CN103127325A - Traditional Chinese medicine compound for treatment of hepatitis and preparation method thereof - Google Patents

Traditional Chinese medicine compound for treatment of hepatitis and preparation method thereof Download PDF

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CN103127325A
CN103127325A CN2013100969097A CN201310096909A CN103127325A CN 103127325 A CN103127325 A CN 103127325A CN 2013100969097 A CN2013100969097 A CN 2013100969097A CN 201310096909 A CN201310096909 A CN 201310096909A CN 103127325 A CN103127325 A CN 103127325A
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radix
chinese medicine
hepatitis
herba
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华梅
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Abstract

The invention relates to a traditional Chinese medicine compound for treatment of hepatitis and a preparation method thereof. The traditional Chinese medicine compound is characterized by being prepared by the following raw materials according to parts by weight: 10-20 parts of oldenlandia diffusa, 10-20 parts of dandelion, 10-20 parts of lucid ganoderma, 10-20 parts of barbary wolfberry fruit, 7-13 parts of gentian, 8-12 parts of astragalus mongholicus, 8-12 parts of oriental wormwood, 8-12 parts of radix bupleuri, 8-12 parts of schisandra chinensis, 6-10 parts of rhizoma alismatis, 6-10 parts of salvia miltiorrhiza, and 4-8 parts of golden cypress. The traditional Chinese medicine compound has the advantages of good and fast curative effect, no side effects, advanced preparation technology, good stability of the preparation, high availability of the compound, and the like; and clinical verifications show that the effect rate of the traditional Chinese medicine compound in treating hepatitis is 94%.

