CN101658625A

CN101658625A - Hardness-softening antiphlogistine

Info

Publication number: CN101658625A
Application number: CN200910044416A
Authority: CN
Inventors: 刘小杨
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-09-22
Filing date: 2009-09-22
Publication date: 2010-03-03
Anticipated expiration: 2029-09-22
Also published as: CN101658625B

Abstract

The invention relates to hardness-softening antiphlogistine which belongs to pharmaceuticals and comprises buffalo horn slice, baked turtle shell, monkshood, Korean monkshood root (made in Jilin province), rhizoma anemarrhenae, radix salvia, Chinese thorowax root, Vietnamese sophora root, Szechuan lovage rhizome, Chinese polyphaga, tuber fleeceflower root, leech, lightyellow sophora root, angelica, white paeony root, angelica root, oriental waterplantain rhizome and pangolin. The hardness-softening antiphlogistine belongs to a pure traditional Chinese preparation, has no toxic and side effects, can release swelling and soften hardness by external application and achieves the aim of radically treating compensatory hepatocirrhosis and hepatosplenomegaly.

Description

Hardness-softening antiphlogistine

Technical field:

The present invention relates to a kind of hardness-softening antiphlogistine for the treatment of compensatory cirrhosis, hepatosplenomegaly, belong to pharmaceuticals.

Background technology:

Current medical circle is thought " method that liver cirrhosis is cured, reversing liver cirrhosis difficulty "." process of liver cirrhosis can not reverse "." liver cirrhosis changes because of organizational structure, causes dysfunction, does not more have the radical cure way "." for hepatopathy, there is no hiding the fact, also do not find to have what specific drug even to this day "." no matter be hepatitis or liver cirrhosis, still do not have specific Therapeutic Method "." wherein high, as to select excision to finalize the design " to megalosplenia and spleen.Therefore, medical effect still is relatively poor.

Summary of the invention:

The purpose of this invention is to provide a kind of hardness-softening antiphlogistine, is pure Chinese medicinal preparation, without any side effects, by external application, compensatory cirrhosis, hepatosplenomegaly is reached the purpose of radical cure.

Technical scheme of the present invention is: by Cornu Bubali slice, Carapax Trionycis (processed), Radix Aconiti Lateralis Preparata, Radix Aconiti Coreani, the Rhizoma Anemarrhenae, Radix Salviae Miltiorrhizae, Radix Bupleuri, Radix Sophorae Tonkinensis, Rhizoma Chuanxiong, Radix Polygoni Multiflori, Radix Sophorae Flavescentis, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, Rhizoma Alismatis, Squama Manis, Eupolyphaga Seu Steleophaga, Hirudo, vegetable oil, Plumbum preparatium is formed, with Cornu Bubali slice, Carapax Trionycis (processed), Radix Aconiti Lateralis Preparata, Radix Aconiti Coreani, the Rhizoma Anemarrhenae, Radix Salviae Miltiorrhizae, Radix Bupleuri, Radix Sophorae Tonkinensis, Rhizoma Chuanxiong, Radix Polygoni Multiflori, Radix Sophorae Flavescentis, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, Rhizoma Alismatis, Squama Manis places vegetable oil to soak altogether, place vegetable oil to soak in addition Eupolyphaga Seu Steleophaga and Hirudo, with pasta a little more than medicine plane degree of being, season in winter (summer) steeped ten (five) days, be sealed in the drying receptacle after Plumbum preparatium fried the branch that anhydrates, the weight ratio of Plumbum preparatium and vegetable oil is season in winter (summer) 0.35 (0.45): 1.

Advantage of the present invention is: (1) is pure Chinese medicinal preparation, and is without any side effects; (2) raw material sources are wide, and it is low to produce composition; (3) easy to use, the patient is acceptant; (4) evident in efficacy, can thoroughly eradicate source of disease.

