CN103193759A - 生物质有机胍催化法合成光学纯l-/d-丙交酯的工艺方法 - Google Patents
生物质有机胍催化法合成光学纯l-/d-丙交酯的工艺方法 Download PDFInfo
- Publication number
- CN103193759A CN103193759A CN2013101464691A CN201310146469A CN103193759A CN 103193759 A CN103193759 A CN 103193759A CN 2013101464691 A CN2013101464691 A CN 2013101464691A CN 201310146469 A CN201310146469 A CN 201310146469A CN 103193759 A CN103193759 A CN 103193759A
- Authority
- CN
- China
- Prior art keywords
- lactide
- rac
- lactic acid
- organic guanidine
- thick
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 title claims abstract description 37
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 title claims abstract description 25
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims abstract description 21
- 239000002028 Biomass Substances 0.000 title claims abstract description 13
- 230000003287 optical effect Effects 0.000 title claims abstract description 11
- 239000003054 catalyst Substances 0.000 title claims abstract description 10
- 230000002194 synthesizing effect Effects 0.000 title claims abstract description 8
- 238000006243 chemical reaction Methods 0.000 claims abstract description 30
- JVTAAEKCZFNVCJ-UWTATZPHSA-N D-lactic acid Chemical compound C[C@@H](O)C(O)=O JVTAAEKCZFNVCJ-UWTATZPHSA-N 0.000 claims abstract description 18
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229940109239 creatinine Drugs 0.000 claims abstract description 9
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229930182843 D-Lactic acid Natural products 0.000 claims abstract description 6
- 229940022769 d- lactic acid Drugs 0.000 claims abstract description 6
- 238000006555 catalytic reaction Methods 0.000 claims abstract description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 claims abstract description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 36
- 239000004310 lactic acid Substances 0.000 claims description 18
- 235000014655 lactic acid Nutrition 0.000 claims description 18
- 238000005406 washing Methods 0.000 claims description 16
- 239000008367 deionised water Substances 0.000 claims description 14
- 230000007935 neutral effect Effects 0.000 claims description 14
- 238000001291 vacuum drying Methods 0.000 claims description 14
- 238000006297 dehydration reaction Methods 0.000 claims description 13
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 12
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 8
- 238000003672 processing method Methods 0.000 claims description 6
- 239000012670 alkaline solution Substances 0.000 claims description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 4
- 235000015320 potassium carbonate Nutrition 0.000 claims description 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 4
- 230000006837 decompression Effects 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 239000012535 impurity Substances 0.000 claims description 2
- 238000006068 polycondensation reaction Methods 0.000 claims description 2
- 235000011118 potassium hydroxide Nutrition 0.000 claims description 2
- 238000000066 reactive distillation Methods 0.000 claims description 2
- 235000017550 sodium carbonate Nutrition 0.000 claims description 2
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000018044 dehydration Effects 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 abstract description 5
- 239000002184 metal Substances 0.000 abstract description 5
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 238000004821 distillation Methods 0.000 abstract 1
