CN103142857A - Chinese medicinal granules for treating bronchitis combined emphysema and preparation method thereof - Google Patents
Chinese medicinal granules for treating bronchitis combined emphysema and preparation method thereof Download PDFInfo
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Abstract
The invention discloses Chinese medicinal granules for treating bronchitis combined emphysema. The Chinese medicinal granules mainly consist of honeysuckle, weeping forsythiae capsule, dahurian angelica roots, red peony roots, szechuan lovage rhizome, cocklebur fruits, divaricate saposhnikovia roots, dandelion, largetrifoliolious bugbane rhizome, licorice root, astragalus mongholicus, manchurian wildginger, common bletilla pseudobulb, mary rhododendron leaf and twig, alums, stiff silkworm, cassia twig, dangshen, nutgall and brown rat dung, has functions of reducing phlegm, relieving a cough and relieving chest tightness, relieves each discomfort symptoms caused by the bronchitis combined emphysema and has an obvious treatment function on the bronchitis combined emphysema.
Description
Technical field
The invention discloses a kind of Chinese medicine granules, especially treat bronchitis and merge emophysematous Chinese medicine granules and preparation method thereof.Genus Chinese medicine field.
Background technology
Bronchitis refers to the chronic nonspecific inflammation of trachea, bronchial mucosa and surrounding tissue thereof.Clinically take long-term cough, expectoration or with pant and repeatedly outbreak as feature.
Chronic bronchitis and acute bronchitis difference are easier, can differentiate according to following three aspects:: 1. medical history: acute bronchitis generally at premorbid without bronchitic medical history, namely without chronic cough, expectoration and the medical history such as pant.And chronic bronchitis previously all has above-mentioned respiratory tract medical history.2. the course of disease and symptom: the acute bronchitis onset is very fast, begins to be dry cough, coughs later on sticking expectorant or purulent sputum.Vexed swollen or pain after normal companion's breastbone. the heating General Symptoms of etc.ing is many to take a turn for the better in 3～5 days, but cough, expectoration symptom often continue 2～3 all just recoveries.Chronic bronchitis take for a long time, the cough that repeatedly and gradually increases the weight of is as outstanding symptom, with expectoration.The expectoration symptom with whether infect relevant, the time heavy when light.Also can be with panting, the course of disease is delayed.3. complication: acute bronchitis is many without obstructive emphysema and pulmonary heart disease, and chronic bronchitis develops into certain phase all with above-mentioned disease.
The bronchitis main cause has formed bronchial chronic nonspecific inflammation for the repeated infection of virus and antibacterial.When there's a sudden fall in temperature, degradation is beneficial to pathogenic under respiratory tract small blood vessel spasm ischemia, defense function; The chronic stimulations such as smog dust, atmosphere pollution also can be fallen ill; Smoking makes bronchospasm, mucosa variation, ciliary movement reduction, mucous secretion increase favourable infection; Irritated factor also has certain relation.
Emphysema refer to the air flue elasticity attenuation of terminal bronchiole far-end (alveolar bronchiole, alveolar duct, alveolar sac and alveolar), the pathological state that excessive expansion, inflation and lung volume increase or destroy with airway walls simultaneously.Its clinical manifestation mild symptoms is paid attention to the emphysema degree and is decided.Can asymptomatic or only feel to breathe hard when work, motion in early days, be difficult to gradually competent original work.Along with emphysema progress, the dyspnea degree increases the weight of thereupon, even so that slightly still feel during movable rest fully and breathing hard.Still can feel in addition weak, weight loss, loss of appetite, upper abdomen distension.Cause that emophysematous main cause is chronic bronchitis, therefore also have the symptoms such as cough, expectoration except breathing hard, only have in early days expiratory phase prolongation or nothing abnormal.Typical case emphysema person thorax anteroposterior diameter increases, and is barrel chest, and respiratory movement weakens, and vocal fremitus weakens, the percussion hyperresonant note, border of cardiac dullness dwindles, and liver dullness circle moves down, and respiratory murmur lowers, sometimes can hear dried, moist rale, increased heart rate, hear sounds is low far away, and P2 is hyperfunction.
2 kinds of patterns occur to exist in emphysema: the cause of disease-emphysema-chronic bronchitis, the cause of disease-chronic bronchitis-emphysema.Its common complication has: 1, spontaneous pneumothorax.Spontaneous pneumothorax is concurrent much in obstructive emphysema person, and how because the large Blisters of lung under pleura breaks, air leaks into due to pleural space.If patient basis pulmonary function is relatively poor, pneumothorax is tension force, even gas flow is few, clinical manifestation is also heavier, and actively rescue can not be adopted a casual attitude.The bright degree of emphysema patient's lung field is higher, and often has the large Blisters of lung to exist, and sign is the typical case not, brings certain difficulty for the diagnosis of local pneumothorax.2, respiratory failure.Obstructive emphysema often respiratory function is badly damaged, in some inducement such as respiratory tract infection, the dry and hard retention of secretions, inappropriate oxygen therapy, use that the vein agent is excessive, under the impact of surgical operation etc., ventilation and dysfunction of ventilation further increase the weight of, and can bring out respiratory failure.3, chronic pulmonary heart disease.With right heart failure hypoxemia and carbon dioxide retention and alveolar capillary bed destruction etc., all can cause pulmonary hypertension.In cardiac functional compensatory period, there is no the right heart failure performance.When breathing is that pathological changes further increases the weight of, when arterial blood gas worsened, pulmonary artery pressure significantly increased, and cardiac load increases the weight of, and adds the factors such as myocardial ischemia and dysbolismus, can bring out right heart failure.4, gastric ulcer.Postmortem confirms that Patients with Obstructive Emphysema approximately has 18%～30% concurrent gastric ulcer.Its pathogeny is not yet fully clear and definite.5, sleep disordered breathing: in normal person sleep, ventilation can slightly have reduction, and ventilation reduces comparatively obvious during the Patients with Obstructive Emphysema sleep.Especially the arterial partial pressure of oxygen low 8.00kPa(60mmHg that reaches under patient's waking state) during the left and right, further reduce in sleep, just more dangerous.Patient's sleep quality reduces, and cardiac arrhythmia and pulmonary hypertension etc. can occur.
