CN103099998A - 治疗糖尿病肾病的中药汤剂 - Google Patents
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Abstract
本发明涉及一种药物配方领域，具体地说是一种治疗糖尿病肾病的中药汤剂，其特征是，原料药组成以重量百分比计为：法半夏10～11％，陈皮7～10％，白术7～10％，茯苓7～10％，薏苡仁4～6％，山药7～10％，黄芪7～10％，熟地4～6％，山萸肉7～10％，桂枝4～6％，甘草2～3％，益母草7～10％，泽兰7～10％，红花2～3％，丹参4～6％，将上述15味原料药用水浸泡，煎熬后去渣得滤液。本发明疗效确切，成本低廉，无毒副作用。
Description
技术领域
本发明涉及一种中成药制剂，具体地说是一种用于治疗糖尿病肾病的中药汤剂。
背景技术
众所周知，糖尿病(diabetes mellitus)是一组由于胰岛素分泌和(或)作用缺陷所引起的以慢性血糖水平增高为特征的代谢性疾病。长期碳水化合物以及脂肪、蛋白质代谢紊乱可引起多系统损害，导致眼、肾、神经、心脏、血管等组织器官的慢性进行性病变、功能减退及衰竭。糖尿病病人一旦发生肾脏损害出现持续性蛋白尿，则病情很难逆转，临床特征为蛋白尿，渐进性肾功能损害，高血压，水肿，晚期出现严重肾功能衰竭。糖尿病肾病使患者生活质量降低，寿命缩短，病死率增高，已成为糖尿病病人死亡的主要原因之一，应积极防治。糖尿病的病因和发病机制尚未完全阐明，因此缺乏针对病因的治疗，目前糖尿病肾病的治疗主要是应用西药降低血糖、血压，配合低盐低脂优质低蛋白糖尿病饮食，强调早期、长期、积极而理性地纠正代谢紊乱，避免加重肾脏负担的因素，预防或延缓其发展。应用西药难免要经过肾脏代谢，加重肾脏毒性，且长期应用花费较大，效果不佳。中医药在糖尿病肾病的治疗中有其独特性与优越性，成本低，毒副作用小，疗效好。然而到目前为止，较理想且定型批量生产的治疗糖尿病肾病的中药制剂国内外尚未见到。
发明内容
本发明的目的就是为了克服上述现有的技术不足，提供一种疗效确切，成本低廉，无毒副作用的治疗糖尿病肾病的中药汤剂。
本发明解决上述技术问题采用的技术方案是：一种治疗糖尿病肾病的中药汤剂，其特征是，原料药组成以重量百分比计为：法半夏10～11％，陈皮7～10％，白术7～10％，茯苓7～10％，薏苡仁4～6％，山药7～10％，黄芪7～10％，熟地4～6％，山萸肉7～10％，桂枝4～6％，甘草2～3％，益母草7～10％，泽兰7～10％，红花2～3％，丹参4～6％，将上述15味原料药用水浸泡，煎熬后去渣得滤液。
本发明的有益效果是，疗效确切，成本低廉，无毒副作用。
具体实施方式
下面结合实施例对本发明作进一步的描述：
治疗原则
本发明原料成本低，治疗糖尿病肾病效果好，安全无毒副作用。我国传统医学中曾有“消渴”症发生机理的记载：“饮入于胃，游溢精气，上输于脾，脾气散精，上归于肺，通调水道，下输膀胱，水精四布，今人多嗜食寒凉，损伤脾胃，致运化失职，精气不能送达各脏腑、经脉，致痰湿内盛，久之发为消渴”。痰由湿生，脾为生痰之源，治痰当健脾，肾主水，若肾不治水，则水泛亦可为痰。治之当健脾补肾。消渴多伴有血脉涩滞、瘀血痹阻等病变，治之当活血化瘀。法半夏、陈皮为君药，燥湿化痰，主治痰湿内盛。茯苓、薏苡仁、白术、桂枝为臣药，茯苓、薏苡仁利水渗湿，健脾；白术补气健脾，燥湿利水；桂枝助阳化气，以行水湿。山药、黄芪、熟地、山萸肉、益母草、红花、丹参、泽兰为佐药，山药益气养阴，补脾肺肾；黄芪补气升阳，利水消肿；熟地益肾滋阴；山萸肉温肾助阳；益母草、泽兰活血化瘀、利水消肿；丹参、红花活血化瘀。甘草为使药，益气补中，调和药性。15味中药之间相偎相依，使药物疗效增强，提高主药功效，并使其毒副作用减轻或消失，以达到健脾、补肾、燥湿化疾、利水消肿，治疗糖尿病肾病之特效。
下面结合我院，即山东省威海市文登中心医院进行的临床试验对本发明作进一步、详细地描述：
1、入组标准：年龄35～75岁，糖尿病病程为10～40年，无严重急性糖尿病并发症者，存在III期及III期以上糖尿病肾病，但尚不需要透析的患者。
2、糖尿病诊断标准：根据1999年WHO关于糖尿病的诊断标准：(1)糖尿病症状(多饮、多尿、多食、消瘦)+任意时间血浆葡萄糖水平≥11.1mmol/L或(2)空腹血浆葡萄糖水平≥7.0mmol/L或(3)OGTT试验中，2h血浆葡萄糖水平≥11.1mmol/L。(注：对于无糖尿病症状，仅一次血糖水平达标者，需复测一次，予以证实，诊断才能成立。)
