CN103182046B - Traditional Chinese medicine granule for treating pulmonary heart disease, and preparation method thereof - Google Patents
Traditional Chinese medicine granule for treating pulmonary heart disease, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine granule for treating a pulmonary heart disease, which mainly comprises the following components: honeysuckle flower, balloonflower root, root of seesile stemona, red peony root, chuanxiong rhizome, cocklebur fruit, ledebouriella root, dalbergia wood, cimicifuga rhizome, storax styrax liquidus, astragalus root, hyacinth bletilla, flower of lilac daphne (vinegar bake), mary rhododendron leaf and twig, alum, batryticated silkworm, cassia twig, pilose asiabell root, turpinia formosana and chinese sage. The traditional Chinese medicine granule has the effects of quickly clearing up the phlegm and stopping coughing, and has remarkable curative effect for various pulmonary heart diseases.
Description
Technical field
The invention discloses a kind of Chinese medicine granules, especially can treat Chinese medicine granules of pulmonary heart disease and preparation method thereof.Belong to Chinese medicine field.
Background technology
The most common person of chronic pulmonary heart disease is chronic hypoxia ischemic pulmonary heart disease, claim again obstructive emphysema heart disease, refer to that the pulmonary vascular resistance being caused by pulmonary's thorax or Pulmonic chronic disease increases, cause pulmonary hypertension and right ventricular hypertrophy, with or without a class heart disease of right heart failure, be commonly encountered diseases in China, frequently-occurring disease.
Primary disease course advancement is slow, can be divided into compensatory and lose compensatory two stages, but its boundary is sometimes also unclear.
Functional compensation phase performance: patient has chronic cough, expectoration or asthma history, progressively occurs weak, dyspnea.Health check-up is the performances of obvious emphysema, comprises that barrel chest, pulmonary's percussion are that excessive sore throat relieving, the liver dullness upper bound decline, border of cardiac dullness dwindles, and even disappear.Auscultation respiratory murmur is low, can have dry moist rale, and hear sounds is light, sometimes can only under xiphoid-process, locate to hear.Pulmonary area the second sound is hyperfunction, has obvious heartbeat under epigastrium xiphoid-process, is the main manifestations that pathological changes is involved heart.Jugular vein can have slight anger to open, but venous pressure not obvious increasing.The Early manifestation of chronic cardiopulmonary disease is long-term cough, expectoration and dyspnea in various degree, particularly movable after or in cold season symptom more obvious.Pulmonary heart disease early stage, cardio-pulmonary function was tasted the phase in generation, and patient does not have specific symptom, and patient can not have symptom when quiet, so this disease is difficult for coming into the picture.But as long as there is following situation, often prompting has suffered from pulmonary heart disease: 1, prolonged and repeated cough, expectoration; 2, every cold season aggravation, cough aggravation, amount of expectoration increases, thickens or is yellow.3, movable a little as when going upstairs or walking at a quick pace, feel to breathe hard, rapid breathing, cardiopalmus, precordialgia, the symptom such as weak, uncomfortable in chest, after rest, can take a turn for the better.4, finger tip, lip and lip surrounding are livid purple color.5, heart rate is accelerated, arrhythmia.
Function is lost compensatory phase performance, and lung tissue infringement seriously causes anoxia, and carbon dioxide retention can cause breathing and (or) heart failure.1, respiratory failure; The early stage main manifestations of anoxia is cyanosis, cardiopalmus and uncomfortable in chest etc., and hypoxemia and hypercapnia occur when pathological changes further develops, and can occur various spiritual neurological disorder symptoms, is called pulmonary encephalopathy.Show as headache, feeling of fullness in the head, dysphoria, aphasis, and have hallucination, mental disorder, twitch or tremble etc.Central nervous system symptom is obvious, occurs that mind is indifferent, drowsiness, and then stupor is so that dead.2, heart failure: mostly occur after acute respiratory infection, be therefore often associated with respiratory failure, patient occurs that asthma, cardiopalmus, oliguria, cyanosis increase the weight of, upper abdomen distending pain, inappetence, the right heart failure symptoms such as even vomiting of feeling sick.Distension of jugular vein, increased heart rate, pareordia audible gallop rhythm or the systolic murmur that has relative tricuspid insufficiency to cause are shown in health check-up, and noise can disappear with sb.'s illness took a favorable turn.Can there are various arrhythmia, particularly atrial arrhythmia, hepatomegaly companion tenderness, the anti-hydraulic pressure of liver neck is levied the positive, edema and ascites, the person of being in a bad way can suffer a shock.
In addition,, because pulmonary heart disease is the injured disease of many internal organs that becomes basis with the heart, pneumonopathy, therefore in patient with severe symptoms, can there be due to renal insufficiency, disseminated inravascular coagulation, hypoadrenocorticism the performances such as buccal pigmentation.