In the medicine of existing treatment, Chinese patent CN02134087.0 discloses a kind of " a kind of medicine for the treatment of cough " by name in 2003, formed by Premna microphylla Turez, Rhizoma Polygonati, Herba Aletridis Khasianae, Fructus Forsythiae, Herba Saxifragae, Folium Eriobotryae, Herba Ephedrae, Cortex Mori, Pericarpium Papaveris, its prescription is too simple, effect is single, can only cough-relieving, alleviate the symptom that bronchitis brings, but without therapeutical effect, treatment bronchitis that therefore can not be real merges emphysema for emphysema.
Summary of the invention
The present situation that merges emphysema curative effect deficiency for existing treatment bronchitis, one of purpose of the present invention is to provide a kind of bronchitis for the treatment of to merge emophysematous Chinese medicine granules, have characteristics easy to operate, evident in efficacy, and it adopts comparatively common in the localities Chinese crude drug as raw material, and is with low cost.
Another object of the present invention just is to provide the preparation method of above-mentioned Chinese medicine granules.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
a kind of bronchitis for the treatment of merges emophysematous Chinese medicine granules, preferred scheme, taking off the primary raw material of stating weight proportion is prepared from: Flos Lonicerae 10-20 part, Fructus Forsythiae 3-9 part, Radix Angelicae Dahuricae 3-10 part, Radix Paeoniae Rubra 6-12 part, Rhizoma Chuanxiong 3-9 part, Fructus Xanthii 3-10 part, Radix Saposhnikoviae 5-10 part, Herba Taraxaci 10-30 part, Rhizoma Cimicifugae 3-6 part, Radix Glycyrrhizae 2-6 part, Radix Astragali 10-30 part, Herba Asari 2-6 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 4-15 part, Folium et Cacumen Rhododendri Mariae 8-16 part, Alumen 3-9 part, Bombyx Batryticatus 3-10 part, Ramulus Cinnamomi 8-16 part, Radix Codonopsis 10-30 part, Galla Turcica (Galla Helepensis) 10-20 part, Oletum Ratti norvegici 7-15 part is (preferred, Oletum Ratti norvegici 7.5-14.5 part).
A kind of bronchitis for the treatment of merges emophysematous Chinese medicine granules, and the scheme that is more preferably is taken off the primary raw material of stating weight proportion and is prepared from: Flos Lonicerae 12-18 part, Fructus Forsythiae 4-7 part, Radix Angelicae Dahuricae 4-8 part, Radix Paeoniae Rubra 7-10 part, Rhizoma Chuanxiong 4-6 part, Fructus Xanthii 5-8 part, Radix Saposhnikoviae 6-8 part, Herba Taraxaci 12-20 part, Rhizoma Cimicifugae 4-5 part, Radix Glycyrrhizae 3-5 part, Radix Astragali 12-28 part, Herba Asari 3-5 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 7-12 part, Folium et Cacumen Rhododendri Mariae 10-15 part, Alumen 4-8 part, Bombyx Batryticatus 4-9 part, Ramulus Cinnamomi 10-14 part, Radix Codonopsis 15-25 part, Galla Turcica (Galla Helepensis) 12-18 part, Oletum Ratti norvegici 10-14 part.
A kind of bronchitis for the treatment of merges emophysematous Chinese medicine granules, and best scheme is taken off the primary raw material of stating weight proportion and is prepared from: 15 parts of Flos Loniceraes, 6 parts of Fructus Forsythiaes, 6 parts of the Radixs Angelicae Dahuricae, 8 parts of Radix Paeoniae Rubra, 5 parts of Rhizoma Chuanxiongs, 6 parts of Fructus Xanthii, 7 parts of Radix Saposhnikoviaes, 15 parts of Herba Taraxacis, 4.5 parts of Rhizoma Cimicifugaes, 4 parts, Radix Glycyrrhizae, 15 parts of the Radixs Astragali, 4 parts of Herba Asaris, 11 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 12 parts of Folium et Cacumen Rhododendri Mariaes, 5 parts of Alumens, 5 parts of Bombyx Batryticatus, 12 parts of Ramulus Cinnamomi, 20 parts of Radix Codonopsis, 15 parts of Galla Turcica (Galla Helepensis)s, 12 parts of Oletum Ratti norvegicis.
