CN103169838A - Medicine for treating hepatitis B - Google Patents

Abstract

The invention discloses a medicine for treating hepatitis B, which consists of Chinese aralis bark and root bark, cornu bubali tablets, Indian strawberry, solanum lyratum, Shuliang yam rhizome, serissa serissoides, Indian damnacanthus herb, goldhair hedyotis herb, all-grass of Chinese brake, chinese fevervine herb, scabrous elephantfoot herb, capsella bursapastoris, sarel spleenwort herb, cordyceps sinensis, schisandra chinensis powder, honey and softening detumescence paste. The medicine disclosed by the invention has the functions of clearing heat, diminishing inflammation, removing toxicity and soothing the liver, takes effect quickly in treating hepatitis B, and realizes a high cure rate.

Description

A kind of medicine for the treatment of hepatitis B

Technical field the present invention relates to a kind of medicine for the treatment of hepatitis B, belongs to the field of Chinese medicines.

Background technology " treatment of chronic viral hepatitis B is a global difficult problem "." the medical circle problem of turning out cloudy for hepatitis B virus serological markers has carried out inquiring into research, but does not find out so far desirable Therapeutic Method." " up to the present, the specific drug that there is no the treatment hepatitis B comes out, and the treatment of hepatitis B faces high investment, low return state, in order to control hepatitis B, spares no high price from external introduction high amount of drug.China, when actively imitating these foreign medicines of production, developed in a large number many Chinese medicine preparation, but curative effect is all unsatisfactory." " hepatitis B virus often infects since the childhood, deep-rooted, and various treatments all are difficult to thoroughly remove virus, no matter spends how much treatment, and curative effect is all unsatisfactory." " thousands of hepatitis B patient, after attempting multiple antiviral therapy, curative effect is not good enough often.”

Summary of the invention the purpose of this invention is to provide a kind of Chinese medicine composition of effective treatment hepatitis B, is pure Chinese medicinal preparation, has the function of heat clearing away, antiinflammatory, soothing the liver, removing toxic substances, without any side effects, treatment hepatitis B instant effect, and cure rate is high.

Technical scheme of the present invention is: a kind of Chinese medicine dispensing medicament is provided, by Chinese medicine A, Chinese medicine B, Chinese medicine C, formed, wherein Chinese medicine A Shi You Cortex araliae chinensis and root bark, each 7-10 part of Cornu Bubali slice, Herba Duchesneae Indicae, Herba Solani Lyrati, each 6-9 part of Rhizoma Dioscoreae Cirrhosae, Radix Serissae, Herba Damnacanthi, Herba Hedyotidis Chrysotrichae, Herba Pteridis multifidae, Herba Paederiae, Herba Elephantopi scaberis, Herba Capsellae, each 5-8 part of Herba Asplenii Sarelii, Cordyceps 1-4 part forms; Chinese medicine B is comprised of Fructus Schisandrae Chinensis powder 2-5 part, Mel 0.5-1 part; Chinese medicine C is hardness-softening antiphlogistine; The fresh urine immersion that Cornu Bubali slice is placed in to healthy children below ten years old, after 36 hours, is taken out and is cleaned, and shines or dries; Cornu Bubali slice after Chinese medicine A described weight proportion Cortex araliae chinensis and root bark, processing, Herba Duchesneae Indicae, Herba Solani Lyrati, Rhizoma Dioscoreae Cirrhosae 5 flavor medicines are decocted with water, amount of water is boiled medicine than usual and is added water and do not have that the powder amount is higher is advisable, decoct after 2 hours, add Radix Serissae, Herba Damnacanthi, Herba Hedyotidis Chrysotrichae, Herba Pteridis multifidae, Herba Paederiae, Herba Elephantopi scaberis, Herba Capsellae, Herba Asplenii Sarelii, Cordyceps 9 flavor medicines, decoct with water again twice, each amount of water, not have powder to be advisable, merges decocting liquid twice, filters to get filtrate 500 milliliters; The Fructus Schisandrae Chinensis powder of the described weight proportion of Chinese medicine B is mixed while hot with refined honey, repeatedly stir and rub to all moistening mix homogeneously, with pellet processing machine, make the impartial pill of size, shine or dry; Chinese medicine C hardness-softening antiphlogistine is put to shady and cool dry place.