The traditional Chinese medical science is thought: " the main blood of the heart, lung governing qi " is to say that H&L is two organs adjacent in thoracic cavity, and the heart is at front lung rear, and heart is responsible for advancing the motion of blood, the main breathing of lung.The traditional Chinese medical science is reasoned out cardiopulmonary relation, has following 3 points: 1, the oxygen of heart consumption all derives from lung, and lung goes wrong and directly causes heart disease.The traditional Chinese medical science think " cardiopulmonary homology " this be the theoretical source that cardiopulmonary are ruled together.The oxygen consumption of heart own accounts for 20% left and right of whole human body, if pathological changes appears in pulmonary, anoxia is exactly heart at first.If long time mild anoxia, can make myocardial contraction strengthen, heart rate is accelerated to cause coronary heart disease, and when severe depletion of oxygen, blood pressure, heart rate all decline, and cause myocardial necrosis, the main exhaustion of mental and physical efforts, even sudden cardiac arrest.2, treatment heart, Xian Zhi pulmonary effect is best.3, cardiac, drives power aroused in interest by lung power, can reach and rescue the heart, protects the object of the heart, even can prevent the generation of heart infarction SUD.
Summary of the invention
For the present situation of existing treatment pulmonary heart disease, one of object of the present invention is to provide a kind of Chinese medicine granules for the treatment of safely and effectively pulmonary heart disease, there is feature easy to operate, evident in efficacy, and its adopts, and comparatively common Chinese crude drug is as raw material, with low cost in the localities.
Another object of the present invention is just to provide the preparation method of above-mentioned Chinese medicine granules.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of Chinese medicine granules for the treatment of pulmonary heart disease, taking off the primary raw material of stating weight proportion is prepared from: Flos Lonicerae 10-20 part, Radix Platycodonis 3-9 part, Radix Stemonae 3-10 part, Radix Paeoniae Rubra 6-12 part, Rhizoma Chuanxiong 3-9 part, Fructus Xanthii 3-10 part, Radix Saposhnikoviae 5-10 part, Lignum Dalbergiae Odoriferae 10-30 part, Rhizoma Cimicifugae 3-6 part, Styrax 2-6 part, Radix Astragali 10-30 part, Radix Angelicae Sinensis 6-12 part, Radix Salviae Miltiorrhizae 9-15 part, Flos Genkwa (vinegar system) 6-12 part, Folium et Cacumen Rhododendri Mariae 8-16 part, Alumen 3-9 part, Bombyx Batryticatus 3-10 part, Ramulus Cinnamomi 8-16 part, Radix Codonopsis 10-30 part, Turpinia pomifera(Roxb) D O. 15-30 part, Herba Salviae Chinensis 6-15 part is (preferred, Herba Salviae Chinensis 6.5-14.5 part).
Treat a Chinese medicine granules for pulmonary heart disease, the scheme being more preferably, takes off the primary raw material of stating weight proportion and is prepared from: Flos Lonicerae 12-16 part, Radix Platycodonis 5-8 part, Radix Stemonae 5-8 part, Radix Paeoniae Rubra 5-7 part, Rhizoma Chuanxiong 4-6 part, Fructus Xanthii 5-9 part, Radix Saposhnikoviae 6-8 part, Lignum Dalbergiae Odoriferae 15-25 part, Rhizoma Cimicifugae 4-5 part, Styrax 3-5 part, Radix Astragali 15-25 part, Radix Angelicae Sinensis 5-8 part, Radix Salviae Miltiorrhizae 10-13 part, Flos Genkwa (processed with vinegar) 7-10 part, Folium et Cacumen Rhododendri Mariae 10-14 part, Alumen 5-8 part, Bombyx Batryticatus 5-8 part, Ramulus Cinnamomi 10-14 part, Radix Codonopsis 15-25 part, Turpinia pomifera(Roxb) D O. 18-25 part, Herba Salviae Chinensis 8-12 part.
Treat a Chinese medicine granules for pulmonary heart disease, best scheme, takes off the primary raw material of stating weight proportion and is prepared from: 15 parts of Flos Loniceraes, 6 parts of Radix Platycodoniss, 7 parts of the Radixs Stemonae, 6 parts of Radix Paeoniae Rubra, 5 parts of Rhizoma Chuanxiongs, 6 parts of Fructus Xanthii, 7 parts of Radix Saposhnikoviaes, 20 parts of Lignum Dalbergiae Odoriferaes, 4.5 parts of Rhizoma Cimicifugaes, 4 parts of Styrax, 20 parts of the Radixs Astragali, 7 parts of Radix Angelicae Sinensis, 12 parts of Radix Salviae Miltiorrhizaes, 8 parts of Flos Genkwas (processed with vinegar), 12 parts of Folium et Cacumen Rhododendri Mariaes, 6 parts of Alumens, 7 parts of Bombyx Batryticatus, 12 parts of Ramulus Cinnamomi, 20 parts of Radix Codonopsis, 20 parts of Turpinia pomifera(Roxb) D O.s, 10 parts of Herba Salviae Chinensiss.