糖尿病肾病诊断标准：常见于有10年以上糖尿病病史者，根据肾损害的发生发展可分为五期：I期：为糖尿病初期，肾体积增大，肾小球滤过率升高，肾小球入球小动脉扩张，肾小球内压增加；II期：肾小球毛细血管基底膜增厚，尿蛋白排泄率多数在正常范围内，或呈间歇性增高(如运动后)；III期：早期肾病，出现微量白蛋白尿，即尿蛋白排泄率持续在20～199ug/min(或在30～300mg/24h之间)；IV期：临床肾病，增多，尿蛋白逐渐增多，尿蛋白排泄率大于300mg/24h，肾小球滤过率下降，可伴有浮肿和高血压，肾功能逐渐减退；V期：尿毒症，多数肾单位闭锁，肾小球滤过率降低，血肌酐、尿素氮升高，血压升高。
3、排除标准：不符合上述入组标准或诊断标准者；妊娠或哺乳期妇女、过敏体质及对本药过敏者；合并有糖尿病急性并发症如糖尿病酮症酸中毒、高血糖高渗状态、乳酸酸中毒等严重代谢紊乱或严重感染者；合并有急性心血管、脑血管病变、精神病者；需要行透析治疗者；不能停用影响该药疗效药物者；其他可能引起其增加的原因，如泌尿系感染、运动、原发性高血压、心衰及水负荷增加等。
4、疗效标准：显效：尿蛋白、血肌酐降至正常。有效：尿蛋白下降50％及以上，但仍高于正常，血肌酐无进一步升高。无效：尿蛋白无明显下降甚至升高或血肌酐进一步升高者。
5、治疗方法：每日一剂分两次口服，每次空腹服150ml左右，七天一疗程，一般用五个疗程。
下面结合实施例对本发明进一步描述：
实施例1：本实施例按上述标准共选择糖尿病肾病患者50例，男28例，女22例，平均年龄60.5岁，平均病程16.7年。均服用此汤剂，采用法半夏、陈皮、白术、茯苓、薏苡仁、山药、黄芪、熟地、山萸肉、桂枝、甘草、益母草、泽兰、红花、丹参为原料制备而成。其组成(重量％)，每付为法半夏10.0、陈皮7.3、白术7.2、茯苓7.4、薏苡仁5.7、山药8.1、黄芪8.8、熟地4.9、山萸肉8.9、桂枝5.5、甘草2.4、益母草7.9、泽兰8.7、红花2.6、丹参4.6。取上述15种原料，总重量为250g，在室温下将15种中草药加水至900～1000ml，浸泡4小时，然后用武火煮沸文火煎熬至100～120分钟左右，去渣得滤液200ml左右，药渣再加水300～400ml，煎熬30～40分钟，去渣得滤液100ml左右，两遍共煎熬药汤300ml左右。每日一剂分两次口服，每次空腹服150ml左右，七天一疗程，用五个疗程。
治疗结果：显效4例，有效43例，无效3例，显效率8％，有效率86％，无效率6％，总有效率为94％。
实施例2：本实施例按上述标准共选择糖尿病肾病患者50例，男30例，女20例，平均年龄65.6岁，平均病程18.6年。均服用此汤剂。采用法半夏、陈皮、白术、茯苓、薏苡仁、山药、黄芪、熟地、山萸肉、桂枝、甘草、益母草、泽兰、红花、丹参为原料药制备而成。其组成(重量％)，每付为法半夏10.0、陈皮8.3、白术7.3、茯苓7.3、薏苡仁5.7、山药8.0、黄芪8.0、熟地5.9、山萸肉7.9、桂枝5.3、甘草2.4、益母草8.0、泽兰8.7、红花2.6、丹参4.6。取上述15种原料，总重量为250g，在室温下将15种中草药加水至900～1000ml，浸泡4小时，然后用武火煮沸文火煎熬至100～120分钟左右，去渣得滤液200ml左右，药渣再加水300～400ml，煎熬30～40分钟，去渣得滤液100ml左右，两遍共煎熬药汤300ml左右。每日一剂分两次口服，每次空腹服150ml左右，七天一疗程，用五个疗程。
治疗结果：显效8例，有效38例，无效4例，显效率16％，有效率76％，无效率8％，总有效率为92％。
本发明各原料药还可按下表所列比例(重量百分比)混合的实施例来实现。其加工工艺与实施例1相同。
Claims (1)
1.一种治疗糖尿病肾病的中药汤剂，其特征是：原料药组成以重量百分比计为：法半夏10～11％，陈皮7～10％，白术7～10％，茯苓7～10％，薏苡仁4～6％，山药7～10％，黄芪7～10％，熟地4～6％，山萸肉7～10％，桂枝4～6％，甘草2～3％，益母草7～10％，泽兰7～10％，红花2～3％，丹参4～6％，将上述15味原料药用水浸泡，煎熬后去渣得滤液。
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| CN108324843A (zh) * | 2018-05-17 | 2018-07-27 | 重庆跃龙生物制药有限公司 | 用于治疗肾病的中药组合物及其制备方法 |
| CN115779029A (zh) * | 2022-12-23 | 2023-03-14 | 广州市番禺区中医院 | 一种低钾含量的口服肾病中药汤剂的制备方法 |
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| CN115779029A (zh) * | 2022-12-23 | 2023-03-14 | 广州市番禺区中医院 | 一种低钾含量的口服肾病中药汤剂的制备方法 |
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