The specific embodiment:

Embodiment: place vegetable oil to soak altogether Cornu Bubali slice, Carapax Trionycis (processed), Radix Aconiti Lateralis Preparata, Radix Aconiti Coreani, the Rhizoma Anemarrhenae, Radix Salviae Miltiorrhizae, Radix Bupleuri, Radix Sophorae Tonkinensis, Rhizoma Chuanxiong, Radix Polygoni Multiflori, Radix Sophorae Flavescentis, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, Rhizoma Alismatis, Squama Manis, place vegetable oil to soak in addition Eupolyphaga Seu Steleophaga and Hirudo, with pasta a little more than medicine plane degree of being, season in winter (summer) steeped ten (five) days, be sealed in the drying receptacle after Plumbum preparatium fried the branch that anhydrates, the weight ratio of Plumbum preparatium and vegetable oil is season in winter (summer) 0.35 (0.45): 1.

Earlier with whole vegetable oil of soak medicine together with Cornu Bubali slice; Carapax Trionycis (processed); Radix Aconiti Lateralis Preparata; Radix Aconiti Coreani; the Rhizoma Anemarrhenae; Radix Salviae Miltiorrhizae; Radix Bupleuri; Radix Sophorae Tonkinensis; Rhizoma Chuanxiong; Radix Polygoni Multiflori; Radix Sophorae Flavescentis; Radix Angelicae Sinensis; the Radix Paeoniae Alba; the Radix Angelicae Dahuricae; Rhizoma Alismatis; on putting and set fire in the iron pan, Squama Manis is heated to medicine by fried when brown and crisp; add Hirudo; Eupolyphaga Seu Steleophaga; two flavors are fried during to withered charcoal to the back; cease fire a moment; drag for medicine; pot fire heating will be gone into after the filtration of medicine oil again; simultaneously do not stop to stir medicine oil; observing oil smoke begins gradually to change black and dense from light cyan; and then become white dense smoke; and oil bloom also make into to gather to pot central authorities near being dispersed in pot wall periphery; at this moment; being stained with a little medicine oil droplets goes in the cold water; when being agglomerated into pearl again after scattering as oil droplet; one side ceaselessly stirs to same clockwise, but does not touch the bottom of a pan, and one side is neither fast nor slow to the pasta uniformly dispersing with Plumbum preparatium; extremely white dense smoke mist emits to the greatest extent; when red decoloration, oil colours were pitchy from palm fibre (brown) complexion changed, the medicine oil droplet that takes a morsel was gone into cold water; take out after several seconds; tack-free as cream, denseness is suitable, then slowly pours cream into cold water; do not stop to stir with waddy simultaneously; make it become band shape, water temperature is changeed heat and is then changed cold water, treats to take out after cream condenses; pinch pressure repeatedly; go clean its internal moisture, and make agglomerate, three round the clock in the bubble cold water; change water every day once with releasing fire-toxin; finished product plaster agglomerate is put in the canister, and slow fire dissolves, and bamboo chip is stained with and is coated with on paper or the cloth.

