CN103110795A - Soft capsule for improving memory and preparation method thereof - Google Patents

Abstract

The invention mainly relates to a soft capsule for improving memory, which is characterized by comprising the following raw materials in parts by weight: 360-507 of linseed oil, 10-20 of astragalus mongholicus extract, 10-30 of prepared rehmannia root extract, 10-30 of rhizoma anemarrhenae extract, 10-20 of spina date seed extract, 10-20 of centella extract, 0.5-1 of folic acid, 1-3 of tea polyphenol, 10-20 of taurine, and 10-20 of cephalin. According to the invention, by taking traditional Chinese medicine theory as guide and modern research results of traditional Chinese medicines as support, the soft capsule is careful in material selection, rigorous in composition and reasonable in compatibility of medicines; furthermore, natural components for strengthening memory are added, so that the composition follows the functions of tonifying Qi, nourishing blood, calming nerves, promoting sleep, clearing heat, promoting diuresis, supplying brain nutrition and improving body functions on the whole, therefore, qi-blood operation is smooth, bodies are strong, sleep is sufficient, human bodies are in cool-thermal balance, nutrition is enough, and metabolism of cerebral cortical cells is increased; in the composition, astragalus mongholicus and prepared rehmannia root are matched to tonify qi and enrich blood; rhizoma anemarrhenae, centella and prepared rehmannia root are matched to nourish yin, promote the secretion of saliva or body fluid, clear heat and promote dieresis; spina date seed, rhizoma anemarrhenae and centella are matched to calm nerves and promote sleep; taurine, cephalin, folic acid and linseed oil (alpha-linolenic acid) are used for supplying and strengthening brain nutrition; tea polyphenol has strong oxidation resistance and physiological activity and is a good natural product for improving memory; and the composition has the effects of improving body condition and improving memory on the whole.

Description

Improve memory soft capsule and preparation method thereof

Technical field:

The present invention relates generally to and improves memory soft capsule and preparation method thereof.

Background technology:

At present, improve the formula of memory, existing relevant report.Conventional formulation is main mainly with single raw material, and some negative interactions can appear in informal dress, and easily specially partially, and this integral formulation is nursed one's health the bodily fuctions and strengthened brain nutrition, and negative interaction can not appear in cold and heat balance, equilibrium between yin and yang, informal dress; The conventional formulation soft capsule considers that content is the effect of solute and ignore the effect of solvent more, and this formula solvent is siritch, the alpha-linolenic acid that wherein contains 50-60%, produce in vivo DHA and the EPA of high-load after wherein alpha-linolenic acid is taken, DHA and EPA are chief component compositions in brain essence, being real " NAOHUANGJIN ", is most important brain nutrient substance; Effective component content wretched insufficiency in conventional formulation is taken rear effect limited, and the Chinese medicine extract content of respectively distinguishing the flavor of in this formula is sufficient, adds again other brain nutrient substance and siritch, and nutritional labeling is complete and sufficient, can bring into play greatly the effect of improving memory.

Modern biology research thinks, after people in middle age, in brain with remember relevant material-acetylcholine and can reduce gradually.This is because the ability of utilizing choline to make acetylcholine in brain descends increasingly, and due to dying down, the Chinese medicine modern study confirms that the Radix Astragali, Herba Centellae, Radix Rehmanniae Preparata, the Rhizoma Anemarrhenae, Semen Ziziphi Spinosae etc. can delay the disappearance speed of acetylcholine; Siritch mainly contains DHA and the EPA that alpha-linolenic acid produces in human body be very important brain nutrient substance; Taurine, cephalin, folic acid all have the effect that delays preferably acetylcholine disappearance speed.

Raw material that this formula adopts all belongs to natural material, and is without any side effects, and has the wide applications such as enhancing immunity, resisting fatigue, radioprotective, anti-hypoxia and adjusting gastrointestinal function concurrently, can indirectly improve the health allomeric function.During preparation, extract and siritch are mixed, make solute, solvent be effective ingredient, and form the single material effect that is beyond one's reach.

Summary of the invention:

The object of the invention is to avoid the deficiencies in the prior art part and a kind of improvement memory soft capsule and preparation method thereof, the problem that exists to solve prior art are provided.

Purpose of the present invention can be by realizing by the following technical solutions: a kind of improvement memory soft capsule, its main feature is the raw material that includes following weight portion: siritch 360-507 weight portion, Radix Astragali extract 10-20 weight portion, Radix Rehmanniae Preparata extract 10-30 weight portion, Rhizoma Anemarrhenae extract 10-30 weight portion, Semen Ziziphi Spinosae extract 10-20 weight portion.

Soft capsule is remembered in described improvement, also includes the raw material of following weight portion: Herba Centellae extract 10-20 weight portion, folic acid 0.5-1 weight portion, tea polyphenols 1-3 weight portion.

Soft capsule is remembered in described improvement, also includes the raw material of following weight portion: taurine 10-20 weight portion, cephalin 10-20 weight portion.

A kind of improvement memory soft capsule and preparation method thereof, its main feature is, comprises the steps:

(1) raw material preparation

The Radix Astragali, Radix Rehmanniae Preparata, the Rhizoma Anemarrhenae, Semen Ziziphi Spinosae, Herba Centellae are carried out respectively selected, rinsing twice is drenched and to be anhydrated minute; Be 60～80 ℃ of oven dry 1.5-2 hour in temperature, making its moisture is 5-6%, after coarse pulverization granularity be 5-50mm to add water be 8 times of material, boiled 1.5-2 hour, extract 2 times; Twice filtrate merged, concentrated, be 60-80 ℃ of oven dry 1.5-2 hour in temperature, make its moisture 5-6% of being divided into; Pulverize, sieve, granularity is 0.1-0.5mm, is the Chinese medicine extract fine powder.

Folic acid, tea polyphenols, taurine are pulverized respectively, and granularity is 0.1-0.5mm;

The selected slag of removing of flaxseed; Adopt pressafiner that selected flaxseed is squeezed; Again siritch is removed slag, add water and regulate pH value 5.5-6.5, at water temperature 55-65 ℃, fully stir, remove moisture after then precipitating two hours namely to get the refine siritch;

(2) with siritch, the extract such as the Radix Astragali, Radix Rehmanniae Preparata, the Rhizoma Anemarrhenae, Semen Ziziphi Spinosae, Herba Centellae and folic acid, tea polyphenols, taurine, cephalin mix homogeneously;

(3) press 0.6g/ grain dress soft capsule after mix homogeneously;

(4) sterilization bottling, vanning.

1, the invention has the beneficial effects as follows: the method screening raw material that our section of use emulates the advanced, rigorous prescription, the check of the various raw materials of process and chemical analysis thereof, function, the total analysis result of the present invention of cash is as follows:

(1) siritch:

1 〉. contain the unsaturated fatty acid useful to human body in siritch, and the ratio that forms is suitable, is not easy oxidation;

2 〉. especially be rich in and can enhance metabolism, improve the blood capillary circulation, bring the γ type vitamin e of skin cell nutrition, γ type vitamin is that excellent polyphenoils mass-energy prevents cell senescence effectively;

3 〉. the oleic acid composition that contains in siritch is also confirmed that the diseases such as the gastric ulcer of inhibition, asthma are arranged, prevents that skin quality from worsening, and improves the effect of immunity by medical science;

Alpha-linolenic acid in siritch again can blood fat reducing, anticoagulant, vessel softening, tonification brain, cancer, coronary heart disease, diabetes, carcinoma of prostate etc. there is the effect of prevention and treatment, so as long as we are long-term edible siritch, take precautions against fully resource just can for health, could promote the immunologic function of health, so siritch is the best health care condiment in edible oil.

