CN103189108B - 用于治疗的可可碱与祛痰剂或粘液溶解剂的组合 - Google Patents

用于治疗的可可碱与祛痰剂或粘液溶解剂的组合 Download PDF

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Publication number
CN103189108B
CN103189108B CN201180052248.7A CN201180052248A CN103189108B CN 103189108 B CN103189108 B CN 103189108B CN 201180052248 A CN201180052248 A CN 201180052248A CN 103189108 B CN103189108 B CN 103189108B
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China
Prior art keywords
theobromine
amount
agent
cough
combination
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Expired - Fee Related
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CN201180052248.7A
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English (en)
Chinese (zh)
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CN103189108A (zh
Inventor
罗宾·马克·班尼斯特
约翰·布鲁
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Biocopea Ltd
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Biocopea Ltd
Infirst Healthcare Ltd
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
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    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
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    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
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    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
CN201180052248.7A 2010-08-27 2011-08-25 用于治疗的可可碱与祛痰剂或粘液溶解剂的组合 Expired - Fee Related CN103189108B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1014391.5A GB201014391D0 (en) 2010-08-27 2010-08-27 Drug composition and its use in therapy
GB1014391.5 2010-08-27
PCT/GB2011/051610 WO2012025761A1 (en) 2010-08-27 2011-08-25 Theobromine in combination with an expectorant or a mucolytic for use in therapy

Publications (2)

Publication Number Publication Date
CN103189108A CN103189108A (zh) 2013-07-03
CN103189108B true CN103189108B (zh) 2017-02-08

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CN201180052248.7A Expired - Fee Related CN103189108B (zh) 2010-08-27 2011-08-25 用于治疗的可可碱与祛痰剂或粘液溶解剂的组合

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EP (1) EP2608847B1 (cg-RX-API-DMAC10.html)
JP (2) JP2013536257A (cg-RX-API-DMAC10.html)
CN (1) CN103189108B (cg-RX-API-DMAC10.html)
AU (1) AU2011294905B2 (cg-RX-API-DMAC10.html)
BR (1) BR112013004659A8 (cg-RX-API-DMAC10.html)
CA (1) CA2809767A1 (cg-RX-API-DMAC10.html)
CO (1) CO6700840A2 (cg-RX-API-DMAC10.html)
EA (1) EA201390287A1 (cg-RX-API-DMAC10.html)
EC (1) ECSP13012524A (cg-RX-API-DMAC10.html)
ES (1) ES2672128T3 (cg-RX-API-DMAC10.html)
GB (1) GB201014391D0 (cg-RX-API-DMAC10.html)
IL (1) IL224953A (cg-RX-API-DMAC10.html)
MX (1) MX343598B (cg-RX-API-DMAC10.html)
NZ (1) NZ607670A (cg-RX-API-DMAC10.html)
PE (1) PE20140013A1 (cg-RX-API-DMAC10.html)
PH (1) PH12013500392A1 (cg-RX-API-DMAC10.html)
PL (1) PL2608847T3 (cg-RX-API-DMAC10.html)
SG (1) SG188322A1 (cg-RX-API-DMAC10.html)
UA (1) UA112760C2 (cg-RX-API-DMAC10.html)
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Publication number Priority date Publication date Assignee Title
US9314465B2 (en) 2009-06-16 2016-04-19 Infirst Healthcare Limited Drug combinations and uses in treating a coughing condition
GB201111485D0 (en) * 2011-07-05 2011-08-17 Biocopea Ltd Drug composition and its use in therapy
GB0910375D0 (en) 2009-06-16 2009-07-29 Biocopea Ltd Drug composition and its use in therapy
US9308211B2 (en) 2009-06-16 2016-04-12 Infirst Healthcare Limited Drug combinations and uses in treating a coughing condition
US10016437B2 (en) 2009-06-16 2018-07-10 Infirst Healthcare Limited Drug combinations and uses in treating a coughing condition
JP2017527618A (ja) * 2014-09-08 2017-09-21 ゴッサム バイオファーマシューティカルズ，インコーポレイティド 肺サルコイドーシスの治療方法
CN108601755B (zh) * 2015-09-09 2021-08-10 韩国生命工学研究院 用于预防或治疗肌无力相关疾病的、包含水合蒎醇的组合物