Description

A kind of Chinese medicine composition for the treatment of hepatitis B and preparation method thereof
Technical field
The present invention relates to technical field of traditional Chinese medicine pharmacy, particularly relate to a kind of Chinese medicine composition for the treatment of hepatitis B and preparation method thereof.
Background technology
Hepatitis B is a kind of by caused disease after hepatitis B virus (HBV) infection body.Hepatitis B virus is a kind of Hepadna Virus, mainly is present in hepatocyte and damages hepatocyte, causes hepatocyte inflammation, necrosis, fibrosis.
At present, although there is the medicine of multiple treatment hepatitis B, curative effect is not good enough mostly, and treatment time is long, and side effect is large, therefore studies a kind of good effect, instant effect, and the Chinese medicine composition of the treatment hepatitis B that side effect is little is very necessary.
Summary of the invention
The technical problem to be solved in the present invention is: for solving the deficiencies in the prior art, the invention provides a kind of Chinese medicine composition for the treatment of hepatitis B and preparation method thereof, the present invention has good effect, instant effect has no side effect, and preparation technology is advanced, better stability of preparation, drug utilization degree advantages of higher.
A kind of Chinese medicine composition for the treatment of hepatitis B is characterized in that: the crude drug by following weight portion is made: Herba Hedyotidis Diffusae 10-20 part, Herba Taraxaci 10-20 part, Ganoderma 10-20 part, Fructus Lycii 10-20 part, Radix Gentianae 7-13 part, Radix Astragali 8-12 part, Herba Artemisiae Scopariae 8-12 part, Radix Bupleuri 8-12 part, Fructus Schisandrae Chinensis 8-12 part, Rhizoma Alismatis 6-10 part, Radix Salviae Miltiorrhizae 6-10 part, Cortex Phellodendri 4-8 part.
The Chinese medicine composition for the treatment of hepatitis B according to claim 1 is characterized in that: the crude drug by following weight portion is made: 15 parts of Herba Hedyotidis Diffusaes, 15 parts of Herba Taraxacis, 15 parts of Ganodermas, 15 parts of Fructus Lycii, 10 parts of Radix Gentianaes, 10 parts of the Radixs Astragali, 10 parts of Herba Artemisiae Scopariaes, 10 parts of Radix Bupleuri, 10 parts of Fructus Schisandrae Chinensis, 8 parts of Rhizoma Alismatis, 8 parts of Radix Salviae Miltiorrhizaes, 6 parts of Cortex Phellodendris.
The preparation method of the Chinese medicine composition of described treatment hepatitis B comprises the following steps:
(1) according to described parts by weight weighting raw materials: Herba Hedyotidis Diffusae, Herba Taraxaci, Ganoderma, Fructus Lycii, Radix Gentianae, the Radix Astragali, Herba Artemisiae Scopariae, Radix Bupleuri, Fructus Schisandrae Chinensis, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Cortex Phellodendri are standby;
(2) add 8-12 times of water gaging of total raw material medicine to soak 1-1.5 hour, heating decocted 1-3 hour, filtered, and medicinal residues add 6-8 times of water gaging again, and heating decocted 1-1.5 hour, filtered, and filtrate merges, and gets supernatant;
When (3) supernatant concentration to relative density is 1.1-1.3, advance spray dryer, inlet temperature is controlled 140-180 ℃, and leaving air temp 80-110 ℃, charging rate is 1L/ minute, gets spray drying powder;
(4) with dry powder with No. 0 capsule fill, sterilization, packing gets final product.
Instructions of taking: one day three times, one time 10,30 days is a course for the treatment of.
The pharmaceutical characteristic of each crude drug of the present invention is as follows:
Herba Hedyotidis Diffusae: meridian distribution of property and flavor: sweet, light, cool, return stomach, large intestine, small intestine meridian; Effect: heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.
Herba Taraxaci: meridian distribution of property and flavor: bitter, sweet, cold liver, the stomach warp of returning; Effect: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.
Ganoderma: meridian distribution of property and flavor: sweet, flat, GUIXIN, lung, liver, kidney channel; Effect: invigorating QI and tranquilization, relieving cough and asthma.
Fructus Lycii: meridian distribution of property and flavor: sweet, flat, return liver, kidney channel; Effect: nourishing the liver and kidney, replenishing vital essence to improve eyesight.
Radix Gentianae: meridian distribution of property and flavor: bitter, cold, return liver, gallbladder meridian; Effect: heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.
The Radix Astragali: meridian distribution of property and flavor: sweet, tepor is returned lung, spleen, liver, kidney channel; Effect: polishing consolidating superficial resistance, holder skin ulcer granulation promoting.
Herba Artemisiae Scopariae: meridian distribution of property and flavor: bitter, hot, be slightly cold, return spleen, stomach, liver, gallbladder meridian; Effect: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.