The preparation process of above-mentioned Chinese medicine granules is as follows:
1. get Herba Asari, Alumen, Bombyx Batryticatus and Galla Turcica (Galla Helepensis) and pulverize, cross the 60-120 mesh sieve;
2. Fructus Xanthii is placed in preheated container, fries to surperficial buff and thorn burntly with moderate heat, the inner taking-up when light yellow dried in the air coolly to room temperature, grinds deburring, makes Fructus Xanthii (parched);
3. Radix Saposhnikoviae is placed in pot interior little a stir-fry to buff, taking-up is dried in the air cool to room temperature, makes Radix Saposhnikoviae (parched);
4. Flos Lonicerae, Fructus Forsythiae, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Fructus Xanthii (parched), Radix Saposhnikoviae (parched), Herba Taraxaci, Rhizoma Cimicifugae, Radix Glycyrrhizae, the Radix Astragali, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium et Cacumen Rhododendri Mariae, Ramulus Cinnamomi, Radix Codonopsis and Oletum Ratti norvegici are decocted with water 2 times, 1.5 hours for the first time, 1.0 hours for the second time, collecting decoction, standing 20-30 hour, filter, it is 1.20 that filtrate is concentrated into relative density, lets cool;
5. with step 4. gained filtrate add ethanol, the ethanol consumption be filtrate weight 0.5-1.5 doubly, standing 20-30 hour, filter filtrate recycling ethanol and to be concentrated into relative density be 1.30-1.40;
6. 5. add Herba Asari and Alumen, Bombyx Batryticatus powder in gained filtrate to step, also add appropriate amount of starch, drying, granulation.
1. the preparation method of above-mentioned Chinese medicine preparation, step cross 60-120 mesh sieve (preferred 80-100 mesh sieve is more preferably 90 mesh sieves).
The preparation method of above-mentioned Chinese medicine preparation, step 4. standing 20-30 hour (preferred 22-28 hour, be more preferably 26 hours).
The preparation method of above-mentioned Chinese medicine preparation, step 5. ethanol consumption are 0.5-1.5 times (preferred 0.8-1.2 doubly is more preferably 1.0 times) of filtrate weight.
The preparation method of above-mentioned Chinese medicine preparation, step 5. standing 20-30 hour (preferred 22-26 hour, be more preferably 24 hours) filter.
The preparation method of above-mentioned Chinese medicine preparation, step be filtrate recycling ethanol and to be concentrated into relative density be 1.35 5..
Using method: reach optimum therapeuticing effect for making Chinese medicine granules of the present invention, half an hour after meal sooner or later, get 12g every day twice, take after mixing it with hot water.
It is remarkable that this Chinese medicine granules merges the emphysema effect to bronchitis, and the effect of preventing phlegm from forming and stopping coughing is not only arranged, and can also effect a radical cure the disease that bronchitis merges emphysema, causes lethargy for prolonged illness, and look tired person has good medical treatment effect.Multiselect of the present invention is with local common medical material, and is cheap, alleviated patient's financial burden.
The pharmacological effect of each crude drug is respectively:
Flos Lonicerae: sweet in the mouth, little hardship, cold nature.Heat-clearing and toxic substances removing is arranged, and expelling pathogenic factors from the exterior is gone out, and the effect of stomach function regulating preventing or arresting vomiting is used for pathogenic heat and stops up resistance, disorder of stomach-QI, fever and irritability.
Fructus Forsythiae: bitter in the mouth, cold nature.Heat-clearing and toxic substances removing is arranged, and the effect of dispersing swelling and dissipating binds is used for anemopyretic cold, and epidemic febrile disease is from the beginning of, high hot excessive thirst.
The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature.For inducing sweat, medicine dispels the wind.Expelling wind and removing dampness is arranged, understand things pain-stopping, the effect of detumescence and apocenosis is used for the flu headache, nasal obstruction, nasal sinusitis.
Radix Paeoniae Rubra: sour in the mouth, hardship, cool in nature.Eliminating stasis to stop pain is arranged, and the effect of removing heat from blood detumescence is used for stomachache, hypochondriac pain, discharging fresh blood stool, conjunctival congestion, carbuncle.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Blood-activating and qi-promoting is arranged, and the effect of wind-expelling pain-stopping is used for stagnation of QI and blood pain disease, the disease of headache.
Fructus Xanthii: sweet in the mouth, warm in nature, slightly poisonous.Dispersing wind and cold is arranged, clearing the nasal passage, the effect of wind-damp dispelling is used for nasal sinusitis, headche due to wind-cold.
Radix Saposhnikoviae: acrid in the mouth, slightly warm in nature.Expelling pathogenic wind from the body surface is arranged, and the effect of removing dampness to relieve pain is used for affection of exogenous wind-cold, headache general pain, rheumatic arthralgia.
Herba Taraxaci: sweet in the mouth, little hardship, cold in nature.Heat-clearing and toxic substances removing is arranged, and the effect of dispersing swelling and dissipating binds is used for pharyngitis, upper respiratory tract infection.
Rhizoma Cimicifugae: acrid in the mouth, little sweet, cold nature.Deliver rash, the effect of heat-clearing and toxic substances removing is used for the wind heat headache, laryngopharynx swelling and pain.
Radix Glycyrrhizae: sweet in the mouth, property is flat.The QI invigorating invigorating middle warmer is arranged, relieving spasm to stop pain, the effect of eliminating fire and detoxication is for the disease of laryngopharynx swelling and pain.
The Radix Astragali: sweet in the mouth, slightly warm in nature.Benefiting QI for strengthening the superficies is arranged, and arresting sweating takes off admittedly, and the effect of inducing diuresis to remove edema is used for the deficiency of vital energy weak, sinking of QI of middle-JIAO, and blood deficiency and yellow complexion, bronchitis merges emphysema.