The preparation process of above-mentioned Chinese medicine granules is as follows:
1. get Alumen and Bombyx Batryticatus and pulverize, cross 60-120 mesh sieve;
2. Fructus Xanthii is placed in preheated container, fries to surperficial buff and thorn burntly with moderate heat, inner taking-up when light yellow dried in the air coolly to room temperature, grinds deburring, makes Fructus Xanthii (parched);
3. Radix Saposhnikoviae is placed in to pot interior micro-a stir-fry to buff, taking-up is dried in the air cool to room temperature, makes Radix Saposhnikoviae (parched);
4. decoct with water 2 times having fried Fructus Xanthii, Radix Saposhnikoviae and Flos Lonicerae, Radix Platycodonis, the Radix Stemonae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Lignum Dalbergiae Odoriferae, Rhizoma Cimicifugae, Styrax, the Radix Astragali, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, processed with vinegar Flos Genkwa, Folium et Cacumen Rhododendri Mariae, Ramulus Cinnamomi, Radix Codonopsis, Turpinia pomifera(Roxb) D O. and Herba Salviae Chinensis, 1.5 hours for the first time, 1.0 hours for the second time, collecting decoction, leave standstill 20-30 hour, filter, it is 1.20 that filtrate is concentrated into relative density, lets cool;
5. by step 4. gained filtrate add ethanol, ethanol consumption be filtrate weight 0.5-1.5 doubly, leave standstill 20-30 hour, filter filtrate recycling ethanol to be concentrated into relative density be 1.30-1.40;
6. 5. in gained filtrate, drip Styrax to step, Styrax consumption is the 0.5-1.5% of filtrate weight;
7. 6. in gained filtrate, add Alumen and Bombyx Batryticatus powder to step, also add appropriate amount of starch, dry, granulation.
The preparation method of above-mentioned Chinese medicine granules, 1. step crosses 60-120 mesh sieve (preferably 80-100 mesh sieve, is more preferably 90 mesh sieves).
The preparation method of above-mentioned Chinese medicine granules, 4. step leaves standstill 20-30 hour (preferably 22-27 hour, is more preferably 24 hours).
The preparation method of above-mentioned Chinese medicine granules, step 5. ethanol consumption is doubly (preferably 0.8-1.2 doubly, is more preferably 1.0 times) of 0.5-1.5 of filtrate weight.
The preparation method of above-mentioned Chinese medicine granules, 5. step leaves standstill 20-30 hour (preferably 22-28 hour, is more preferably 26 hours), filters.
The preparation method of above-mentioned Chinese medicine granules, 5. filtrate recycling ethanol to be concentrated into relative density be 1.35 of step.
The preparation method of above-mentioned Chinese medicine granules, step 6. Styrax consumption is the preferred 0.8-1.2% of 0.5-1.5%(of filtrate weight, is more preferably 1.0%).
Using method: for making Chinese medicine granules of the present invention reach optimum therapeuticing effect, every day twice, half an hour after meal morning and evening, get 12g, take after mixing it with hot water.
This Chinese medicine granules is remarkable to the effect of pulmonary heart disease, not only has effect of expectorant cough suppressant and anti-asthmatic, can also nurse one's health cardio-pulmonary function from root, causes lethargy for prolonged illness, and look tired person has good recovery and opsonic action.Local common medical material for multiselect of the present invention, cheap, alleviate patient's financial burden.
The pharmacological effect of each crude drug is respectively:
Flos Lonicerae: sweet in the mouth, micro-hardship, cold nature.Have heat-clearing and toxic substances removing, expelling pathogenic factors from the exterior is gone out, and effect of stomach function regulating preventing or arresting vomiting is stopped up resistance, disorder of stomach-QI, fever and irritability for pathogenic heat.
Radix Platycodonis: bitter in the mouth, pungent, slightly warm in nature.There is expelling phlegm for arresting cough, lung qi dispersing evacuation of pus, sharp the five internal organs, the effect filling blood, for laryngopharynx swelling and pain, fullness in the chest and hypochondriac pain.
The Radix Stemonae: micro-sweet, slightly warm in nature.Have nourishing the lung to keep the adverse QI downward cough-relieving, effect of parasite killing, coughs for new chronic cough, pulmonary tuberculosis cough, deficiency of YIN chronic cough.
Radix Paeoniae Rubra: bitter in the mouth, cold nature.There is clearing away heat and cooling blood, effect of eliminating stasis to stop pain, for maculae caused by violent heat pathogen, hematemesis and epistaxis.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Have blood-activating and qi-promoting, effect of wind-expelling pain-stopping, for stagnation of QI and blood pain disease, the disease of headache.
Fructus Xanthii: sweet in the mouth, warm in nature, slightly poisonous.There is dispersing wind and cold, clearing the nasal passage, effect of wind-damp dispelling, for nasal sinusitis, headche due to wind-cold.
Radix Saposhnikoviae: acrid in the mouth, slightly warm in nature.There is expelling pathogenic wind from the body surface, effect of removing dampness to relieve pain, for affection of exogenous wind-cold, headache general pain, rheumatic arthralgia.
Lignum Dalbergiae Odoriferae: acrid in the mouth, warm in nature.There is promoting flow of QI and blood, pain relieving, effect of hemostasis, for epigastric pain, thoracic obstruction twinge.
Rhizoma Cimicifugae: acrid in the mouth, micro-sweet, cold nature.Deliver rash, effect of heat-clearing and toxic substances removing, for wind heat headache, laryngopharynx swelling and pain.
Styrax: acrid in the mouth, warm in nature.Have and have one's ideas straightened out, keep away dirtyly, effect of pain relieving, for apoplexy syncope due to accumulation of phlegm, suddenly faints.
