CN103119057B - 基于酰胺的胰岛素前药 - Google Patents

基于酰胺的胰岛素前药 Download PDF

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Publication number
CN103119057B
CN103119057B CN201180040875.9A CN201180040875A CN103119057B CN 103119057 B CN103119057 B CN 103119057B CN 201180040875 A CN201180040875 A CN 201180040875A CN 103119057 B CN103119057 B CN 103119057B
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China
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alkyl
chain
prodrug
insulin
amino acid
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Expired - Fee Related
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Chinese (zh)
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CN103119057A (zh
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R.D.迪马基
寇宾宾
程抒江
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Indiana University Research and Technology Corp
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Indiana University Research and Technology Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201180040875.9A 2010-06-24 2011-06-23 基于酰胺的胰岛素前药 Expired - Fee Related CN103119057B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35819210P 2010-06-24 2010-06-24
US61/358192 2010-06-24
US61/358,192 2010-06-24
PCT/US2011/041603 WO2011163462A2 (en) 2010-06-24 2011-06-23 Amide-based insulin prodrugs

Publications (2)

Publication Number Publication Date
CN103119057A CN103119057A (zh) 2013-05-22
CN103119057B true CN103119057B (zh) 2016-06-15

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CN201180040875.9A Expired - Fee Related CN103119057B (zh) 2010-06-24 2011-06-23 基于酰胺的胰岛素前药

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US (1) US8946147B2 (enExample)
EP (1) EP2585102B1 (enExample)
JP (1) JP5912112B2 (enExample)
CN (1) CN103119057B (enExample)
AU (1) AU2011270832B2 (enExample)
CA (1) CA2803164C (enExample)
WO (1) WO2011163462A2 (enExample)

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AU2011268327B2 (en) 2010-06-16 2016-02-25 Indiana University Research And Technology Corporation Single chain insulin agonists exhibiting high activity at the insulin receptor
EP2585102B1 (en) 2010-06-24 2015-05-06 Indiana University Research and Technology Corporation Amide-based insulin prodrugs
WO2013096386A1 (en) 2011-12-20 2013-06-27 Indiana University Research And Technology Corporation Ctp-based insulin analogs for treatment of diabetes
WO2014052451A2 (en) 2012-09-26 2014-04-03 Indiana University Research And Technology Corporation Insulin analog dimers
US20160024169A1 (en) 2013-03-14 2016-01-28 Indiana University Research And Technology Corporation Insulin-incretin conjugates
CN108271356A (zh) 2014-09-24 2018-07-10 印第安纳大学研究及科技有限公司 肠降血糖素-胰岛素缀合物
JP6701208B2 (ja) * 2014-09-24 2020-05-27 インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション 脂質化アミド系インスリンプロドラッグ
CA3093383A1 (en) 2014-10-24 2016-04-28 Merck Sharp & Dohme Corp. Co-agonists of the glucagon and glp-1 receptors
WO2019034726A1 (en) 2017-08-17 2019-02-21 Novo Nordisk A/S NOVEL ACYLATED INSULIN ANALOGUES AND USES THEREOF
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WO2020176637A1 (en) 2019-02-26 2020-09-03 Pantheryx, Inc. Compositions for management of disorders of the gastrointestinal tract

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2009099763A1 (en) * 2008-01-30 2009-08-13 Indiana University Research And Technology Corporation Ester-based peptide prodrugs

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EP2585102B1 (en) 2015-05-06
CA2803164C (en) 2018-08-21
CA2803164A1 (en) 2011-12-29
AU2011270832A1 (en) 2013-01-10
EP2585102A4 (en) 2013-12-18
WO2011163462A3 (en) 2012-04-05
EP2585102A2 (en) 2013-05-01
US8946147B2 (en) 2015-02-03
AU2011270832B2 (en) 2016-05-12
CN103119057A (zh) 2013-05-22
WO2011163462A2 (en) 2011-12-29
JP5912112B2 (ja) 2016-04-27
JP2013531660A (ja) 2013-08-08
US20130123171A1 (en) 2013-05-16

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