Herba Asari: acrid in the mouth, warm in nature.Expelling wind and cold is arranged, understand things pain-stopping, the effect of warming the lung to resolve fluid-retention is used for anemofrigid cold, headache, nasal sinusitis, phlegm retention is breathed with cough.
Pseudobulbus Bletillae (Rhizoma Bletillae): bitter in the mouth, cold nature.Astringing to arrest bleeding is arranged, and the effect of detumescence and promoting granulation is used for spitting of blood and spits blood.
Folium et Cacumen Rhododendri Mariae: be ericad, the counties such as main product Guangdong is high wants, Fengkai.Have another name called: clock (Guangdong) is hung in Folium et Cacumen Rhododendri Mariae, vacation, native Flos Moutan (Guangxi), and the Mary Cuculus polioephalus has cough-relieving, and the effect of eliminating the phlegm is used for tracheitis.
Alumen: sour in the mouth, cold in nature.The detoxifcation parasite killing is arranged, dampness removing to stop itchin, the wind-phlegm of dispelling for oral administration is used for eczema, epistaxis.
Bombyx Batryticatus: salty in the mouth, property is flat.Expelling wind for relieving convulsion is arranged, and the effect of dissipating phlegm and resolving masses is used for convulsion with spasms, laryngopharynx swelling and pain.
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature.The diaphoresis expelling pathogenic factors from muscles is arranged, promoting the flow of QI-blood by warming the meridian, the effect of the flat gas that spins is used for anemofrigid cold, edema, phlegm retention.
Radix Codonopsis: sweet in the mouth, property is flat.Invigorating the spleen and replenishing QI is arranged, and the effect of spleen invigorating lung benefiting is used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, dyspnea due to deficiency cough.
Galla Turcica (Galla Helepensis): have another name called black stone, without infanticide, for gall wasps sections cynipid belongs to the insect gall that the parasitized larvaes of insecticide gall wasps produces on Fagaceae oak plant Galla Turcica (Galla Helepensis) tree sprout.Bitter in the mouth, warm in nature.Astringing intestine to stop diarrhea, controlling nocturnal emission with astringent drugs arranged, astringe the lung, the effect of hemostasis and pain-relieving, be used for the chronic diarrhea chronic dysentery, night sweat, cough, spitting of blood is had blood in stool.
Oletum Ratti norvegici: have another name called Mus arrow, Rhizoma Anemones Raddeanae, male Oletum Ratti norvegici, for the male Rattus norvegicus of Muridae Mustella animal, Rattusflauipectus etc. get dry feces.Bitter in the mouth, salty, cold in nature.There is heat clearing away to lead to the effect of the stasis of blood, promoting urination and defecation for reducing the turbid pathogen, is used for the heating of typhoid fever recurrence caused by overexertion, stomachache, acute mastitis, furuncle is swollen.
Chinese medicine granules of the present invention merges emophysematous principle based on the traditional Chinese medical herbal treatment bronchitis.The effect that the medical material of selecting all has relieving cough and resolving phlegm to relieving asthma belongs to the prescription for the treatment of both the principal and secondary aspects of a disease.Bronchitis is merged emphysema fabulous therapeutical effect is arranged.
The specific embodiment
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1
Flos Lonicerae 10 grams, Fructus Forsythiae 3 grams, the Radix Angelicae Dahuricae 3 grams, Radix Paeoniae Rubra 6 grams, Rhizoma Chuanxiong 3 grams, Fructus Xanthii 3 grams, Radix Saposhnikoviae 5 grams, Herba Taraxaci 10 grams, Rhizoma Cimicifugae 3 grams, Radix Glycyrrhizae 2 grams, the Radix Astragali 10 grams, Herba Asari 2 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 4 grams, Folium et Cacumen Rhododendri Mariae 8 grams, Alumen 3 grams, Bombyx Batryticatus 3 grams, Ramulus Cinnamomi 8 grams, Radix Codonopsis 10 grams, Galla Turcica (Galla Helepensis) 10 grams, Oletum Ratti norvegici 7 grams.
1. get Herba Asari, Alumen, Bombyx Batryticatus and Galla Turcica (Galla Helepensis) and pulverize, cross 60 mesh sieves;
2. Fructus Xanthii is placed in preheated container, fries to surperficial buff and thorn burntly with moderate heat, the inner taking-up when light yellow dried in the air coolly to room temperature, grinds deburring, makes Fructus Xanthii (parched);
3. Radix Saposhnikoviae is placed in pot interior little a stir-fry to buff, taking-up is dried in the air cool to room temperature, makes Radix Saposhnikoviae (parched);
4. Flos Lonicerae, Fructus Forsythiae, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Fructus Xanthii (parched), Radix Saposhnikoviae (parched), Herba Taraxaci, Rhizoma Cimicifugae, Radix Glycyrrhizae, the Radix Astragali, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium et Cacumen Rhododendri Mariae, Ramulus Cinnamomi, Radix Codonopsis and Oletum Ratti norvegici are decocted with water 2 times, 1.5 hours for the first time, 1.0 hours for the second time, collecting decoction, standing 20 hours, filter, it is 1.20 that filtrate is concentrated into relative density, lets cool;
5. with step 4. gained filtrate add ethanol, the ethanol consumption is 0.5 times of filtrate weight, standing 20 hours, filters filtrate recycling ethanol and to be concentrated into relative density be 1.30;
6. 5. add Herba Asari and Alumen, Bombyx Batryticatus powder in gained filtrate to step, also add appropriate amount of starch, drying, granulation.
