CN103179970B - 透皮吸收制剂 - Google Patents
透皮吸收制剂 Download PDFInfo
- Publication number
- CN103179970B CN103179970B CN201180047107.6A CN201180047107A CN103179970B CN 103179970 B CN103179970 B CN 103179970B CN 201180047107 A CN201180047107 A CN 201180047107A CN 103179970 B CN103179970 B CN 103179970B
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- parts
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- preparation
- effective ingredient
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
透皮吸收促进剂或添加剂 | 24小时累积透过量(μg/cm2) | |
实施例1 | 油醇 | 3638 |
实施例3 | 辛酸 | 1228 |
实施例4 | 月桂酸 | 6587 |
实施例5 | 肉豆蔻酸 | 2895 |
实施例6 | 油酸 | 5860 |
实施例8 | 己酸乙酯 | 1346 |
实施例9 | 月桂酸乙酯 | 4106 |
实施例10 | 肉豆蔻酸异丙酯 | 3446 |
实施例11 | 棕榈酸异丙酯 | 3269 |
实施例15 | (±)-柠檬烯 | 2685 |
实施例17 | 桉树油 | 2819 |
实施例27 | 对薄荷烷 | 2201 |
实施例29 | 别罗勒烯 | 4363 |
实施例30 | 2-蒎烯 | 2499 |
实施例32 | 莰烯 | 3758 |
实施例33 | 对伞花烃 | 4381 |
实施例34 | 麝香草酚 | 6073 |
实施例35 | 薄荷油 | 3297 |
比较例1 | - | 29 |
比较例2 | 己二酸二异丙酯 | 90 |
比较例3 | 癸二酸二乙酯 | 56 |
比较例4 | 邻苯二甲酸二乙酯 | 47 |
比较例5 | 水杨酸 | 27 |
比较例6 | 聚山梨酯80 | 35 |
比较例7 | 尿素 | 23 |
肉豆蔻酸异丙酯的重量(%) | 24小时累积透过量(μg/cm2) | |
实施例12 | 10 | 3627 |
实施例13 | 1 | 1241 |
实施例20 | 实施例23 | |
有效成分 | 3 | 3 |
乙醇 | 70 | 30 |
2-丙醇 | - | 20 |
丙二醇 | 10 | 20 |
肉豆蔻酸异丙酯 | 3 | 0.6 |
l-薄荷醇 | 5 | 0.5 |
精制水 | 9 | 25.9 |
24小时累积透过量(μg/cm2) | 4929 | 2961 |
pH | 24小时累积透过量(μg/cm2) | |
实施例21 | 5.38 | 4662 |
实施例22 | 7.62 | 6128 |
Claims (5)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010221604 | 2010-09-30 | ||
JP2010-221604 | 2010-09-30 | ||
JP2011064431 | 2011-03-23 | ||
JP2011-064431 | 2011-03-23 | ||
PCT/JP2011/072334 WO2012043701A1 (ja) | 2010-09-30 | 2011-09-29 | 経皮吸収製剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103179970A CN103179970A (zh) | 2013-06-26 |
CN103179970B true CN103179970B (zh) | 2015-11-25 |
Family
ID=45893140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201180047107.6A Active CN103179970B (zh) | 2010-09-30 | 2011-09-29 | 透皮吸收制剂 |
Country Status (12)
Country | Link |
---|---|
US (1) | US20130197036A1 (zh) |
EP (1) | EP2623102B1 (zh) |
JP (1) | JP5827954B2 (zh) |
CN (1) | CN103179970B (zh) |
BR (1) | BR112013005822B1 (zh) |
DK (1) | DK2623102T3 (zh) |
ES (1) | ES2708107T3 (zh) |
HK (1) | HK1181999A1 (zh) |
PL (1) | PL2623102T3 (zh) |
RU (1) | RU2576612C2 (zh) |
TW (1) | TWI544924B (zh) |
WO (1) | WO2012043701A1 (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111454155A (zh) * | 2020-04-27 | 2020-07-28 | 汪冰心 | 一种透皮吸收促进剂及其制备方法和在化妆品中的应用 |
CN117442695B (zh) * | 2023-10-25 | 2024-06-07 | 陕西省中医医院 | 一种治疗银屑病的中药组合物及其制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5230897A (en) * | 1991-10-31 | 1993-07-27 | G. D. Searle & Co. | Transdermal pentamidine |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2276177C2 (ru) * | 2001-05-01 | 2006-05-10 | Институт Нефтехимического Синтеза Имени А.В. Топчиева Российской Академии Наук | Получение гидрофильных, чувствительных к давлению адгезивов с оптимизированными адгезионными свойствами |
SI1481966T1 (sl) * | 2002-03-06 | 2011-11-30 | Toyama Chemical Co Ltd | Nov derivat arilamidina ali sol le-tega |
US20080279917A1 (en) * | 2003-11-25 | 2008-11-13 | Walzer Peter D | Bisbenzamidines for the Treatment of Pneumonia |