The Radix Astragali: sweet in the mouth, slightly warm in nature.Have benefiting QI for strengthening the superficies, arresting sweating is admittedly de-, and effect of inducing diuresis to remove edema is weak for the deficiency of vital energy, sinking of QI of middle-JIAO, blood deficiency and yellow complexion, treatment pulmonary heart disease.
Radix Angelicae Sinensis: sweet in the mouth, warm in nature.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation, for blood deficiency and yellow complexion, dizzy cardiopalmus, rheumatic arthralgia.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature.There is stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, effect of the relieving restlessness that clears away heart-fire, for breast ventral spine pain, dysphoria and insomnia, hepatosplenomegaly, angina pectoris.
Flos Genkwa (processed with vinegar): bitter in the mouth, pungent, warm in nature.Have sewage by drink, effect of removing toxic substances parasite killing, gathers for phlegm retention, and QI rising in reverse order is breathed with cough.
Folium et Cacumen Rhododendri Mariae: be ericad, the counties such as main product Guangdong height is wanted, Fengkai.Have another name called: clock (Guangdong) is hung in Folium et Cacumen Rhododendri Mariae, vacation, native Flos Moutan (Guangxi), Mary Cuculus polioephalus, has cough-relieving, and the effect of eliminating the phlegm, for tracheitis.
Alumen: sour in the mouth, cold in nature.Have removing toxic substances parasite killing, dampness removing to stop itchin, takes orally and dispels wind-phlegm, for eczema, and epistaxis.
Bombyx Batryticatus: salty in the mouth, property is flat.There is expelling wind for relieving convulsion, effect of dissipating phlegm and resolving masses, for convulsion with spasms, laryngopharynx swelling and pain.
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature.There is diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, effect of the flat gas that spins, for anemofrigid cold, edema, phlegm retention.
Radix Codonopsis: sweet in the mouth, property is flat.There is invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting, for deficiency of the spleen and lung, the cardiopalmus of breathing hard, dyspnea due to deficiency cough.
Herba Salviae Chinensis: having another name called Herba Salviae Chinensis, little Radix Salviae Miltiorrhizae, stone great river, is the herb of Labiatae salvia Salvia chinensis.Acrid in the mouth, hardship, cold nature.There is effect of blood stasis-eliminating and stagnation-dissipating, clearing away heat-damp and promoting diuresis, for phlegm dyspnea, carbuncle, jaundice due to damp-heat, the diseases such as hepatitis.
Turpinia pomifera(Roxb) D O.: have another name called two point sword at, seven cun of nails, be root or the leaf of the sharp sharp Turpinia pomifera(Roxb) D O. of Staphyleaceae Turpinia pomifera(Roxb) D O. platymiscium.Bitter in the mouth, cold in nature.There is effect of antibacterial, antiinflammatory, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, for traumatic injury, spleen enlargement, pharyngolaryngitis etc.
The principle of Chinese medicine granules of the present invention based on traditional Chinese medical herbal treatment pulmonary heart disease.The medical material of selecting all has effect of relieving cough and resolving phlegm, for pulmonary heart disease symptom, starts with from root, belongs to the prescription for the treatment of both the principal and secondary aspects of a disease.Pulmonary heart disease is had to fabulous therapeutical effect.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1
10 grams of Flos Loniceraes, 3 grams of Radix Platycodoniss, 3 grams of the Radixs Stemonae, 4 grams of Radix Paeoniae Rubra, 3 grams of Rhizoma Chuanxiongs, 3 grams of Fructus Xanthii, 5 grams of Radix Saposhnikoviaes, 10 grams of Lignum Dalbergiae Odoriferaes, 3 grams of Rhizoma Cimicifugaes, 2 grams of Styrax, 10 grams of the Radixs Astragali, 6 grams of Radix Angelicae Sinensis, 9 grams of Radix Salviae Miltiorrhizaes, 6 grams of Flos Genkwas (processed with vinegar), 8 grams of Folium et Cacumen Rhododendri Mariaes, 3 grams of Alumens, 3 grams of Bombyx Batryticatus, 8 grams of Ramulus Cinnamomi, 10 grams of Radix Codonopsis, 15 grams of Turpinia pomifera(Roxb) D O.s, 6 grams of Herba Salviae Chinensiss.
1. get Alumen and Bombyx Batryticatus and pulverize, cross 60 mesh sieves;
2. Fructus Xanthii is placed in preheated container, fries to surperficial buff and thorn burntly with moderate heat, inner taking-up when light yellow dried in the air coolly to room temperature, grinds deburring, makes Fructus Xanthii (parched);
3. Radix Saposhnikoviae is placed in to pot interior micro-a stir-fry to buff, taking-up is dried in the air cool to room temperature, makes Radix Saposhnikoviae (parched);
4. decoct with water 2 times having fried Fructus Xanthii, Radix Saposhnikoviae and Flos Lonicerae, Radix Platycodonis, the Radix Stemonae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Lignum Dalbergiae Odoriferae, Rhizoma Cimicifugae, Styrax, the Radix Astragali, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, processed with vinegar Flos Genkwa, Folium et Cacumen Rhododendri Mariae, Ramulus Cinnamomi, Radix Codonopsis, Turpinia pomifera(Roxb) D O. and Herba Salviae Chinensis, 1.5 hours for the first time, 1.0 hours for the second time, collecting decoction, leave standstill 20 hours, filter, it is 1.20 that filtrate is concentrated into relative density, lets cool;
5. by step 4. gained filtrate add ethanol, ethanol consumption is 0.5 times of filtrate weight, leaves standstill 20 hours, filters filtrate recycling ethanol to be concentrated into relative density be 1.30;
6. 5. in gained filtrate, drip Styrax to step, Styrax consumption is 0.5% of filtrate weight;
7. 6. in gained filtrate, add Alumen and Bombyx Batryticatus powder to step, also add appropriate amount of starch, dry, granulation.