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JP2002193839A (ja) * 2000-12-27 2002-07-10 Meiji Seika Kaisha Ltd ココア製剤
US20050220897A1 (en) * 2004-04-05 2005-10-06 Hack Jacob C Indium supplement compositions and methods therefor
US20080085312A1 (en) * 2006-10-04 2008-04-10 Auriga Laboratories, Inc. Multi-Phase Release Potassium Guaiacolsulfonate Compositions

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HUP9700654A2 (hu) * 1997-03-26 1999-09-28 Dezső Korbonits Teobromin tartalmú köhögéscsillapító készítmények
JP2003055258A (ja) * 2001-08-16 2003-02-26 Rohto Pharmaceut Co Ltd 安定化された組成物
US20060148837A1 (en) * 2005-01-04 2006-07-06 Everett Laboratories, Inc. Compositions and methods for treatment of coughing, sneezing, rhinorrhea, and/or nasal obstruction
GB2424185B (en) * 2005-03-16 2009-12-30 Atulkumar Sumanbhai Patel A cough mixture
KR20080009994A (ko) * 2006-07-25 2008-01-30 안국약품 주식회사 기침 치료용 조성물
WO2008089260A2 (en) * 2007-01-16 2008-07-24 Victory Pharma, Inc. Combined administration of benzonatate and guaifenesin
DE102007000521A1 (de) * 2007-10-18 2009-04-23 Renate Conrad Hustenpräparat
GB0910375D0 (en) * 2009-06-16 2009-07-29 Biocopea Ltd Drug composition and its use in therapy
GB201111485D0 (en) * 2011-07-05 2011-08-17 Biocopea Ltd Drug composition and its use in therapy
WO2011146031A1 (en) * 2010-05-18 2011-11-24 Bilgic Mahmut Pharmaceutical composition comprising n- acetylcysteine and a xanthine

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Publication number Priority date Publication date Assignee Title
WO2000000212A1 (en) * 1998-06-26 2000-01-06 Nutracorp Scientific, Inc. Promoting nitric oxide and cyclic gmp activity
JP2002193839A (ja) * 2000-12-27 2002-07-10 Meiji Seika Kaisha Ltd ココア製剤
US20050220897A1 (en) * 2004-04-05 2005-10-06 Hack Jacob C Indium supplement compositions and methods therefor
US20080085312A1 (en) * 2006-10-04 2008-04-10 Auriga Laboratories, Inc. Multi-Phase Release Potassium Guaiacolsulfonate Compositions

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JP2013536257A (ja) 2013-09-19
ES2672128T3 (es) 2018-06-12
EP2608847A1 (en) 2013-07-03
GB201014391D0 (en) 2010-10-13
BR112013004659A2 (pt) 2016-08-02
AU2011294905B2 (en) 2015-01-15
ECSP13012524A (es) 2013-05-31
JP2016196504A (ja) 2016-11-24
BR112013004659A8 (pt) 2018-01-02
CO6700840A2 (es) 2013-06-28
CA2809767A1 (en) 2012-03-01
EP2608847B1 (en) 2018-03-21
UA112760C2 (uk) 2016-10-25
PL2608847T3 (pl) 2018-08-31
PH12013500392A1 (en) 2013-05-27
WO2012025761A1 (en) 2012-03-01
MX2013002334A (es) 2013-03-18
SG188322A1 (en) 2013-04-30
PE20140013A1 (es) 2014-01-24
MX343598B (es) 2016-11-11
CN103189108A (zh) 2013-07-03
EA201390287A1 (ru) 2013-07-30
NZ607670A (en) 2015-06-26
AU2011294905A1 (en) 2013-03-21
IL224953A (en) 2016-03-31

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