CN102614405B - Traditional Chinese medicine decoction for curing limb pain caused by diabetic neuropathy - Google Patents
Traditional Chinese medicine decoction for curing limb pain caused by diabetic neuropathy Download PDFInfo
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- CN102614405B CN102614405B CN201210108983.1A CN201210108983A CN102614405B CN 102614405 B CN102614405 B CN 102614405B CN 201210108983 A CN201210108983 A CN 201210108983A CN 102614405 B CN102614405 B CN 102614405B
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Abstract
The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine decoction for curing limb pain caused by diabetic neuropathy, which is composed of corn stigma, Coptis chinensis, root of rehmannia, Radix Ophiopogonis, radix scrophulariae, Angelica sinensis, the root of red-rooted salvia, root of common peony, Ligusticum wallichii, leonurus, peach kernel paste, Astragalus mongholicus, rhizoma atractylodis, Asarum sieboldi Mig, Poria cocos, rhizoma alismatis, red flower, Caulis Spatholobi, corydalis tuber, Schisandra chinensis, liquorice and spina date seed. The traditional Chinese medicine decoction for curing limb pain caused by diabetic neuropathy is low in cost, high in curing rate and free of toxic and side effects and has the function of nourishing yin and engendering liquid, promoting blood circulation and removing stasis and dredging collateral and removing pain. The total effective rate is 95%, the remission rate is 80%, the improvement rate is 15% and the failure rate is 5%.
Description
Technical field:
The present invention relates to the field of Chinese medicines, is a kind of Chinese medicine decoction for the treatment of the limbs pain of diabetic neuropathy specifically.
Background technology:
Caused by diabetic neuropathy strengthens primarily of microangiopathies and sorbitol bypass metabolism so that sorbitol increases and wait, its diseased region is the most common with peripheral nerve, is generally symmetry, lower limb comparatively upper limb seriously, disease progression is slow.First there is acroparesthesia clinically, sometimes accompany hyperpathia.Have acroesthesia subsequently, in dull pain, twinge or burn sample pain, night and cold season increase the weight of.The cause of disease of primary disease is relevant with influencing each other of the many factors such as genetic predisposition, hyperglycemia, oxidative stress, nonenzymatic glycosylation and polyhydric alcohol metabolic bypass, Protein kinase C.In treatment mainly application controls blood glucose, improve microcirculation, trophic nerve and pain management, but to cure the symptoms, not the disease, and therapeutic effect is poor, brings painful and spirit greatly, burden economically to patient.For this reason, we use theory of Chinese medical science, and gather 22 taste Chinese herbal medicine and decoct soup, the treatment for the limbs pain of diabetic neuropathy creates a kind of new method.
Summary of the invention:
The present invention, for overcoming the deficiencies in the prior art, provides that a kind of cost is low, curative effect is high, has no side effect, have YIN nourishing and the production of body fluid promoting, blood circulation promoting and blood stasis dispelling, the Chinese medicine decoction of the limbs pain of the treatment diabetic neuropathy of the function of activating meridians to stop pain.
A kind of Chinese medicine decoction for the treatment of the limbs pain of diabetic neuropathy, it is characterized in that being made up of the component of the material medicine of following weight proportion: Stigma Maydis 10-13%, Rhizoma Coptidis 2-3%, Radix Rehmanniae 7-8%, Radix Ophiopogonis 7-8%, Radix Scrophulariae 5-6%, Radix Angelicae Sinensis 5-6%, Radix Salviae Miltiorrhizae 8-9%, Radix Paeoniae Rubra 2-3%, Rhizoma Chuanxiong 2-3%, Herba Leonuri 8-9%, Semen Persicae mud 2-3%, Radix Astragali 6-7%, Rhizoma Atractylodis 3-4%, Herba Asari 1-2%, Poria 4-5%, Rhizoma Alismatis 3-4%, Flos Carthami 1-2%, Caulis Spatholobi 6-7%, Rhizoma Corydalis 3-4%, Fructus Schisandrae Chinensis 1-2%, Radix Glycyrrhizae 1-2%, Semen Ziziphi Spinosae 3-4%.