embodiment 2
12 grams of Flos Loniceraes, 5 grams of Radix Platycodoniss, 5 grams of the Radixs Stemonae, 5 grams of Radix Paeoniae Rubra, 4 grams of Rhizoma Chuanxiongs, 5 grams of Fructus Xanthii, 6 grams of Radix Saposhnikoviaes, 15 grams of Lignum Dalbergiae Odoriferaes, 4 grams of Rhizoma Cimicifugaes, 3 grams of Styrax, 15 grams of the Radixs Astragali, 5 grams of Radix Angelicae Sinensis, 10 grams of Radix Salviae Miltiorrhizaes, 7 grams of Flos Genkwas (processed with vinegar), 10 grams of Folium et Cacumen Rhododendri Mariaes, 5 grams of Alumens, 5 grams of Bombyx Batryticatus, 10 grams of Ramulus Cinnamomi, 15 grams of Radix Codonopsis, 18 grams of Turpinia pomifera(Roxb) D O.s, 8 grams of Herba Salviae Chinensiss.
1. get Alumen and Bombyx Batryticatus and pulverize, cross 80 mesh sieves;
2. Fructus Xanthii is placed in preheated container, fries to surperficial buff and thorn burntly with moderate heat, inner taking-up when light yellow dried in the air coolly to room temperature, grinds deburring, makes Fructus Xanthii (parched);
3. Radix Saposhnikoviae is placed in to pot interior micro-a stir-fry to buff, taking-up is dried in the air cool to room temperature, makes Radix Saposhnikoviae (parched);
4. decoct with water 2 times having fried Fructus Xanthii, Radix Saposhnikoviae and Flos Lonicerae, Radix Platycodonis, the Radix Stemonae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Lignum Dalbergiae Odoriferae, Rhizoma Cimicifugae, Styrax, the Radix Astragali, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, processed with vinegar Flos Genkwa, Folium et Cacumen Rhododendri Mariae, Ramulus Cinnamomi, Radix Codonopsis, Turpinia pomifera(Roxb) D O. and Herba Salviae Chinensis, 1.5 hours for the first time, 1.0 hours for the second time, collecting decoction, leave standstill 22 hours, filter, it is 1.20 that filtrate is concentrated into relative density, lets cool;
5. by step 4. gained filtrate add ethanol, ethanol consumption is 0.8 times of filtrate weight, leaves standstill 22 hours, filters filtrate recycling ethanol to be concentrated into relative density be 1.35;
6. 5. in gained filtrate, drip Styrax to step, Styrax consumption is 0.8% of filtrate weight;
7. 6. in gained filtrate, add Alumen and Bombyx Batryticatus powder to step, also add appropriate amount of starch, dry, granulation.
embodiment 3
16 grams of Flos Loniceraes, 8 grams of Radix Platycodoniss, 8 grams of the Radixs Stemonae, 7 grams of Radix Paeoniae Rubra, 6 grams of Rhizoma Chuanxiongs, 9 grams of Fructus Xanthii, 8 grams of Radix Saposhnikoviaes, 25 grams of Lignum Dalbergiae Odoriferaes, 5 grams of Rhizoma Cimicifugaes, 5 grams of Styrax, 25 grams of the Radixs Astragali, 8 grams of Radix Angelicae Sinensis, 13 grams of Radix Salviae Miltiorrhizaes, 10 grams of Flos Genkwas (processed with vinegar), 14 grams of Folium et Cacumen Rhododendri Mariaes, 8 grams of Alumens, 8 grams of Bombyx Batryticatus, 14 grams of Ramulus Cinnamomi, 25 grams of Radix Codonopsis, 25 grams of Turpinia pomifera(Roxb) D O.s, 12 grams of Herba Salviae Chinensiss.
1. get Alumen and Bombyx Batryticatus and pulverize, cross 100 mesh sieves;
2. Fructus Xanthii is placed in preheated container, fries to surperficial buff and thorn burntly with moderate heat, inner taking-up when light yellow dried in the air coolly to room temperature, grinds deburring, makes Fructus Xanthii (parched);
3. Radix Saposhnikoviae is placed in to pot interior micro-a stir-fry to buff, taking-up is dried in the air cool to room temperature, makes Radix Saposhnikoviae (parched);
4. decoct with water 2 times having fried Fructus Xanthii, Radix Saposhnikoviae and Flos Lonicerae, Radix Platycodonis, the Radix Stemonae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Lignum Dalbergiae Odoriferae, Rhizoma Cimicifugae, Styrax, the Radix Astragali, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, processed with vinegar Flos Genkwa, Folium et Cacumen Rhododendri Mariae, Ramulus Cinnamomi, Radix Codonopsis, Turpinia pomifera(Roxb) D O. and Herba Salviae Chinensis, 1.5 hours for the first time, 1.0 hours for the second time, collecting decoction, leave standstill 27 hours, filter, it is 1.20 that filtrate is concentrated into relative density, lets cool;
5. by step 4. gained filtrate add ethanol, ethanol consumption is 1.2 times of filtrate weight, leaves standstill 28 hours, filters filtrate recycling ethanol to be concentrated into relative density be 1.35;
6. 5. in gained filtrate, drip Styrax to step, Styrax consumption is 1.2% of filtrate weight;
7. 6. in gained filtrate, add Alumen and Bombyx Batryticatus powder to step, also add appropriate amount of starch, dry, granulation.
