A kind of Chinese medicine composition for the treatment of viral myocarditis and preparation method thereof
Technical field
The present invention relates to technical field of traditional Chinese medicine pharmacy, particularly relate to a kind of Chinese medicine composition for the treatment of viral myocarditis and preparation method thereof.
Background technology
Viral myocarditis is acute by the various cardiac muscle caused addicted to Cardiovirus or chronic inflammatory disease, and be more common in child and between twenty and fifty people, male is more than women.Symptoms often first has the symptoms such as heating, systemic pain, pharyngalgia, asthenia, nausea,vomiting,diarrhea for patient, then there is cardiopalmus, uncomfortable in chest, chest pain or pareordia dull pain, dizziness, dyspnea, edema, even Adams-Stokes syndrome, there is heart failure or cardiogenic shock in only a few patient.
At present, although there is the medicine of multiple treatment viral myocarditis, curative effect is not good enough mostly, and side effect is large, not easily effect a radical cure, treatment cost is too high, therefore study a kind of good effect, instant effect, the Chinese medicine composition of what side effect was little cure the disease viral myocarditis is very necessary.
Summary of the invention
The technical problem to be solved in the present invention is: for solving the deficiencies in the prior art, the invention provides a kind of Chinese medicine composition for the treatment of viral myocarditis and preparation method thereof, the present invention has good effect, instant effect, have no side effect, preparation technology is advanced, better stability of preparation, drug availability advantages of higher.
Treat a Chinese medicine composition for viral myocarditis, it is characterized in that: be made up of the crude drug of following weight portion: Radix Astragali 10-15 part, Radix Codonopsis 6-15 part, Fructus Schisandrae Chinensis 6-10 part, Radix Ophiopogonis 6-10 part, Fructus Citri Sarcodactylis 10-15 part, Radix Bupleuri 10-15 part, Rhizoma Polygonati Odorati 6-15 part, Fructus Crataegi 5-13 part, Rhizoma Coptidis 2-5 part, Flos Lonicerae 6-10 part, Radix Paeoniae Rubra 8-12 part, Radix Paeoniae Alba 8-12 part, Ramulus Cinnamomi 4-8 part, Radix Salviae Miltiorrhizae 10-15 part, Radix Glycyrrhizae Preparata 10-20 part, Folium Isatidis 10-20 part, Fructus Ligustri Lucidi 10-15 part, Radix Curcumae 6-12 part.
The Chinese medicine composition of described treatment viral myocarditis, it is preferably: be made up of the crude drug of following weight portion: the Radix Astragali 12 parts, Radix Codonopsis 10 parts, Fructus Schisandrae Chinensis 8 parts, Radix Ophiopogonis 8 parts, Fructus Citri Sarcodactylis 12 parts, Radix Bupleuri 12 parts, Rhizoma Polygonati Odorati 10 parts, Fructus Crataegi 9 parts, Rhizoma Coptidis 3 parts, Flos Lonicerae 8 parts, Radix Paeoniae Rubra 10 parts, the Radix Paeoniae Alba 10 parts, Ramulus Cinnamomi 6 parts, Radix Salviae Miltiorrhizae 12 parts, Radix Glycyrrhizae Preparata 15 parts, Folium Isatidis 15 parts, Fructus Ligustri Lucidi 12 parts, Radix Curcumae 9 parts.
The preparation method of the Chinese medicine composition of described treatment viral myocarditis, comprises the following steps:
(1) according to described parts by weight weighting raw materials: the Radix Astragali, Radix Codonopsis, Fructus Schisandrae Chinensis, Radix Ophiopogonis, Fructus Citri Sarcodactylis, Radix Bupleuri, Rhizoma Polygonati Odorati, Fructus Crataegi, Rhizoma Coptidis, Flos Lonicerae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Ramulus Cinnamomi, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae Preparata, Folium Isatidis, Fructus Ligustri Lucidi, Radix Curcumae are for subsequent use;
(2) add total raw material medicine 8-12 times amount water soaking 1-1.5 hour, heating decocts 1-3 hour, and filter, medicinal residues add 6-8 times of water gaging again, and heating decocts 1-1.5 hour, filters, and filtrate merges, and obtains supernatant;
(3) when supernatant concentration to relative density is 1.1-1.3, enter spray dryer, inlet temperature control 140-180 DEG C, leaving air temp 80-110 DEG C, charging rate is 1L/ minute, obtains spray drying powder;
(4) dry powder pure water is diluted 100 times, if need to add flavoring agent and/or antiseptic, and adjust total amount, embedding, sterilizing, packaging, obtains oral liquid;
(5) by No. 0 capsule fill of dry powder, sterilizing, packaging, obtains capsule;
(6) dry powder made watered pill by the conventional method of medicine or make honeyed pill, sterilizing, packaging, obtains pill.