Cornu Bubali slice in this prescription is joined the army into blood, and the effect of heat clearing away, detoxifcation, removing heat from blood is arranged, and its main constituent keratin can clear away heart-fire, liver, stomach three be through burning hot, especially can removing summer-heat noxious heat in the blood system.Carapax Trionycis (processed) has the effect of suppressing the hyperactive liver to relieve the wind syndrome, hard masses softening and resolving, be used for the lump in the abdomen mass beside the umbilicus, compositions such as its animal glue that contains, keratin, vitamin D and iodine can suppress connective tissue proliferation, play the effect of soft liver, spleen, event is effective to liver cirrhosis, hepatosplenomegaly, and can promote plasma albumin, and prolong the immunoglobulin half life, be usually used in the albumen that hepatopathy merges anemia and be inverted the patient.But the Radix Aconiti Lateralis Preparata recuperating depleted YANG is mended fire, dispelling cold and removing dampness, the effect that supporing yang capable water is still arranged, be used for decline of kidney-YANG, body and face edema and spleen YANG deficiency, limbs edema, abdominal distention loose stool, the rat skin vascular permeability that its contained main constituent aconitine can suppress to be caused by histamine increases, the granulation tissue that suppresses on the Embryo Gallus domesticus chorioallantois forms, and the transudate of angiogenesis, inflammatory cell migration, granulation capsule is all had the strongest inhibitory action.Radix Aconiti Coreani is gone into liver, spleen channel, contains hypaconitine, Radix Aconiti Coreani first, second, third, fourth, penta plain six kinds of alkaloids, has strengthened effect after interpolation this product in the softening hardness and disperse swelling paste formulation.Rhizoma Anemarrhenae bitter cold, last clearing away lung-heat, the kidney fire that drops, the double liver sthenia gastropyrexia that moves back, its ingredient timosaponin can suppress the alpha-fetoprotein gene expression of rat ZISHU, and the Rhizoma Anemarrhenae has been used to treat hepatocarcinoma, and in addition, Rhizoma Anemarrhenae extractum also has lipotropism fat enzymatic activity.Radix Salviae Miltiorrhizae has the effect of blood-nourishing blood-generating, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, be used for abdomen enclosed mass, hypochondriac pain due to stagnation of liverQI, early stage hepatitis interstitialis chronica has hepatosplenomegaly person, zoopery proof Radix Salviae Miltiorrhizae can be expanded peripheral vessels, bring high blood pressure down, promote the liver physiology function to take a turn for the better, and can make the liver spleen of enlargement dwindle deliquescing, external, Radix Salviae Miltiorrhizae can anticoagulant, promotes the PGI of blood vessel endothelium ₂Produce, can suppress platelet T XA ₂Synthetic, suppress the generation of cAMP, suppress the blood vessel endothelium obstacle, suppress the interaction between blood vessel endothelium and the hemocyte, the effect of microcirculation improvement is arranged.Radix Bupleuri can improve liver function, the effect that dispersing the stagnated live-QI to relieve the stagnation of QI is arranged, be used for full vexed, the distending pain over the hypochondrium of stagnation of QI due to depression of the liver, chest and diaphragm, hepatic depression and blood deficiency, dysfunction of the spleen in transportation, Radix Bupleuri extractum points out it can suppress the immunological liver cell injury in experiment in vitro, in following four kinds of compositions that Radix Bupleuri contains: (1) bupleurumol has the effect of easypro, receipts, soft liver spleen, low dose of (6-12g) can reach the purpose of the soft liver spleen that relaxes, and middle dosage (15-21g) can be received soft liver spleen with heavy dose of (24-45g); (2) Saponin has refrigeration function; (3) fatty acid has antiinflammation; (4) saikoside has analgesic activity, in addition, in the test of the subcutaneous granulation cyst (Oleum Tiglii and cotton pellet method) of rat, determine that saikoside has exudation, suppresses the effect of granuloma growth, saikoside can suppress the increasing of vascular permeability due to histamine, the 5-hydroxy tryptamine.Radix Sophorae Tonkinensis has the effect of clearing heat, releasing toxin, removing swelling, zoopery proves, the contained alkaloid of Radix Sophorae Tonkinensis, matrine, all kinds of flavone components have certain inhibitory action to early stage malignant tumor, the experimental animal general state is good, side effect is little, safety, and do not make leukopenia, mouse gavaging Radix Sophorae Tonkinensis decoct 60 gram/kilograms/day 16-21 days altogether, reach more than 25% the suppression ratio of S-180, the matrine of from Radix Sophorae Tonkinensis, separating, all effective to mice ehrlich carcinoma test tube test or whole animal test, also all effective to murine sarcoma-180, contained pterocarpoid in the Radix Sophorae Tonkinensis, d-maackianin-also has inhibitory action to S-180.Rhizoma Chuanxiong has the effect of blood-activating and qi-promoting, be used for stagnation of QI-blood, the stagnation of QI breast side of body, congestive edema is had a pain, the excited vasomotor center of energy, directly the expansion peripheral vessels increases coronary artery blood flow, brings high blood pressure down, in addition, the effect that also has vitamin antagonist E to lack, Rhizoma Chuanxiong extractum also has