Advantage of the present invention is: (1) is pure Chinese medicinal preparation, without any side effects; (2) raw material sources are wide, and production cost is not for too high; (3) taking convenience, the patient is acceptant; (4) remove source of disease, evident in efficacy.

Hepatitis B virus allows hepatitis B great three positive one, 3 two and first of hepatitis B small three positive be positive in the existence of body, makes hepatitis B patient that weak, poor appetite can be arranged, detests oil, abdominal distention, jaundice, hepatalgia, abnormal liver function, routine blood test are undesired, hepatic fibrosis, B ultrasonic show that the liver parenchyma luminous point increases thick Echoenhance etc.

Chinese Medical Association's hepatopathy credit meeting and Chinese Medical Association infect relevant expert in disease credit meeting organizing nation, on the basis with reference to domestic and international newest research results, according to following the principle of levying medical science, " the guideline " worked out in December, 2005 (being called for short " guide ") point out " overall goal for the treatment of of chronic is: long term inhibition or eliminate HBV to greatest extent ...." and point out in new " guide " that this medical association 2010 works out that " overall goal for the treatment of of chronic is: long term inhibition HBV to greatest extent ...”

Chinese medicine A in medicine of the present invention, Chinese medicine B, Chinese medicine C are as long as used hepatitis B patient simultaneously, can comparatively fast eliminate hepatitis B virus, allow hepatitis B patient is weak, poor appetite, detesting oil, abdominal distention, jaundice, hepatalgia, abnormal liver function, four of hepatic fibrosis, liver parenchyma luminous point, to increase thick Echoenhance, routine blood test undesired etc. all along with improvement; After eliminating hepatitis B virus fully, hepatitis B great three positive one, 3 two and first of hepatitis B small three positive are turned out cloudy, and it is normal that its above-mentioned symptom recovers, and cures hepatitis B fully.

Chinese medicine A in medicine of the present invention, Chinese medicine B, Chinese medicine C only have hepatitis B patient are used simultaneously, just above-mentioned curative effect be can reach, if only use Chinese medicine A or Chinese medicine B or Chinese medicine C, or Chinese medicine A and Chinese medicine B only used, or only use Chinese medicine A and Chinese medicine C, or only use Chinese medicine B and Chinese medicine C, and all can not all eliminate hepatitis B virus, can not improve above-mentioned symptom fully, fine four of liver can not be recovered to normal, can not recover liver function fully, can not allow hepatitis B treating, not reach the purpose of curing hepatitis B fully.

After cured substance of the present invention, part Hepatitis B virus one, 3 two are turned out cloudy, second is positive, can exempt from re-infection (being commonly called as bounce-back), but if any part Hepatitis B virus one, 3 two rear second persons of being negative that turn out cloudy, should continue, with medicine treatment of the present invention or by " 0,1,6 " scheme injection hepatitis vaccine, to make its second to be positive.

Specific embodiment embodiment: the fresh urine immersion that Cornu Bubali slice is placed in to healthy children below ten years old, after 36 hours, is taken out and is cleaned, and shines or dries; Cornu Bubali slice after Chinese medicine A described weight proportion Cortex araliae chinensis and root bark, processing, Herba Duchesneae Indicae, Herba Solani Lyrati, Rhizoma Dioscoreae Cirrhosae 5 flavor medicines are decocted with water, amount of water is boiled medicine than usual and is added water and do not have that the powder amount is higher is advisable, decoct after 2 hours, add Radix Serissae, Herba Damnacanthi, Herba Hedyotidis Chrysotrichae, Herba Pteridis multifidae, Herba Paederiae, Herba Elephantopi scaberis, Herba Capsellae, Herba Asplenii Sarelii, Cordyceps 9 flavor medicines, decoct with water again twice, each amount of water, not have powder to be advisable, merges decocting liquid twice, filters to get filtrate 500 milliliters; The Fructus Schisandrae Chinensis powder of the described weight proportion of Chinese medicine B is mixed while hot with refined honey, repeatedly stir and rub to all moistening mix homogeneously, with pellet processing machine, make the impartial pill of size, shine or dry; Chinese medicine C hardness-softening antiphlogistine is put to shady and cool dry place.