The shortage of finding alpha-linolenic acid is the thing of the seventies in last century, the founder Xi Mo Prose doctor at American Genetic nutrient health center, from the omega-fatty acid that begins one's study in 1984 problem of having the balanced diet, China just began one's study in the nineties, provided the more diet style of science from nutrition and healthy angle for the mankind.The formation of omega-fatty acid theory comes from the large essential fatty acid of human body two: alpha-linolenic acid (omega-fatty acid) and linoleic acid (ω-6 fatty acid).Research finds, in the fat that human body is taken in, if the ratio of these two groups of essential fatty acid less than 1: 4, the function of human body will the most efficient, the risk that the various diseases such as cardiovascular, cancer, diabetes, obesity, arthritis, asthma are brought out in reduction.

In recent years, along with the progress of science and technology, the nutritive value of linum and health care have caused many field scientists' such as medical treatment, food, agricultural concern.A large amount of results of study show, siritch is a kind of high-quality edible oil, is rich in alpha-linolenic acid and various unsaturated fatty acid, can directly change into DHA and EPA in human body.Contain 55% linolenic acid in siritch, this is the highest in vegetable oil, is a kind of economical and practical " bathypelagic fish oil ".As everyone knows, " fish oil " refers to EPA and DHA, is to be become in the body of fish by alpha-linolenic acid (mainly being contained in Sargassum) in the sea.The people takes alpha-linolenic acid (mainly being contained in siritch), also can synthesize EPA and DHA in vivo.So eat the siritch that is rich in alpha-linolenic acid, just can play the effect of similar eating " fish oil "; The unsaturated fatty acid chain of restoration updating cranial nerve cell film plays brain-strengthening, nootropics, blood fat reducing, antiplatelet aggregation, expansion small artery and antithrombotic etc.

(2) Radix Astragali:

By chromatography and Wave Spectrum technology, the main chemical compositions in the Radix Astragali is carried out separation and purification and Structural Identification, and application HPLC-PDAD-ELSD has set up the method for assay, analyze the content of main chemical compositions in the Radix Astragali, also the extraction process of astragaloside is inquired in relevant paper.Purpose: Radix Astagali Astragalus membranaceus Bunge var.mongolicus (Bunge) Hsiao is pulse family (Leguminosae) Astragalus (Astragalus) plant, is China's Chinese medicine.Property is sweet, and tepor is returned spleen, lung meridian, has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, the effect of expelling pus and promoting granulation.Separate the compound that obtains from the Radix Astragali, mainly contain saponins, flavonoid, biphenyl derivatives, polysaccharide etc., modern pharmacology studies show that, the bioactive ingredients of the Radix Astragali, with saponins, flavonoid is the most important.At present, Radix Astragali quality evaluation study is mainly concentrated in the research of finger printing, the assay research of Radix Astragali active component is mainly concentrated on the research of astragaloside.In the Radix Astragali bioactive ingredients various except saponin constituent the Radix Astragali flavone constituents also have significant biological activity, the content of single-activity composition can not react the bioactive overall picture of the Radix Astragali.For evaluation provides reliable method to Chinese medicine tragacanthin amount; Also for instructing clinical rational drug use that foundation is provided, we are prepared the main active in the Radix Astragali, and with its in contrast product carry out the multiple active components assay.Method: adopt modern chromatography technology to comprise that silica gel column chromatography, Sephadex LH-20 column chromatography, ODS column chromatography, activated-charcoal column, preparation liquid phase etc. partly separate the n-butyl alcohol of Radix Astragali extract, monomer component adopts the Wave Spectrum means to identify.In paper, 6 kinds of main biological activities are as reference substance in the Radix Astragali, and wherein two kinds of Radix Astragali saponin compositions, comprise astragaloside (5) and Radix Astragali saponin II (6); Four kinds of Radix Astragali flavone compositions, comprise Lignum pterocarpi indici alkane type flavone-3 glucoside (1), 3 '-hydroxyl-5 '-methoxyl group isoflavone-7-O-β-D-pyranglucoside (3), Formononetin (12), 7,3 '-hydroxyl-5 ' methoxyl group isoflavone (13) is used High Performance Liquid Chromatography/Photodiode Array Detection-evaporative light scattering detector (HPLC-PDAD-ELSD) multiple techniques, sets up content assaying method.result and conclusion: draw 13 of compounds, be respectively: Lignum pterocarpi indici alkane type flavone-3 glucoside (1), isoflavan-7 glucoside (2), 3 '-hydroxyl-5 '-methoxyl group isoflavone-7-O-β-D-pyranglucoside (3), 4 '-methoxyl group isoflavone-7-O-β-D-glucopyranose glycosides (4) astragaloside (5) Radix Astragali saponin II (6), cupreol (7), hexadecanoic acid (8), daucosterol (9) ribosidoadenine (10), sucrose (11), Formononetin (12), 7,3 '-hydroxyl-5 ' methoxyl group isoflavone (13).Investigated respectively the content difference of 6 kinds of Main Ingredients and Appearances in Radix Astagali and Radix Astragali in paper, result shows that compound 13 and 6 does not have significant difference, and other all have significant difference.Wherein, the compound 5,3,1 in Radix Astragali covers the compound 12 of stilbene higher than Radix Astragali all higher than Radix Astagali.In paper also the extraction process to astragaloside further investigate, the rate of transform 0.2% of astragaloside.The Radix Astragali has the function of enhancing immunity, the energy health invigorating, thus improve memory.

(3) Rhizoma Anemarrhenae:

The Rhizoma Anemarrhenae is the rhizome of the liliaceous plant Rhizoma Anemarrhenae (Anemarrhena asphodeloidesBunge), begins to be stated from Shennong's Herbal, and the property bitter cold has the effects such as sliding dry, the relieving restlessness of quenching the thirst of nourishing YIN to lower pathogenic fire, intestine moistening, sharp defecation, is traditional Chinese medical science conventional medicament.Modern study finds that the Rhizoma Anemarrhenae has the alzheimer disease of improvement, blood sugar lowering, analgesic, antiinflammatory, antiviral, the effect such as anticancer, is one of focus medicine in modern medicine research, and progress in recent years is rapid.This paper summarizes the main chemical compositions of the Rhizoma Anemarrhenae and composition pharmacological research in recent years.The main chemical compositions of the Rhizoma Anemarrhenae still has lignanoids, flavonoid, polysaccharide, organic acid etc. take steroidal saponin, two benzene pyrrones as main.Steroidal saponin steroidal saponin quantity in the Rhizoma Anemarrhenae is many, content is high, and the compound of having identified has kind more than 20.Its sapogenin has Sarsasapogenin (sarsasapogein, also claim Sarsasapogenin), markogenin (markogein), neogitogenin (neogito-gein) and diosgenin (dosgenin), be spirostanol saponin unit.1-timosaponin A-1 III (timosaponin AIII) is take Sarsasapogenin as parent nucleus, timosaponin B I (timosaponin B I is again timosaponin E, anemarsaponin E), timosaponin BII (timosaponin BII) ...