- 231100000783 metal toxicity Toxicity 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 24
- -1 guanidine compound Chemical class 0.000 description 19
- 239000003513 alkali Substances 0.000 description 13
- 239000000243 solution Substances 0.000 description 13
- 229910052786 argon Inorganic materials 0.000 description 12
- 241001024099 Olla Species 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 229920000747 poly(lactic acid) Polymers 0.000 description 5
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 239000004626 polylactic acid Substances 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 1
- 229910021626 Tin(II) chloride Inorganic materials 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229920006238 degradable plastic Polymers 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 231100001083 no cytotoxicity Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000007151 ring opening polymerisation reaction Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000011150 stannous chloride Nutrition 0.000 description 1
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 1
- KSBAEPSJVUENNK-UHFFFAOYSA-L tin(ii) 2-ethylhexanoate Chemical compound [Sn+2].CCCCC(CC)C([O-])=O.CCCCC(CC)C([O-])=O KSBAEPSJVUENNK-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/12—1,4-Dioxanes; Hydrogenated 1,4-dioxanes not condensed with other rings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0201—Oxygen-containing compounds
- B01J31/0205—Oxygen-containing compounds comprising carbonyl groups or oxygen-containing derivatives, e.g. acetals, ketals, cyclic peroxides
- B01J31/0208—Ketones or ketals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0235—Nitrogen containing compounds
- B01J31/0241—Imines or enamines
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0271—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds also containing elements or functional groups covered by B01J31/0201 - B01J31/0231
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/30—Addition reactions at carbon centres, i.e. to either C-C or C-X multiple bonds
- B01J2231/34—Other additions, e.g. Monsanto-type carbonylations, addition to 1,2-C=X or 1,2-C-X triplebonds, additions to 1,4-C=C-C=X or 1,4-C=-C-X triple bonds with X, e.g. O, S, NH/N
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Polyesters Or Polycarbonates (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
Description
Claims (4)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310146469.1A CN103193759B (zh) | 2013-04-24 | 2013-04-24 | 生物质有机胍催化法合成光学纯l-/d-丙交酯的工艺方法 |
JP2016509263A JP6031213B2 (ja) | 2013-04-24 | 2013-08-17 | バイオマス有機グアニジン触媒法による光学的に純粋なl−/d−ラクチドの合成方法 |
PCT/CN2013/081710 WO2014173047A1 (zh) | 2013-04-24 | 2013-08-17 | 生物质有机胍催化法合成光学纯l-/d-丙交酯的工艺方法 |
US14/782,627 US9630942B2 (en) | 2013-04-24 | 2013-08-17 | Technological method for synthesis of optically pure L-/D-lactide catalyzed by biogenic guanidine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310146469.1A CN103193759B (zh) | 2013-04-24 | 2013-04-24 | 生物质有机胍催化法合成光学纯l-/d-丙交酯的工艺方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103193759A true CN103193759A (zh) | 2013-07-10 |
CN103193759B CN103193759B (zh) | 2014-11-26 |
Family
ID=48716595
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310146469.1A Active CN103193759B (zh) | 2013-04-24 | 2013-04-24 | 生物质有机胍催化法合成光学纯l-/d-丙交酯的工艺方法 |
Country Status (4)