Embodiment 2
Flos Lonicerae 12 grams, Fructus Forsythiae 4 grams, the Radix Angelicae Dahuricae 4 grams, Radix Paeoniae Rubra 7 grams, Rhizoma Chuanxiong 4 grams, Fructus Xanthii 5 grams, Radix Saposhnikoviae 6 grams, Herba Taraxaci 12 grams, Rhizoma Cimicifugae 4 grams, Radix Glycyrrhizae 3 grams, the Radix Astragali 12 grams, Herba Asari 3 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 7 grams, Folium et Cacumen Rhododendri Mariae 10 grams, Alumen 4 grams, Bombyx Batryticatus 4 grams, Ramulus Cinnamomi 10 grams, Radix Codonopsis 15 grams, Galla Turcica (Galla Helepensis) 12 grams, Oletum Ratti norvegici 10 grams.
1. get Herba Asari, Alumen, Bombyx Batryticatus and Galla Turcica (Galla Helepensis) and pulverize, cross 80 mesh sieves;
2. Fructus Xanthii is placed in preheated container, fries to surperficial buff and thorn burntly with moderate heat, the inner taking-up when light yellow dried in the air coolly to room temperature, grinds deburring, makes Fructus Xanthii (parched);
3. Radix Saposhnikoviae is placed in pot interior little a stir-fry to buff, taking-up is dried in the air cool to room temperature, makes Radix Saposhnikoviae (parched);
4. Flos Lonicerae, Fructus Forsythiae, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Fructus Xanthii (parched), Radix Saposhnikoviae (parched), Herba Taraxaci, Rhizoma Cimicifugae, Radix Glycyrrhizae, the Radix Astragali, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium et Cacumen Rhododendri Mariae, Ramulus Cinnamomi, Radix Codonopsis and Oletum Ratti norvegici are decocted with water 2 times, 1.5 hours for the first time, 1.0 hours for the second time, collecting decoction, standing 22 hours, filter, it is 1.20 that filtrate is concentrated into relative density, lets cool;
5. with step 4. gained filtrate add ethanol, the ethanol consumption is 0.2 times of filtrate weight, standing 22 hours, filters filtrate recycling ethanol and to be concentrated into relative density be 1.35;
6. 5. add Herba Asari and Alumen, Bombyx Batryticatus powder in gained filtrate to step, also add appropriate amount of starch, drying, granulation.
Embodiment 3
Flos Lonicerae 18 grams, Fructus Forsythiae 7 grams, the Radix Angelicae Dahuricae 8 grams, Radix Paeoniae Rubra 10 grams, Rhizoma Chuanxiong 6 grams, Fructus Xanthii 8 grams, Radix Saposhnikoviae 8 grams, Herba Taraxaci 20 grams, Rhizoma Cimicifugae 5 grams, Radix Glycyrrhizae 5 grams, the Radix Astragali 28 grams, Herba Asari 5 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 12 grams, Folium et Cacumen Rhododendri Mariae 15 grams, Alumen 8 grams, Bombyx Batryticatus 9 grams, Ramulus Cinnamomi 14 grams, Radix Codonopsis 25 grams, Galla Turcica (Galla Helepensis) 18 grams, Oletum Ratti norvegici 14 grams.
1. get Herba Asari, Alumen, Bombyx Batryticatus and Galla Turcica (Galla Helepensis) and pulverize, cross 100 mesh sieves;
2. Fructus Xanthii is placed in preheated container, fries to surperficial buff and thorn burntly with moderate heat, the inner taking-up when light yellow dried in the air coolly to room temperature, grinds deburring, makes Fructus Xanthii (parched);
3. Radix Saposhnikoviae is placed in pot interior little a stir-fry to buff, taking-up is dried in the air cool to room temperature, makes Radix Saposhnikoviae (parched);
4. Flos Lonicerae, Fructus Forsythiae, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Fructus Xanthii (parched), Radix Saposhnikoviae (parched), Herba Taraxaci, Rhizoma Cimicifugae, Radix Glycyrrhizae, the Radix Astragali, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium et Cacumen Rhododendri Mariae, Ramulus Cinnamomi, Radix Codonopsis and Oletum Ratti norvegici are decocted with water 2 times, 1.5 hours for the first time, 1.0 hours for the second time, collecting decoction, standing 28 hours, filter, it is 1.20 that filtrate is concentrated into relative density, lets cool;
5. with step 4. gained filtrate add ethanol, the ethanol consumption is 1.2 times of filtrate weight, standing 26 hours, filters filtrate recycling ethanol and to be concentrated into relative density be 1.35;
6. 5. add Herba Asari and Alumen, Bombyx Batryticatus powder in gained filtrate to step, also add appropriate amount of starch, drying, granulation.
Embodiment 4
Flos Lonicerae 20 grams, Fructus Forsythiae 9 grams, the Radix Angelicae Dahuricae 10 grams, Radix Paeoniae Rubra 12 grams, Rhizoma Chuanxiong 9 grams, Fructus Xanthii 10 grams, Radix Saposhnikoviae 10 grams, Herba Taraxaci 30 grams, Rhizoma Cimicifugae 6 grams, Radix Glycyrrhizae 6 grams, the Radix Astragali 30 grams, Herba Asari 6 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 15 grams, Folium et Cacumen Rhododendri Mariae 16 grams, Alumen 9 grams, Bombyx Batryticatus 10 grams, Ramulus Cinnamomi 16 grams, Radix Codonopsis 30 grams, Galla Turcica (Galla Helepensis) 20 grams, Oletum Ratti norvegici 15 grams.