Along with the aggravation of aged tendency of population, cerebrovascular, especially ischemic cerebrovascular more and more become one of principal disease that threatens human health, it not only grievous injury patient's health and lives quality, brought white elephant also for society and family.Therefore, the control medicine novel, effective, that side effect is little is developed and developed to the pathophysiological mechanism of clear and definite cerebral ischemia imperative.The pathophysiological mechanism of cerebral ischemia is complicated, and research thinks that it is relevant to the factors such as energy metabolism impairment, toxicity of excitatory amino acid, free radical generation in a large number, intracellular calcium overload, platelet activation, inflammation damnification after ischemia-reperfusion.Under the regulation and control of platelet activation, inflammation immunologic injury, nuclear factor, the mechanism such as expression of the release of cytokine and adhesion molecule more and more are subject to the attention of researcher now.Rhizoma Anemarrhenae effective ingredient (compound 9714) is a kind of Shuirongxin Zaiti Zaogan compound that contains two sugar chains that derives from Anemarrhena asphodeloides Bge that Radiation Medical Science Inst., Chinese Academy of Military Medical Science (CN provides, the similar glucocorticoid.This problem is according to the architectural feature of Rhizoma Anemarrhenae effective ingredient (compound 9714), and in conjunction with the Present study of cerebral ischemia, from varying levels such as integral body, cell, molecules, in vivo and in vitro combines, utilize the several different methods systematic analysiss such as biochemical measurement, immunohistochemistry, enzyme linked immunological, molecular biology, cell culture to inquire into pharmacological action and the mechanism of compound 9714 control cerebral ischemia, for research and development anti-cerebral ischemia new drug provides certain theory and experimental basis.Research is divided into and is following five parts: 1 compound 9714 is that cerebral ischemia causes a kind of typical case's performance in disordered brain function to the improvement effect ability of learning and memory decline of laboratory animal brain function decline.This classical cerebral ischemic model of bilateral ligation is adopted in this experiment, measure the difference of each treated animal space learning memory ability with the Morris water maze, with the impact on cerebral ischemic model rat pathomorphology and nerve growth factor, adhesion molecule expression of HE dyeing and SABC immunohistochemical staining analysis of compounds 9714; Simultaneously in view of the important relationship between dysfunction, the reduction of cholinoceptor density and the learning and memory of choline system, cognitive disorder, brain function decline, adopt m receptor blocker scopolamine ip 0.5mg/kg to cause acquired dysmnesia mouse model in experiment, observe compound 9714 to the impact of model mice ability of learning and memory, reach the impact on cholinoceptor in its Hippocampus.Result shows, after compound 9714 10mg/kg, 20mg/kg, 40mg/kg modeling, successive administration is 40 days, can obviously improve the learning memory disorder of rats with cerebral ischemia; Improve the degeneration necrosis of neurocyte; Strengthen the expression of Brain Derived Neurotrophic Factor (BDNF) in brain cortex, reduce the expression of intercellular adhesion molecule-1 (ICAM-1); Compound 9714 15mg/kg, 30mg/kg, 60mg/kg prevented administration 30 days continuously, can obviously improve the ability of learning and memory of acquired dysmnesia model mice, and obviously raise cholinergic M1 receptor in its Hippocampus, the effect trend that has simultaneously obvious rise n receptor subtype alpha 7 (N α 7), compared significant difference with the blank group, to n receptor subtype alpha 4 without obvious effect.2 compound 9714s comprise global brain ischemia model and the large class of focal cerebral ischemia in rats two to the protective effect of Level In Rats With Focal Cerebral Ischemia cerebral ischemic model commonly used.This experiment adopts FeCl3 chemistry application method to cause middle cerebral artery thrombosis (MCAT) model and the bolt collimation method causes middle cerebral artery (MCA) ischemia-reperfusion injury model, observe compound 9714 on rats with cerebral ischemia nervous symptoms, Range of Cerebral Infarction, brain water content, cerebral blood flow 2 Rhizoma Anemarrhenae effective ingredient on the protective effect of cerebral ischemia and the impact of Mechanism Study amount and Multiple biomarkers thereof.The result demonstration, compound 9714 20mg/kg, 40mg/kg can obviously dwindle the Range of Cerebral Infarction of MCAT rat model, improve its nervous symptoms, and significantly reduce the Ipsilateral brain water content, improve cerebral edema; Compound 9714 10mg/kg, 20mg/kg, 40mg/kg can significantly lower the cerebral tissue surface cerebral blood flow fall when dripping 50min after the modeling of FeCl3 hyperamization bolt formation model rat, and extend cerebral blood flow 50% required time that descends; Compound 9714 20mg/kg, 40mg/kg can obviously reduce the bolt collimation method cause MCAO fill with again in the rat model cerebral tissue MPO active, improve T-SOD active, reduce MDA content, and reduce T-NOS, i-NOS active, reduce NO content.3 compound 9714s are one of important pathological processes that causes ischemic cerebrovascular and thrombotic disease on thrombosis, platelet aggregation and the hemorheological thrombosis that affects, and extremely reach hemodynamics with vascular damaged, blood constituent and change closely related.Studies show that, platelet activation after cerebral ischemia, Abnormal Blood Rheology, thrombosis are easy to form.Platelet activation is the initiation factor of arterial thrombus, and arachidonic acid metabolism pathway is one of important channel of its activation.The arteriovenous shut thrombotic model is adopted in this experiment, collagen, ADP induced platelet Aggregation Model, and subcutaneous injection epinephrine water soaking on the rocks causes the stasis syndrome model, observed the impact of compound 9714 on arteriovenous shut thrombosis, platelet aggregation, hemorheology and arachidonic acid metabolism pathway.Result shows, compound 9714 10mg/kg, 20mg/kg, 40mg/kg can obviously suppress artery-vein bypass thrombosis; The rat platelet aggregation that obvious inhibition collagen, ADP induce; Obviously reduce stasis syndrome rat model whole blood viscosity and plasma viscosity, improve its red cell deformability, reduce erythrocyte aggregation; And can obviously reduce TXB2/6-Keto-PGF1 α ratio in MCAO re-perfusion model rat plasma.In experiment in vitro, we find first simultaneously, and the effective ingredient of compound 9714 performance platelet aggregation is its metabolite (10-4,10-5,10-6mol/L), and 9714 former medicines act on without this.This just in pharmacodynamic experiment this medicine onset slower, one of reason that administration time is long.The inflammatory and immune response that affects after ischemic brain injury and ischemia-reperfusion that 4 compound 9714s are expressed the cerebral ischemia reperfusion rat cell factor, adhesion molecule, nuclear factor NF-κ B is closely related.Studies show that, the activation of the release of cytokine, the expression of adhesion molecule and inflammation immunity target cell is significant in the cerebral ischemia process.

