CN103145706A - 一类具有抗炎作用的咪唑并吡啶类化合物及其在制备抗炎药物中的应用 - Google Patents
一类具有抗炎作用的咪唑并吡啶类化合物及其在制备抗炎药物中的应用 Download PDFInfo
- Publication number
- CN103145706A CN103145706A CN2012104847041A CN201210484704A CN103145706A CN 103145706 A CN103145706 A CN 103145706A CN 2012104847041 A CN2012104847041 A CN 2012104847041A CN 201210484704 A CN201210484704 A CN 201210484704A CN 103145706 A CN103145706 A CN 103145706A
- Authority
- CN
- China
- Prior art keywords
- compound
- pyridine
- methyl
- imidazoles
- piperazinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 8
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 100
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 50
- 125000004193 piperazinyl group Chemical group 0.000 claims description 40
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- RSIWALKZYXPAGW-NSHDSACASA-N 6-(3-fluorophenyl)-3-methyl-7-[(1s)-1-(7h-purin-6-ylamino)ethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one Chemical compound C=1([C@@H](NC=2C=3N=CNC=3N=CN=2)C)N=C2SC=C(C)N2C(=O)C=1C1=CC=CC(F)=C1 RSIWALKZYXPAGW-NSHDSACASA-N 0.000 claims description 2
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Cited By (5)
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CN104557926A (zh) * | 2015-01-30 | 2015-04-29 | 何思伟 | 一种医药中间体3-取代咪唑并吡啶类化合物的合成方法 |
CN105814054A (zh) * | 2013-12-09 | 2016-07-27 | Ucb生物制药私人有限公司 | 作为tnf活性调节剂的稠合咪唑和吡唑衍生物 |
CN111423435A (zh) * | 2020-03-30 | 2020-07-17 | 厦门大学 | (1H-咪唑并[4,5-b]吡啶-6-基)吡啶衍生物及其应用 |
CN111450101A (zh) * | 2020-01-18 | 2020-07-28 | 温州广成生物科技有限公司 | 一种咪唑吡啶衍生物在药物制备中的应用 |
CN117257810A (zh) * | 2023-09-22 | 2023-12-22 | 湖南普瑞玛药物研究中心有限公司 | 一种咪唑吡啶衍生物在制备治疗或预防骨髓增殖性肿瘤药物中的应用 |
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CN105814054A (zh) * | 2013-12-09 | 2016-07-27 | Ucb生物制药私人有限公司 | 作为tnf活性调节剂的稠合咪唑和吡唑衍生物 |
CN105814054B (zh) * | 2013-12-09 | 2018-09-25 | Ucb生物制药私人有限公司 | 作为tnf活性调节剂的稠合咪唑和吡唑衍生物 |
CN104557926A (zh) * | 2015-01-30 | 2015-04-29 | 何思伟 | 一种医药中间体3-取代咪唑并吡啶类化合物的合成方法 |
CN104557926B (zh) * | 2015-01-30 | 2016-06-22 | 深圳市祥根生物科技有限公司 | 一种医药中间体3-取代咪唑并吡啶类化合物的合成方法 |
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CN111450101B (zh) * | 2020-01-18 | 2023-12-05 | 温州广成生物科技有限公司 | 一种咪唑吡啶衍生物在药物制备中的应用 |
CN111423435A (zh) * | 2020-03-30 | 2020-07-17 | 厦门大学 | (1H-咪唑并[4,5-b]吡啶-6-基)吡啶衍生物及其应用 |
CN111423435B (zh) * | 2020-03-30 | 2021-10-15 | 厦门大学 | (1H-咪唑并[4,5-b]吡啶-6-基)吡啶衍生物及其应用 |
CN117257810A (zh) * | 2023-09-22 | 2023-12-22 | 湖南普瑞玛药物研究中心有限公司 | 一种咪唑吡啶衍生物在制备治疗或预防骨髓增殖性肿瘤药物中的应用 |
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