This prescription Zhong Cortex araliae chinensis and root bark enter the heart, liver, kidney three warps, the effect that detumescence poison, dissipating blood stasis blood, strong Liver and kidney, strengthening the spleen and stomach, dehumidifying diuresis are arranged, can be used for treating the diseases such as urgency or chronic hepatitis, cirrhotic ascites, gastric ulcer, oedema due to nephritis, phage method test for this product, the antiphagin effect is arranged, experiment in body, this product has inhibitory action to mice SAK liver substance type, and this product water decoction has higher suppression ratio to murine sarcoma-180.The Cornu Bubali GUIXIN, liver, the stomach warp, join the army into blood, its main constituent keratoprotein has heart tonifying, calm, heat clearing away, removing heat from blood, the effect of removing toxic substances, can clear away heart-fire, liver, stomach three is through burning hot, outstanding energy removing summer-heat noxious heat in the blood system, the power of removing toxic substances is stronger, the height that can be used for hot infectious disease appearance is warm and hemorrhage, the normal saline solution extractum of this product has refrigeration function to the rabbit of coliform vaccine pyrogenicity, its body temperature is down to normally, the water decoction of this product or extract have gentle cardiotonic to Rana nigromaculata isolated heart specimen and Bufo siccus heart in place, the function particularly caused giving pyrrocaine suppresses to have obvious restitution, normal or weak isolated rabbit and Isolated Toad Heart are all had to the effect of strengthening contractility, but comparatively obvious to weak key role, after being shunk, the animal blood vessels short time shows dilating effect, still can significantly increase intestinal movement, the isolated rabbit intestinal is had to excitation, rabbit vein injection this product decoct can make clotting time shorten, platelet count increases, in order to treat idiopathic thrombocytopenic purpura disease and encephalitis b, the heat such as Infantile Summer Fever enter the hyperpyrexia disease disease of nutrient blood, all received effect preferably, the decocting liquid of this product and the ether of this product or 95% ethanol extract all have obvious sedation to rat, this product is taken safety, few side effects.Herba Duchesneae Indicae has heat-clearing and toxic substances removing, the effect of removing heat from blood detumescence, this product has the effect of anti-cell halmatogenesis in vitro, this product has to ehrlich carcinoma and murine sarcoma-180 activity of inhibition, experiment in vitro is more than 90% to the JTC-26 suppression ratio, in the screening to 60 kinds of Chinese herbal medicine, the active anticancer of finding Herba Duchesneae Indicae is the highest, it is material that external Eca-109 cell is take in experiment, studied the growth of the boiling water extraction thing of Herba Duchesneae Indicae to cancerous cell, division, propagation, the impact of multiplication capacity and Synthesis of DNA again, result shows: its water extract has stronger depression effect to growth of cancer cells, with 15mg/ml effect 48 hours, can make cancerous cell completely lose fertility again, mitosis suppression ratio to cancerous cell can reach respectively 46% (10mg/ml) and 49% (15mg/ml), DNA (deoxyribonucleic acid) is also had to inhibitory action.Herba Solani Lyrati enters liver, gallbladder meridian, removing pathogenic heat from blood and toxic substance from the body is arranged, the effect of clearing away heat-damp and promoting diuresis, can be used for early stage liver cirrhosis, hepatitis, cholecystitis, children's's liver-heat, its extract has antiinflammatory action to animal, anaphylaxis to animal, burn property, histamine's property shock has protective effect, can also increase the survival rate of mouse islets element shock, its contained solanine composition can strengthen animal (rabbit in a small amount, rat) central nervous system's process of excitation, can also reduce blood coagulation, calmness is still arranged, cooling effect, this product forms the antibody that promotes body and protein synthetic has certain effect, but the nonspecific immunobiologic reaction of enhancing body, experiment in vitro, this product hot water extract is except having the effect of alleviating or removing to hepatalgia, to the JTC-26 suppression ratio up to 100%, and on not impact of normal cell, this product all has inhibitory action to ascitic type and the solid type of white mice ehrlich carcinoma and spindle cell sarcoma.Rhizoma Dioscoreae Cirrhosae has the effect of blood circulation promoting and enriching, regulating QI to relieve pain, its contained composition Aristolochic Acid C has effect anticancer and the enhancing phagocytic function, the analgesic activity of the contained magnoline of this product extract is better than morphine, have and Aristolochic Acid is made to " rising white spirit ", its leukocyte increasing effective percentage reaches more than 89%, be better than original leucocyte increasing agent, rabbit gavages this product decoct 1.5 grams/kilogram, its hemorrhage and all significantly shortening of clotting time, this product extracting solution also has similar hematoblastic blood coagulation enhancing effect, and the contained tannin composition of this product tincture or decoct has medium degree bacteriostasis.Radix Serissae has the effect of heat-clearing and toxic substances removing, soothing liver-QI for relieving