Instructions of taking: patient takes night and morning every day 30 days is a course for the treatment of.
The pharmaceutical characteristic of each crude drug of the present invention is as follows:
The Radix Astragali: meridian distribution of property and flavor: sweet, tepor, returns lung, spleen, liver, kidney channel; Effect: polishing consolidating superficial resistance, holder skin ulcer granulation promoting.
Radix Codonopsis: meridian distribution of property and flavor: sweet, flat, returns spleen, lung meridian; Effect: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.
Fructus Schisandrae Chinensis: meridian distribution of property and flavor: warm, sour, sweet, returns lung, the heart, kidney channel; Effect: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.
Radix Ophiopogonis: meridian distribution of property and flavor: sweet, micro-hardship, to be slightly cold, GUIXIN, lung, stomach warp; Effect: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.
Fructus Citri Sarcodactylis: meridian distribution of property and flavor: warm, pungent, bitter, sour, returns liver, spleen, lung meridian; Effect: liver-smoothing, qi-regulating, and stomach and alleviating pain.
Radix Bupleuri: meridian distribution of property and flavor: to be slightly cold, bitter, returns liver, gallbladder meridian; Effect: reconciling superficies and interior, soothing the liver, yang invigorating.
Rhizoma Polygonati Odorati: meridian distribution of property and flavor: to be slightly cold, sweet, attaches to the lung and stomach meridians; Effect: nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.
Fructus Crataegi: meridian distribution of property and flavor: tepor, acid, sweet, returns spleen, stomach, Liver Channel; Effect: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.
Rhizoma Coptidis: meridian distribution of property and flavor: cold, bitter, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel; Effect: heat clearing and damp drying, eliminating fire and detoxication.
Flos Lonicerae: meridian distribution of property and flavor: cold, sweet, returns lung, the heart, stomach warp; Effect: heat-clearing and toxic substances removing, wind-heat dissipating.
Radix Paeoniae Rubra: meridian distribution of property and flavor: to be slightly cold, bitter, returns Liver Channel; Effect: clearing away heat and cooling blood, eliminating stasis to stop pain.
The Radix Paeoniae Alba: meridian distribution of property and flavor: to be slightly cold, bitter, sour, returns liver, spleen channel; Effect: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.
Ramulus Cinnamomi: meridian distribution of property and flavor: acrid, sweet, warm, GUIXIN, lung, urinary bladder channel; Diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, dispersing cold for relieving pain.
Radix Salviae Miltiorrhizae: meridian distribution of property and flavor: bitter, be slightly cold, GUIXIN, Liver Channel; Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind.
Radix Glycyrrhizae Preparata: meridian distribution of property and flavor: sweet, flat, GUIXIN, lung, spleen, stomach warp; Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery.
Folium Isatidis: meridian distribution of property and flavor: cold, bitter, GUIXIN, stomach warp; Effect: thermal detoxification, blood cooling and ecchymoses removing.
Fructus Ligustri Lucidi: meridian distribution of property and flavor: cool, sweet, bitter, returns liver, kidney channel; Effect: nourishing the liver and kidney, improving eyesight black hair.
Radix Curcumae: meridian distribution of property and flavor: cold, pungent, bitter, returns liver, the heart, lung meridian; Effect: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.
The beneficial effect that the present invention is compared with prior art had is: the present invention is that choose each crude drug and proportioning thereof, reach supplementing QI and nourishing YIN, clear away heart-fire and surely throb with fear, blood circulation and channel invigorating, nourish heart the effect of allaying excitement under Traditional Chinese medical theory and clinical experience instruct; The present invention has good effect, instant effect, has no side effect, and preparation technology is advanced, better stability of preparation, drug availability advantages of higher; Through clinical verification, it is 94% that the present invention treats viral myocarditis effective percentage.
Detailed description of the invention
Embodiment 1: oral liquid preparation of the present invention
Treat a Chinese medicine composition for viral myocarditis, be made up of the crude drug of following weight portion: the Radix Astragali 10 parts, Radix Codonopsis 6 parts, Fructus Schisandrae Chinensis 6 parts, Radix Ophiopogonis 6 parts, Fructus Citri Sarcodactylis 10 parts, Radix Bupleuri 10 parts, Rhizoma Polygonati Odorati 6 parts, Fructus Crataegi 5 parts, Rhizoma Coptidis 2 parts, Flos Lonicerae 6 parts, Radix Paeoniae Rubra 8 parts, the Radix Paeoniae Alba 8 parts, Ramulus Cinnamomi 4 parts, Radix Salviae Miltiorrhizae 10 parts, Radix Glycyrrhizae Preparata 10-part, Folium Isatidis 10 parts, Fructus Ligustri Lucidi 10 parts, Radix Curcumae 6 parts.