embodiment 4
20 grams of Flos Loniceraes, 9 grams of Radix Platycodoniss, 10 grams of the Radixs Stemonae, 12 grams of Radix Paeoniae Rubra, 9 grams of Rhizoma Chuanxiongs, 10 grams of Fructus Xanthii, 10 grams of Radix Saposhnikoviaes, 30 grams of Lignum Dalbergiae Odoriferaes, 6 grams of Rhizoma Cimicifugaes, 6 grams of Styrax, 30 grams of the Radixs Astragali, 12 grams of Radix Angelicae Sinensis, 15 grams of Radix Salviae Miltiorrhizaes, 12 grams of Flos Genkwas (processed with vinegar), 16 grams of Folium et Cacumen Rhododendri Mariaes, 9 grams of Alumens, 10 grams of Bombyx Batryticatus, 16 grams of Ramulus Cinnamomi, 30 grams of Radix Codonopsis, 30 grams of Turpinia pomifera(Roxb) D O.s, 15 grams of Herba Salviae Chinensiss.
1. get Alumen and Bombyx Batryticatus and pulverize, cross 120 mesh sieves;
2. Fructus Xanthii is placed in preheated container, fries to surperficial buff and thorn burntly with moderate heat, inner taking-up when light yellow dried in the air coolly to room temperature, grinds deburring, makes Fructus Xanthii (parched);
3. Radix Saposhnikoviae is placed in to pot interior micro-a stir-fry to buff, taking-up is dried in the air cool to room temperature, makes Radix Saposhnikoviae (parched);
4. decoct with water 2 times having fried Fructus Xanthii, Radix Saposhnikoviae and Flos Lonicerae, Radix Platycodonis, the Radix Stemonae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Lignum Dalbergiae Odoriferae, Rhizoma Cimicifugae, Styrax, the Radix Astragali, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, processed with vinegar Flos Genkwa, Folium et Cacumen Rhododendri Mariae, Ramulus Cinnamomi, Radix Codonopsis, Turpinia pomifera(Roxb) D O. and Herba Salviae Chinensis, 1.5 hours for the first time, 1.0 hours for the second time, collecting decoction, leave standstill 30 hours, filter, it is 1.20 that filtrate is concentrated into relative density, lets cool;
5. by step 4. gained filtrate add ethanol, ethanol consumption is 1.5 times of filtrate weight, leaves standstill 30 hours, filters filtrate recycling ethanol to be concentrated into relative density be 1.40;
6. 5. in gained filtrate, drip Styrax to step, Styrax consumption is 1.5% of filtrate weight;
7. 6. in gained filtrate, add Alumen and Bombyx Batryticatus powder to step, also add appropriate amount of starch, dry, granulation.
embodiment 5
A kind of Chinese medicine granules for the treatment of pulmonary heart disease: 15 grams of Flos Loniceraes, 6 grams of Radix Platycodoniss, 7 grams of the Radixs Stemonae, 6 grams of Radix Paeoniae Rubra, 5 grams of Rhizoma Chuanxiongs, 6 grams of Fructus Xanthii, 7 grams of Radix Saposhnikoviaes, 20 grams of Lignum Dalbergiae Odoriferaes, 4.5 grams of Rhizoma Cimicifugaes, 4 grams of Styrax, 20 grams of the Radixs Astragali, 7 grams of Radix Angelicae Sinensis, 12 grams of Radix Salviae Miltiorrhizaes, 8 grams of Flos Genkwas (processed with vinegar), 12 grams of Folium et Cacumen Rhododendri Mariaes, 6 grams of Alumens, 7 grams of Bombyx Batryticatus, 12 grams of Ramulus Cinnamomi, 20 grams of Radix Codonopsis, 20 grams of Turpinia pomifera(Roxb) D O.s, 10 grams of Herba Salviae Chinensiss.