depression, invigorating spleen to remove dampness, and its contained tannin and glycoside can be used for treating acute hepatitis, chronic hepatitis and oedema due to chronic nephritis.Herba Damnacanthi has the effect of dehumidifying detumescence, promoting blood circulation to remove blood stasis, for mass in the abdomen (hepatosplenomegaly) and edema and to treat acute and chronic infectious hepatitis effective.Herba Hedyotidis Chrysotrichae has the effect of heat-clearing and toxic substances removing, suppressing the hyperactive liver improving eyesight, dehumidifying removing heat from blood, circulation of qi promoting dissipating blood stasis, effective for the chronic infection hepatitis, in addition, with the phage body of laws, screens outward, and this product has the antiphagin effect, points out it that active anticancer is arranged.Herba Pteridis multifidae (different name Herba Pteridis Multifidae) enters kidney, liver, stomach, heart channel, and the effect of heat-clearing and toxic substances removing, inducing diuresis and reducing edema, cooling blood for hemostasis is arranged, and can be used for treating chronic hepatitis.Herba Paederiae has the effect of suppressing the hyperactive liver to relieve the wind syndrome, strengthening the spleen to promote digestion, dehumidifying detumescence, can treat hepatosplenomegaly, liver and gall and gastrointestinal angor, this product alcohol formulations has hypotensive effect to anesthetized animal (dog, cat, rabbit), this product decocting distillate has obvious analgesic activity (hot plate method) to mice, this product extract has been tested the effect of cortisone sample in vitro, in order to inject the rabbit articular cavity, can reduce inflammatory disorders, this product decoct was to Oral Administration in Rats 10 days, and PARA FORMALDEHYDE PRILLS(91,95) " arthritis " has inhibitory action.Herba Elephantopi scaberis enters liver, spleen, lung meridian, the effect that heat clearing away, removing toxic substances, removing heat from blood, diuretic are arranged, this product injection is made extracorporeal bacteria inhibitor test, bacteriostasis is arranged, with dull and stereotyped tilt-pour process, bacteriostasis is also arranged, by phage method proof this product, the antiphagin effect is arranged, this product ingredient Elephantopus scaber L. booth is effective to WM, this product ingredient Elephantopus scaber L. tells product has inhibitory action to lymphocyte-388, and this product can be used for cirrhotic ascites, and it all has the effect of active anticancer to various tumors.Herba Capsellae enters liver, kidney, urinary bladder channel, removing heat in the liver for improving eyesight is arranged, clearing away heat to stop bleeding, effect with the blood pressure lowering of spleen diuretic, cause the vertigo for excessive rising of liver-YANG, blood pressure is hyperfunction, this product alcohol extract can suppress the dextran of rat lower limb, the permeability of the blood capillary that chondrus ocellatus Holmes colloidality edema and 5-hydroxy tryptamine cause increases, shay ulcer is had to 90% suppression ratio, and can accelerate the healing of stress ulcer, mice is had to diuresis, to the rabbit of artificial fever antipyretic effect slightly, can allow the anesthetized dog excitement breathe, dry Herba Capsellae preserved material low concentration (below 2%) can distend the blood vessels, its alcohol extract is dilating effect to the lower limb vascular of dog, the effective ingredient of this product can make dog, cat, rabbit, chicken, Mus has the property a crossed blood pressure drops, its contained bursic acid has anastalsis.Herba Asplenii Sarelii has heat-clearing and toxic substances removing, inducing diuresis and reducing edema effect.Cordyceps enters lung, the stomach warp, the effect that enriching yin and nourishing kidney are arranged, the energy anticoagulant, suppress the MAO-B activity, antitumor, Cordyceps have and suppresses cell division and antitumaous effect, and there is the nonspecific stimulation immunoreation, suppress nucleic acid metabolism, thereby raising antiviral ability, all and the mycelia of this product can be improved Phagocytosis By The Peritoneal Macrophages In Mice, suppress the lymphocytic rejection of T, this product has stronger ImmunopharmacologicaAction Action, can improve serum albumin, suppress gamma globulin, improve liver function, to the HBsAg certain effect of having turned out cloudy, to abnormal humour, immunity has dual regulation, adjust Proteometabolism, correcting A/G is inverted, to patient's cellular immunization, humoral immunization all has clear improvement, Cordyceps mycelium can be suppressed to fibrocyte and transform to fibroblast, suppress its collagen synthetic, to experimental rat immunologic injury hepatic fibrosis, can alleviate infiltration and the hepatocellular degeneration necrosis of the inflammatory cell of liver, can suppress total collagen simultaneously, the deposition of type i collagen in liver, and can make established collagen again decompose and absorb, rat liver fibrosis to Carbon Tetrachloride Induced also has remarkable preventive and therapeutic effect, oral cordyceps sinensis polysaccharide liposome has protective effect to carbon tetrachloride hepatic injury and D-Gal hepatic injury mice, to the mouse liver injury due to thioamides, can reduce its rising ALT activity.Fructus Schisandrae Chinensis powder enters the heart, lung, liver, kidney channel, have the lung benefiting kidney, tonify deficiency labor, the effect of