The preparation method of the Chinese medicine composition of described treatment viral myocarditis, comprises the following steps:
(1) according to described parts by weight weighting raw materials: the Radix Astragali 10 parts, Radix Codonopsis 6 parts, Fructus Schisandrae Chinensis 6 parts, Radix Ophiopogonis 6 parts, Fructus Citri Sarcodactylis 10 parts, Radix Bupleuri 10 parts, Rhizoma Polygonati Odorati 6 parts, Fructus Crataegi 5 parts, Rhizoma Coptidis 2 parts, Flos Lonicerae 6 parts, Radix Paeoniae Rubra 8 parts, the Radix Paeoniae Alba 8 parts, Ramulus Cinnamomi 4 parts, Radix Salviae Miltiorrhizae 10 parts, Radix Glycyrrhizae Preparata 10-part, Folium Isatidis 10 parts, Fructus Ligustri Lucidi 10 parts, Radix Curcumae 6 parts are for subsequent use;
(2) add total raw material medicine 12 times amount water soaking 1.5 hours, heating decoction 2 hours, filter, medicinal residues add 8 times of water gagings again, and heating decoction 1.5 hours, filters, and filtrate merges, and obtains supernatant;
(3) when supernatant concentration to relative density is 1.1, enter spray dryer, inlet temperature controls 160 DEG C, leaving air temp 100 DEG C, and charging rate is 1L/ minute, obtains spray drying powder;
(4) dry powder pure water is diluted 100 times, if need to add flavoring agent and/or antiseptic, and adjust total amount, embedding, sterilizing, packaging, obtains oral liquid.
Embodiment 2: capsule preparation of the present invention
Treat a Chinese medicine composition for viral myocarditis, be made up of the crude drug of following weight portion: the Radix Astragali 12 parts, Radix Codonopsis 10 parts, Fructus Schisandrae Chinensis 8 parts, Radix Ophiopogonis 8 parts, Fructus Citri Sarcodactylis 12 parts, Radix Bupleuri 12 parts, Rhizoma Polygonati Odorati 10 parts, Fructus Crataegi 9 parts, Rhizoma Coptidis 3 parts, Flos Lonicerae 8 parts, Radix Paeoniae Rubra 10 parts, the Radix Paeoniae Alba 10 parts, Ramulus Cinnamomi 6 parts, Radix Salviae Miltiorrhizae 12 parts, Radix Glycyrrhizae Preparata 15 parts, Folium Isatidis 15 parts, Fructus Ligustri Lucidi 12 parts, Radix Curcumae 9 parts.
The preparation method of the Chinese medicine composition of described treatment viral myocarditis, comprises the following steps:
(1) according to described parts by weight weighting raw materials: the Radix Astragali 12 parts, Radix Codonopsis 10 parts, Fructus Schisandrae Chinensis 8 parts, Radix Ophiopogonis 8 parts, Fructus Citri Sarcodactylis 12 parts, Radix Bupleuri 12 parts, Rhizoma Polygonati Odorati 10 parts, Fructus Crataegi 9 parts, Rhizoma Coptidis 3 parts, Flos Lonicerae 8 parts, Radix Paeoniae Rubra 10 parts, the Radix Paeoniae Alba 10 parts, Ramulus Cinnamomi 6 parts, Radix Salviae Miltiorrhizae 12 parts, Radix Glycyrrhizae Preparata 15 parts, Folium Isatidis 15 parts, Fructus Ligustri Lucidi 12 parts, Radix Curcumae 9 parts are for subsequent use;
(2) add total raw material medicine 10 times amount water soaking 1 hour, heating decoction 3 hours, filter, medicinal residues add 6 times of water gagings again, and heating decoction 1 hour, filters, and filtrate merges, and obtains supernatant;
(3) when supernatant concentration to relative density is 1.2, enter spray dryer, inlet temperature controls 150 DEG C, leaving air temp 900 DEG C, and charging rate is 1L/ minute, obtains spray drying powder;
(4) by No. 0 capsule fill of dry powder, sterilizing, packaging, obtains capsule.
