CN103153308B - Trpa1受体拮抗剂 - Google Patents
Trpa1受体拮抗剂 Download PDFInfo
- Publication number
- CN103153308B CN103153308B CN201180049452.3A CN201180049452A CN103153308B CN 103153308 B CN103153308 B CN 103153308B CN 201180049452 A CN201180049452 A CN 201180049452A CN 103153308 B CN103153308 B CN 103153308B
- Authority
- CN
- China
- Prior art keywords
- pain
- compound
- purposes
- antalgesic
- various
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- LSUGPAVXOXLORK-UHFFFAOYSA-N CC(C)(C)C(C(c(cc1)ccc1C#N)=O)NC(N(CC1)CCN1c1cccc(C)n1)=O Chemical compound CC(C)(C)C(C(c(cc1)ccc1C#N)=O)NC(N(CC1)CCN1c1cccc(C)n1)=O LSUGPAVXOXLORK-UHFFFAOYSA-N 0.000 description 1
- JBRUJOFLPITHIV-UHFFFAOYSA-N CC(C)(C)C(C(c(cc1)ccc1C#N)=O)NC(OC(C)(C)C)=O Chemical compound CC(C)(C)C(C(c(cc1)ccc1C#N)=O)NC(OC(C)(C)C)=O JBRUJOFLPITHIV-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Description
Claims (14)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39213010P | 2010-10-12 | 2010-10-12 | |
US61/392,130 | 2010-10-12 | ||
PCT/SE2011/051213 WO2012050512A1 (en) | 2010-10-12 | 2011-10-11 | Trpa1 receptor antagonist |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103153308A CN103153308A (zh) | 2013-06-12 |
CN103153308B true CN103153308B (zh) | 2015-06-03 |
Family
ID=45938532
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201180049452.3A Active CN103153308B (zh) | 2010-10-12 | 2011-10-11 | Trpa1受体拮抗剂 |
Country Status (5)
Country | Link |
---|---|
US (1) | US8859556B2 (zh) |
EP (1) | EP2627329B1 (zh) |
JP (1) | JP5847827B2 (zh) |
CN (1) | CN103153308B (zh) |
WO (1) | WO2012050512A1 (zh) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2843965A1 (en) | 2011-08-09 | 2013-02-14 | Hydra Biosciences, Inc. | Inhibiting transient receptor potential ion channel trpa1 |
JP6182072B2 (ja) | 2012-01-17 | 2017-08-16 | Eaファーマ株式会社 | 複素環アミド誘導体及びそれを含有する医薬 |
US9394308B2 (en) | 2013-01-18 | 2016-07-19 | Merck Sharp & Dohme Corp. | Inhibiting the transient receptor potential A1 ion channel |
WO2014184248A2 (en) * | 2013-05-15 | 2014-11-20 | Acturum Life Science AB | Trpa1 antagonist compounds |
CN103760286A (zh) * | 2014-01-14 | 2014-04-30 | 北京万全德众医药生物技术有限公司 | 一种用高效液相色谱法测定琥珀酸索非那新中间体光学纯度的方法 |
WO2017060488A1 (en) | 2015-10-09 | 2017-04-13 | Almirall, S.A. | New trpa1 antagonists |
WO2017064068A1 (en) | 2015-10-14 | 2017-04-20 | Almirall, S.A. | New trpa1 antagonists |
IT202100015098A1 (it) * | 2021-06-09 | 2022-12-09 | Flonext S R L | Composto antagonista del canale trpa1 per uso in patologie degenerative della retina |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1832935A (zh) * | 2003-08-01 | 2006-09-13 | 欧洲凯尔特公司 | 用于治疗疼痛的治疗药 |
WO2008007103A1 (en) * | 2006-07-14 | 2008-01-17 | Amura Therapeutics Limited | Furo [3, 2-b] pyrrol derivatives |
WO2010075353A1 (en) * | 2008-12-22 | 2010-07-01 | Hydra Biosciences, Inc. | Compositions useful for treating disorders related to trpa1 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1770091A1 (de) * | 2005-09-29 | 2007-04-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
TWI423819B (zh) | 2005-12-22 | 2014-01-21 | Hydra Biosciences Inc | 用於調節trpa1功能之化合物 |
EP2249820A1 (en) | 2008-01-04 | 2010-11-17 | Abbott Laboratories | Trpa1 antagonists |
WO2010004390A1 (en) | 2008-06-17 | 2010-01-14 | Glenmark Pharmaceuticals, S.A. | Quinazoline dione derivatives as trpa1 modulators |
-
2011
- 2011-10-11 JP JP2013533819A patent/JP5847827B2/ja active Active
- 2011-10-11 EP EP11832839.2A patent/EP2627329B1/en active Active
- 2011-10-11 WO PCT/SE2011/051213 patent/WO2012050512A1/en active Application Filing
- 2011-10-11 US US13/878,862 patent/US8859556B2/en active Active
- 2011-10-11 CN CN201180049452.3A patent/CN103153308B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1832935A (zh) * | 2003-08-01 | 2006-09-13 | 欧洲凯尔特公司 | 用于治疗疼痛的治疗药 |
WO2008007103A1 (en) * | 2006-07-14 | 2008-01-17 | Amura Therapeutics Limited | Furo [3, 2-b] pyrrol derivatives |
WO2010075353A1 (en) * | 2008-12-22 | 2010-07-01 | Hydra Biosciences, Inc. | Compositions useful for treating disorders related to trpa1 |
Also Published As
Publication number | Publication date |
---|---|
CN103153308A (zh) | 2013-06-12 |
EP2627329B1 (en) | 2015-07-08 |
EP2627329A4 (en) | 2014-03-05 |
JP2013539781A (ja) | 2013-10-28 |
EP2627329A1 (en) | 2013-08-21 |
US8859556B2 (en) | 2014-10-14 |
US20140148466A1 (en) | 2014-05-29 |
WO2012050512A1 (en) | 2012-04-19 |
JP5847827B2 (ja) | 2016-01-27 |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: AKETURAM LIFE SCIENCES AG Free format text: FORMER OWNER: ASTRAZENECA AB Effective date: 20141209 |
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C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20141209 Address after: Solna, Sweden Applicant after: ACTURUM LIFE SCIENCE AB Address before: Swedish Sodertalje Applicant before: ASTRAZENECA AB |
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C14 | Grant of patent or utility model | ||
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Effective date of registration: 20190821 Address after: Solna, Sweden Patentee after: Akturam Life Co.,Ltd. Address before: Solna, Sweden Patentee before: Akturam Real Estate Co.,Ltd. Effective date of registration: 20190821 Address after: Solna, Sweden Patentee after: Akturam Real Estate Co.,Ltd. Address before: Solna, Sweden Patentee before: ACTURUM LIFE SCIENCE AB |
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