CN103172509A - 苹果酸连续化动态结晶的方法 - Google Patents
苹果酸连续化动态结晶的方法 Download PDFInfo
- Publication number
- CN103172509A CN103172509A CN2013100344298A CN201310034429A CN103172509A CN 103172509 A CN103172509 A CN 103172509A CN 2013100344298 A CN2013100344298 A CN 2013100344298A CN 201310034429 A CN201310034429 A CN 201310034429A CN 103172509 A CN103172509 A CN 103172509A
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- Prior art keywords
- crystallization
- oxysuccinic acid
- crystallization kettle
- kettle
- temperature
- Prior art date
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Links
- 238000000034 method Methods 0.000 title claims abstract description 32
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 title abstract 5
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 title abstract 5
- 235000011090 malic acid Nutrition 0.000 title abstract 5
- 239000001630 malic acid Substances 0.000 title abstract 5
- 238000002425 crystallisation Methods 0.000 claims abstract description 114
- 230000008025 crystallization Effects 0.000 claims abstract description 108
- 239000000463 material Substances 0.000 claims abstract description 33
- 238000003756 stirring Methods 0.000 claims abstract description 8
- 238000001816 cooling Methods 0.000 claims abstract description 6
- 239000000498 cooling water Substances 0.000 claims abstract description 6
- 239000002253 acid Substances 0.000 claims description 29
- 230000005484 gravity Effects 0.000 claims description 11
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 7
- 229910052719 titanium Inorganic materials 0.000 claims description 7
- 239000010936 titanium Substances 0.000 claims description 7
- 239000011230 binding agent Substances 0.000 claims description 3
- 239000002131 composite material Substances 0.000 claims description 2
- 239000002826 coolant Substances 0.000 claims description 2
- 230000007797 corrosion Effects 0.000 claims description 2
- 238000005260 corrosion Methods 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000013078 crystal Substances 0.000 description 6
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 4
- 238000000605 extraction Methods 0.000 description 3
- 235000012976 tarts Nutrition 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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Abstract
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Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201310034429.8A CN103172509B (zh) | 2013-01-29 | 2013-01-29 | 苹果酸连续化动态结晶的方法 |
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CN201310034429.8A CN103172509B (zh) | 2013-01-29 | 2013-01-29 | 苹果酸连续化动态结晶的方法 |
Publications (2)
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CN103172509A true CN103172509A (zh) | 2013-06-26 |
CN103172509B CN103172509B (zh) | 2015-05-13 |
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CN201310034429.8A Active CN103172509B (zh) | 2013-01-29 | 2013-01-29 | 苹果酸连续化动态结晶的方法 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109369418A (zh) * | 2018-10-10 | 2019-02-22 | 河南师范大学 | 一种节能环保型烷基苯胺类液体抗氧剂的连续合成工艺及合成装置 |
CN115121002A (zh) * | 2021-03-26 | 2022-09-30 | 南京理工大学 | 一种可调控高氯酸铵粒度的连续冷却结晶工艺 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1560016A (zh) * | 2004-02-17 | 2005-01-05 | 李云政 | 苹果酸的制备方法 |
CN1944364A (zh) * | 2006-10-30 | 2007-04-11 | 盐城市华业医药化工有限公司 | 邻苯基苯酚连续精制生产方法 |
JP2011036762A (ja) * | 2009-08-07 | 2011-02-24 | Mitsubishi Rayon Co Ltd | 晶析方法 |
-
2013
- 2013-01-29 CN CN201310034429.8A patent/CN103172509B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1560016A (zh) * | 2004-02-17 | 2005-01-05 | 李云政 | 苹果酸的制备方法 |
CN1944364A (zh) * | 2006-10-30 | 2007-04-11 | 盐城市华业医药化工有限公司 | 邻苯基苯酚连续精制生产方法 |
JP2011036762A (ja) * | 2009-08-07 | 2011-02-24 | Mitsubishi Rayon Co Ltd | 晶析方法 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109369418A (zh) * | 2018-10-10 | 2019-02-22 | 河南师范大学 | 一种节能环保型烷基苯胺类液体抗氧剂的连续合成工艺及合成装置 |
CN115121002A (zh) * | 2021-03-26 | 2022-09-30 | 南京理工大学 | 一种可调控高氯酸铵粒度的连续冷却结晶工艺 |
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Publication number | Publication date |
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CN103172509B (zh) | 2015-05-13 |
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Denomination of invention: Method for continuously and dynamically crystallizing malic acid Effective date of registration: 20160406 Granted publication date: 20150513 Pledgee: Bengbu financing guarantee Group Co.,Ltd. Pledgor: ANHUI SEALONG BIOTECHNOLOGY Co.,Ltd. Registration number: 2016990000269 |
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Denomination of invention: Method for continuously and dynamically crystallizing malic acid Effective date of registration: 20170303 Granted publication date: 20150513 Pledgee: Bengbu financing guarantee Group Co.,Ltd. Pledgor: ANHUI SEALONG BIOTECHNOLOGY Co.,Ltd. Registration number: 2017340000030 |
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Denomination of invention: Method for continuously and dynamically crystallizing malic acid Effective date of registration: 20180601 Granted publication date: 20150513 Pledgee: Bengbu financing guarantee Group Co.,Ltd. Pledgor: ANHUI SEALONG BIOTECHNOLOGY Co.,Ltd. Registration number: 2018340000196 |
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Denomination of invention: The method of continuous dynamic crystallization of malic acid Effective date of registration: 20231228 Granted publication date: 20150513 Pledgee: Bengbu Branch of China Postal Savings Bank Co.,Ltd. Pledgor: ANHUI SEALONG BIOTECHNOLOGY Co.,Ltd. Registration number: Y2023980075323 |
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