Pharmacology analysis: Stigma Maydis is sweet in the mouth, flat.Return liver, kidney, urinary bladder channel.Promoting diuresis to eliminate damp pathogen, suppressing the hyperactive liver function of gallbladder promoting, promoting the production of body fluid to quench thirst.Stop gathering for water is wet, damp-heat in the urinary bladder, is suitable for thirsty polydipsia more than, consumption of YIN caused by febrile disease.Rhizoma Coptidis, bitter in the mouth, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, heat-clearing and toxic substances removing, clearing away heat-fire.There is the effect of antioxidation, scavenging free radicals.The Radix Rehmanniae, sweet in the mouth, cold.GUIXIN, liver, kidney channel.Clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.Enter high fever caused by nutrient blood, excessive thirst with controlling heat, the caused heating of consumption of body fluid caused by febrile disease and yin asthenia generating intrinsic heat is thirsty.Radix Ophiopogonis, sweet in the mouth, micro-hardship, to be slightly cold.GUIXIN, lung, stomach warp.Nourishing YIN and moistening the lung, reinforcing stomach reg fluid, clear away heart-fire relieving restlessness.With controlling, interior-heat is quenched one's thirst, the few Tianjin of dry tongue, has the effect of anti-hypoxia, blood sugar lowering and anti peroxidation of lipid.Radix Scrophulariae, sweet in the mouth, hardship, salty, cold.Return lung, stomach, kidney channel.Clearing away heat and cooling blood, heat-clearing and toxic substances removing, clearing away heat and nourishing YIN.Enter nutrient blood for heat, consumption of YIN caused by febrile disease, excessive thirst is just dry.Radix Angelicae Sinensis, sweet in the mouth, pungent, warm.Return liver, the heart, spleen channel.Promoting blood circulation and stopping pain.There is antiinflammatory, analgesic effect.Radix Salviae Miltiorrhizae, bitter in the mouth, is slightly cold.GUIXIN, Liver Channel.Promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing, removing heat from blood is subsided a swelling, and clear away heart-fire relieving restlessness.Be improved circulation, the effect of antiplatelet aggregation and adhesion.Radix Paeoniae Rubra, bitter in the mouth, is slightly cold.Return Liver Channel.Clearing away heat and cooling blood, eliminating stasis to stop pain.Cure mainly heat and enter nutrient blood, hypochondriac pain due to stagnation of liverQI, obstruction of collaterals by blood stasis.Rhizoma Chuanxiong, acrid in the mouth, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.For pain card various caused by stagnation of blood stasis, control the joint caused cold type of pain of anemofrigid-damp arthralgia.Herba Leonuri, bitter in the mouth, pungent, be slightly cold.Return liver, the heart, kidney channel.Blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema, heat-clearing and toxic substances removing.Semen Persicae mud is bitter in the mouth, sweet, flat.GUIXIN, liver, large intestine channel.Blood circulation promoting and blood stasis dispelling.Pain caused for stagnation of blood stasis, there is the effect reducing peripheral vascular resistance.The Radix Astragali, sweet in the mouth, tepor.Return lung, spleen channel.Tonifying Qi and lifting yang, supplementing QI to induce diuresis, nourishing qi to stop, benefiting QI for activating blood circulation.With controlling, numbness of the skin caused by blood stasis due to qi deficiency is meciless.Rhizoma Atractylodis, taste acrid, bitter, warm.Return spleen, stomach, Liver Channel.Drying damp and strengthening spleen, expelling wind and removing dampness, expelling cold and relieving exterior syndrome.With controlling arthralgia that wind-cold damp pathogen causes, limbs are tired heavy, and decoct can make blood glucose reduce.Herba Asari, acrid in the mouth, temperature.GUIXIN, lung, kidney channel.Expelling cold and relieving exterior syndrome, wind-expelling pain-stopping.For extremities joint pain caused by anemofrigid-damp arthralgia, there is obvious analgesic activity.Poria is sweet in the mouth, light, flat.GUIXIN, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, invigorating middle warmer spleen invigorating, mind tranquilizing and the heart calming.There is sedation.Rhizoma Alismatis, sweet in the mouth, cold.Return kidney, urinary bladder channel.Clearing away heat-damp and promoting diuresis, eliminating dampness by diuresis antidiarrheal.There is the effect of antiinflammatory, blood fat reducing.Flos Carthami, acrid in the mouth, temperature.GUIXIN, Liver Channel.Blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain.There is anticoagulant, analgesia, calmness and expand peripheral vascular effect.Caulis Spatholobi, bitter in the mouth, sweet, warm.Return liver, kidney channel.Invigorate blood circulation, channels sootheing