1. get Herba Asari, Alumen, Bombyx Batryticatus and Galla Turcica (Galla Helepensis) and pulverize, cross 120 mesh sieves;
2. Fructus Xanthii is placed in preheated container, fries to surperficial buff and thorn burntly with moderate heat, the inner taking-up when light yellow dried in the air coolly to room temperature, grinds deburring, makes Fructus Xanthii (parched);
3. Radix Saposhnikoviae is placed in pot interior little a stir-fry to buff, taking-up is dried in the air cool to room temperature, makes Radix Saposhnikoviae (parched);
4. Flos Lonicerae, Fructus Forsythiae, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Fructus Xanthii (parched), Radix Saposhnikoviae (parched), Herba Taraxaci, Rhizoma Cimicifugae, Radix Glycyrrhizae, the Radix Astragali, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium et Cacumen Rhododendri Mariae, Ramulus Cinnamomi, Radix Codonopsis and Oletum Ratti norvegici are decocted with water 2 times, 1.5 hours for the first time, 1.0 hours for the second time, collecting decoction, standing 30 hours, filter, it is 1.20 that filtrate is concentrated into relative density, lets cool;
5. with step 4. gained filtrate add ethanol, the ethanol consumption is 1.5 times of filtrate weight, standing 30 hours, filters filtrate recycling ethanol and to be concentrated into relative density be 1.40;
6. 5. add Herba Asari and Alumen, Bombyx Batryticatus powder in gained filtrate to step, also add appropriate amount of starch, drying, granulation.
Embodiment 5
A kind of bronchitis for the treatment of merges emophysematous Chinese medicine granules: Flos Lonicerae 15 grams, Fructus Forsythiae 6 grams, the Radix Angelicae Dahuricae 6 grams, Radix Paeoniae Rubra 8 grams, Rhizoma Chuanxiong 5 grams, Fructus Xanthii 6 grams, Radix Saposhnikoviae 7 grams, Herba Taraxaci 15 grams, Rhizoma Cimicifugae 4.5 grams, Radix Glycyrrhizae 4 grams, the Radix Astragali 15 grams, Herba Asari 4 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 11 grams, Folium et Cacumen Rhododendri Mariae 12 grams, Alumen 5 grams, Bombyx Batryticatus 5 grams, Ramulus Cinnamomi 12 grams, Radix Codonopsis 20 grams, Galla Turcica (Galla Helepensis) 15 grams, Oletum Ratti norvegici 12 grams.
1. get Herba Asari, Alumen, Bombyx Batryticatus and Galla Turcica (Galla Helepensis) and pulverize, cross 90 mesh sieves;
2. Fructus Xanthii is placed in preheated container, fries to surperficial buff and thorn burntly with moderate heat, the inner taking-up when light yellow dried in the air coolly to room temperature, grinds deburring, makes Fructus Xanthii (parched);
3. Radix Saposhnikoviae is placed in pot interior little a stir-fry to buff, taking-up is dried in the air cool to room temperature, makes Radix Saposhnikoviae (parched);
4. Flos Lonicerae, Fructus Forsythiae, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Fructus Xanthii (parched), Radix Saposhnikoviae (parched), Herba Taraxaci, Rhizoma Cimicifugae, Radix Glycyrrhizae, the Radix Astragali, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium et Cacumen Rhododendri Mariae, Ramulus Cinnamomi, Radix Codonopsis and Oletum Ratti norvegici are decocted with water 2 times, 1.5 hours for the first time, 1.0 hours for the second time, collecting decoction, standing 26 hours, filter, it is 1.20 that filtrate is concentrated into relative density, lets cool;
5. with step 4. gained filtrate add ethanol, the ethanol consumption is 1.0 times of filtrate weight, standing 24 hours, filters filtrate recycling ethanol and to be concentrated into relative density be 1.35;
6. 5. add Herba Asari and Alumen, Bombyx Batryticatus powder in gained filtrate to step, also add appropriate amount of starch, drying, granulation.
Using method: reach optimum therapeuticing effect for making Chinese medicine granules of the present invention, half an hour after meal sooner or later, get 12g every day twice, take after mixing it with hot water.
Model case one
Liu XX, female, 56 years old, Dezhou City Shandong Province Ningjin County.Symptom: asthma, cough, expectorant is multi-band point brown not, and left chest pain pain is tired, loss of appetite, body weight obviously descends, and is that chronic bronchitis merges slight emphysema through hospital diagnosis, once takes the anti-inflammatory type Western medicine, alleviate to some extent after taking, but still like this after drug withdrawal.Sick age: 2 years.Examine the time: on April 17th, 2011; Use Chinese drugs agentia of the present invention, half an hour after meal sooner or later, get 12g every day twice, take after mixing it with hot water.Used 5 days, asthma symptom alleviates; Used 15 days, left chest pain pain, asthma symptom disappears substantially, and the cough symptom has obvious alleviation; Used 1 month, appetite increases, and body weight is recovered to some extent, has once in a while the cough symptom except rising morning, and other malaise symptoms disappear; Continue to use two weeks, chronic bronchitis is cured, and emphysema disappear, and recovers, and drug withdrawal is so far without recurrence.