(4) Radix Rehmanniae Preparata

contain Herba Leonuri glycoside (leonuride), aucubin (aucubin), catalpol (catalpol), rehmannioside (rehmannioside) A, B, C, D, U.S. profit appropriate pair of glycoside (melittoside), rehmanin (rehma-glutin) A, D, the smelly formaldehyde glycoside of Radix Rehmanniae chlorination (glutinoside), burnt rehmanin (jioglutin) A, B, C, burnt Radix Rehmanniae lactone (jioglutolide), burnt jiofuran (jiofuran), , the bitter glycoside unit of Radix Rehmanniae (rehmapicrogenin), separately contain trihydroxy-alpha, beta-lonone (trihydroxy-β-lonone), dihydroxy-alpha, beta-lonone (dihydroxy-p-lonone), aeginetic acid (aegineticacid), 5-hydroxyl aeginetic acid (sec-hydroxyaeginetic acid), succinic acid (succinic acid), 5-pidolic acid (5-oxoproline), 5-HMFA (5-hydroxymethylfuroic acid), uracil (uracil), uridine (uridine) etc.separate from ligroin extraction again and obtain: linoleic acid (linoleic acid), Palmic acid (palmitic acid), stearic acid (stearic acid), arachidic acid (arachidic acid), behenic acid (be-henic acid), pentadecanoic acid (pentadecanoic acid), palmitoleic acid (palmitoleic acid), myristic acid (myristic acid), 19 carbonic acid (nonadecanOic acid), 20-carbonic acid (heneicosanoic acid), 17 carbonic acid (margaric acid).

To remember on chemical learning memory disorder mouse model and obtain reproduction and behavioral experiment. result: the piracetam group compares significance with the Radix Rehmanniae Preparata group with Normal group. and conclusion: Radix Rehmanniae Preparata has the effect that improves learning memory disorder model mice ability of learning and memory. and suggesting effect is machine-processed and reduce the cerebral tissue cholinesterase activity, the inhibition aluminium ion is relevant in the cerebral tissue accumulation.

Give birth to marrow, fill the function that brain theory and Radix Rehmanniae Preparata kidney tonifying, essence replenishing are given birth to marrow according to motherland medical science kidney, use in the compound recipe of the diseases such as treatment is forgetful, dull-witted in conjunction with it, learn that Radix Rehmanniae Preparata has clinically the forgetful card for the treatment of, improves the learning and memory effect.We are summarised as " " intelligence development functions " " with this effect, and use pharmacological experimental method, and Radix Rehmanniae Preparata Fructus Alpiniae Oxyphyllae drug effect and the mechanism of action thereof are studied.Kunming mouse, SD male rat are used in experiment.Reagent is bosom celebrating Radix Rehmanniae Preparata water extraction liquid.Positive control drug: piracetam, LIUWEI DIHUANG TANG.Recall acquired disturbance model, ethanol memory represents Disorder Model, aluminum chloride plan Model of Dementia and glutaminol list sodium (monosodium glutamate, MSG) at scopolamine and damage the upper Radix Rehmanniae Preparata of observing of nucleus arcuatus hypothalami model (deficiency of the kidney yin learning memory disorder model) to the impact of learning and memory behavior and related neural endocrine factors.Result is as follows: 1. Radix Rehmanniae Preparata can improve scopolamine induced mice memory acquisition disturbance, reduces acetylcholinesterase (AchE) active (P＜0.01) in cerebral tissue.2. Radix Rehmanniae Preparata can obviously improve 40% ethanol induced mice memory represents obstacle.3. Radix Rehmanniae Preparata obviously improves aluminum chloride plan dementia mice learning memory disorder, significantly reduce aluminum chloride and intend aluminium ion (Al3+) content (P＜0.01) in the dementia mice cerebral tissue, AchE active (P＜0.05), glutamic acid (Glu) content (P＜0.01, P＜0.05), rising r-aminobutyric acid (GABA) content (P＜0.01, P＜0.05).4, Radix Rehmanniae Preparata significantly improves MSG learning and memory function obstacle, reduces MSG rat plasma hydrocortisone (CORT) level (p＜0.05) and hippocampal glucocorticoid receptors mRNA (GRmRNA) and expresses; Improve Glu content (p＜0.01) in cerebral tissue, increase Hippocampus NMDAR1 receptor, GABA receptor, nerve growth factor (NGF), c-fos gene expression (p＜0.05, p＜0.01).Nissl body (nissl body) dyeing shows: hippocampal neuron Nissl body granule is abundant, and form is normal.At present, it is more that domestic compound recipe take Radix Rehmanniae Preparata as principal agent improves learning and memory experimentation report, but this area research of single Radix Rehmanniae Preparata still belongs to blank.What this project first passage experimental technique had been observed Radix Rehmanniae Preparata improves the learning and memory effect, and to associated Factors Affecting Neuroendocrine Mechanisms-carried out System Approach in the expression of brain as cholinergic transmitter, amino acid neurotransmitters and receptor, hypothalamic-pituitary-adrenal-Hippocampus axle and c-fos, NGF, GRmRNA, obtained Radix Rehmanniae Preparata and had the conclusion of nootropic effect.This project is damaged monosodium glutamate first the nucleus arcuatus hypothalami rat model and is used and succeed as deficiency of the kidney yin learning memory disorder model, has started the new application of this model.Provide new method with practical value in particular for the nootropic effect of studying YIN nourishing side's medicine, discussion mechanism.This project result of study is used and deeply developed for the expansion of our province special product medical material Radix Rehmanniae Preparata provides new direction, established Research foundation, and the industrialization process that exploitation Radix Rehmanniae Preparata Fructus Alpiniae Oxyphyllae product is also promoted the bosom Radix Rehmanniae is significant.

(5) Semen Ziziphi Spinosae:

Semen Ziziphi Spinosae contains jujuboside A and B (Jujuboside A and B), flavonoid (Sipinosine and Zivulgarin), triterpenoid compound betulic acid and betulin (Betulic acid and Betulin) alkaloid and ferulic acid (Lysicamine and juzirine), also fatty, protein, sterol and volume vitamin etc. still contain the volatile oil of micro-intense stimulus.

Jujuboside A, B in Semen Ziziphi Spinosae and flavone compound are its main pharmacodynamics compositions, and it is fried that parch is beneficial to effective ingredient, but can not too, fry for a long time oil cake and easily lose efficacy.Prove that simultaneously Semen Ziziphi Spinosae is given birth to, goods all have calmness, syngignoscism.Semen Ziziphi Spinosae also has significant blood fat reducing and antiplatelet aggregative activity; Chinese People's Anti-Japanese Military and Political College's Mus myocardial ischemia is arranged, lipoid peroxidization resistant; The reduction of induced by endotoxin heating SOD in Mice has protective effect etc.

