CN103168032A - 抑制间变性淋巴瘤激酶的苯并咪唑和氮杂苯并咪唑化合物 - Google Patents

抑制间变性淋巴瘤激酶的苯并咪唑和氮杂苯并咪唑化合物 Download PDF

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CN103168032A
CN103168032A CN2011800470711A CN201180047071A CN103168032A CN 103168032 A CN103168032 A CN 103168032A CN 2011800470711 A CN2011800470711 A CN 2011800470711A CN 201180047071 A CN201180047071 A CN 201180047071A CN 103168032 A CN103168032 A CN 103168032A
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alkyl
tautomer
alkylidene group
pharmaceutical salts
group
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克里斯蒂安·M·博埃齐奥
艾伦·C·程
德博拉·肖凯特
理查德·T·刘易斯
米凯莱·H·波塔什曼
卡琳娜·罗梅罗
约翰·C·施特尔瓦根
道格拉斯·A·惠廷顿
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Amgen Inc
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Amgen Inc
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN2011800470711A 2010-08-05 2011-07-28 抑制间变性淋巴瘤激酶的苯并咪唑和氮杂苯并咪唑化合物 Pending CN103168032A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37104110P 2010-08-05 2010-08-05
US61/371,041 2010-08-05
PCT/US2011/045703 WO2012018668A1 (en) 2010-08-05 2011-07-28 Benzimidazole and azabenzimidazole compounds that inhibit anaplastic lymphoma kinase

Publications (1)

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CN103168032A true CN103168032A (zh) 2013-06-19

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US (2) US9115127B2 (https=)
EP (1) EP2611784A4 (https=)
JP (2) JP5795635B2 (https=)
KR (1) KR20130108543A (https=)
CN (1) CN103168032A (https=)
AU (2) AU2011286005B2 (https=)
BR (1) BR112013002879A2 (https=)
CA (1) CA2807093A1 (https=)
MX (1) MX2013001313A (https=)
RU (1) RU2013109143A (https=)
SG (2) SG187209A1 (https=)
TW (1) TWI500610B (https=)
WO (1) WO2012018668A1 (https=)

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CN104202982A (zh) * 2011-11-14 2014-12-10 泰萨罗公司 调节某些酪氨酸激酶
CN108290879A (zh) * 2015-09-18 2018-07-17 默克专利有限公司 用作irak抑制剂的杂芳基化合物及其用途

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JP7590996B2 (ja) 2019-06-24 2024-11-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｅｇｆｒ阻害剤としての新たな大環状化合物および誘導体
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AU2015218439A1 (en) 2015-09-17
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US20160046625A1 (en) 2016-02-18
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US9115127B2 (en) 2015-08-25
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US20130217668A1 (en) 2013-08-22
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