born fluid, for night sweat due to yin deficiency or spontaneous perspiration due to yang insufficiency, deficiency of body fluid, xerostomia is done thirsty, its contained effective ingredient schizandrin can strengthen liver detoxification function, but also adrenal cortex reinforcing function and the body defence capability to nonspecific stimulation, and the effect that promotes bile secretion is arranged, can also affect hepatic glycogen, the effects such as biosynthesis of existing promotion hepatic protein and hepatic glycogen, have again the hepatic glycogen of quickening to decompose, promote the hepatic glycogen heteroplasia, glycogen storage disease to one of Metabolic liver disease has certain effect, works as work, hungry, when the blood glucose such as heating consume in a large number, this effect promotion hepatocyte is decomposed into glucose by liver glycogen and enters blood circulation, because liver is to regulate the most important organ of blood sugar concentration, it maintains the constant of blood sugar concentration by above-mentioned two kinds of effects, guarantee that whole body respectively organizes particularly brain and erythrocytic energy source, its contained schizandrin can increase the liver regeneration ability after hepatectomy, at CCl ₄and bring out in the chronic hepatic injury model after the galactosamine long term administration, can alleviate the fibrosis of liver, can strengthen again the liver regeneration ability after its fibrosis Partial Resection, and arachidonic acid release-leukotriene increase due to activating macrophage is brought out to hepatic injury antagonism is arranged, this effect is because suppressing due to arachidonic acid discharges, in the glucose tolerance test to rabbit, the extract of this product can improve body to sugared effect, zoopery proves, a small amount of Fructus Schisandrae Chinensis can improve the activeness of trained reflex, improve corticocerebral ability to work, simultaneously, excited respiratory system, regulate cardiovascular system morbid state physiological function and improve not normal blood circulation, at vasomotor center, when above-mentioned maincenter is suppressed, effect is more obvious especially, so Fructus Schisandrae Chinensis is weak to heart, overfatigue, asthenia universalis etc. are all effective in cure, can reduce blood pressure again, and the circulatory failure person is had to the blood pressure effect that raises rather significantly, it has the effect of obvious reduction glutamate pyruvate transaminase to infectious hepatitis, to hepatitis convalescent period transaminase Gao Erjiu not the recuperator positive effect is also arranged, prove effective very fast, non-evident effect, application type is more, especially symptom is hidden, depression of liver-QI, incoordination between the liver and spleen three types are effective, the immunologic liver injury that the bacterium acidi propionici of this product after to heat sterilization and lipopolysaccharide (LPS) bring out again is significantly improved the liver function effect, the hepatic injury given due to medicine cosolvent Tween80 and carboxymethyl cellulose (CMC) is had to antagonism, its contained effective ingredient not only is improved effect to drug-induced hepatitis, also immunologic liver injury is improved to effect simultaneously and (reduces GPT in blood, the GOT activity, improve the synthetic underactivity of hepatic protein), in addition, this product has regulating action to gastric secretion, can suppress due to acetylcholine Ileum activity hyperfunction, due to the autonomic movement of inhibition stomach and medicine (pilocarpine etc.), the stomach motion is hyperfunction, during wuweizisu B 99 μ g/ml, to the Murine Ascitic Hepatoma Cells suppression ratio, be 85%, add wuweizisu B in the Murine Ascitic Hepatoma Cells culture fluid simultaneously, mensuration is 56%～66% to hepatoma carcinoma cell ATP suppression ratio, prompting this product all has inhibitory action to propagation and the metabolism of hepatoma carcinoma cell, Fructus Schisandrae Chinensis is also influential to immunity of organisms: improve the lymphocyte conversion ratio, enhancing body humoral immunization ability, improve the adaptability of body, play the effect of righting tonify deficiency, separately, the ethanol extraction of Fructus Schisandrae Chinensis has obvious effect of reducing enzyme levels, this extract preparation that water proposes again is invalid, illustrate that Fructus Schisandrae Chinensis falls the composition of enzyme in the molten and water-insoluble part of alcohol, this can explain that the effect of how applying clinically the Fructus Schisandrae Chinensis water decoction is not as its honeyed pill or Fructus Schisandrae Chinensis powder.Mel enters spleen, lung, large intestine channel, heat-clearing and toxic substances removing is arranged, invigorate blood circulation and delay the effect of pain, energy and battalion defend, moisten internal organs, tune taste, lower food drink, the chronic diseases such as inflammation, hypertension, gastric and duodenal ulcers, hepatopathy there is is certain therapeutical effect or adjust the benefit effect, this product can increase respiratory capacity in human body, in vitro tests, this product has bactericidal action.The patent No. ZL2009100444162 of hardness-softening antiphlogistine is that patent of the present invention " a kind of medicine for the treatment of hepatitis B " the second applicant applies for to State Intellectual Property Office in JIUYUE in 2009 on the 22nd.