The Semen Ziziphi Spinosae tool is calm, oral or lumbar injection all can resist the excitement that caffeine sodium benzoate causes and behaves with composure and drowsiness to rat for syngignoscism, its decoct, with the barbiturates sedative hypnotic with using, obvious synergism is arranged, and proof give birth to product to rat without excitation.Relatively give birth to, Semen Ziziphi Spinosae (parched), with the concentrated solution of its 2gml-1, by every 10g with the dosage of 0.425～0.5ml to mouse stomach, observation is on the mice passive activity and impact spontaneous activity, its result, two groups sedation all occurs, its strong and weak no significant difference.5gkg-1 injects to mouse peritoneal with the Semen Ziziphi Spinosae decoct, shows that with the hot plate method test analgesic activity is arranged.The Semen Ziziphi Spinosae water solubility extract can obviously reduce convulsions rate and the mortality rate that the mice half causes the pentylenetetrazole of convulsions amount, further research, give birth to, the Semen Ziziphi Spinosae (parched) water decoction all presents calmness, sleeps peacefully and anticonvulsant action central nervous system of mice, both between also no significant difference.Carry out in addition Semen Ziziphi Spinosae and jujuboside A to the experimentation of central nervous system's effect, result shows, Semen Ziziphi Spinosae and penthiobarbital or sodium pentobarbital central inhibitory action have synergism, the excited central action that can suppress significantly amfetamine obviously reduces movable number of times and the activity intensity of mice; Simultaneously can also obviously reduce the coordination exercise of rat, and the central inhibitory action of jujuboside A and pentobarbital sodium is without obvious synergism, intensity to the mice autonomic activities when heavy dose has obvious inhibitory action, and with the central excitation effect of amfetamine, obvious synergism is arranged, coordination exercise to rat also has no significant effect, this result tentatively illustrates, jujuboside A may not be the effective ingredient of Semen Ziziphi Spinosae sedative action.Experimental results show that in addition, Semen Ziziphi Spinosae total flavonoids can obviously suppress the spontaneous activity of mice, strengthen pentobarbital sodium, penthiobarbital and chloral hydrate to central nervous system's inhibitory action, the mice psychomotor excitement that the antagonism caffeine brings out, these effects are similar to Semen Ziziphi Spinosae.Therefore think that total flavones is the effective ingredient of central inhibitory action in Semen Ziziphi Spinosae.Thereby the effective ingredient of Semen Ziziphi Spinosae sedative action and the mechanism of action need further be studied.

Hou Jianping observes Semen Ziziphi Spinosae to the impact of ability of learning and memory in mice.Adopt diving tower method and complicated water maze to observe Semen Ziziphi Spinosae to the impact of mouse memory acquired disturbance, memory represents obstacle mice and normal mouse ability of learning and memory.Result shows, Semen Ziziphi Spinosae can shorten normal mouse and be arrived at by starting point the time of terminal point in complicated water maze, reduces errors number, extends the wrong time of occurrence first of memory acquisition disturbance and memory represents Disorder Model mice, reduces wrong incidence rate.

(6) taurine:

Taurine claims again taurine, and its chemical name is 2-aminoethyl sulfonic acid, and is water-soluble for white, needle-shaped crystals, odorless, the little acid of flavor, is insoluble to ethanol, ether and acetone, without any side effects.With the hydrolysis of the bile of cattle, or with the fish and shellfish such as sepiellae seu sepiae and Octopus and mammiferous meat or internal organs with water extraction after, reconcentration is refining to be formed.Also refuse (internal organs, blood and the meat in available processing of aquatic products, irrelevant with freshness) with the water hot extraction by decolouring, deodorize, degrease, separate through cation exchange resin again after making with extra care, extract in the gained eluant can reach 66%～67%, then processes post crystallization and get through ethanol.

Taurine energy enhancing immunity, fatigue alleviating.Taurine is a kind of special aminoacid, is the requisite a kind of nutrient of human body, and in daily life, it is enhancing immunity and fatigue alleviating that taurine acts on the most significantly.Require mental skill and do not feel sleepy, the protection brain is healthy.Have in a large number taurine in people's brain, when requiring mental skill for a long time, when the taurine in cell is consumed in a large number, easily occur absent-minded, feel sleepy, the tired phenomenon such as absent minded.Supplementation of taurine can obviously promote the growth promoter of brain neuroblastoma system and cell proliferation, differentiation, the protection brain health.Repair the eye wound, preventing ophthalmic diseases.Also have a large amount of taurines in people's retina, taurine has facilitation to the photoreceptor cell，photosensory cell in retina, and supplementation of taurine can be promoted the self-repairing capability of cornea when coming to harm, preventing ophthalmic diseases.

Aspect medical treatment and pharmacy, that this product has is analgesic, ease pain, protect the liver, blood sugar lowering, keep the normal vision function, regulate nerve conduction, regulate lipid metabolism, gallbladder phosphorus juice decomposition-function of gallbladder promoting hepatoprotective, participate in Endocrine Activity, increase the heart contraction ability, improve human body immunity's effect.Be mainly used in clinically treating flu, heating, neuralgia, tonsillitis, bronchitis, rheumatic arthritis, all kinds of ophthalmic and drug intoxication.

1. analgesic and antiinflammatory action: this product may reduce body temperature by the effect to maincenter 5-HT system or catecholamine system, and it is reported has certain refrigeration function to infectious hyperpyretic patient oral taurine 3.6-4.8g.Zoopery proves, this product still has the staphylococcus effect, and the effect of the immunologic function that may improve.2. depressed liver-energy dispersing and function of gallbladder promoting effect: Cavia porcellus experiment showed, that taurine can remove cholestasis, is choleretic effect.Taurine and cholic acid combination can increase the bile permeability, and relevant with the backflow of bile.Taurine also can reduce the liver cholesterol level, reduces the formation of cholesterol calculus, and liver is shielded.Also be confirmed in zoopery, can reduce alanine aminotransferase.3. auxiliary improving memory function:

A. Wei Haifeng observe taurine on beta amyloid peptide 1-40 hippocampal injection to the ability of learning and memory of dementia rats in the impact of inflammatory cytokine, provide foundation for taurine is applied to prevent and treat the Aizheimer disease.The SD rat is divided into Normal group, A β injection model group, taurine 0.3g/ (kg.d), 0.6g/ (kg.d) dosage group at random.After gavage gave taurine 7d, except matched group, the equal bilateral hippocampus injection of other groups 10 μ gA β 1-40 carried out the test of Morris water maze after 2 weeks, get hippocampal tissue, carry out IL-6, TNF-α with radioimmunology and measure.Result shows, compares with the model group rat, and the heavy dose of group of taurine is escaped incubation period and swum apart from significantly shortening; After removing platform, extend in target quadrant detection range; Hippocampal tissue IL-6, TNF-alpha content significantly reduce.Conclusion: taurine can improve A β hippocampal injection significantly to the ability of learning and memory of dysmnesia rat;

B. Yang Feng inquires into the neural effect of taurine antagonism lead loss evil.Adopt and measure increased weight and Y type maze experiment; observation is drunk and is contained variable concentrations lead acetate (0.02g/L; 0.2g/L) water and contain various dose taurine (5g/kg; 10g/kg) the rat of forage feed, and drink single difference of steaming increased weight and ability of learning and memory between the rat that water and normal diet feed.Result shows, taurine can promote obviously to dye that plumbous rat body weight increases and ability of learning and memory strengthens.Conclusion: taurine has obvious antagonism to lead loss evil nervous system.

