CN103143023A - α7烟碱激动剂和抗精神病药的组合 - Google Patents

α7烟碱激动剂和抗精神病药的组合 Download PDF

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Publication number
CN103143023A
CN103143023A CN2013100500436A CN201310050043A CN103143023A CN 103143023 A CN103143023 A CN 103143023A CN 2013100500436 A CN2013100500436 A CN 2013100500436A CN 201310050043 A CN201310050043 A CN 201310050043A CN 103143023 A CN103143023 A CN 103143023A
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Prior art keywords
methyl
azabicyclo
oct
pyridine radicals
urea
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CN2013100500436A
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English (en)
Chinese (zh)
Inventor
M·本切里夫
G·J·加托
T·豪瑟
K·G·乔丹
S·R·莱特克沃斯
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Gyre Therapeutics Inc
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Targacept Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
CN2013100500436A 2008-02-13 2009-02-13 α7烟碱激动剂和抗精神病药的组合 Pending CN103143023A (zh)

Applications Claiming Priority (2)

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US2828208P 2008-02-13 2008-02-13
US61/028,282 2008-02-13

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CN103143023A true CN103143023A (zh) 2013-06-12

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CN2009801102033A Pending CN101977628A (zh) 2008-02-13 2009-02-13 α7烟碱激动剂和抗精神病药的组合

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EP (2) EP2254598B1 (https=)
JP (1) JP2011511845A (https=)
KR (1) KR20100113163A (https=)
CN (2) CN103143023A (https=)
AU (1) AU2009214625A1 (https=)
BR (1) BRPI0907570A2 (https=)
CA (1) CA2715268A1 (https=)
CO (1) CO6290706A2 (https=)
CY (1) CY1114492T1 (https=)
DK (1) DK2254598T3 (https=)
EC (1) ECSP10010471A (https=)
ES (1) ES2430622T3 (https=)
HR (1) HRP20130749T1 (https=)
IL (1) IL207389A0 (https=)
MX (1) MX2010008875A (https=)
NZ (1) NZ587312A (https=)
PL (1) PL2254598T3 (https=)
PT (1) PT2254598E (https=)
RS (1) RS52941B (https=)
RU (1) RU2481123C2 (https=)
SG (1) SG188144A1 (https=)
SI (1) SI2254598T1 (https=)
WO (1) WO2009102962A2 (https=)
ZA (1) ZA201005999B (https=)

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CN103180321A (zh) 2010-09-23 2013-06-26 Abbvie公司 氮杂金刚烷衍生物的一水合物
TW201242600A (en) * 2011-01-18 2012-11-01 Targacept Inc Treatment of cognitive dysfunction in schizophrenia
US9139576B2 (en) 2011-05-03 2015-09-22 Merck Sharp & Dohme Corp. Aminomethyl biaryl benzotriazole derivatives
WO2014054635A1 (ja) * 2012-10-02 2014-04-10 大日本住友製薬株式会社 イミダゾール誘導体
JP6807094B2 (ja) * 2016-04-29 2021-01-06 国立大学法人秋田大学 クロザピン又はその誘導体の血中薬剤濃度上昇リスク判定方法及び薬剤投与量判定方法
ES2769286T3 (es) 2016-12-20 2020-06-25 Lts Lohmann Therapie Systeme Ag Sistema terapéutico transdérmico que contiene asenapina
WO2018115010A1 (en) 2016-12-20 2018-06-28 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene
ES2881783T3 (es) 2017-06-26 2021-11-30 Lts Lohmann Therapie Systeme Ag Sistema terapéutico transdérmico que contiene asenapina y polímero de acrílico y silicona
CN107469087A (zh) * 2017-09-10 2017-12-15 孙永丽 用于治疗精神病的制剂
CA3101420A1 (en) 2018-06-20 2019-12-26 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine
CN112533593A (zh) 2018-06-20 2021-03-19 罗曼治疗系统股份公司 含有阿塞那平的透皮治疗系统
JP2024502470A (ja) * 2021-01-08 2024-01-19 アイエフエム デュー インコーポレイテッド Sting活性に関連する状態を治療するための化合物および組成物
TW202235073A (zh) 2021-01-08 2022-09-16 美商Ifm Due有限公司 用於治療與sting活性相關的病狀之化合物及組合物
DE102022114269A1 (de) 2022-06-07 2023-12-07 Rational Aktiengesellschaft Gargerät mit einem Selbstreinigungssystem sowie ein Verfahren zum Ändern von Reinigungsparametern für das Gargerät

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Publication number Priority date Publication date Assignee Title
CN108727416A (zh) * 2017-04-20 2018-11-02 北京大学 三环杂芳香体系酰胺衍生物及其制备和用途
CN108727416B (zh) * 2017-04-20 2021-03-09 北京大学 三环杂芳香体系酰胺衍生物及其制备和用途

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MX2010008875A (es) 2010-08-31
RU2481123C2 (ru) 2013-05-10
PL2254598T3 (pl) 2013-12-31
WO2009102962A2 (en) 2009-08-20
RS52941B (sr) 2014-02-28
RU2010137787A (ru) 2012-03-20
EP2254598A2 (en) 2010-12-01
ES2430622T3 (es) 2013-11-21
CA2715268A1 (en) 2009-08-20
HRP20130749T1 (en) 2013-10-11
CO6290706A2 (es) 2011-06-20
SG188144A1 (en) 2013-03-28
BRPI0907570A2 (pt) 2019-09-24
JP2011511845A (ja) 2011-04-14
IL207389A0 (en) 2010-12-30
US20110059947A1 (en) 2011-03-10
WO2009102962A3 (en) 2009-10-08
HK1147954A1 (en) 2011-08-26
ZA201005999B (en) 2011-05-25
EP2633868A1 (en) 2013-09-04
CY1114492T1 (el) 2016-10-05
NZ587312A (en) 2011-12-22
CN101977628A (zh) 2011-02-16
AU2009214625A1 (en) 2009-08-20
DK2254598T3 (da) 2013-07-29
PT2254598E (pt) 2013-10-16
KR20100113163A (ko) 2010-10-20
SI2254598T1 (sl) 2013-10-30
ECSP10010471A (es) 2010-10-30
EP2254598B1 (en) 2013-07-10

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Application publication date: 20130612