1. get Alumen and Bombyx Batryticatus and pulverize, cross 90 mesh sieves;
2. Fructus Xanthii is placed in preheated container, fries to surperficial buff and thorn burntly with moderate heat, inner taking-up when light yellow dried in the air coolly to room temperature, grinds deburring, makes Fructus Xanthii (parched);
3. Radix Saposhnikoviae is placed in to pot interior micro-a stir-fry to buff, taking-up is dried in the air cool to room temperature, makes Radix Saposhnikoviae (parched);
4. decoct with water 2 times having fried Fructus Xanthii, Radix Saposhnikoviae and Flos Lonicerae, Radix Platycodonis, the Radix Stemonae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Lignum Dalbergiae Odoriferae, Rhizoma Cimicifugae, Styrax, the Radix Astragali, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, processed with vinegar Flos Genkwa, Folium et Cacumen Rhododendri Mariae, Ramulus Cinnamomi, Radix Codonopsis, Turpinia pomifera(Roxb) D O. and Herba Salviae Chinensis, 1.5 hours for the first time, 1.0 hours for the second time, collecting decoction, leave standstill 24 hours, filter, it is 1.20 that filtrate is concentrated into relative density, lets cool;
5. by step 4. gained filtrate add ethanol, ethanol consumption is 1.0 times of filtrate weight, leaves standstill 26 hours, filters filtrate recycling ethanol to be concentrated into relative density be 1.35;
6. 5. in gained filtrate, drip Styrax to step, Styrax consumption is 1.0% of filtrate weight;
7. 6. in gained filtrate, add Alumen and Bombyx Batryticatus powder to step, also add appropriate amount of starch, dry, granulation.
Using method: for making Chinese medicine granules of the present invention reach optimum therapeuticing effect, every day twice, half an hour after meal morning and evening, get 12g, take after mixing it with hot water.
model case one
Zhao XX, man, 45 years old, Yinan County, Linyi.For many years, uncomfortable in chest, nervous 3 years, after catching a cold before first quarter moon, above-mentioned symptom increased the weight of, and occurs abdominal distention for cough, expectoration, inappetence, dizzy, headache, mental status extreme difference.Be pulmonary heart disease after diagnosing.Sick age: 5 years.Examine the time: on October 14th, 2011; Use Chinese drugs agentia of the present invention, every day twice, half an hour after meal morning and evening, get 12g, take after mixing it with hot water.Use 7 days, abundant expectoration symptom alleviates; Use 1 month, abdominal distention, inappetence, dizzy, headache transference cure; Use 2 months, cough symptom disappears substantially, and abundant expectoration symptom disappears completely; Use 2 first quarter moons, recover; During using Chinese medicine of the present invention, have no side effect, drug withdrawal is so far without recurrence.
model case twozhu XX, man, 53 years old, Licang District, Qingdao of Shandong province.Symptom: recurrent cough appears in patient for many years, coughs yellow thick sputum, and occurs breathing hard, precordialgia, the symptom such as weak, uncomfortable in chest, movable or suffer from cold after symptom obvious, finger tip is livid purple color, is pulmonary heart disease after diagnosing.Sick age: 3 years.Examine the time: on July 14th, 2011; Use Chinese drugs agentia of the present invention, every day twice, half an hour after meal morning and evening, get 12g, take after mixing it with hot water.Use 10 days, expectoration remission; Use 1 month, pained, weak, disease such as grade uncomfortable in chest alleviates; Use 1 first quarter moon, abundant expectoration transference cure, rises and have once in a while cough symptom morning, does not also occur the symptoms such as uncomfortable in chest, pained after activity again; Use 3 months, every ill symptoms disappears completely, recovers; After use again Chinese drugs agentia of the present invention to consolidate 10 days, drug withdrawal so far without recurrence.
model case three
Cui XX, female, 46 years old, Changdao County, Yantai City.Symptom: cough, expectoration all day, when rise morning, symptom aggravation, feels cardiopalmus, tachypnea as stair climbing, skelp etc. after activity, after rest, can alleviate, be pulmonary heart disease through hospital diagnosis.After this in many ways seek medical drugs, effect is all undesirable.Sick age: 2 years.Examine the time: on June 9th, 2011; Use Chinese drugs agentia of the present invention, every day twice, half an hour after meal morning and evening, get 12g, take after mixing it with hot water.Use 4 days, play cough morning, expectoration is alleviated to some extent; Use 10 days, movable rear cardiopalmus, tachypnea symptom are obviously improved; Use 20 days, the number of times of coughing every day significantly reduces, and abundant expectoration symptom almost disappears; Use 1 month, every ill symptoms disappears completely, recovers; After use again Chinese drugs agentia of the present invention to consolidate 7 days, drug withdrawal so far without recurrence.
experimental example
In order to verify the effect of Chinese medicine composition of the present invention (embodiment 5), we have extracted 300 patients and have carried out the experiment of medicine, be equally divided into three groups, every group of 100 people, experimental group and matched group, experimental group is taken embodiment 5 gained Chinese medicine granules, and matched group is taken Chinese medicine and the Western medicine medicine of other treatment pulmonary heart disease.
Inclusion criteria: be diagnosed as the patient of pulmonary heart disease, in age 40-55 year, had the one or more of pulmonary heart disease symptom, sick time 2-5.
Using method is: Chinese medicine granules of the present invention, every day twice, half an hour after meal morning and evening, get 12g, and take after mixing it with hot water.
Curative effect situation criterion (contrasting with the data of taking 40 days): 1, cure.After drug administration 40 days, malaise symptoms disappears completely; 2, effective.After drug administration 40 days, malaise symptoms alleviates or part disappears; 3, invalid.After drug administration 40 days, malaise symptoms is unchanged.