(7) Herba Centellae:

The Triterpenoid that contains multiple α-Amyrin type, Asiaticoside (Asiaticoside), thankuniside (Thankuniside), isothankuniside (Isothankuniside) are wherein arranged, madecassoside (Madecas-soside), brahmoside (Brahmoside), broken heat rice glycoside (Brah-minoside) and Brahmic acid (Brahmic acid) etc., and madasiatic acid (Madasiatic acid).In addition, still contain meso inositol (Meso-inositol), centellose (Centellose, a kind of oligosaccharide), wax, Radix Dauci Sativae hydro carbons (Carotenoids), chlorophyll, and the flavonoid glycoside of nimbecetin, Quercetin and glucose, rhamnose.Herb mainly contains triterpenic acid and triterpenoid saponin.Triterpene has asiatic acid (asiatic acid), Madecassic acid (brahmic acid), different Madecassic acid (isobrahmic acid) and birch skin acid (be-tulinic acid) etc.Triterpenoid saponin has Asiaticoside (asiaticoside, madecassol), madecassoside (madecassoside), Herba sambuci chinensis three glucosides (brahmoside) and Herba sambuci chinensis tetrose glycoside (brahminoside), meaning contains ginseng withered glycoside (thankuniside) and the withered glycoside of different ginseng (isothankuniside) again.Separately contain kaempferol and Quercetin and glycoside thereof, accumulated snow potash (hydrocotyline), meso inositol (inositol), Herba Centellae oligosaccharide (centellose), sitosterol, vitamin C, carotene, green volatile oil and resinoid.Herba Centellae contains the number of chemical compositions such as triterpene saponin, polyacetylene vinyl compound, alkaloid, has various active, as improves memory.Hindu medicine research thinks, Herba Centellae contains a kind of " adaptogen ", can keep the physiological equilibrium of human body, and help the oxygen supply of human body, thereby play refreshment, improve spiritual acuity, step up vigilance, the even effect of life lengthening of memory reinforcing.Modern experiment confirm, Herba Centellae can be improved cognitive competence and the memory of mouse.Herba Centellae is very safe, even more than people every day edible 20 grams, also have no any side effect.External existing multiple Herba Centellae health preparation as Herba Centellae teabag, Herba Centellae capsule etc., is used for improving intelligence, preventing hypomnesis.Herba Centellae is arranged in pairs or groups mutually with other nourishing the brain and improving intelligence plants such as Semen Ginkgo, can improve better the catabiosis of brain.Both take food jointly, can reach more preferably effect to improving memory.

(8) cephalin:

Cephalin claims again ethylaminoethanol phospholipid, and its molecular structure is similar to lecithin.Cephalin usually and lecithin coexist in the brain, nervous tissue, heart, liver etc. of animal, especially maximum with content in animal brain, account for the 4%-6% of brain stem material total amount.Approximately containing cephalin in soybean phospholipid is 21.4%.

Phospholipid is as a kind of basic substance of life; be described as " patron saint of cell ", " street cleaner of blood vessel ", " healthy supplementing the brain juice " etc. in medicine and health care industry; be protection human normal metabolism and the requisite nutrient substance of healthy existence, very important effect is all played in the vigor in the keeping of cell activation, existence and the organ function of human body, muscle joint and the metabolism of fat etc.

Phospholipid is the main component of brain cell, is the bioactive substance of cranial nerve cell transmission of information.Phospholipid participates in the metabolism of cranial nerve cell, is the precursor of the chemical substance acetylcholine of neurocyte transmission of information, and is most important for brain and neural normal function, closely related with man memory power and intelligence:

1. keep and the normal function that strengthens brain cell, improve or the various neurosiss of partner treatment and sacred disease;

2. prevent and improve senile dementia, promoting the arteriosclerosis piece to disappear;

3. improve because of symptoms such as the nervous irritability that causes, irritabilities, promote the growth of cerebral nervous system and cranial capacity;

Infant is that brain forms the most critical period of growing period, and U.S. food and drug administration are defined in baby milk must add phospholipid.The phospholipid health food one supplementing the brain juice that the U.S. releases the earliest, main subject of a sale is the student of college, is brain worker's special dietary tonic.The international lecithin chairman of association, medicine scholar Neal Israel are breathed out and are rather pointed out: " heavy dose of lecithin can improve old people's memory and aging brain cell activity, particularly to just the child's effect at growth promoter is better ".

(9) folic acid:

Folic acid is the necessary material of human body when utilizing sugar and aminoacid, is the necessary material of body cell Growth and reproduction.Folic acid works with the form of tetrahydrofolic acid in vivo, and tetrahydrofolic acid participates in vivo the synthetic of purine nucleic acid and pyrimidine nucleotide and transforms.Folic acid is played the part of important role on manufacturing nucleic acid (ribonucleic acid, DNA (deoxyribonucleic acid)).Folic acid helps the metabolism of protein, and and vitamin B ₁₂Common erythrocytic generation and the maturation of promoting is to make the indispensable material of erythrocyte.Folic acid is also as the promotion multiplicaiton factor of lactobacillus casei (Lactobacillus casei) and other microorganism and work.

Domestic expert thinks, folic acid intensified foodstuff is not carried out by China, masses do not have conscious from food the custom of Supplement of folic acid, the serum folic acid level is low, the factors such as Plasma Homocysteine height, with the essential hypertension combined effect, may be to cause China's incidence of stroke and the high major reason of mortality rate.The demonstration of Ministry of Public Health statistics, China is apoplexy big country occurred frequently, annual neopathy 2,000,000 people.Apoplexy causes dead 1,500,000 people every year, is to occupy tumor urban and rural residents' second cause of the death afterwards.In the patient of survival, about 3/4ths disabilities in various degree, severe disabled person accounts for 40%.Annual this sick medical expense that is used in the whole nation is more than 10,000,000,000 yuan, and the financial burden of country and family is heavy.The world hypertension chairman professor Liu Lisheng of alliance think, the effect of value and strengthen folic acid aspect the control apoplexy answered by China.Compare the statins for the treatment of apoplexy, the use of folic acid has more the advantage of cost performance, more suits the national conditions of China.Can be used for Aged Normal group's prevention such as " depressor adds folic acid ", especially northern China Stroke Incidence rate is high, and folate level is low, and the expection of Supplement of folic acid is better than western countries.

The research worker of Wageningen, Netherlands university, report in the seminar that U.S. degenerative brain disorder association holds recently, they allowed in 3 years, and 818 brain cognitive competence are sound, the people of age between 50 years old～75 years old, it is the folic acid of 800 milligrams that day takes total amount, then these man memory power and cognitive competence is tested.The result of study demonstration, in the memory test, Supplement of folic acid person's memory level is equivalent to the level than its young 5.5 years old person; In Cognitive Aptitude Test, Supplement of folic acid person's cognitive competence is equivalent to the level than its young 1.9 years old person.This shows, folic acid is improved the effect of above the average age for marriage person's memory and protection brain cognitive competence.

(10) tea polyphenols:

This product is yellowish to dark brown slightly aqueous solution, powdery solid or the crystal of tea perfume (or spice), and the tool astringent taste is easy to become solution in water, ethanol, ethyl acetate, is slightly soluble in oils and fats.