Model case two
Yuan XX, man, 52 years old, Liaocheng of Shandong Province Gaotang County.Symptom: the patient has chronic bronchitis to merge slight emphysema for many years, and smoking history is arranged, normal recurrent cough, and expectoration, easily tired, motion or day cool rear sx↑ of cyclostrophic, the normal upper abdomen distension of patient, without appetite, body weight obviously descends.Sick age: 5 years.Examine the time: on July 13rd, 2011; Use Chinese drugs agentia of the present invention, half an hour after meal sooner or later, get 12g every day twice, take after mixing it with hot water.Used 5 days, upper abdomen distension transference cure, expectoration reduces; Used 10 days, the cough number of times obviously reduces, tired transference cure; Used 1 month, the expectoration symptom disappears fully, and the cough symptom disappears substantially, and appetite increases; Used 2 months, every ill symptoms all disappears, and body weight also increases to some extent, recovers; After use again Chinese drugs agentia of the present invention to consolidate 10 days, drug withdrawal so far without the recurrence.
Model case three
King XX, female, 49 years old, Accessories during Binzhou Wudi County, Shandong Province.Symptom: the patient the symptoms such as uncomfortable in chest, dyspnea can occur in recent years every autumn and winter, and every day with cough, expectoration, sx↑ after motion is and with asthma.Find that through examination in hospital patient's thorax anteroposterior diameter increases, be barrel chest, after be diagnosed as the emphysema that caused by chronic bronchitis, the medication effect of once in many ways seeking medical advice is all undesirable.Sick age: 4 years.Examine the time: on November 23rd, 2011; Use Chinese drugs agentia of the present invention, half an hour after meal sooner or later, get 12g every day twice, take after mixing it with hot water.Used sx↓ uncomfortable in chest 5 days; Used 10 days, the abundant expectoration symptom has obvious alleviation, and the dyspnea symptom disappears substantially; Used 1 month, abundant expectoration, asthma symptom disappear fully, and the cough symptom disappears substantially; Use 1 first quarter moon, every ill symptoms takes a turn for the better fully, recovers; After use again medicament of the present invention to consolidate 7 days, drug withdrawal is used appearance without any side effects during medicament of the present invention so far without recurrence.
Experimental example
In order to verify the effect of Chinese medicine composition of the present invention (embodiment 5), we have extracted 300 patients and have carried out the experiment of medicine, be equally divided into three groups, every group of 100 people, experimental group and matched group, experimental group is taken embodiment 5 gained Chinese medicine granules, and matched group is taken other treatment bronchitis and merged emophysematous Chinese medicine and Western medicine medicine.
Inclusion criteria: merge the emphysema patient through being diagnosed as bronchitis, disease 2-5 in age has bronchitis to merge the emphysema clinical symptoms one or more.
Using method is: Chinese medicine granules of the present invention, half an hour after meal sooner or later, get 12g every day twice, and take after mixing it with hot water.
Curative effect situation criterion (comparing with the data of taking 2 months): 1, cure.Drug administration 2 months, malaise symptoms disappears fully; 2, effective.Drug administration 2 months, malaise symptoms alleviate or part disappears; 3, invalid.Drug administration 2 months, malaise symptoms is unchanged.
We have carried out accurate statistics and mathematical analysis to experimental data.Concrete experimental result such as following table:
Chinese medicine granules of the present invention and other treatment bronchitis merge emophysematous medicine, and to compare cure rate high, total effective rate is 95%, higher by 40% than matched group oral western medicine effective percentage, higher by 15% than matched group oral Chinese medicine effective percentage, successful is better than matched group, the cough ant phlegm symptom that the Chinese medicine granules of this invention not only can rapid recovery be caused by bronchitis can also effectively be treated emphysema, is the prescription for the treatment of both the principal and secondary aspects of a disease.One routine side effect situation does not appear in the present invention in clinical experiment, safety merges emophysematous similar Chinese and western drugs far above the treatment bronchitis, and instant effect has alleviated patient's misery, is to treat at present the Chinese medicine that bronchitis merges the comparatively desirable safety of emphysema.
The application's prescription is the distinguished veteran doctors of TCM proved recipe, has the prospect of industrialized implementation.Completing of this invention has benefited from Shandong Province's 12 Planning emphasis subjects---the support of Law of Economy subject fund.
It should be noted that at last, embodiment is the specific embodiment of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment, the present invention is had been described in detail, for a person skilled in the art, it still can be modified to the technical scheme that aforementioned each embodiment puts down in writing, and perhaps part technical characterictic wherein is equal to replacement.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (9)
1. a treatment bronchitis merges emophysematous Chinese medicinal granule, it is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: Flos Lonicerae 10-20 part, Fructus Forsythiae 3-9 part, Radix Angelicae Dahuricae 3-10 part, Radix Paeoniae Rubra 6-12 part, Rhizoma Chuanxiong 3-9 part, Fructus Xanthii 3-10 part, Radix Saposhnikoviae 5-10 part, Herba Taraxaci 10-30 part, Rhizoma Cimicifugae 3-6 part, Radix Glycyrrhizae 2-6 part, Radix Astragali 10-30 part, Herba Asari 2-6 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 4-15 part, Folium et Cacumen Rhododendri Mariae 8-16 part, Alumen 3-9 part, Bombyx Batryticatus 3-10 part, Ramulus Cinnamomi 8-16 part, Radix Codonopsis 10-30 part, Galla Turcica (Galla Helepensis) 10-20 part, Oletum Ratti norvegici 7-15 part.