The therapeutical effect of medicine of the present invention to hepatitis B:

1, patient profile is accepted out-patient's 30 examples for medical treatment: male 20 examples wherein, and female's 10 examples, men and women's ratio is 2: 1.16～20 years old age, 7 examples, 21～30 years old 9 example, 31～40 years old 6 example, 41～50 years old 4 example, 51～60 years old 4 example.Workman 3 people wherein, peasant 11 people, teacher 4 people, university students 3 people, middle school student 4 people, civil servant 3 people, driver 2 people.Great three positive 13 people wherein, small three positive 17 people.1～2 year person's 4 example of the course of disease wherein, 2～3 years person's 11 examples, 3～4 years person's 12 examples, person's 3 examples more than 5 years and 5 years.Above case was with all taking Western medicine and injection injection of western medicine before Drug therapy of the present invention, all because bearing side effect inactive Western medicine voluntarily that can't stand Western medicine.

2, the diagnostic criteria hepatitis B patient can have weak, poor appetite, detest the symptoms such as oil, abdominal distention, jaundice, hepatalgia; Some abnormal liver function: turn the risings such as phthalein enzyme as globulin, transaminase, serum bilirubin, alkali phosphatase, lactic acid dehydrogenase, gamma-glutamyl, the reductions such as serum cholinesterase, thrombinogen mobility, total protein, albumin, white/globulin ratio inversion etc.; B ultrasonic shows that the liver parenchyma luminous point increases thick Echoenhance etc.; Routine blood test is undesired; Fine four detections of liver find to enter hepatic fibrosis; Hepatitis B virus is quantitative low or high; Hepatitis B great three positive one, 3 two or first of small three positive are positive.

3, Therapeutic Method every agent medicine liquid dose every day is 500 milliliters, and each oral 250 milliliters sooner or later, divide three time warm water delivery service by the Fructus Schisandrae Chinensis honeyed pill morning, noon and afternoon every day, each 1.5 grams, the hepatic region of applying ointment or plaster while simultaneously with hardness-softening antiphlogistine, being heated to slightly temperature.Treat 90 days is a course for the treatment of.

4, with in Chinese medicine preparation therapeutic process of the present invention, taking other any Chinese medicine and western medicine and injection, and forbid wine, cigarette, disgruntled, tired, indulge in sensual pleasures, avoid pungent rich food, the sugar of taking food every day is lower than 50 grams.

5, the anemia of pregnant woman who suffers from hepatitis B forbids with Chinese medicine preparation treatment of the present invention in the pregnancy period.

6, efficacy evaluation

Produce effects: weak, poor appetite, detest oil, abdominal distention, jaundice, hepatalgia and disappear, the liver function full recovery is normal, and B ultrasonic shows the liver Non Apparent Abnormality, and it is normal that routine blood test recovers, hepatitis B great three positive one, 3 two are turned out cloudy or first of small three positive turned out cloudy, and it is zero that hepatitis B virus is quantitatively removed.