Its effect: the effect that 1. has the harmful free radical of very strong elimination: the Scavenger of ROS free radical, blocking-up lipid peroxidation process improves the activity of human body endoenzyme, thereby plays the effect of mutation, anticancer.Many medical experiments are verified, and tea polyphenols has extremely strong removing to be harmful to free radical, stop the effect of lipid peroxidation; Induce the increasing of activity of human body metabolism's enzyme, promote carcinogenic detoxifcation; Suppress and blocking-up human body endogenous nitrosation reaction, prevent canceration and gene mutation.Suppress the covalent bond of carcinogen and cell DNA, prevent the DNA single chain interruption; Improve the cellular immune function of human body.Studies show that, take in for each person every day the 160mg tea polyphenols and namely nitrosation process in human body is produced significantly inhibition and blocking effect, the tea polyphenols inhibitory action of taking in 480mg reaches the highest.2. anti-aging effects: according to the theory of free radical theory, old and feeble reason is the change of free-radical contents in tissue, and this change is destroyed cell function, thus the senescence process of acceleration human body.Studies show that, lipid peroxide increase in vivo is consistent with the senility of humanbody process, when interior free yl is superfluous state, just shows the old and feeble gradually of human body.Tea polyphenols makes it also can stop like that the body lipid peroxidating to be carried out to the interior derived components (superoxide dismutase, catalase, peroxidase) that consists of human body defence lipid peroxidation system to the scavenging action of free radical.Tea polyphenols can suppress lipoxygenase and lipid peroxidation in the skin line solid, thereby plays the defying age effect.Studies show that, the antioxygen of tea polyphenols obviously is better than vitamin E, and with vitamin C, E, synergy is arranged.3. radiation resistance: the person confronted by danger of Japan after the hiroshima bomb blast moved to the tea district and lived and drink a large amount of excellent green teas the fifties, this factfinding discovery of not only still survival, and euthesia, and tea is a kind of radiation antidote.Tea polyphenols has excellent radiation-resisting functional, and tea polyphenols can absorb radioactive substance, stops it at the human body internal diffusion, is called as natural ultraviolet filter.Tea polyphenols can shielding of ultraviolet and is removed the free radical of ultraviolet induction, thus the normal function of protection melanocyte, the formation of check melanin.Simultaneously lipid oxidation is produced and suppress, alleviate pigmentation.4. digestion-aid effect: tea polyphenols can strengthen gastral wriggling, thereby also just helps the digestion of food, prevention chylopoietic disease's generation.The tea polyphenols compound can filminess be attached on the wound of stomach in addition, and ulcer wound surface is played a protective role.Tea polyphenols is being fulfiled unique chemical cleaning method effect to stomach, kidney, liver.5. antibiotic, bactericidal action.6. to the inhibitory action of HIV (human immunodeficiency virus) (Human Immunodeficiency Virus).

Inquire into the pretreatment of various dose tea polyphenols to the impact of learning and memory in rats obstacle due to beta-amyloid polypeptide 1-(A β).50 healthy SD rats are divided into sham operated rats at random; Model group; Tea polyphenols group (basic, normal, high 3 dosage groups).Adopt A β 25-35 to set up the AD model, front 2 weeks of administration group modeling gavage tea polyphenols by basic, normal, high 3 kinds of various dose, gavage continuously 2 weeks, every day 1 time after modeling again.After intervening end, utilize the Morris water maze laboratory to observe the Rats With Memory ability and change.Put to death afterwards rat, detect content or the activity of respectively organizing Hippocampus position Ach, ChAT and AchE.Result: model group is compared with sham operated rats, the number of times that rat is found the time of platform and passes through the platform position obviously reduces, and Ach content and ChAT are active obviously to be reduced, and the AchE activity has increase trend, but compare with sham operated rats, there is no significant difference (P0.05); The tea polyphenols that gives various dose can improve the learning memory disorder of AD rat in various degree, improves the activity of AD rat Ach content and ChAT, with model group, significant difference is arranged relatively, but not obvious to the AchE activity influence.Conclusion: tea polyphenols can improve AD rat model ability of learning and memory, improves the ChAT of rat cerebral tissue active, and the effect of prompting medicine may be relevant with the synthetic increase of choline mediator.

Above-mentioned formula after the science screening is compared with other formula, and is strong through taking effect property of animals and human beings body clinical experiment, successful.

Through zoopery, experiment conclusion: mice through acute toxicity LD50 greater than 21.0g/KgBW, genetoxic experiment (Ams experiment, micronucleus test, the sperm deformity experiment) result is negative, fed experiment in 30 days and find no the overt toxicity effect, according to the criterion in health food check and assessment technique standard (version in 2003) toxicological evaluation program, the food test agent improves the soft capsule of memory without overt toxicity.

Through human experimentation, experiment conclusion: the experimenter of 30 routine brain memory weaknesses requires to take the soft capsule 30 days that improves memory, memory be improved significantly, reach enhancing immunity, fatigue alleviating, astringing QI is calmed the nerves again, and flourish muscle is supported marrow, stomach function regulating activating the spleen, also improve simultaneously the blood oxygen circulation, illustrate that the soft capsule that improves memory is improved the effect of memory.After the soft capsule test-meal of improvement memory was used, routine blood test, routine urinalysis and blood biochemistry index illustrated that all in normal range this product has no adverse effects for the experimenter is healthy.

Improve memory soft capsule dose every day and be every day three times, each two.Main edible crowd is the mnemasthenia person.

The present invention compares the outstanding feature of following aspect with existing improvement memory formula: the present invention adopts the compound recipe form, meticulously select materials, rigorous prescription, pursue integral body and improve the human body situation, from improving memory, calm, hypnosis, enhancing immunity, fatigue alleviating, the aspect across-the-board regulation healths such as balanced nutrients.The human qi and blood running is unobstructed, Metabolism of Normal, and Sufficient Sleeping, memory could strengthen.The Radix Astragali strengthens immunologic function and promotes organism metabolism; The Radix Rehmanniae Preparata nourishing YIN and supplementing blood; The Herba Centellae clearing away heat-damp and promoting diuresis, the detoxifcation diuresis; Rhizoma Anemarrhenae nourishing YIN to lower pathogenic fire is moisturized laxation; The Semen Ziziphi Spinosae astringing QI is calmed the nerves, and flourish muscle is supported marrow, stomach function regulating activating the spleen; The siritch vessel softening, cardioprotection; The taurine enhancing immunity, fatigue alleviating; The cephalin blood circulation promoting improves the blood oxygen circulation; Folic acid helps lend some impetus to its brain cell growth, and is improved the effect of intelligence; Tea polyphenols has very strong non-oxidizability and physiologically active, is the good merchantable brand that natural improvement is remembered, and prescription improves health, memory reinforcing on the whole.

2, technique of the present invention is advanced, the high-grade fashion of dosage form.

The related raw material of this formula is allotment after extracting, and has dwindled volume, is convenient to produce, and is comparatively advanced.Select siritch to make solvent, strengthened the effect of this formula.Siritch contains very high unsaturated fatty acid, and linolenic acid content at 55%-60%, is natural health care, and cardiovascular system is had protective effect, also has health-care effect very widely, comprises improving memory.Can reconcile blood glucose, blood fat, blood pressure, supplementing the brain, vision protection etc.

Adopt soft capsule dosage form, can protect to greatest extent active ingredient, can be convenient to again take and digest and assimilate, the high-grade fashion of dosage form.

The most of single components such as the Rhizoma Anemarrhenae, the Radix Astragali, Radix Rehmanniae Preparata linolenic acid that adopt of the formula of the existing improvement memory relevant to the invention of this class, and the problem that this type of formula exists is that potentiation is relatively poor, and the present invention is more comprehensive, formula has increased antioxidant, Herba Centellae, folic acid, tea polyphenols, with strong complementarity, and potentiation is strong.