Country | Link |
---|---|
US (1) | US9630942B2 (zh) |
JP (1) | JP6031213B2 (zh) |
CN (1) | CN103193759B (zh) |
WO (1) | WO2014173047A1 (zh) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106831700A (zh) * | 2017-03-28 | 2017-06-13 | 南京大学 | 一种全绿色封闭循环工艺生产光学纯l‑/d‑丙交酯的方法 |
WO2018045941A1 (zh) * | 2016-09-07 | 2018-03-15 | 南京大学 | 一种合成乙交酯的方法 |
CN110105324A (zh) * | 2019-06-10 | 2019-08-09 | 南京大学 | 异辛酸锌催化合成丙交酯的方法 |
CN110656396A (zh) * | 2019-09-28 | 2020-01-07 | 孔令孝 | 一种聚乳酸烟用丝束、制备方法及其应用 |
CN112250661A (zh) * | 2020-11-18 | 2021-01-22 | 南京大学 | 一种催化合成丙交酯的方法 |
CN112427048A (zh) * | 2020-12-15 | 2021-03-02 | 江苏景宏新材料科技有限公司 | 一种亚锡盐配合物催化剂及其生产l-丙交酯的方法 |
CN113582965A (zh) * | 2021-08-23 | 2021-11-02 | 扬州惠通科技股份有限公司 | 一种基于有机胍配合物催化裂解制备高纯度丙交酯的方法 |
CN114773310A (zh) * | 2022-04-20 | 2022-07-22 | 长兴电子(苏州)有限公司 | 一种复合催化法合成光学纯丙交酯的方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10266512B2 (en) | 2017-08-10 | 2019-04-23 | Novus International, Inc. | Processes for preparing heteroatom containing cyclic dimers |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102161752A (zh) * | 2011-03-14 | 2011-08-24 | 南京大学 | 肌酐催化乳酸缩聚合成医用生物降解性聚乳酸的工艺方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3708915C2 (de) | 1987-03-19 | 1996-04-04 | Boehringer Ingelheim Kg | Verfahren zur Herstellung von Lactid |
EP2072508A1 (fr) * | 2007-12-19 | 2009-06-24 | Galactic S.A. | Procédé d'obtention de lactide |
CN102675607B (zh) * | 2012-05-22 | 2013-08-14 | 南京大学 | 乳酸自催化熔融缩聚—肌酐催化固相缩聚联用法合成高分子量聚乳酸 |
CN102702487A (zh) * | 2012-07-02 | 2012-10-03 | 南京大学 | 肌酐催化缩聚d-乳酸合成高生物安全性聚d-乳酸的工艺方法 |
-
2013
- 2013-04-24 CN CN201310146469.1A patent/CN103193759B/zh active Active
- 2013-08-17 WO PCT/CN2013/081710 patent/WO2014173047A1/zh active Application Filing
- 2013-08-17 US US14/782,627 patent/US9630942B2/en not_active Expired - Fee Related
- 2013-08-17 JP JP2016509263A patent/JP6031213B2/ja not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102161752A (zh) * | 2011-03-14 | 2011-08-24 | 南京大学 | 肌酐催化乳酸缩聚合成医用生物降解性聚乳酸的工艺方法 |
Non-Patent Citations (2)
Title |
---|
CHENHONG WANG,ET AL.,: "Ring opening polymerization of L-lactide initiated by creatinine", 《BIOMATERIALS》 * |
李弘,等,: "肌酐乳酸胍催化L-丙交酯活性开环聚合反应研究", 《高分子学报》 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018045941A1 (zh) * | 2016-09-07 | 2018-03-15 | 南京大学 | 一种合成乙交酯的方法 |
CN106831700A (zh) * | 2017-03-28 | 2017-06-13 | 南京大学 | 一种全绿色封闭循环工艺生产光学纯l‑/d‑丙交酯的方法 |
WO2018176884A1 (zh) * | 2017-03-28 | 2018-10-04 | 南京大学 | 一种全绿色封闭循环工艺生产光学纯l-/d-丙交酯的方法 |
CN110105324A (zh) * | 2019-06-10 | 2019-08-09 | 南京大学 | 异辛酸锌催化合成丙交酯的方法 |
CN110656396A (zh) * | 2019-09-28 | 2020-01-07 | 孔令孝 | 一种聚乳酸烟用丝束、制备方法及其应用 |
CN110656396B (zh) * | 2019-09-28 | 2022-04-29 | 孔令孝 | 一种聚乳酸烟用丝束、制备方法及其应用 |
CN112250661A (zh) * | 2020-11-18 | 2021-01-22 | 南京大学 | 一种催化合成丙交酯的方法 |
CN112427048A (zh) * | 2020-12-15 | 2021-03-02 | 江苏景宏新材料科技有限公司 | 一种亚锡盐配合物催化剂及其生产l-丙交酯的方法 |
CN113582965A (zh) * | 2021-08-23 | 2021-11-02 | 扬州惠通科技股份有限公司 | 一种基于有机胍配合物催化裂解制备高纯度丙交酯的方法 |
CN113582965B (zh) * | 2021-08-23 | 2022-04-26 | 扬州惠通科技股份有限公司 | 一种基于有机胍配合物催化裂解制备丙交酯的方法 |
CN114773310A (zh) * | 2022-04-20 | 2022-07-22 | 长兴电子(苏州)有限公司 | 一种复合催化法合成光学纯丙交酯的方法 |
Also Published As
Publication number | Publication date |
---|---|
JP2016520568A (ja) | 2016-07-14 |
JP6031213B2 (ja) | 2016-11-24 |
US9630942B2 (en) | 2017-04-25 |
US20160039782A1 (en) | 2016-02-11 |
WO2014173047A1 (zh) | 2014-10-30 |
CN103193759B (zh) | 2014-11-26 |
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