CN103145712A - 取代的8-[6-氨基-3-吡啶基]黄嘌呤 - Google Patents
取代的8-[6-氨基-3-吡啶基]黄嘌呤 Download PDFInfo
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- CN103145712A CN103145712A CN2013100513402A CN201310051340A CN103145712A CN 103145712 A CN103145712 A CN 103145712A CN 2013100513402 A CN2013100513402 A CN 2013100513402A CN 201310051340 A CN201310051340 A CN 201310051340A CN 103145712 A CN103145712 A CN 103145712A
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
Landscapes
- Health & Medical Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80503006P | 2006-06-16 | 2006-06-16 | |
| US60/805,030 | 2006-06-16 | ||
| US80556406P | 2006-06-22 | 2006-06-22 | |
| US60/805,864 | 2006-06-26 | ||
| US11/811,823 | 2007-06-12 | ||
| US11/811,823 US7884100B2 (en) | 2006-06-16 | 2007-06-12 | Substituted 8-[6-amino-3-pyridyl]xanthines |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007800222077A Division CN101466382A (zh) | 2006-06-16 | 2007-06-13 | 取代的8-[6-氨基-3-吡啶基]黄嘌呤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103145712A true CN103145712A (zh) | 2013-06-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2013100513402A Pending CN103145712A (zh) | 2006-06-16 | 2007-06-13 | 取代的8-[6-氨基-3-吡啶基]黄嘌呤 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7884100B2 (https=) |
| EP (1) | EP2029143B1 (https=) |
| JP (1) | JP5417558B2 (https=) |
| KR (1) | KR101413404B1 (https=) |
| CN (1) | CN103145712A (https=) |
| AU (1) | AU2007261568B2 (https=) |
| BR (1) | BRPI0712001B8 (https=) |
| CA (1) | CA2655598C (https=) |
| DK (1) | DK2029143T3 (https=) |
| EA (1) | EA016791B1 (https=) |
| ES (1) | ES2548437T3 (https=) |
| HU (1) | HUE026457T2 (https=) |
| IL (1) | IL195916A (https=) |
| MX (1) | MX2008015954A (https=) |
| MY (1) | MY152178A (https=) |
| NZ (1) | NZ597222A (https=) |
| PL (1) | PL2029143T3 (https=) |
| PT (1) | PT2029143E (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7317017B2 (en) * | 2002-11-08 | 2008-01-08 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| KR101222364B1 (ko) * | 2003-08-25 | 2013-01-15 | 트로비스 파마슈티칼스 엘엘씨 | 치환된 8-헤테로아릴 크산틴 |
| WO2006091936A2 (en) * | 2005-02-25 | 2006-08-31 | Adenosine Therapeutics, Llc | Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines |
| US7618962B2 (en) * | 2005-02-25 | 2009-11-17 | Pgx Health, Llc | Pyrazolyl substituted xanthines |
| US7579348B2 (en) * | 2005-02-25 | 2009-08-25 | Pgxhealth, Llc | Derivatives of 8-substituted xanthines |
| US7884100B2 (en) | 2006-06-16 | 2011-02-08 | Pgxhealth, Llc | Substituted 8-[6-amino-3-pyridyl]xanthines |
| US7875608B2 (en) * | 2007-12-17 | 2011-01-25 | Thompson Robert D | Substituted 8-[6-amino-3pyridyl]xanthines |
| BR112023023996A2 (pt) | 2021-05-18 | 2024-01-30 | Adovate Llc | Xantinas de piridil contendo amida cíclica como antagonistas de a2b |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050065341A1 (en) * | 2003-08-25 | 2005-03-24 | Guoquan Wang | Substituted 8-heteroaryl xanthines |
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| US6117878A (en) * | 1998-02-24 | 2000-09-12 | University Of Virginia | 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors |
| US6060481A (en) | 1998-05-28 | 2000-05-09 | The Penn State Research Foundation | Method for improving insulin sensitivity using an adenosine receptor antagonist |
| GB9817623D0 (en) | 1998-08-13 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
| EP1255550A2 (en) * | 2000-02-17 | 2002-11-13 | Cv Therapeutics, Inc. | Method for identifying and using a 2b adenosine receptor antagonists to mediate mammalian cell proliferation |
| US7317017B2 (en) * | 2002-11-08 | 2008-01-08 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| ATE520694T1 (de) | 2001-11-09 | 2011-09-15 | Gilead Palo Alto Inc | A2b-adenosinrezeptorantagonisten |