Embodiment 3: pill preparation of the present invention
Treat a Chinese medicine composition for viral myocarditis, be made up of the crude drug of following weight portion: the Radix Astragali 15 parts, Radix Codonopsis 15 parts, Fructus Schisandrae Chinensis 10 parts, Radix Ophiopogonis 10 parts, Fructus Citri Sarcodactylis 15 parts, Radix Bupleuri 15 parts, Rhizoma Polygonati Odorati 15 parts, Fructus Crataegi 13 parts, Rhizoma Coptidis 5 parts, Flos Lonicerae 10 parts, Radix Paeoniae Rubra 12 parts, the Radix Paeoniae Alba 12 parts, Ramulus Cinnamomi 8 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Glycyrrhizae Preparata 20 parts, Folium Isatidis 20 parts, Fructus Ligustri Lucidi 15 parts, Radix Curcumae 12 parts.
The preparation method of the Chinese medicine composition of described treatment viral myocarditis, comprises the following steps:
(1) according to described parts by weight weighting raw materials: the Radix Astragali 15 parts, Radix Codonopsis 15 parts, Fructus Schisandrae Chinensis 10 parts, Radix Ophiopogonis 10 parts, Fructus Citri Sarcodactylis 15 parts, Radix Bupleuri 15 parts, Rhizoma Polygonati Odorati 15 parts, Fructus Crataegi 13 parts, Rhizoma Coptidis 5 parts, Flos Lonicerae 10 parts, Radix Paeoniae Rubra 12 parts, the Radix Paeoniae Alba 12 parts, Ramulus Cinnamomi 8 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Glycyrrhizae Preparata 20 parts, Folium Isatidis 20 parts, Fructus Ligustri Lucidi 15 parts, Radix Curcumae 12 parts are for subsequent use;
(2) add total raw material medicine 11 times amount water soaking 1.2 hours, heating decoction 1.5 hours, filter, medicinal residues add 7 times of water gagings again, and heating decoction 1 hour, filters, and filtrate merges, and obtains supernatant;
(3) when supernatant concentration to relative density is 1.18, enter spray dryer, inlet temperature controls 170 DEG C, leaving air temp 95 DEG C, and charging rate is 1L/ minute, obtains spray drying powder;
(4) dry powder made watered pill by the conventional method of medicine or make honeyed pill, sterilizing, packaging, obtains pill.
Experimental example:
One, clinical data: adopt the present invention to treat 98 routine Patients with Viral Myocarditis altogether, wherein man 63 example, female 35 example, the oldest 60 years old, minimum 4 years old of age.
Two, clinical symptoms: heating, systemic pain, pharyngalgia, asthenia, nausea,vomiting,diarrhea, cardiopalmus, uncomfortable in chest, chest pain or pareordia dull pain, dizziness, dyspnea, edema, heart failure etc.
Three, Therapeutic Method: patient takes night and morning every day 30 days is a course for the treatment of.
Four, the standard of curative effect evaluation:
Cure: transference cure, experimental check is normal;
Take a turn for the better: symptom is obviously improved, and lab testing is improved;
Do not heal: primary symptom is not improved or deterioration person.
Five, model case:
1, congratulate certain, man, 23 years old, within 2 months, cause was had cold water bath and catches a cold, and continue then dizzy, cardiopalmus, is diagnosed as viral myocarditis, and hospitalization takes a turn for the better and leaves hospital, and now still felt dizzy, time and have palpitation, weak, low grade fever; After taking 2 courses for the treatment of of Chinese medicine composition of the present invention, symptom is obviously improved, and takes 4 recoveries from illness courses for the treatment of; Follow up a case by regular visits to 1 year, do not recur.
2, Liu, female, 32 years old, chest distress and palpitation symptoms, insomnia, more than dysphoria with feverish sensation in the chest palms and soles March, be diagnosed as viral myocarditis, hospitalization, leave hospital after improvement, after first quarter moon, all diseases are sent out again; After taking 1 course for the treatment of of Chinese medicine composition of the present invention, symptom is obviously improved, and takes 2 recoveries from illness courses for the treatment of; Follow up a case by regular visits to 2 years, do not recur.
3, Zhang, man, 19 years old, after fatigue, occur cardiac insufficiency, cardiac arrhythmia, there is upper respiratory tract infection in 2 weeks in premorbid, occurs grade fever symptom, continue there is cardiopalmus, the rhythm of the heart speeds, chest pain; After taking 1 course for the treatment of of Chinese medicine composition of the present invention, symptom is obviously improved, and takes 4 recoveries from illness courses for the treatment of; Follow up a case by regular visits to 1 year, do not recur.
Six, therapeutic outcome:
It is routine that employing the present invention treats Patients with Viral Myocarditis 98 altogether, and through the treatment of 1-6 the course for the treatment of, wherein cure 87 examples, improvement 5 is routine, and do not heal 6 examples, and effective percentage is 94%; Result shows, the present invention has good effect, instant effect to treatment viral myocarditis, has no side effect, and preparation technology is advanced, better stability of preparation, drug availability advantages of higher.