and network vessel quickening, nourishes blood and enriches blood.Cure mainly rheumatic arthralgia, blood failing to nourish tendons.Rhizoma Corydalis, taste acrid, bitter, warm.Return liver, spleen channel.Promoting blood circulation to remove obstruction in the collateral, promoting the circulation of QI to relieve pain.Cure mainly qi depression to blood stasis, stagnation of QI due to depression of the liver, all kinds of pain card.Fructus Schisandrae Chinensis, sour in the mouth, sweet, warm.Return lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, promoting the production of body fluid to quench thirst, mind tranquilizing and the heart calming.With controlling yin asthenia generating intrinsic heat, polydipsia of quenching one's thirst.Radix Glycyrrhizae, sweet in the mouth, flat.GUIXIN, lung, spleen, stomach warp.QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Lose foster caused contraction by treating disorders in tendons and vessels suddenly to have a pain, alleviate or relax bias and the toxicity of medicine.Semen Ziziphi Spinosae is sweet in the mouth, acid, flat.GUIXIN, liver, gallbladder meridian.Tranquilizing by nourishing the heart, arresting sweating promotes the production of body fluid.There are obvious analgesia, sedation.The ingenious prescription of 22 taste Chinese medicine, nourishes blood and enriches blood, YIN nourishing and the production of body fluid promoting.Reach the effect of mutual reinforcement between, the mutual-assistance, mutual restraint between two drugs between medicine, curative effect of medication is strengthened, improve principal agent effect, and make its toxic and side effects alleviate or disappear.To reach blood circulation promoting and blood stasis dispelling, activating meridians to stop pain, the specially good effect of the limbs pain for the treatment of diabetic neuropathy.
Dosage form and usage: get above-mentioned side's medicine 350g, at room temperature 22 kinds of Chinese herbal medicine are added water to 900-1000ml, soak 4 hours, intense fire boils and can change slow fire and decoct to about 100-120 minute, remove slag to obtain filtrate 200ml, and medicinal residues add water 300-400ml again, decoct 30-40 minute, remove slag to obtain filtrate 100ml, decocts medicine soup 300ml for twice altogether.Every day, potion was oral at twice, each (medicine) being taken before meal 150ml, once a day, seven days courses for the treatment of, take to clinical symptom disappearance, then consolidate curative effect took a course for the treatment of, generally with five courses for the treatment of.
Clinical efficacy is summed up:
(1) physical data: admitted patient 36 example altogether, wherein male 20 example, women 16 example; The oldest 73 years old, minimum 24 years old, 45 years old mean age; The most elder of the course of disease 60 days, the shortest person 15 days, average 28 days.
(2) diagnostic criteria: have clear and definite diabetes medical history, when diagnosing diabetes or occur that extremity or two lower limb have rest pain and (or) sensory disturbance afterwards.Have in 5 below more than 2 or 2 abnormal: 1. thermo aesthesia is abnormal; 2. nylon yarn inspection, foot is felt to go down or disappear; 3. vibration sense is abnormal; 4. the Achilles jerk disappears; 5. nerve conduction velocity has more than 2 or 2 to slow down.Except the disease such as cervical and lumbar diseases, cerebral infarction, Guillain Barre.
(3) efficacy assessment standard.
Alleviate: conscious clinical symptom disappearance, nerve conduction velocity or foot sensation are improved.
Take a turn for the better: subjective symptoms alleviates.
Do not heal: after taking medicine, the state of an illness is unchanged.
Therapeutic effect.
Taking medicine 7 days is a course for the treatment of, and the lighter 2-3 is alleviated the course for the treatment of, and severe one 4-5 takes a turn for the better the course for the treatment of.Total effective rate 95%, remission rate 80%, improvement rate 15%, invalid 5%.
Detailed description of the invention:
Below in conjunction with embodiment, the present invention is further described:
Embodiment 1: a kind of Chinese medicine decoction for the treatment of the limbs pain of diabetic neuropathy, it is made up of the component of the material medicine of following weight (%) proportioning: Stigma Maydis 10.7, Rhizoma Coptidis 2.6, the Radix Rehmanniae 7.1, Radix Ophiopogonis 7.6, Radix Scrophulariae 5.1, Radix Angelicae Sinensis 5.6, Radix Salviae Miltiorrhizae 8.7, Radix Paeoniae Rubra 2.3, Rhizoma Chuanxiong 2.8, Herba Leonuri 8.4, Semen Persicae mud 2.5, the Radix Astragali 6.2, Rhizoma Atractylodis 3.4, Herba Asari 1.1, Poria 4.8, Rhizoma Alismatis 3.7, Flos Carthami 1.3, Caulis Spatholobi 6.6, Rhizoma Corydalis 3.4, Fructus Schisandrae Chinensis 1.3, Radix Glycyrrhizae 1.1, Semen Ziziphi Spinosae 3.7.