the interferon inducer effect in external effect with raising tumor cell killing activity relevant with antibody and complement.Eupolyphaga Seu Steleophaga goes into Liver Channel, go into blood with softening the hard mass, the special removing blood stasis with potent drugs blood of merit, detumescence piece, be usually used in hepatomegaly and belong to chronic hepatitis or early stage hepatitis interstitialis chronica and the person that do not disappear, methanol extractum can suppress forming of experiment DIC (multiple IC symptom) the rats'liver hemorrhagic necrosis nest that caused by endotoxin in its body, make the fibrinolytic system activation, external methanol extractum also has the fibrinolytic system activation.Radix Polygoni Multiflori is gone into Liver Channel, be used for invigorating the liver and kidney deficiency, hyperactivity of YANG due to deficiency of YIN (as old sclerosis of blood vessels hypertension), zoopery, contained lecithin, methoxyl group anthraquinone derivative can stop cholesterol at intrahepatic deposition in the Radix Polygoni Multiflori composition, can alleviate atherosclerotic formation, stop lipoids in serum, to be detained or be penetrated into endarterium, increasing of experimental rabbit anteserum cholesterol there is inhibitory action, in addition, in the influence test of Chinese medicine, find that Radix Polygoni Multiflori has the effect of similar adrenocortical hormone sample to adrenalectomy Hepar Mus glycogen content.Hirudo goes into the Liver Channel blood system, saltyly can walk blood, the drop-down of bitter energy, have blood stasis dispelling blood, dissolving Blood clotting, be the product of removing blood stasis, be used for the abdomen lump, blood stasis is had a pain, there is the effect of blood vessel dilating in contained a kind of H-subst in its composition, also contain heparin and antithrombotic element, its so-called removing blood stasis effect can make blood-retention or long-pending stagnation resolvation loose and be absorbed in the blood circulation or from stool and gush and separate.Radix Sophorae Flavescentis energy heat clearing and damp drying is used for jaundice due to damp-heat, and its contained matrine has antitumor action, and the contained oxymatrine of Radix Sophorae Flavescentis all shows very strong active anticancer to salcoma-180 solid tumor and its contained matrine to ehrlich carcinoma.When being included into liver; spleen channel; blood circulation and promoting silt is arranged; the effect of promoting the circulation of QI to relieve pain; be used for coagulation of QI-blood; its ingredient volatile oil; water-soluble alkaloid; energy such as sucrose the liver protecting; prevent that hepatic glycogen from reducing; and the effect of vitamin antagonist E deficiency disease arranged; hepatic tissue oxidation glutamic acid and cysteine also there is booster action; in the hot water extraction extractum commonly used; Radix Angelicae Sinensis just has very high inducing interferon activity when low concentration; in addition; but the effect of Radix Angelicae Sinensis microcirculation improvement and energy blood stasis dispelling blood is based on the effect that Radix Angelicae Sinensis composition adenosine suppresses platelet aggregation, its hot water extract's polysaccharide component; the mice ehrlich's ascites carcinoma is had active anticancer, and the material that shows this active anticancer is the Arabic galactose AR-4E-2 of colloid sample.The Radix Paeoniae Alba goes into liver, spleen channel, the effect that the yin nourishing suppressing the hyperactive liver is arranged: be used for deficiecny of liver-YIN, the high Sheng of liver-yang, the effect that easing the affected liver to relieve pain is arranged again: be used for the side of body, abdomen pain due to the disharmony in liver-QI, the Radix Paeoniae Alba has the immune activation effect, to mice quiet notes carbon granules observe its phagocytic activity and get rid of in the experiment of time, peoniflorin can make the half-life shorten, the phagocytic activity that makes mice cultivate peritoneal macrophage strengthens.The Radix Angelicae Dahuricae has the effect of reducing swelling and alleviating pain, in hot water extraction extractum commonly used, the Radix Angelicae Dahuricae just has very high inducing interferon activity when low concentration, the Radix Angelicae Dahuricae also has the antitumor catalytic action, the normal hexane of the Radix Angelicae Dahuricae, ether and ethyl acetate extract extractum, reach isolated furocoumarin class from these active components, external, the phosphorus Absorption of HeLa cells is significantly suppressed under the tumor catalyst stimulates.The effect that Rhizoma Alismatis has eliminating dampness and diuresis to expel the heat-evil, its water and benzene abstract have the lipotropism liver components, zoopery finds that Rhizoma Alismatis has inhibitory action to cholesterol level in the tame Sanguis Leporis seu oryctolagi regulating liver-QI, can alleviate the rabbit development of atherosclerosis, blood pressure lowering, blood sugar lowering, also can suppress higher fatty acid hepatomegaly Adips Mus fat accumulates, reduce the rat hyperlipidemia, rat because of the hepatic injury that carbon tetrachloride causes, is had the effect of prevention and treatment.Squama Manis has the routed carbuncle of detumescence, searches the active effect of wind, adds the process that an amount of Squama Manis can be accelerated softening hardness and disperse swelling in the softening hardness and disperse swelling paste formulation.