2. a treatment bronchitis merges emophysematous Chinese medicine granules, it is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: Flos Lonicerae 12-18 part, Fructus Forsythiae 4-7 part, Radix Angelicae Dahuricae 4-8 part, Radix Paeoniae Rubra 7-10 part, Rhizoma Chuanxiong 4-6 part, Fructus Xanthii 5-8 part, Radix Saposhnikoviae 6-8 part, Herba Taraxaci 12-20 part, Rhizoma Cimicifugae 4-5 part, Radix Glycyrrhizae 3-5 part, Radix Astragali 12-28 part, Herba Asari 3-5 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 7-12 part, Folium et Cacumen Rhododendri Mariae 10-15 part, Alumen 4-8 part, Bombyx Batryticatus 4-9 part, Ramulus Cinnamomi 10-14 part, Radix Codonopsis 15-25 part, Galla Turcica (Galla Helepensis) 12-18 part, Oletum Ratti norvegici 10-14 part.
3. a treatment bronchitis merges emophysematous Chinese medicine granules, it is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: 15 parts of Flos Loniceraes, 6 parts of Fructus Forsythiaes, 6 parts of the Radixs Angelicae Dahuricae, 8 parts of Radix Paeoniae Rubra, 5 parts of Rhizoma Chuanxiongs, 6 parts of Fructus Xanthii, 7 parts of Radix Saposhnikoviaes, 15 parts of Herba Taraxacis, 4.5 parts of Rhizoma Cimicifugaes, 4 parts, Radix Glycyrrhizae, 15 parts of the Radixs Astragali, 4 parts of Herba Asaris, 11 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 12 parts of Folium et Cacumen Rhododendri Mariaes, 5 parts of Alumens, 5 parts of Bombyx Batryticatus, 12 parts of Ramulus Cinnamomi, 20 parts of Radix Codonopsis, 15 parts of Galla Turcica (Galla Helepensis)s, 12 parts of Oletum Ratti norvegicis.
4. the preparation method of according to claim 1-3 arbitrary described Chinese medicine granules, is characterized in that, step is as follows:
1. get Herba Asari, Alumen, Bombyx Batryticatus and Galla Turcica (Galla Helepensis) and pulverize, cross the 60-120 mesh sieve;
2. Fructus Xanthii is placed in preheated container, fries to surperficial buff and thorn burntly with moderate heat, the inner taking-up when light yellow dried in the air coolly to room temperature, grinds deburring, makes Fructus Xanthii (parched);
3. Radix Saposhnikoviae is placed in pot interior little a stir-fry to buff, taking-up is dried in the air cool to room temperature, makes Radix Saposhnikoviae (parched);
4. Flos Lonicerae, Fructus Forsythiae, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Fructus Xanthii (parched), Radix Saposhnikoviae (parched), Herba Taraxaci, Rhizoma Cimicifugae, Radix Glycyrrhizae, the Radix Astragali, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium et Cacumen Rhododendri Mariae, Ramulus Cinnamomi, Radix Codonopsis and Oletum Ratti norvegici are decocted with water 2 times, 1.5 hours for the first time, 1.0 hours for the second time, collecting decoction, standing 20-30 hour, filter, it is 1.20 that filtrate is concentrated into relative density, lets cool;
5. with step 4. gained filtrate add ethanol, the ethanol consumption be filtrate weight 0.5-1.5 doubly, standing 20-30 hour, filter filtrate recycling ethanol and to be concentrated into relative density be 1.30-1.40;
6. 5. add Herba Asari and Alumen, Bombyx Batryticatus and Galla Turcica (Galla Helepensis) powder in gained filtrate to step, also add appropriate amount of starch, drying, granulation.
5. preparation method according to claim 4, is characterized in that, 1. step crosses 60-120 mesh sieve (preferred 80-100 mesh sieve is more preferably 90 mesh sieves).
6. preparation method according to claim 4, is characterized in that, step 4. standing 20-30 hour (preferred 22-28 hour, be more preferably 26 hours).
7. preparation method according to claim 4, is characterized in that, step 5. ethanol consumption is 0.5-1.5 times (preferred 0.8-1.2 doubly is more preferably 1.0 times) of filtrate weight.
8. preparation method according to claim 4, is characterized in that, step 5. standing 20-30 hour (preferred 22-26 hour, be more preferably 24 hours) filters.
9. preparation method according to claim 4, is characterized in that, step is filtrate recycling ethanol and to be concentrated into relative density be 1.35 5..
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| CN104208185A (en) * | 2014-09-14 | 2014-12-17 | 吴俊川 | Traditional Chinese medicine granule for treating bronchitis and preparation method thereof |
| CN104491632A (en) * | 2014-12-19 | 2015-04-08 | 广东聚智诚科技有限公司 | Application of traditional Chinese medicine composition in preparing medicine for treating bronchitis with emphysema |
| CN104826032A (en) * | 2015-06-01 | 2015-08-12 | 青岛友诚高新技术有限公司 | Pure traditional Chinese medicine preparation for treating emphysema and preparing method thereof |
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| CN104491632A (en) * | 2014-12-19 | 2015-04-08 | 广东聚智诚科技有限公司 | Application of traditional Chinese medicine composition in preparing medicine for treating bronchitis with emphysema |
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