Radix Bupleuri: meridian distribution of property and flavor: bitter, be slightly cold, return liver, gallbladder meridian; Effect: reconciling superficies and interior, soothing the liver, yang invigorating.
Fructus Schisandrae Chinensis: meridian distribution of property and flavor: sour, sweet, warm, return lung, the heart, kidney channel; Effect: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.
Rhizoma Alismatis: meridian distribution of property and flavor: sweet, cold, return kidney, urinary bladder channel; Effect: diuresis, clearing away damp-heat.
Radix Salviae Miltiorrhizae: meridian distribution of property and flavor: bitter, be slightly cold, GUIXIN, Liver Channel; Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.
Cortex Phellodendri: meridian distribution of property and flavor: bitter, cold, return kidney, urinary bladder channel; Effect: heat clearing and damp drying, pathogenic fire purging is except steaming, detoxification sore treatment.
The beneficial effect that the present invention compared with prior art has is: the present invention is under Traditional Chinese medical theory and clinical experience guidance, chooses each crude drug and proportioning thereof, reaches benefiting QI for activating blood circulation, purging liver-fire, kidney-supplementing liver-boosting, yin nourishing easing the affected liver, promoting blood circulation and stopping pain, the effect of heat-clearing and toxic substances removing; The present invention has good effect, and instant effect has no side effect, and preparation technology is advanced, better stability of preparation, drug utilization degree advantages of higher; Through clinical verification, it is 94% that the present invention treats the hepatitis B effective percentage.
The specific embodiment
Embodiment 1:
A kind of Chinese medicine composition for the treatment of hepatitis B is made by the crude drug of following weight portion: 10 parts of Herba Hedyotidis Diffusaes, 10 parts of Herba Taraxacis, 10 parts of Ganodermas, Fructus Lycii 10,7 parts of Radix Gentianaes, 8 parts of the Radixs Astragali, 8 parts of Herba Artemisiae Scopariaes, 8 parts of Radix Bupleuri, 8 parts of Fructus Schisandrae Chinensis, 6 parts of Rhizoma Alismatis, 6 parts of Radix Salviae Miltiorrhizaes, 4 parts of Cortex Phellodendris.
The preparation method of the Chinese medicine composition of described treatment hepatitis B comprises the following steps:
(1) according to described parts by weight weighting raw materials: 10 parts of Herba Hedyotidis Diffusaes, 10 parts of Herba Taraxacis, 10 parts of Ganodermas, Fructus Lycii 10,7 parts of Radix Gentianaes, 8 parts of the Radixs Astragali, 8 parts of Herba Artemisiae Scopariaes, 8 parts of Radix Bupleuri, 8 parts of Fructus Schisandrae Chinensis, 6 parts of Rhizoma Alismatis, 6 parts of Radix Salviae Miltiorrhizaes, 4 parts of Cortex Phellodendris are standby;
(2) add 12 times of water gagings of total raw material medicine to soak 1.5 hours, heating decocted 2 hours, filtered, and medicinal residues add 8 times of water gagings again, and heating decocted 1.5 hours, filtered, and filtrate merges, and gets supernatant;
(3) supernatant concentration to relative density is 1.1 o'clock, advances spray dryer, and inlet temperature is controlled 160 ℃, 100 ℃ of leaving air temps, and charging rate is 1L/ minute, gets spray drying powder;
(4) with dry powder with No. 0 capsule fill, sterilization, packing gets final product.
Embodiment 2:
A kind of Chinese medicine composition for the treatment of hepatitis B is made by the crude drug of following weight portion: 15 parts of Herba Hedyotidis Diffusaes, 15 parts of Herba Taraxacis, 15 parts of Ganodermas, 15 parts of Fructus Lycii, 10 parts of Radix Gentianaes, 10 parts of the Radixs Astragali, 10 parts of Herba Artemisiae Scopariaes, 10 parts of Radix Bupleuri, 10 parts of Fructus Schisandrae Chinensis, 8 parts of Rhizoma Alismatis, 8 parts of Radix Salviae Miltiorrhizaes, 6 parts of Cortex Phellodendris.
The preparation method of the Chinese medicine composition of described treatment hepatitis B comprises the following steps:
(1) according to described parts by weight weighting raw materials: 15 parts of Herba Hedyotidis Diffusaes, 15 parts of Herba Taraxacis, 15 parts of Ganodermas, 15 parts of Fructus Lycii, 10 parts of Radix Gentianaes, 10 parts of the Radixs Astragali, 10 parts of Herba Artemisiae Scopariaes, 10 parts of Radix Bupleuri, 10 parts of Fructus Schisandrae Chinensis, 8 parts of Rhizoma Alismatis, 8 parts of Radix Salviae Miltiorrhizaes, 6 parts of Cortex Phellodendris are standby;
(2) add 10 times of water gagings of total raw material medicine to soak 1 hour, heating decocted 3 hours, filtered, and medicinal residues add 6 times of water gagings again, and heating decocted 1 hour, filtered, and filtrate merges, and gets supernatant;
(3) supernatant concentration to relative density is 1.2 o'clock, advances spray dryer, and inlet temperature is controlled 150 ℃, 900 ℃ of leaving air temps, and charging rate is 1L/ minute, gets spray drying powder;