Embodiment 2: a kind of Chinese medicine decoction for the treatment of the limbs pain of diabetic neuropathy, it is made up of the component of the material medicine of following weight (%) proportioning: Stigma Maydis 12.7, Rhizoma Coptidis 2.1, the Radix Rehmanniae 7.6, Radix Ophiopogonis 7.2, Radix Scrophulariae 5.4, Radix Angelicae Sinensis 5.1, Radix Salviae Miltiorrhizae 8.4, Radix Paeoniae Rubra 2.5, Rhizoma Chuanxiong 2.3, Herba Leonuri 8.1, Semen Persicae mud 2.7, the Radix Astragali 6.4, Rhizoma Atractylodis 3.1, Herba Asari 1.5, Poria 4.2, Rhizoma Alismatis 3.1, Flos Carthami 1.6, Caulis Spatholobi 6.2, Rhizoma Corydalis 3.5, Fructus Schisandrae Chinensis 1.4, Radix Glycyrrhizae 1.5, Semen Ziziphi Spinosae 3.4.
The Chinese medicine decoction that this kind treats the limbs pain of diabetic neuropathy is different because of patient, only adjust the addition of Stigma Maydis, Rhizoma Coptidis, the Radix Rehmanniae, Radix Ophiopogonis, Radix Scrophulariae, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Herba Leonuri, Semen Persicae mud, the Radix Astragali, Rhizoma Atractylodis, Herba Asari, Poria, Rhizoma Alismatis, Flos Carthami, Caulis Spatholobi, Rhizoma Corydalis, Fructus Schisandrae Chinensis, Radix Glycyrrhizae, Semen Ziziphi Spinosae, other operational approach and embodiment one or embodiment two substantially identical, its content is as shown in the table, and unit of weight is gram.
Medicine soup embodiment (% by weight)
| Embodiment | Example 13 | Example 14 | Example 18 |
| Stigma Maydis | 10.7 | 11.1 | 11.1 |
| Rhizoma Coptidis | 2.7 | 2.3 | 2.4 |
| The Radix Rehmanniae | 7.2 | 7.8 | 7.3 |
| Radix Ophiopogonis | 7.1 | 7.5 | 7.8 |
| Radix Scrophulariae | 5.2 | 5.8 | 5.5 |
| Radix Angelicae Sinensis | 5.3 | 5.5 | 5.2 |
| Radix Salviae Miltiorrhizae | 8.2 | 8.3 | 8.6 |
| Radix Paeoniae Rubra | 2.4 | 2.7 | 2.1 |
| Rhizoma Chuanxiong | 2.5 | 2.7 | 2.4 |
| Herba Leonuri | 8.6 | 8.2 | 8.5 |
| Semen Persicae mud | 2.3 | 2.1 | 2.2 |
| The Radix Astragali | 6.6 | 6.3 | 6.7 |
| Rhizoma Atractylodis | 3.7 | 3.5 | 3.2 |
| Herba Asari | 1.6 | 1.2 | 1.4 |
| Poria | 4.3 | 4.6 | 4.4 |
| Rhizoma Alismatis | 3.5 | 3.2 | 3.4 |
| Flos Carthami | 1.7 | 1.2 | 1.8 |
| Caulis Spatholobi | 6.3 | 6.8 | 6.4 |
| Rhizoma Corydalis | 3.7 | 3.2 | 3.1 |
| Fructus Schisandrae Chinensis | 1.2 | 1.6 | 1.5 |
| Radix Glycyrrhizae | 1.7 | 1.2 | 1.4 |
| Semen Ziziphi Spinosae | 3.5 | 3.2 | 3.6 |
| Amount to | 100 | 100 | 100 |
Model case:
Case 1: Zhang, female, 48 years old, peasant, in October, 2007 went to a doctor.Before being set forth in 30 days, occurring extremity persistence burning pain, attaching most importance to two lower limb, companion is numb, and light night in daytime is heavy.Non-diagnosis and treatment.Toward there being " type 2 diabetes mellitus " medical history 10 years.Have a medical check-up: biped cutaneous pain goes down, thermohypesthesia, white and greasy fur, deep-thready pulse.According to its symptom and sign, dialectical is Cold-dampness, gives blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain.Took for three courses for the treatment of with our medicine, symptom obviously alleviates, following the service one course for the treatment of, and all diseases disappear and alleviate.