The specific embodiment:

Most preferred embodiment shown below is described in further detail:

Feed intake and produce 1000 of 0.6g/ grain soft capsules, formed by following weight portion:

Embodiment 1, a kind of improvement memory soft capsule comprises: siritch 496 weight portions, Radix Astragali extract 20 weight portions, Rhizoma Anemarrhenae extract 10 weight portions, Radix Rehmanniae Preparata extract 20 weight portions, Semen Ziziphi Spinosae extract 10 weight portions, Herba Centellae extract 20 weight portions, tea polyphenols 3 weight portions, folic acid 1 weight portion, taurine 10 weight portions, cephalin 10 weight portions;

Embodiment 2, a kind of improvement memory soft capsule comprises: siritch 507 weight portions, Radix Astragali extract 10 weight portions, Rhizoma Anemarrhenae extract 20 weight portions, Radix Rehmanniae Preparata extract 10 weight portions, Semen Ziziphi Spinosae extract 20 weight portions, Herba Centellae extract 10 weight portions, tea polyphenols 2 weight portions, folic acid 1 weight portion, taurine 10 weight portions, cephalin 10 weight portions;

Embodiment 3, a kind of improvement memory soft capsule comprises: siritch 463 weight portions, Radix Astragali extract 20 weight portions, Rhizoma Anemarrhenae extract 30 weight portions, Radix Rehmanniae Preparata extract 30 weight portions, Semen Ziziphi Spinosae extract 10 weight portions, Herba Centellae extract 20 weight portions, tea polyphenols 5 weight portions, folic acid 2 weight portions, taurine 10 weight portions, cephalin 10 weight portions;

Embodiment 4, a kind of improvement memory soft capsule comprises: siritch 464 weight portions, Radix Astragali extract 20 weight portions, Rhizoma Anemarrhenae extract 30 weight portions, Radix Rehmanniae Preparata extract 30 weight portions, Semen Ziziphi Spinosae extract 20 weight portions, Herba Centellae extract 10 weight portions, tea polyphenols 5 weight portions, folic acid 1 weight portion, taurine 10 weight portions, cephalin 10 weight portions;

Embodiment 5, a kind of improvement memory soft capsule comprises: siritch 506 weight portions, Radix Astragali extract 20 weight portions, Rhizoma Anemarrhenae extract 10 weight portions, Radix Rehmanniae Preparata extract 20 weight portions, Semen Ziziphi Spinosae extract 10 weight portions, Herba Centellae extract 10 weight portions, tea polyphenols 3 weight portions, folic acid 1 weight portion, taurine 10 weight portions, cephalin 10 weight portions;

Embodiment 6, a kind of improvement memory soft capsule comprises: siritch 470 weight portions, Radix Astragali extract 10 weight portions, Rhizoma Anemarrhenae extract 30 weight portions, Radix Rehmanniae Preparata extract 30 weight portions, Semen Ziziphi Spinosae extract 20 weight portions, Herba Centellae extract 20 weight portions, tea polyphenols 3 weight portions, folic acid 2 weight portions, taurine 10 weight portions, cephalin 5 weight portions;

Embodiment 7, a kind of memory soft capsule and preparation method thereof that improves.Comprise the steps:

(1) raw material preparation

The Radix Astragali, Radix Rehmanniae Preparata, the Rhizoma Anemarrhenae, Semen Ziziphi Spinosae, Herba Centellae are carried out respectively selected, rinsing twice is drenched and to be anhydrated minute; Be 60～80 ℃ of oven dry 1.5-2 hour in temperature, making its moisture is 5-6%, after coarse pulverization granularity be 5-50mm to add water be 8 times of material, boiled 1.5-2 hour, extract 2 times; Twice filtrate merged, concentrated, be 60-80 ℃ of oven dry 1.5-2 hour in temperature, make its moisture 5-6% of being divided into; Pulverize, sieve, granularity is 0.1-0.5mm, is the Chinese medicine extract fine powder.

Folic acid, tea polyphenols, taurine are pulverized respectively, and granularity is 0.1-0.5mm;

The selected slag of removing of flaxseed; Adopt pressafiner that selected flaxseed is squeezed; Again siritch is removed slag, add water and regulate pH value 5.5-6.5, at water temperature 55-65 ℃, fully stir, remove moisture after then precipitating two hours namely to get the refine siritch;

(2) with siritch, the extract such as the Radix Astragali, Radix Rehmanniae Preparata, the Rhizoma Anemarrhenae, Semen Ziziphi Spinosae, Herba Centellae and folic acid, tea polyphenols, taurine, cephalin mix homogeneously;

(3) press 0.6g/ grain dress soft capsule after mix homogeneously;

(4) sterilization bottling, mounted box;

(5) vanning warehouse-in, sale after the assay was approved.

Claims (4)

1. one kind is improved the memory soft capsule, it is characterized in that including the raw material of following weight portion: siritch 360-507 weight portion, Radix Astragali extract 10-20 weight portion, Radix Rehmanniae Preparata extract 10-30 weight portion, Rhizoma Anemarrhenae extract 10-30 weight portion, Semen Ziziphi Spinosae extract 10-20 weight portion.

2. soft capsule is remembered in improvement as claimed in claim 1, characterized by further comprising the raw material of following weight portion: Herba Centellae extract 10-20 weight portion, folic acid 0.5-1 weight portion, tea polyphenols 1-3 weight portion.

3. as claim 1 and 2 described improvement memory soft capsules, characterized by further comprising the raw material of following weight portion: taurine 10-20 weight portion, cephalin 10-20 weight portion.

4. improvement memory soft capsule as described in claims 1 to 3 and preparation method thereof, is characterized in that, also comprises the steps:

(1) raw material preparation

The Radix Astragali, Radix Rehmanniae Preparata, the Rhizoma Anemarrhenae, Semen Ziziphi Spinosae, Herba Centellae are carried out respectively selected, rinsing twice is drenched and to be anhydrated minute; Be 60～80 ℃ of oven dry 1.5-2 hour in temperature, making its moisture is 5-6%, after coarse pulverization granularity be 5-50mm to add water be 8 times of material, boiled 1.5-2 hour, extract 2 times; Twice filtrate merged, concentrated, be 60-80 ℃ of oven dry 1.5-2 hour in temperature, make its moisture 5-6% of being divided into; Pulverize, sieve, granularity is 0.1-0.5mm, is the Chinese medicine extract fine powder.

Taurine, folic acid, tea polyphenols are pulverized respectively, and granularity is 0.1-0.5mm;

The selected slag of removing of flaxseed; Adopt pressafiner that selected flaxseed is squeezed; Again siritch is removed slag, add water and regulate pH value 5.5-6.5, at water temperature 55-65 ℃, fully stir, remove moisture after then precipitating two hours namely to get the refine siritch;

(2) with siritch, the extract such as the Radix Astragali, Radix Rehmanniae Preparata, the Rhizoma Anemarrhenae, Semen Ziziphi Spinosae, Herba Centellae and folic acid, tea polyphenols, taurine, cephalin mix in proportion;

(3) press 0.6g/ grain dress soft capsule after mix homogeneously.