(4) with dry powder with No. 0 capsule fill, sterilization, packing gets final product.
Embodiment 3:
A kind of Chinese medicine composition for the treatment of hepatitis B is made by the crude drug of following weight portion: 20 parts of Herba Hedyotidis Diffusaes, 20 parts of Herba Taraxacis, 20 parts of Ganodermas, 20 parts of Fructus Lycii, 13 parts of Radix Gentianaes, 12 parts of the Radixs Astragali, 12 parts of Herba Artemisiae Scopariaes, 12 parts of Radix Bupleuri, 12 parts of Fructus Schisandrae Chinensis, 10 parts of Rhizoma Alismatis, 10 parts of Radix Salviae Miltiorrhizaes, 8 parts of Cortex Phellodendris.
The preparation method of the Chinese medicine composition of described treatment hepatitis B comprises the following steps:
(1) according to described parts by weight weighting raw materials: 20 parts of Herba Hedyotidis Diffusaes, 20 parts of Herba Taraxacis, 20 parts of Ganodermas, 20 parts of Fructus Lycii, 13 parts of Radix Gentianaes, 12 parts of the Radixs Astragali, 12 parts of Herba Artemisiae Scopariaes, 12 parts of Radix Bupleuri, 12 parts of Fructus Schisandrae Chinensis, 10 parts of Rhizoma Alismatis, 10 parts of Radix Salviae Miltiorrhizaes, 8 parts of Cortex Phellodendris are standby;
(2) add 11 times of water gagings of total raw material medicine to soak 1.2 hours, heating decocted 1.5 hours, filtered, and medicinal residues add 7 times of water gagings again, and heating decocted 1 hour, filtered, and filtrate merges, and gets supernatant;
(3) supernatant concentration to relative density is 1.18 o'clock, advances spray dryer, and inlet temperature is controlled 170 ℃, 95 ℃ of leaving air temps, and charging rate is 1L/ minute, gets spray drying powder;
(4) with dry powder with No. 0 capsule fill, sterilization, packing gets final product.
Experimental example:
One, clinical data: adopt the present invention to treat altogether 108 routine hepatitis B patients, male 73 examples wherein, female's 35 examples, the oldest 60 years old, minimum 10 years old of age.
Two, clinical symptoms: low grade fever, weak, dizzy, loss of appetite, feel sick, vomit, detest oil, abdominal distention, yellowish urine, uncomfortable liver area, sleep is not good enough etc.
Three, Therapeutic Method: the patient takes night and morning every day, and 30 days is a course for the treatment of.
Four, the standard of curative effect evaluation:
Cure: transference cure, experimental check is normal;
Take a turn for the better: symptom is obviously improved, and lab testing is improved;
Do not heal: primary symptom is not improved or deterioration person.
Five, model case:
1, Wang, the man 48 years old, suffered from hepatitis B more than ten years.Outpatient service disease is seen: complexion is white, coldness of the body with chills, and the epigastrium cold type of pain is liked warm aversion to cold, limbs fatigue, the poor dreaminess of sleeping is felt sick sometimes.Laboratory report: ALT fluctuation is in the 120IU/L left and right, and the serum bilirubin fluctuation is in the 30mol/L left and right.Take Chinese medicine composition of the present invention after 2 courses for the treatment of symptom obviously improve, take 3 recoveries from illness courses for the treatment of; Followed up a case by regular visits to 1 year, not recurrence.
2, Liu, the man, 36 years old, before January, ALT 340IU/L was found in health check-up, and serum bilirubin fluctuates at 20mol/L, and hepatitis B three is that chemical examination is great three positive, and except fatiguability one disease, all the other are showed no obvious abnormalities.Outpatient service disease is seen: red tongue with thin and yellow fur is greasy and dry, and xerostomia is thirsty, constipation with dry stool, and complexion is partially red.Take Chinese medicine composition of the present invention after 1 course for the treatment of liver function test all normal, take after 2 courses for the treatment of hepatitis B three and be that chemical examination turns entirely is shady, clinical symptom disappearance and fully recovering.
3, Zhao so-and-so, the man, 24 years old, suffer from hepatitis B more than a year, feel uncomfortable liver area when dry weight is lived, the time have weak, anorexia, yellow urine is liked angryly, is afraid of to suffer from cold, take Chinese medicine composition of the present invention after 1 course for the treatment of all diseases disappear, more after without recurrence.
Six, therapeutic outcome:
Adopt the present invention to treat altogether hepatitis B patient 118 examples, through the treatment of 1-6 the course for the treatment of, wherein cure 99 examples, 12 examples that take a turn for the better, 7 examples that do not heal, effective percentage is 94%; Result shows, the present invention has good effect to the treatment hepatitis B, and instant effect has no side effect, and preparation technology is advanced, better stability of preparation, drug utilization degree advantages of higher.