Hardness-softening antiphlogistine was treated 34 liver cirrhosis, hepatosplenomegaly person altogether, except that invalid to 3 persons that enter the decompensated liver cirrhosis wherein, in addition 31 compensatory cirrhosis, hepatosplenomegaly persons not only liver is soft, not bitterly, and freedom of movement, diet and ordinary person are as good as, the participation labor in general is produced, and it is normal that the liver spleen channel CT examination of enlargement is recovered, and the liver function full recovery is normal, therefore, hardness-softening antiphlogistine has been subjected to satisfied effect to compensatory cirrhosis, hepatosplenomegaly person.

Cure mainly the prescription of compensatory cirrhosis, hepatosplenomegaly: Cornu Bubali slice, each 8-12 part of Carapax Trionycis (processed), Radix Aconiti Lateralis Preparata, each 6-10 part of Radix Aconiti Coreani (Jilin product), the Rhizoma Anemarrhenae, Radix Salviae Miltiorrhizae, Radix Bupleuri, each 4-8 part of Radix Sophorae Tonkinensis, Rhizoma Chuanxiong, Eupolyphaga Seu Steleophaga, Radix Polygoni Multiflori, Hirudo, Radix Sophorae Flavescentis, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, each 1-5 part of Rhizoma Alismatis, Squama Manis 0.1-0.5 part.

Claims

1, a kind of hardness-softening antiphlogistine, it is characterized in that: by Cornu Bubali slice, each 8-12 part of Carapax Trionycis (processed), Radix Aconiti Lateralis Preparata, each 6-10 part of Radix Aconiti Coreani (Jilin product), the Rhizoma Anemarrhenae, Radix Salviae Miltiorrhizae, Radix Bupleuri, each 4-8 part of Radix Sophorae Tonkinensis, Rhizoma Chuanxiong, Eupolyphaga Seu Steleophaga, Radix Polygoni Multiflori, Hirudo, Radix Sophorae Flavescentis, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, each 1-5 part of Rhizoma Alismatis, Squama Manis 0.1-0.5 part, vegetable oil, Plumbum preparatium, totally 20 flavors are formed, with Cornu Bubali slice, Carapax Trionycis (processed), Radix Aconiti Lateralis Preparata, Radix Aconiti Coreani, the Rhizoma Anemarrhenae, Radix Salviae Miltiorrhizae, Radix Bupleuri, Radix Sophorae Tonkinensis, Rhizoma Chuanxiong, Radix Polygoni Multiflori, Radix Sophorae Flavescentis, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, Rhizoma Alismatis, Squama Manis places vegetable oil to soak altogether, place vegetable oil to soak in addition Eupolyphaga Seu Steleophaga and Hirudo, with pasta a little more than medicine plane degree of being, season in winter (summer) steeped ten (five) days, be sealed in the drying receptacle after Plumbum preparatium fried the branch that anhydrates, the weight ratio of Plumbum preparatium and vegetable oil is season in winter (summer) 0.35 (0.45): 1.