KR101169694B1 (ko) * | 2004-06-30 | 2012-07-31 | 토야마 케미칼 컴퍼니 리미티드 | 신규의 아릴아미딘유도체 및 그 염과 그들을 함유하는 항진균제 |
JP5021308B2 (ja) * | 2004-07-28 | 2012-09-05 | 富山化学工業株式会社 | 新規なアリールアミジン誘導体およびその塩ならびにそれらを含有する抗真菌剤 |
RU2396955C2 (ru) * | 2005-04-07 | 2010-08-20 | Тояма Кемикал Ко., Лтд. | Фармацевтическая комбинация и способ применения противогрибкового средства в комбинации |
US7879344B2 (en) * | 2006-06-29 | 2011-02-01 | Kimberly-Clark Worldwide, Inc. | Transdermal delivery of oleocanthal for relief of inflammation |
PE20081406A1 (es) * | 2006-12-20 | 2008-10-17 | Schering Plough Ltd | Composiciones farmaceuticas de flunixina |
NZ552816A (en) * | 2007-01-24 | 2009-05-31 | Bomac Research Ltd | Formulation for transdermal administration of antihyperthyroid drug comprising a penetration enhancer selected from oleic acid, d-limonene, pyrrolidones, a C2-C8 alcohol, glycol ethers, triacetin and combinations thereof |
-
2011
- 2011-09-29 ES ES11829254T patent/ES2708107T3/es active Active
- 2011-09-29 US US13/877,036 patent/US20130197036A1/en not_active Abandoned
- 2011-09-29 PL PL11829254T patent/PL2623102T3/pl unknown
- 2011-09-29 EP EP11829254.9A patent/EP2623102B1/en active Active
- 2011-09-29 TW TW100135294A patent/TWI544924B/zh active
- 2011-09-29 CN CN201180047107.6A patent/CN103179970B/zh active Active
- 2011-09-29 JP JP2012536537A patent/JP5827954B2/ja active Active
- 2011-09-29 BR BR112013005822-6A patent/BR112013005822B1/pt active Search and Examination
- 2011-09-29 WO PCT/JP2011/072334 patent/WO2012043701A1/ja active Application Filing
- 2011-09-29 DK DK11829254.9T patent/DK2623102T3/en active
- 2011-09-29 RU RU2013119965/15A patent/RU2576612C2/ru active
-
2013
- 2013-08-08 HK HK13109280.5A patent/HK1181999A1/zh unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5230897A (en) * | 1991-10-31 | 1993-07-27 | G. D. Searle & Co. | Transdermal pentamidine |
Non-Patent Citations (1)
Title |
---|
Uptake of T-2307, a novel arylamidine, in Candida albicans;Hiroshi Nishikawa et al.;《Journal of Antimicrobial Chemotherapy》;20100530;第65卷(第8期);1681-1687 * |
Also Published As
Publication number | Publication date |
---|---|
HK1181999A1 (zh) | 2013-11-22 |
EP2623102A4 (en) | 2015-04-01 |
EP2623102A1 (en) | 2013-08-07 |
CN103179970A (zh) | 2013-06-26 |
TWI544924B (zh) | 2016-08-11 |
US20130197036A1 (en) | 2013-08-01 |
ES2708107T3 (es) | 2019-04-08 |
JPWO2012043701A1 (ja) | 2014-02-24 |
JP5827954B2 (ja) | 2015-12-02 |
BR112013005822B1 (pt) | 2019-09-24 |
RU2576612C2 (ru) | 2016-03-10 |
PL2623102T3 (pl) | 2019-07-31 |
BR112013005822A2 (pt) | 2016-05-10 |
DK2623102T3 (en) | 2019-04-01 |
RU2013119965A (ru) | 2014-11-10 |
WO2012043701A1 (ja) | 2012-04-05 |
EP2623102B1 (en) | 2019-01-09 |
TW201219036A (en) | 2012-05-16 |
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Effective date of registration: 20210421 Address after: Tokyo, Japan Patentee after: TOYAMA CHEMICAL Co.,Ltd. Address before: Tokyo, Japan Patentee before: TOYAMA CHEMICAL Co.,Ltd. Effective date of registration: 20210421 Address after: Nova Scotia, Canada Patentee after: Apili treatment Co. Address before: Tokyo, Japan Patentee before: TOYAMA CHEMICAL Co.,Ltd. |
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