Case 2: grandson, man, 60 years old, retired worker, in August, 2007 went to a doctor.There is two lower limb stabbing pain, numbness before February in readme, night is heavy, cannot fall asleep.Nearby clinic is bought by oneself " vitamin B1 ", " mecobalamin " etc., poor effect after clothes, therefore it is medical to come the court.Have a medical check-up: biped cutaneous pain goes down, white and greasy fur, deep-thready pulse.Examine as Cold-dampness, give our medicine and took for four courses for the treatment of, symptom is slightly improved, following the service one course for the treatment of, all remissions.
Claims (1)
1. treat the Chinese medicine decoction of the limbs pain of diabetic neuropathy for one kind, it is characterized in that being made up of the component of the material medicine of following weight proportion: Stigma Maydis 10-13%, Rhizoma Coptidis 2-3%, Radix Rehmanniae 7-8%, Radix Ophiopogonis 7-8%, Radix Scrophulariae 5-6%, Radix Angelicae Sinensis 5-6%, Radix Salviae Miltiorrhizae 8-9%, Radix Paeoniae Rubra 2-3%, Rhizoma Chuanxiong 2-3%, Herba Leonuri 8-9%, Semen Persicae mud 2-3%, Radix Astragali 6-7%, Rhizoma Atractylodis 3-4%, Herba Asari 1-2%, Poria 4-5%, Rhizoma Alismatis 3-4%, Flos Carthami 1-2%, Caulis Spatholobi 6-7%, Rhizoma Corydalis 3-4%, Fructus Schisandrae Chinensis 1-2%, Radix Glycyrrhizae 1-2%, Semen Ziziphi Spinosae 3-4%.
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| CN201210108983.1A CN102614405B (en) | 2012-04-06 | 2012-04-06 | Traditional Chinese medicine decoction for curing limb pain caused by diabetic neuropathy |
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| CN102614405B true CN102614405B (en) | 2015-03-11 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103463364B (en) * | 2013-09-03 | 2015-03-25 | 薛红云 | Medicine for treating diabetic neuropathy |
| CN103446307B (en) * | 2013-09-13 | 2015-09-02 | 北京师范大学 | A kind of Chinese medicine composition for the treatment of diabetic foot |
| CN104324355A (en) * | 2014-11-26 | 2015-02-04 | 杨其义 | Traditional Chinese medicine composition for treating peripheral neuropathy caused by diabetes |
| CN105796755A (en) * | 2015-10-10 | 2016-07-27 | 烟台市蓝洋之草医药生物科技有限公司 | Traditional Chinese medicinal composition for treating diabetic nephropathy |
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| CN1090193A (en) * | 1993-05-03 | 1994-08-03 | 孙志远 | The medicine and the production method of treatment diabetes |
| CN1111522A (en) * | 1995-01-10 | 1995-11-15 | 李仲岭 | Compound islets Langerhans regenerated capsule |
| CN1311017A (en) * | 2001-02-26 | 2001-09-05 | 吕玉娥 | Medicine for curing diabetes |
| CN1686529A (en) * | 2005-05-20 | 2005-10-26 | 李素梅 | Ready prepared Chinese medicine for treating diabetes |
| CN101816770A (en) * | 2010-06-02 | 2010-09-01 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating diabetes and preparation method thereof |
| CN102293895A (en) * | 2011-08-17 | 2011-12-28 | 张子桂 | Traditional Chinese medicine composition for treating type II diabetes |
| CN102343023A (en) * | 2011-10-18 | 2012-02-08 | 泽中卡 | Medicinal composition and preparation method and application thereof |
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2012
- 2012-04-06 CN CN201210108983.1A patent/CN102614405B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1090193A (en) * | 1993-05-03 | 1994-08-03 | 孙志远 | The medicine and the production method of treatment diabetes |
| CN1111522A (en) * | 1995-01-10 | 1995-11-15 | 李仲岭 | Compound islets Langerhans regenerated capsule |
| CN1311017A (en) * | 2001-02-26 | 2001-09-05 | 吕玉娥 | Medicine for curing diabetes |
| CN1686529A (en) * | 2005-05-20 | 2005-10-26 | 李素梅 | Ready prepared Chinese medicine for treating diabetes |
| CN101816770A (en) * | 2010-06-02 | 2010-09-01 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating diabetes and preparation method thereof |
| CN102293895A (en) * | 2011-08-17 | 2011-12-28 | 张子桂 | Traditional Chinese medicine composition for treating type II diabetes |
| CN102343023A (en) * | 2011-10-18 | 2012-02-08 | 泽中卡 | Medicinal composition and preparation method and application thereof |
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