Claims (3)

1. Chinese medicine composition for the treatment of hepatitis B, it is characterized in that: the crude drug by following weight portion is made: Herba Hedyotidis Diffusae 10-20 part, Herba Taraxaci 10-20 part, Ganoderma 10-20 part, Fructus Lycii 10-20 part, Radix Gentianae 7-13 part, Radix Astragali 8-12 part, Herba Artemisiae Scopariae 8-12 part, Radix Bupleuri 8-12 part, Fructus Schisandrae Chinensis 8-12 part, Rhizoma Alismatis 6-10 part, Radix Salviae Miltiorrhizae 6-10 part, Cortex Phellodendri 4-8 part.
2. the Chinese medicine composition for the treatment of hepatitis B according to claim 1, it is characterized in that: the crude drug by following weight portion is made: 15 parts of Herba Hedyotidis Diffusaes, 15 parts of Herba Taraxacis, 15 parts of Ganodermas, 15 parts of Fructus Lycii, 10 parts of Radix Gentianaes, 10 parts of the Radixs Astragali, 10 parts of Herba Artemisiae Scopariaes, 10 parts of Radix Bupleuri, 10 parts of Fructus Schisandrae Chinensis, 8 parts of Rhizoma Alismatis, 8 parts of Radix Salviae Miltiorrhizaes, 6 parts of Cortex Phellodendris.
3. the preparation method of the Chinese medicine composition of described treatment hepatitis B comprises the following steps:
(1) according to described parts by weight weighting raw materials: Herba Hedyotidis Diffusae, Herba Taraxaci, Ganoderma, Fructus Lycii, Radix Gentianae, the Radix Astragali, Herba Artemisiae Scopariae, Radix Bupleuri, Fructus Schisandrae Chinensis, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Cortex Phellodendri are standby;
(2) add 8-12 times of water gaging of total raw material medicine to soak 1-1.5 hour, heating decocted 1-3 hour, filtered, and medicinal residues add 6-8 times of water gaging again, and heating decocted 1-1.5 hour, filtered, and filtrate merges, and gets supernatant;
When (3) supernatant concentration to relative density is 1.1-1.3, advance spray dryer, inlet temperature is controlled 140-180 ℃, and leaving air temp 80-110 ℃, charging rate is 1L/ minute, gets spray drying powder;
(4) with dry powder with No. 0 capsule fill, sterilization, packing gets final product.
CN2013100969097A 2013-03-25 2013-03-25 Traditional Chinese medicine compound for treatment of hepatitis and preparation method thereof Pending CN103127325A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103751658A (en) * 2014-02-22 2014-04-30 储可英 Drug for treating serum hepatitis caused by damp-heat brewing and preparation method thereof
CN104645082A (en) * 2015-03-23 2015-05-27 傅宇晓 Capsule for treating hepatitis and preparation method thereof
CN104758717A (en) * 2015-03-17 2015-07-08 朱克兰 Traditional Chinese medicine composition for treating chronic hepatitis
CN105999097A (en) * 2016-07-08 2016-10-12 王恩禄 Traditional Chinese medicine composition for treating hepatitis B

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1079157A (en) * 1993-03-20 1993-12-08 赵三立 Medicine " Ganyanfukangling " for curing hepatitis
CN1380098A (en) * 2002-05-20 2002-11-20 张勇飞 Anti-infection compound preparation and its preparation method
CN101040960A (en) * 2007-04-27 2007-09-26 蒋保珍 Medicine for treating hepatitis
CN102698083A (en) * 2012-07-04 2012-10-03 贵阳中医学院 Oldenlandia liver-tonifying and toxicity-eliminating particles and preparation method thereof, as well as detection method
CN102755594A (en) * 2012-07-19 2012-10-31 杨国兴 Traditional Chinese medicine composition for treating acute and chronic hepatitis B and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1079157A (en) * 1993-03-20 1993-12-08 赵三立 Medicine " Ganyanfukangling " for curing hepatitis
CN1380098A (en) * 2002-05-20 2002-11-20 张勇飞 Anti-infection compound preparation and its preparation method
CN101040960A (en) * 2007-04-27 2007-09-26 蒋保珍 Medicine for treating hepatitis
CN102698083A (en) * 2012-07-04 2012-10-03 贵阳中医学院 Oldenlandia liver-tonifying and toxicity-eliminating particles and preparation method thereof, as well as detection method
CN102755594A (en) * 2012-07-19 2012-10-31 杨国兴 Traditional Chinese medicine composition for treating acute and chronic hepatitis B and preparation method thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103751658A (en) * 2014-02-22 2014-04-30 储可英 Drug for treating serum hepatitis caused by damp-heat brewing and preparation method thereof
CN103751658B (en) * 2014-02-22 2015-11-11 储可英 A kind ofly treat medicine of the hepatitis B that damp-heat accumulation causes and preparation method thereof
CN104758717A (en) * 2015-03-17 2015-07-08 朱克兰 Traditional Chinese medicine composition for treating chronic hepatitis
CN104645082A (en) * 2015-03-23 2015-05-27 傅宇晓 Capsule for treating hepatitis and preparation method thereof
CN104645082B (en) * 2015-03-23 2017-12-15 应瑶琪 A kind of capsule for treating hepatitis and preparation method thereof
CN105999097A (en) * 2016-07-08 2016-10-12 王恩禄 Traditional Chinese medicine composition for treating hepatitis B

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Application publication date: 20130605