| US6977300B2 (en) | 2001-11-09 | 2005-12-20 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| US7304070B2 (en) | 2001-11-09 | 2007-12-04 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| WO2003063800A2 (en) | 2002-02-01 | 2003-08-07 | King Pharmaceuticals Research And Development, Inc. | 8-heteroaryl xanthine adenosine a2b receptor antagonists |
| US7034070B2 (en) * | 2002-09-27 | 2006-04-25 | Vincent Chuang | Arylalkyl aminofunctional silanes for epoxy laminates |
| US7148229B2 (en) | 2003-02-19 | 2006-12-12 | Hoffman-La Roche Inc. | Sulfonamide substituted xanthine derivatives |
| US20060058322A1 (en) | 2004-09-01 | 2006-03-16 | Dewan Zeng | Method of wound healing using A2B adenosine receptor antagonists |
| US20060053029A1 (en) | 2004-09-03 | 2006-03-09 | Butler Keith R | Methods and systems for providing an enterprise supply management portal |
| EP1799221A1 (en) | 2004-10-15 | 2007-06-27 | Cv Therapeutics, Inc. | Method of preventing and treating airway remodeling and pulmonary inflammation using a2b adenosine receptor antagonists |
| US7579348B2 (en) * | 2005-02-25 | 2009-08-25 | Pgxhealth, Llc | Derivatives of 8-substituted xanthines |
| WO2006091896A2 (en) * | 2005-02-25 | 2006-08-31 | Adenosine Therapeutics, Llc | Pyridyl substituted xanthines |
| US7618962B2 (en) | 2005-02-25 | 2009-11-17 | Pgx Health, Llc | Pyrazolyl substituted xanthines |
| WO2006091936A2 (en) * | 2005-02-25 | 2006-08-31 | Adenosine Therapeutics, Llc | Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines |
| NZ564326A (en) | 2005-06-16 | 2010-01-29 | Cv Therapeutics Inc | Prodrugs of A2B adenosine receptor antagonists |
| WO2007109547A2 (en) * | 2006-03-17 | 2007-09-27 | Cv Therapeutics, Inc. | Method of preventing and treating hepatic disease using a2b adenosine receptor antagonists |
| AU2006344750A1 (en) * | 2006-06-15 | 2007-12-27 | Targeted Genetics Corporation | Methods for treating target joints in inflammatory arthritis using AAV vectors encoding a TNF antagonist |
| US7884100B2 (en) | 2006-06-16 | 2011-02-08 | Pgxhealth, Llc | Substituted 8-[6-amino-3-pyridyl]xanthines |
| US7767685B2 (en) | 2006-06-29 | 2010-08-03 | King Pharmaceuticals Research And Development, Inc. | Adenosine A2B receptor antagonists |
| US7875608B2 (en) * | 2007-12-17 | 2011-01-25 | Thompson Robert D | Substituted 8-[6-amino-3pyridyl]xanthines |
| JP5460690B2 (ja) | 2008-03-26 | 2014-04-02 | アドヴィナス・セラピューティックス・リミテッド | アデノシンレセプターアンタゴニストとしてのヘテロ環化合物 |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050065341A1 (en) * | 2003-08-25 | 2005-03-24 | Guoquan Wang | Substituted 8-heteroaryl xanthines |
Also Published As
| Publication number | Publication date |
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| KR101413404B1 (ko) | 2014-06-27 |
| MX2008015954A (es) | 2009-03-06 |
| JP2010500284A (ja) | 2010-01-07 |
| PT2029143E (pt) | 2015-10-20 |
| CA2655598A1 (en) | 2007-12-27 |
| US20110082139A1 (en) | 2011-04-07 |
| ES2548437T3 (es) | 2015-10-16 |
| US7884100B2 (en) | 2011-02-08 |
| EP2029143A2 (en) | 2009-03-04 |
| BRPI0712001B8 (pt) | 2021-05-25 |
| NZ597222A (en) | 2013-06-28 |
| HUE026457T2 (en) | 2016-05-30 |
| US20080004292A1 (en) | 2008-01-03 |
| EA200900010A1 (ru) | 2009-10-30 |
| AU2007261568B2 (en) | 2013-05-16 |
| BRPI0712001B1 (pt) | 2020-04-07 |
| EA016791B1 (ru) | 2012-07-30 |
| MY152178A (en) | 2014-08-15 |
| EP2029143B1 (en) | 2015-07-08 |
| IL195916A (en) | 2015-06-30 |
| BRPI0712001A2 (pt) | 2012-01-10 |
| DK2029143T3 (en) | 2015-09-21 |
| AU2007261568A1 (en) | 2007-12-27 |
| KR20090029268A (ko) | 2009-03-20 |
| CA2655598C (en) | 2014-10-28 |
| PL2029143T3 (pl) | 2015-12-31 |
| JP5417558B2 (ja) | 2014-02-19 |
| US8258142B2 (en) | 2012-09-04 |
| IL195916A0 (en) | 2009-09-01 |
| EP2029143A4 (en) | 2009-07-15 |
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