Take a turn for the better: weak, poor appetite, detest the degree such as oil, abdominal distention, jaundice, hepatalgia and obviously alleviate, liver function takes a turn for the better and approaches normal, it is slightly strong or approaching normal that B ultrasonic shows that the liver parenchyma luminous point slightly slightly reaches echo, routine blood test approaches normal, Hepatitis B virus is qualitative weak positive, and hepatitis B great three positive virus quantitatively is less than 4000 copies/ml or hepatitis B small three positive virus quantitatively is less than 500 copies/ml.

Invalid: as not reach improvement standard person.

7, the characteristics of medicine of the present invention are to treat hepatitis B with it, large and small three sun no matter, and stadium length, hepatitis B virus quantitatively reaches 10 ⁸or 10 ⁹, as long as not entering the liver cirrhosis mistakeization repays the phase, need not revise or add and subtract from start to finish medicine and all can reach produce effects.

8, therapeutic effect (in Table 1 and table 2)

Table 1 is observation of curative effect after treatment

Table 2 sign after treating 30 days is improved situation

3 middle of the month, treat 30 examples with medicine of the present invention, produce effects 5 examples as a result, 23 examples that take a turn for the better, invalid 2 examples, obvious effective rate 16.67%, improvement rate 76.67, inefficiency 6.67%, total effective rate 93.3%.

The formula of medicine of the present invention is comprised of Chinese medicine A, Chinese medicine B, Chinese medicine C: wherein Chinese medicine A You Cortex araliae chinensis and root bark, each 7-10 part of Cornu Bubali slice, Herba Duchesneae Indicae, Herba Solani Lyrati, each 6-9 part of Rhizoma Dioscoreae Cirrhosae, Radix Serissae, Herba Damnacanthi, Herba Hedyotidis Chrysotrichae, Herba Pteridis multifidae, Herba Paederiae, Herba Elephantopi scaberis, Herba Capsellae, each 5-8 part of Herba Asplenii Sarelii, Cordyceps 1-4 part forms; Chinese medicine B is comprised of Fructus Schisandrae Chinensis powder 2-5 part, Mel 0.5-1 part; Chinese medicine C is hardness-softening antiphlogistine.

Claims (1)

1. a medicine for the treatment of hepatitis B, it is characterized in that it is a kind of Chinese medicine dispensing medicament, by Chinese medicine A, Chinese medicine B, Chinese medicine C, formed, wherein Chinese medicine A Shi You Cortex araliae chinensis and root bark, each 7-10 part of Cornu Bubali slice, Herba Duchesneae Indicae, Herba Solani Lyrati, each 6-9 part of Rhizoma Dioscoreae Cirrhosae, Radix Serissae, Herba Damnacanthi, Herba Hedyotidis Chrysotrichae, Herba Pteridis multifidae, Herba Paederiae, Herba Elephantopi scaberis, Herba Capsellae, each 5-8 part of Herba Asplenii Sarelii, Cordyceps 1-4 part forms; Chinese medicine B is comprised of Fructus Schisandrae Chinensis powder 2-5 part, Mel 0.5-1 part; Chinese medicine C is hardness-softening antiphlogistine; The fresh urine immersion that Cornu Bubali slice is placed in to healthy children below ten years old, after 36 hours, is taken out and is cleaned, and shines or dries; Cornu Bubali slice after Chinese medicine A described weight proportion Cortex araliae chinensis and root bark, processing, Herba Duchesneae Indicae, Herba Solani Lyrati, Rhizoma Dioscoreae Cirrhosae 5 flavor medicines are decocted with water, amount of water is boiled medicine than usual and is added water and do not have that the powder amount is higher is advisable, decoct after 2 hours, add Radix Serissae, Herba Damnacanthi, Herba Hedyotidis Chrysotrichae, Herba Pteridis multifidae, Herba Paederiae, Herba Elephantopi scaberis, Herba Capsellae, Herba Asplenii Sarelii, Cordyceps 9 flavor medicines, decoct with water again twice, each amount of water, not have powder to be advisable, merges decocting liquid twice, filters to get filtrate 500 milliliters; The Fructus Schisandrae Chinensis powder of the described weight proportion of Chinese medicine B is mixed while hot with refined honey, repeatedly stir and rub to all moistening mix homogeneously, with pellet processing machine, make the impartial pill of size, shine or dry; Chinese medicine C hardness-softening antiphlogistine is put to shady and cool dry place.