CN103191372B - 用于治疗脓毒血症的中药组合物及其制备方法 - Google Patents
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Abstract
Description
组别 | n | 治愈 | 显效 | 有效 | 无效 | 总有效率(%) |
治疗组 | 55 | 14(25.5) | 23(41.8) | 12(21.8) | 6(10.9) | 49(89.1) |
对照组 | 50 | 8(16.0) | 17(34.0) | 15(30.0) | 10(20.0) | 40(80.0) |
Claims (8)
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WO2017039487A1 (ru) * | 2015-08-31 | 2017-03-09 | Николай Владимирович СОЛОВЬЕВ | Композиции для профилактики или лечения сепсиса |
Families Citing this family (4)
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CN104510896A (zh) * | 2014-12-03 | 2015-04-15 | 王玉春 | 一种治疗多器官衰竭的中药配方 |
CN104524263A (zh) * | 2014-12-12 | 2015-04-22 | 山东新希望六和集团有限公司 | 一种用于治疗羊黑疫的药物组合物及其制备方法 |
CN104940635A (zh) * | 2015-07-16 | 2015-09-30 | 王艳娣 | 一种烫烧伤外用中药组合物 |
CN105796881A (zh) * | 2016-04-08 | 2016-07-27 | 广州暨南生物医药研究开发基地有限公司 | 一种含有艾叶的治疗脓毒症的药物组合物及其制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1380098A (zh) * | 2002-05-20 | 2002-11-20 | 张勇飞 | 一种抗感染复合制剂及其制备方法 |
CN1457855A (zh) * | 2003-05-17 | 2003-11-26 | 王若斋 | 阴毒清源丹 |
CN101537141A (zh) * | 2008-03-21 | 2009-09-23 | 北京中泰天和科技有限公司 | 一种清热解毒、疏风消肿、利咽通窍的药物组合 |
CN102349991A (zh) * | 2011-05-29 | 2012-02-15 | 王红芳 | 一种杀病毒防流感的组合物及该组合物所制成的防感冒贴 |
CN102363008A (zh) * | 2011-10-18 | 2012-02-29 | 王若斋 | 阴毒清源丹 |
-
2013
- 2013-04-15 CN CN201310129716.7A patent/CN103191372B/zh not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1380098A (zh) * | 2002-05-20 | 2002-11-20 | 张勇飞 | 一种抗感染复合制剂及其制备方法 |
CN1457855A (zh) * | 2003-05-17 | 2003-11-26 | 王若斋 | 阴毒清源丹 |
CN101537141A (zh) * | 2008-03-21 | 2009-09-23 | 北京中泰天和科技有限公司 | 一种清热解毒、疏风消肿、利咽通窍的药物组合 |
CN102349991A (zh) * | 2011-05-29 | 2012-02-15 | 王红芳 | 一种杀病毒防流感的组合物及该组合物所制成的防感冒贴 |
CN102363008A (zh) * | 2011-10-18 | 2012-02-29 | 王若斋 | 阴毒清源丹 |
Non-Patent Citations (16)
Title |
---|
"毒血症、败血症、脓毒血症"的中医辨证论治;陈树榕;《福建医药杂志》;19800630;49-51 * |
"银黄青蒲汤"治疗外伤继发脓毒血症;李文中;《四川中医》;19840630;第2卷;374 * |
何瑛等.早期大剂量应用参附注射液在治疗剂型脓毒血症中的作用.《中国中医急症》.2013,第22卷(第1期),99-100. |
地塞米松联用血必净辅助治疗脓毒血症临床观察;林朱森等;《中国医药导刊》;20111231;第13卷(第5期);834-835 * |
孙治霞等.血必净对30例血滤后脓毒血症患者内毒素清除效应的临床观察.《中医研究》.2012,第25卷(第3期),30-32. |
张廉君.脓毒血症患者26例临床治疗体会.《湖南中医药大学学报》.2012,第32卷(第12期),31-32. |
早期大剂量应用参附注射液在治疗剂型脓毒血症中的作用;何瑛等;《中国中医急症》;20130131;第22卷(第1期);99-100 * |
李文中."银黄青蒲汤"治疗外伤继发脓毒血症.《四川中医》.1984,第2卷374. |
林朱森等.地塞米松联用血必净辅助治疗脓毒血症临床观察.《中国医药导刊》.2011,第13卷(第5期),834-835. |
活血化瘀法治疗脓毒血症42例疗效观察;赵宇等;《辽宁中医杂志》;20071231;第34卷(第3期);302-303 * |
王丽霞等.脓毒血症1例分析.《中国误诊学杂志》.2009,第9卷(第3期),725. |
脓毒血症1例分析;王丽霞等;《中国误诊学杂志》;20090131;第9卷(第3期);725 * |
脓毒血症患者26例临床治疗体会;张廉君;《湖南中医药大学学报》;20121231;第32卷(第12期);31-32 * |
血必净对30例血滤后脓毒血症患者内毒素清除效应的临床观察;孙治霞等;《中医研究》;20120331;第25卷(第3期);30-32 * |
赵宇等.活血化瘀法治疗脓毒血症42例疗效观察.《辽宁中医杂志》.2007,第34卷(第3期),302-303. |
陈树榕."毒血症、败血症、脓毒血症"的中医辨证论治.《福建医药杂志》.1980,49-51. |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017039487A1 (ru) * | 2015-08-31 | 2017-03-09 | Николай Владимирович СОЛОВЬЕВ | Композиции для профилактики или лечения сепсиса |
RU2622745C2 (ru) * | 2015-08-31 | 2017-06-19 | Энту Фармасьютикалс Лтд | Композиции на основе биоресурсов для профилактики или лечения сепсиса и/или связанных с сепсисом осложнений и состояний, способы профилактики и лечения сепсиса |
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