We have carried out accurate statistics and mathematical analysis to experimental data.Specific experiment result is as following table:
Chinese medicine granules of the present invention cure rate compared with other medicine for the treatment of pulmonary heart disease is high, total effective rate is 94%, higher by 44% than matched group oral western medicine effective percentage, higher by 24% than matched group oral Chinese medicine effective percentage, successful is better than matched group, this invention Chinese medicine granules is cheap, and ordinary people life-time service can not increase health and pecuniary burden yet.In clinical experiment, there is not a routine side effect situation, safety is far above the medicine of other treatment pulmonary heart disease, Chinese medicine instant effect of the present invention, can experience comparatively rapidly the effect that symptom is improved at the initial stage of taking medicine, increase the confidence that patient adheres to treatment, and therapeutic process no pain is to treat at present the safer desirable Chinese medicine of pulmonary heart disease.
The application's prescription is distinguished veteran doctors of TCM proved recipe, has the prospect of industrialized implementation.Completing of this invention has benefited from Shandong Province's 12 Planning emphasis subjects---the support of Law of Economy subject fund.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement.Within the spirit and principles in the present invention all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (3)
1. a Chinese medicine granules for the treatment of pulmonary heart disease, is characterized in that, takes off the raw material of stating weight proportion and is prepared from: Flos Lonicerae 10-20 part, Radix Platycodonis 3-9 part, Radix Stemonae 3-10 part, Radix Paeoniae Rubra 6-12 part, Rhizoma Chuanxiong 3-9 part, Fructus Xanthii 3-10 part, Radix Saposhnikoviae 5-10 part, Lignum Dalbergiae Odoriferae 10-30 part, Rhizoma Cimicifugae 3-6 part, Styrax 2-6 part, Radix Astragali 10-30 part, Radix Angelicae Sinensis 6-12 part, Radix Salviae Miltiorrhizae 9-15 part, vinegar Flos Genkwa 6-12 processed part, Folium et Cacumen Rhododendri Mariae 8-16 part, Alumen 3-9 part, Bombyx Batryticatus 3-10 part, Ramulus Cinnamomi 8-16 part, Radix Codonopsis 10-30 part, Turpinia pomifera(Roxb) D O. 15-30 part, Herba Salviae Chinensis 6-15 part.
2. according to Chinese medicine granules claimed in claim 1, it is characterized in that, take off the raw material of stating weight proportion and be prepared from: Flos Lonicerae 12-16 part, Radix Platycodonis 5-8 part, Radix Stemonae 5-8 part, Radix Paeoniae Rubra 5-7 part, Rhizoma Chuanxiong 4-6 part, Fructus Xanthii 5-9 part, Radix Saposhnikoviae 6-8 part, Lignum Dalbergiae Odoriferae 15-25 part, Rhizoma Cimicifugae 4-5 part, Styrax 3-5 part, Radix Astragali 15-25 part, Radix Angelicae Sinensis 5-8 part, Radix Salviae Miltiorrhizae 10-13 part, vinegar Flos Genkwa 7-10 processed part, Folium et Cacumen Rhododendri Mariae 10-14 part, Alumen 5-8 part, Bombyx Batryticatus 5-8 part, Ramulus Cinnamomi 10-14 part, Radix Codonopsis 15-25 part, Turpinia pomifera(Roxb) D O. 18-25 part, Herba Salviae Chinensis 8-12 part.
3. according to Chinese medicine granules claimed in claim 1, it is characterized in that, take off the raw material of stating weight proportion and be prepared from: 15 parts of Flos Loniceraes, 6 parts of Radix Platycodoniss, 7 parts of the Radixs Stemonae, 6 parts of Radix Paeoniae Rubra, 5 parts of Rhizoma Chuanxiongs, 6 parts of Fructus Xanthii, 7 parts of Radix Saposhnikoviaes, 20 parts of Lignum Dalbergiae Odoriferaes, 4.5 parts of Rhizoma Cimicifugaes, 4 parts of Styrax, 20 parts of the Radixs Astragali, 7 parts of Radix Angelicae Sinensis, 12 parts of Radix Salviae Miltiorrhizaes, 8 parts of vinegar Flos Genkwas processed, 12 parts of Folium et Cacumen Rhododendri Mariaes, 6 parts of Alumens, 7 parts of Bombyx Batryticatus, 12 parts of Ramulus Cinnamomi, 20 parts of Radix Codonopsis, 20 parts of Turpinia pomifera(Roxb) D O.s, 10 parts of Herba Salviae Chinensiss.
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| CN101028507A (en) * | 2007-02-26 | 2007-09-05 | 赵红霞 | Chinese-medicinal composition for treating asthma |
| CN101559180A (en) * | 2008-04-17 | 2009-10-21 | 北京汉潮联创中药科技有限公司 | Drug for clearing away heat and toxic material, relieving cough, reducing phlegm and preventing asthma |
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| CN101822769A (en) * | 2009-03-05 | 2010-09-08 | 李玉根 | Shortcut for curing pulmonary heart disease |
| CN101829296B (en) * | 2010-02-05 | 2011-07-27 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine combination for treating pulmonary atelectasis and preparation method thereof |
| CN101829267B (en) * | 2010-02-05 | 2011-08-31 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine combination for treating lung asthma and preparation method thereof |
| CN101822814A (en) * | 2010-02-06 | 2010-09-08 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating lung failure and preparation method thereof |
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