴天江药业有限公司 | Method for preparing gastrodia tuber dispensing granule |
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| CN1431005A (en) * | 2003-01-23 | 2003-07-23 | 上海诺金科生物科技有限公司 | Product containing extractive of balsam pear and pumpkin possessing functions of reducing blood sugar and fat |
| CN1631193A (en) * | 2004-12-28 | 2005-06-29 | 广东省农业科学院农业生物技术研究所 | Instant balsam pear cold tea and its making method |
| KR100956278B1 (en) * | 2009-08-03 | 2010-05-10 | 대한약품공업 주식회사 | Composition comprising an extract of herbal combination thereof for preventing and treating diabetes mellitus |
| CN102824480A (en) * | 2012-09-17 | 2012-12-19 | 西藏藏真堂藏药产业有限公司 | Auxiliary blood sugar decreasing composite containing tibetan medicine edgeworthia gardneri and preparation method of composite |
| CN102961655A (en) * | 2012-12-19 | 2013-03-13 | 成都中医药大学 | Externally used pharmaceutical composition for treating eruption |
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| 苦瓜降血糖作用机制研究进展;刘秀英 等;《国外医学卫生学分册》;20061231;第33卷(第4期);第224-227页 * |
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